Prion shedding from olfactory neurons into nasal secretions

scientific article (publication date: April 2010)

Prion shedding from olfactory neurons into nasal secretions is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PPAT.1000837
P3181OpenCitations bibliographic resource ID4024563
P932PMC publication ID2855443
P698PubMed publication ID20419120
P5875ResearchGate publication ID43343453

P50authorByron CaugheyQ87076179
P2093author name stringRichard A Bessen
Jason M Wilham
Harold Shearin
James A Wiley
Scott Martinka
Diana Lowe
Ryan Boharski
P2860cites workAsymptomatic deer excrete infectious prions in faecesQ24635252
Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy.Q30420123
Prion infection of oral and nasal mucosaQ33239798
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Prions in milk from ewes incubating natural scrapieQ33392686
Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassayQ33419079
Two alleles of a neural protein gene linked to scrapie in sheepQ33495492
Preclinical deposition of pathological prion protein PrPSc in muscles of hamsters orally exposed to scrapieQ33785315
Measurement of the scrapie agent using an incubation time interval assayQ34270376
Rapid prion neuroinvasion following tongue infectionQ34462142
Infectious prions in the saliva and blood of deer with chronic wasting diseaseQ34571835
Peripheral tissue involvement in sporadic, iatrogenic, and variant Creutzfeldt-Jakob disease: an immunohistochemical, quantitative, and biochemical studyQ35083260
The nasal cavity is a route for prion infection in hamstersQ35857428
Environmental sources of prion transmission in mule deerQ35880452
Experimental transmission of scrapie agent to susceptible sheep by intralingual or intracerebral inoculationQ36226126
Signal transduction in olfactory neuronsQ36422759
Olfactory neurogenesis: genetic or environmental controls?Q36601172
Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteinsQ36919750
Role of the lymphoreticular system in prion neuroinvasion from the oral and nasal mucosaQ37232900
Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion proteinQ37285506
Early postnatal alcohol exposure acutely and permanently reduces the number of granule cells and mitral cells in the rat olfactory bulb: a stereological studyQ41099997
Faecal shedding, alimentary clearance and intestinal spread of prions in hamsters fed with scrapieQ41538796
Olfactory system involvement in natural scrapie disease.Q41936997
Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapieQ42693681
Transmission of prion diseases by blood transfusionQ44186164
Natural infection of Suffolk sheep with scrapie virusQ45794198
Course of experimental scrapie virus infection in the goatQ45825585
The Syrian hamster as a model for the study of slow virus diseases caused by unconventional agentsQ45890576
Restriction fragment length polymorphisms of the scrapie-associated fibril protein (PrP) gene and their association with susceptibility to natural scrapie in British sheepQ47573187
Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob diseaseQ48152236
Scrapie infectivity and proteinase K-resistant prion protein in sheep placenta, brain, spleen, and lymph node: implications for transmission and antemortem diagnosisQ48356179
Isolation and characterization of rat olfactory marker proteinQ48356340
Isolation of scrapie agent from the placenta of sheep with natural scrapie in JapanQ48373302
Detection of pathologic prion protein in the olfactory epithelium in sporadic Creutzfeldt-Jakob diseaseQ48384269
Different prion conformers target the olfactory pathway in sporadic Creutzfeldt-Jakob diseaseQ48483487
Identification of two biologically distinct strains of transmissible mink encephalopathy in hamstersQ48540661
Ablation of the olfactory bulb up-regulates the rate of neurogenesis and induces precocious cell death in olfactory epitheliumQ48555118
Comparison of histological lesions and immunohistochemical staining of proteinase-resistant prion protein in a naturally occurring spongiform encephalopathy of free-ranging mule deer (Odocoileus hemionus) with those of chronic wasting disease of capQ48558348
Coincident scrapie infection and nephritis lead to urinary prion excretionQ48730761
Chronic wasting disease in a Wisconsin white-tailed deer farmQ48934644
Neuroinvasion of the 263K scrapie strain after intranasal administration occurs through olfactory-unrelated pathways.Q51782975
Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking.Q51790930
Urinary excretion and blood level of prions in scrapie-infected hamsters.Q51794689
Evidence for the disproportionate mapping of olfactory airspace onto the main olfactory bulb of the hamster.Q51825553
Expression and localization of the prion protein PrP(C) in the olfactory system of the mouse.Q51962065
PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis.Q54254632
PrPSc in mammary glands of sheep affected by scrapie and mastitisQ57083648
Prion deposition in olfactory biopsy of sporadic Creutzfeldt-Jakob diseaseQ59505845
Elimination of natural scrapie in sheep by sire genotype selectionQ67465436
Epizootiology of chronic wasting disease in free-ranging cervids in Colorado and WyomingQ73207885
Scrapie: A transmissible and hereditary disease of sheepQ79047277
Epidemiology of chronic wasting disease in captive white-tailed and mule deerQ80553962
High incidence of subclinical infection of lymphoid tissues in scrapie-affected sheep flocksQ80567595
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectprion protein familyQ24724413
P304page(s)e1000837
P577publication date2010-04-01
P1433published inPLOS PathogensQ283209
P1476titlePrion shedding from olfactory neurons into nasal secretions
P478volume6

Reverse relations

cites work (P2860)
Q34293962A test for Creutzfeldt-Jakob disease using nasal brushings
Q35689662Accelerated shedding of prions following damage to the olfactory epithelium
Q36734911Antemortem Detection of Chronic Wasting Disease Prions in Nasal Brush Collections and Rectal Biopsy Specimens from White-Tailed Deer by Real-Time Quaking-Induced Conversion
Q34057962Axonal and transynaptic spread of prions
Q90597989Detection of Pathognomonic Biomarker PrPSc and the Contribution of Cell Free-Amplification Techniques to the Diagnosis of Prion Diseases
Q36086340Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype
Q46251829How do PrPSc Prions Spread between Host Species, and within Hosts?
Q35735220Identification of novel putative-binding proteins for cellular prion protein and a specific interaction with the STIP1 homology and U-Box-containing protein 1.
Q37409418Intra-host mathematical model of chronic wasting disease dynamics in deer (Odocoileus).
Q34720600Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay
Q35231240Lesion of the olfactory epithelium accelerates prion neuroinvasion and disease onset when prion replication is restricted to neurons
Q37006741Mucosal transmission and pathogenesis of chronic wasting disease in ferrets
Q37993987New generation QuIC assays for prion seeding activity
Q36159486Particle-size dependent effects in the Balb/c murine model of inhalational melioidosis
Q36326862PrPSc formation and clearance as determinants of prion tropism
Q30436588Preclinical detection of variant CJD and BSE prions in blood
Q46451539Prion Strain Diversity
Q35006294Prion disease blood test using immunoprecipitation and improved quaking-induced conversion
Q39330702Prion pathogenesis and secondary lymphoid organs (SLO): tracking the SLO spread of prions to the brain
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Q35137829The sheddase ADAM10 is a potent modulator of prion disease.
Q27311657Transmission of chronic wasting disease identifies a prion strain causing cachexia and heart infection in hamsters

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