A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle

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A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...988226M
P356DOI10.1371/JOURNAL.PONE.0088226
P932PMC publication ID3914967
P698PubMed publication ID24505439
P5875ResearchGate publication ID260127587

P50authorKevin M. FlaniganQ41827189
P2093author name stringRui Xu
Ajit Varki
Joe N Kornegay
Paul T Martin
Kumaran Chandrasekharan
Marybeth Camboni
Jonathan Okerblom
Bethannie Golden
P2860cites workUtrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophyQ24310537
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Overexpression of the CT GalNAc transferase in skeletal muscle alters myofiber growth, neuromuscular structure, and laminin expression.Q45973809
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Myofiber injury and regeneration in a canine homologue of Duchenne muscular dystrophy.Q32122092
Overexpression of the cytotoxic T cell GalNAc transferase in skeletal muscle inhibits muscular dystrophy in mdx miceQ34025748
Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acidQ34044438
Loss of N-glycolylneuraminic acid in humans: Mechanisms, consequences, and implications for hominid evolutionQ34109076
A Human-Specific Deletion in Mouse Cmah Increases Disease Severity in the mdx Model of Duchenne Muscular DystrophyQ34175938
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A sialylated glycan microarray reveals novel interactions of modified sialic acids with proteins and viruses.Q35213210
Postnatal overexpression of the CT GalNAc transferase inhibits muscular dystrophy in mdx mice without altering muscle growth or neuromuscular development: evidence for a utrophin-independent mechanismQ35867446
Overexpression of the cytotoxic T cell (CT) carbohydrate inhibits muscular dystrophy in the dyW mouse model of congenital muscular dystrophy 1A.Q35928246
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Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies.Q36143635
Metabolism of vertebrate amino sugars with N-glycolyl groups: mechanisms underlying gastrointestinal incorporation of the non-human sialic acid xeno-autoantigen N-glycolylneuraminic acidQ36217161
Role of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junctionQ36321503
Mechanisms of disease: congenital muscular dystrophies-glycosylation takes center stageQ36577280
Diversity in cell surface sialic acid presentations: implications for biology and diseaseQ36882467
N-Glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in α-sarcoglycan-deficient miceQ36900455
Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for diseaseQ36981219
Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type miceQ37139061
Overexpression of Galgt2 reduces dystrophic pathology in the skeletal muscles of alpha sarcoglycan-deficient miceQ37257159
The synaptic CT carbohydrate modulates binding and expression of extracellular matrix proteins in skeletal muscle: Partial dependence on utrophinQ37361308
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Canine models of Duchenne muscular dystrophy and their use in therapeutic strategiesQ37548291
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Characterization of a rat liver Golgi sulphotransferase responsible for the 6-O-sulphation of N-acetylglucosamine residues in beta-linkage to mannose: role in assembly of sialyl-galactosyl-N-acetylglucosamine 6-sulphate sequence of N-linked oligosacQ38352657
Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acidQ40053564
Definition of pre- and postsynaptic forms of the CT carbohydrate antigen at the neuromuscular junction: ubiquitous expression of the CT antigens and the CT GalNAc transferase in mouse tissuesQ40676930
N-acetyllactosamine and the CT carbohydrate antigen mediate agrin-dependent activation of MuSK and acetylcholine receptor clustering in skeletal muscleQ40874394
Distinct contributions of Galgt1 and Galgt2 to carbohydrate expression and function at the mouse neuromuscular junctionQ41267697
Molecular cloning of a murine N-acetylgalactosamine transferase cDNA that determines expression of the T lymphocyte-specific CT oligosaccharide differentiation antigenQ41466937
Distinct structures and functions of related pre- and postsynaptic carbohydrates at the mammalian neuromuscular junctionQ41644137
Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophiesQ42524150
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Eccentric contraction injury in dystrophic canine muscleQ44209525
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcytotoxicityQ246181
P304page(s)e88226
P577publication date2014-01-01
P1433published inPLOS OneQ564954
P1476titleA comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle
P478volume9

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cites work (P2860)
Q35097359A role for Galgt1 in skeletal muscle regeneration
Q39250748Biochemical, Cellular, Physiological, and Pathological Consequences of Human Loss of N-Glycolylneuraminic Acid.
Q49220622Increased Number of Circulating CD8/CD26 T Cells in the Blood of Duchenne Muscular Dystrophy Patients Is Associated with Augmented Binding of Adenosine Deaminase and Higher Muscular Strength Scores.
Q28077544Sialic acids as link to Japanese scientists
Q36105761The immune system in Duchenne muscular dystrophy: Friend or foe.

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