Integrins are Mechanosensors That Modulate Human Eosinophil Activation

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Integrins are Mechanosensors That Modulate Human Eosinophil Activation is …
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scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2015.00525
P8608Fatcat IDrelease_kn4y5syi7vg4va7emn6um4qntq
P932PMC publication ID4611147
P698PubMed publication ID26539194
P5875ResearchGate publication ID283511573

P2093author name stringRoma Sehmi
Luke J Janssen
Gail Gauvreau
Mike Small
Mustafa Ahmadzai
P2860cites workCloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophilsQ24562774
Pharmacology of the eosinophilQ28198022
Integrins in mechanotransductionQ28244898
New perspectives in cell adhesion: RGD and integrinsQ28280381
Eotaxin and the attraction of eosinophils to the asthmatic lungQ28362893
TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neuronsQ28585747
RGD and other recognition sequences for integrinsQ29616331
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophilsQ30504374
Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculatureQ30577853
Molecular basis for selective eosinophil trafficking in asthma: A multistep paradigm.Q33768110
Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective forceQ74582573
Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent mannerQ78807152
Eotaxin and eosinophil recruitment: implications for human diseaseQ33818733
Structural diversity of heparan sulfate binding domains in chemokinesQ34008721
Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases?Q34650918
Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motifQ34957225
Role of integrins in endothelial mechanosensing of shear stressQ34986187
Development of cell adhesion molecule antagonists as therapeutics for asthma and COPD.Q35595398
Structural basis for ligand recognition by RGD (Arg-Gly-Asp)-dependent integrinsQ35780399
Downregulation of Orai1 expression in the airway alleviates murine allergic rhinitisQ35865611
Vascular adhesion and transendothelial migration of eosinophil leukocytesQ35971546
Vascular wall shear stress: basic principles and methodsQ36088108
Interactions between heparan sulfate and proteins: the concept of specificityQ36552851
Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cellsQ36714858
Structure and mechanics of integrin-based cell adhesion.Q36744293
Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthmaQ36955887
Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cellsQ37171421
Beta2-integrin-mediated adhesion and intracellular Ca2+ release in human eosinophilsQ37283120
Recent advances in the pathophysiology of asthmaQ37762906
Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac functionQ37866169
Calcium Signalling during ChemotaxisQ39373105
G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophilsQ40325163
Selective upregulation of a functional beta7 integrin on differentiating eosinophilsQ40852878
Heparin inhibits ligand binding to the leukocyte integrin Mac-1 (CD11b/CD18).Q40925118
Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1.Q41042587
Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in miceQ41892162
Dissection of the hyperadhesive phenotype of airway eosinophils in asthmaQ41975092
A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats.Q42108571
Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch.Q42456153
Regulation of eosinophil adhesion by lysophosphatidylcholine via a non-store-operated Ca2+ channelQ42738483
Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flowQ44028882
Effect of extracellular matrix proteins on platelet-activating factor-induced eosinophil chemotaxisQ44029081
De-activation of neutrophils in suspension by fluid shear stress: a requirement for erythrocytesQ46454804
Expression and function of beta 1 integrins on human eosinophilsQ47707488
A critical role for eosinophils in allergic airways remodelingQ47925478
Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectinQ48080719
Transforming growth factor-β evokes Ca2+ waves and enhances gene expression in human pulmonary fibroblasts.Q50503827
Eotaxin selectively binds heparin. An interaction that protects eotaxin from proteolysis and potentiates chemotactic activity in vivo.Q53563511
VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow.Q54066420
Adhesion of Eosinophils to Endothelial Cells or Substrates Under Flow ConditionsQ55173850
Transcytosis and Surface Presentation of IL-8 by Venular Endothelial CellsQ57419171
Integrin receptors and RGD sequences in human keratinocyte migration: unique anti-migratory function of alpha 3 beta 1 epiligrin receptorQ68101378
Actin polymerization in human eosinophils, unlike human neutrophils, depends on intracellular calcium mobilizationQ71131496
L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivoQ71651106
Recombinant human eotaxin induces oxygen radical production, Ca(2+)-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding proteinQ71692466
Effect of isolation protocol on eosinophil function: Percoll gradients versus immunomagnetic beadsQ71771054
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjecthuman eosinophilQ101405048
P304page(s)525
P577publication date2015-10-20
P1433published inFrontiers in ImmunologyQ27723748
P1476titleIntegrins are Mechanosensors That Modulate Human Eosinophil Activation
P478volume6

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cites work (P2860)
Q56362461DS-70, a novel and potent α integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs
Q90190381In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma
Q37570406Suppression of Eosinophil Integrins Prevents Remodeling of Airway Smooth Muscle in Asthma
Q92825638The Enhanced Adhesion of Eosinophils Is Associated with Their Prolonged Viability and Pro-Proliferative Effect in Asthma

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