| scholarly article | Q13442814 |
| P50 | author | Gary Ruvkun | Q504021 |
| P2093 | author name string | David E Shore | |
| Christopher E Carr | |||
| P2860 | cites work | Fitness cost of extended lifespan in Caenorhabditis elegans | Q81122952 |
| Most Caenorhabditis elegans microRNAs are individually not essential for development or viability | Q21563452 | ||
| Aging and resistance to oxidative damage in Caenorhabditis elegans | Q24561446 | ||
| Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress | Q24564321 | ||
| Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging | Q24643933 | ||
| Is the oxidative stress theory of aging dead? | Q24645213 | ||
| New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen | Q24811634 | ||
| HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans | Q27312348 | ||
| A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans | Q27312436 | ||
| Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegans | Q27318409 | ||
| Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity | Q27339698 | ||
| Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans | Q27347875 | ||
| Aging: a theory based on free radical and radiation chemistry | Q27860549 | ||
| Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans | Q27860971 | ||
| Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution | Q28114871 | ||
| The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans | Q28131830 | ||
| IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA | Q28214814 | ||
| Functional genomic analysis of RNA interference in C. elegans | Q28241721 | ||
| Stress-activated cap'n'collar transcription factors in aging and human disease | Q28384783 | ||
| The cell-non-autonomous nature of electron transport chain-mediated longevity | Q29617238 | ||
| Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans | Q29619580 | ||
| Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor | Q29619759 | ||
| Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. | Q53926483 | ||
| The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. | Q54084101 | ||
| A conserved transcription motif suggesting functional parallels between Caenorhabditis elegans SKN-1 and Cap'n'Collar-related basic leucine zipper proteins | Q73675896 | ||
| MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing | Q29619773 | ||
| Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules | Q30479192 | ||
| Proteasomal regulation of the hypoxic response modulates aging in C. elegans | Q30489976 | ||
| Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans | Q30840424 | ||
| A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans | Q30935411 | ||
| Novel and stress-regulated microRNAs and other small RNAs from Arabidopsis | Q31095568 | ||
| Lifespan regulation by evolutionarily conserved genes essential for viability | Q33281293 | ||
| Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation | Q33292491 | ||
| SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network | Q33690581 | ||
| C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1. | Q33701707 | ||
| Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans | Q33721238 | ||
| FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1. | Q33819103 | ||
| Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity | Q33850583 | ||
| Vascular heat shock protein expression in response to stress. Endocrine and autonomic regulation of this age-dependent response | Q33889535 | ||
| A systematic RNAi screen for longevity genes in C. elegans | Q33891931 | ||
| Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity | Q34006688 | ||
| Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans | Q34197008 | ||
| Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans. | Q34416427 | ||
| The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach | Q34468457 | ||
| MicroRNAs both promote and antagonize longevity in C. elegans. | Q34502279 | ||
| Analysis of homologous gene clusters in Caenorhabditis elegans reveals striking regional cluster domains | Q34587143 | ||
| Mevalonate pathway: a review of clinical and therapeutical implications | Q34623889 | ||
| A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans | Q34684624 | ||
| A whole-genome RNAi Screen for C. elegans miRNA pathway genes | Q34714794 | ||
| Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease. | Q34757207 | ||
| Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans | Q34784199 | ||
| The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation | Q34974831 | ||
| Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity | Q35016513 | ||
| Oxidative stress and aging: beyond correlation | Q35185561 | ||
| Immunity in Caenorhabditis elegans | Q35634005 | ||
| Regulation of aging and innate immunity in C. elegans | Q35842737 | ||
| Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans | Q35875150 | ||
| Oxidative stress enzymes are required for DAF-16-mediated immunity due to generation of reactive oxygen species by Caenorhabditis elegans | Q35910961 | ||
| The role of oxidative damage and stress in aging. | Q35947926 | ||
| Specificity and complexity of the Caenorhabditis elegans innate immune response | Q35950030 | ||
| Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling? | Q36017390 | ||
| Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants | Q36103657 | ||
| A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response | Q36325612 | ||
| Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans | Q36657540 | ||
| Small RNA regulators and the bacterial response to stress | Q36668567 | ||
| Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses | Q36731013 | ||
| Function and localization of microRNAs in mammalian cells | Q36768065 | ||
| The role of small RNAs in abiotic stress. | Q36798714 | ||
| Small RNAs as big players in plant abiotic stress responses and nutrient deprivation | Q36850938 | ||
| Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans | Q37010759 | ||
| Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans | Q37385784 | ||
| Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. | Q37419745 | ||
| Deceptively simple but simply deceptive--Caenorhabditis elegans lifespan studies: considerations for aging and antioxidant effects | Q37611164 | ||
| Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats | Q37679765 | ||
| Small RNAs are on the move. | Q37791829 | ||
| Invited review: decoding the microRNA response to hypoxia. | Q37826096 | ||
| Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods | Q38289471 | ||
| Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance | Q38337791 | ||
| The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner | Q39100343 | ||
| Identification of stress-responsive genes in Caenorhabditis elegans using RT-PCR differential display | Q39512993 | ||
| Synchronous Growth and Aging of Caenorhabditis elegans in the Presence of Fluorodeoxyuridine | Q39872065 | ||
| Sterilization and growth inhibition of Caenorhabditis elegans by 5-fluorodeoxyuridine | Q39874356 | ||
| SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response | Q39896060 | ||
| Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria | Q41462739 | ||
| Activation of SKN-1 by novel kinases in Caenorhabditis elegans | Q41789646 | ||
| C. elegans detects pathogen-induced translational inhibition to activate immune signaling | Q42132857 | ||
| Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans | Q42132873 | ||
| Oxidative stress and ageing in Caenorhabditis elegans | Q42239558 | ||
| Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. | Q42534346 | ||
| The use of FUdR can cause prolonged longevity in mutant nematodes | Q43126160 | ||
| Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone | Q44941219 | ||
| Insulin signaling and the heat shock response modulate protein homeostasis in the Caenorhabditis elegans intestine during infection | Q46939316 | ||
| Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans | Q47068785 | ||
| Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones | Q47069260 | ||
| A small, stable RNA induced by oxidative stress: role as a pleiotropic regulator and antimutator | Q48047346 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | lifetime | Q22675021 |
| P304 | page(s) | e1002792 | |
| P577 | publication date | 2012-01-01 | |
| P1433 | published in | PLOS Genetics | Q1893441 |
| P1476 | title | Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways | |
| P478 | volume | 8 |
| Q40664325 | A Genome-Scale Database and Reconstruction of Caenorhabditis elegans Metabolism |
| Q33754491 | A cytoprotective perspective on longevity regulation |
| Q58734390 | A novel gene-diet pair modulates C. elegans aging |
| Q35019751 | A pharmacological network for lifespan extension in Caenorhabditis elegans |
| Q36003584 | A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes |
| Q27320732 | A shift to organismal stress resistance in programmed cell death mutants |
| Q37699083 | Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans |
| Q92090772 | Air Pollution Alters Caenorhabditis elegans Development and Lifespan: Responses to Traffic-Related Nanoparticulate Matter |
| Q34038251 | Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome |
| Q37361030 | An intestinal microRNA modulates the homeostatic adaptation to chronic oxidative stress in C. elegans |
| Q36410016 | Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response |
| Q58113705 | BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in |
| Q35598545 | Caloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo |
| Q41549003 | Cell cycle controls stress response and longevity in C. elegans |
| Q52621271 | Combined flow cytometry and high-throughput image analysis for the study of essential genes in Caenorhabditis elegans. |
| Q27308709 | DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans |
| Q27308993 | Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans |
| Q36974730 | Detection of Burkholderia pseudomallei toxin-mediated inhibition of protein synthesis using a Caenorhabditis elegans ugt-29 biosensor |
| Q35377033 | Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively |
| Q37234618 | Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes |
| Q37671736 | Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators |
| Q33895695 | Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium. |
| Q90381677 | Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging |
| Q47655102 | Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease. |
| Q33698052 | FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans |
| Q37353652 | Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice |
| Q40627472 | GATA transcription factor as a likely key regulator of the Caenorhabditis elegans innate immune response against gut pathogens |
| Q36494490 | GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling |
| Q60054294 | Glucose negatively affects Nrf2/SKN-1-mediated innate immunity in |
| Q28390350 | Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice |
| Q27005955 | Heart failure and mitochondrial dysfunction: the role of mitochondrial fission/fusion abnormalities and new therapeutic strategies |
| Q36067056 | Hormetic effect of rotenone in primary human fibroblasts |
| Q37651955 | Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans |
| Q90314901 | Hypodermal responses to protein synthesis inhibition induce systemic developmental arrest and AMPK-dependent survival in Caenorhabditis elegans |
| Q34808934 | Hypothalamic microinflammation: a common basis of metabolic syndrome and aging |
| Q27322992 | Identification of a tissue-selective heat shock response regulatory network |
| Q41880704 | Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans |
| Q37214806 | Inactivation of GABAA receptor is related to heat shock stress response in organism model Caenorhabditis elegans |
| Q28081455 | Insulin, aging, and the brain: mechanisms and implications |
| Q92185952 | KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants |
| Q35082235 | Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. |
| Q33626717 | Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice |
| Q26862860 | Mitohormesis |
| Q37035950 | Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis. |
| Q37400090 | Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response |
| Q38588866 | Nuclear hormone receptors: Roles of xenobiotic detoxification and sterol homeostasis in healthy aging |
| Q41348691 | Pharynx mitochondrial [Ca2+] dynamics in live C. elegans worms during aging |
| Q27346904 | Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans |
| Q38656102 | Proteostasis and ageing: insights from long-lived mutant mice. |
| Q38662553 | Proteostasis and aging |
| Q26830832 | Proteostasis and longevity: when does aging really begin? |
| Q101237342 | ROS networks: designs, aging, Parkinson's disease and precision therapies |
| Q35987521 | Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction |
| Q36931039 | Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans |
| Q36998101 | Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion |
| Q35093137 | The GATA transcription factor/MTA-1 homolog egr-1 promotes longevity and stress resistance in Caenorhabditis elegans |
| Q35131077 | The Mediator complex of Caenorhabditis elegans: insights into the developmental and physiological roles of a conserved transcriptional coregulator |
| Q41937140 | The conserved Mediator subunit MDT-15 is required for oxidative stress responses in Caenorhabditis elegans |
| Q33723766 | The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation? |
| Q35866891 | Transdifferentiation mediated tumor suppression by the endoplasmic reticulum stress sensor IRE-1 in C. elegans |
| Q59329148 | Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms |
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