MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice

scientific article (publication date: August 2013)

MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1003535
P8608Fatcat IDrelease_scgshxfbvbdopf4f7uhg5w4nee
P932PMC publication ID3744406
P698PubMed publication ID23966857
P5875ResearchGate publication ID256076751

P50authorCraig W. RobertsQ37379025
Stuart WoodsQ56559654
Robin PlevinQ64500306
Juliane SchroederQ80803993
P2093author name stringJames Alexander
Helen A McGachy
P2860cites workDisruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.Q22255523
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTPQ24679086
Hepatitis C virus targets over-expression of arginase I in hepatocarcinogenesisQ27488846
Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasisQ28475723
Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expressionQ38435511
Effect of cytokines on growth of Toxoplasma gondii in murine astrocytesQ39573333
Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cellsQ39745087
Regulation of Toxoplasma gondii multiplication in BeWo trophoblast cells: cross-regulation of nitric oxide production and polyamine biosynthesisQ40368859
Toxoplasma gondii lacks the enzymes required for de novo arginine biosynthesis and arginine starvation triggers cyst formationQ40581925
Selective inhibition and augmentation of alternative macrophage activation by progesterone.Q42726211
Toxoplasma gondii peroxiredoxin promotes altered macrophage function, caspase-1-dependent IL-1β secretion enhances parasite replicationQ42836798
Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo.Q46423511
Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondiiQ48112512
Inducible nitric oxide synthase is not required for long-term vaccine-based immunity against Toxoplasma gondiiQ48393059
IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondiiQ48393870
A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitisQ48819011
IL-4 is protective against development of toxoplasmic encephalitis.Q48917277
Production of nitric oxide (NO) is not essential for protection against acute Toxoplasma gondii infection in IRF-1-/- mice.Q52518296
Murine CD8+ cytotoxic T lymphocytes lyse Toxoplasma gondii-infected cells.Q54283162
Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondiiQ28506496
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infectionQ28586576
The gamma interferon (IFN-gamma)-inducible GTP-binding protein IGTP is necessary for toxoplasma vacuolar disruption and induces parasite egression in IFN-gamma-stimulated astrocytesQ30484263
The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4, and 5Q33531757
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.Q33591077
MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicanaQ33750045
p47 GTPases regulate Toxoplasma gondii survival in activated macrophagesQ33788028
Toll-like receptor 4 mediates tolerance in macrophages stimulated with Toxoplasma gondii-derived heat shock protein 70.Q33946805
Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection.Q33975360
Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP.Q34008942
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth controlQ34023014
L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenaseQ34116625
Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infectionQ34256786
Induction of bradyzoite-specific Toxoplasma gondii antigens in gamma interferon-treated mouse macrophagesQ34527995
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogensQ34657537
The role of cytokines and their signaling pathways in the regulation of immunity to Toxoplasma gondiiQ35027528
Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.Q35090382
Innate responses to Toxoplasma gondii in mice and humansQ35175437
Mechanisms of innate resistance to Toxoplasma gondii infectionQ35211714
Different roles for interleukin-4 during the course of Toxoplasma gondii infectionQ35474667
Bradyzoite-specific surface antigen SRS9 plays a role in maintaining Toxoplasma gondii persistence in the brain and in host control of parasite replication in the intestineQ35783712
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondiiQ36377044
Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivoQ36384832
Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infectionQ36412040
Understanding the multiple functions of Gr-1(+) cell subpopulations during microbial infectionQ37056347
Inhibition of growth of Toxoplasma gondii in cultured fibroblasts by human recombinant gamma interferon.Q37081863
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologueQ37087502
Arginase: an emerging key player in the mammalian immune systemQ37395887
Toll-like receptor initiated host defense against Toxoplasma gondiiQ37418141
Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection.Q37618059
The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondiiQ37904282
CD8+ T cells are the major lymphocyte subpopulation involved in the protective immune response to Toxoplasma gondii in mice.Q54297083
Partial depletion of CD4(+)CD25(+)Foxp3(+) T regulatory cells significantly increases morbidity during acute phase Toxoplasma gondii infection in resistant BALB/c miceQ57121929
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alphaQ57339973
Inhibition of nitric oxide production exacerbates chronic ocular toxoplasmosisQ61703853
Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2+ and Lyt-1+, L3T4+ T cells in miceQ68093960
Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activationQ72095787
Nitric oxide mediates the toxoplasmastatic activity of murine microglial cells in vitroQ72754512
IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondiiQ73755946
Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expressionQ83891080
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectToxoplasma gondiiQ131003
P304page(s)e1003535
P577publication date2013-08-15
P1433published inPLOS PathogensQ283209
P1476titleMAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice
P478volume9

Reverse relations

cites work (P2860)
Q92495301Dual-Specificity Phosphatases in Immunity and Infection: An Update
Q58542311Dual-specificity MAP kinase phosphatases in health and disease
Q37498932MAP kinase phosphatase 2 deficient mice develop attenuated experimental autoimmune encephalomyelitis through regulating dendritic cells and T cells.
Q39194237Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype
Q90403289Multi-Omics Studies Demonstrate Toxoplasma gondii-Induced Metabolic Reprogramming of Murine Dendritic Cells
Q61797055Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis
Q64232183The MAPK Signaling Pathways as a Novel Way in Regulation and Treatment of Parasitic Diseases
Q35824601Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection
Q92128801Whole Genome Microarray Analysis of DUSP4-Deletion Reveals A Novel Role for MAP Kinase Phosphatase-2 (MKP-2) in Macrophage Gene Expression and Function

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