The C-Terminal Hydrophobic Domain of Hepatitis C Virus RNA Polymerase NS5B Can Be Replaced with a Heterologous Domain of Poliovirus Protein 3A

scientific article (publication date: November 2006)

The C-Terminal Hydrophobic Domain of Hepatitis C Virus RNA Polymerase NS5B Can Be Replaced with a Heterologous Domain of Poliovirus Protein 3A is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.02072-05
P932PMC publication ID1642141
P698PubMed publication ID16971430
P5875ResearchGate publication ID6820432

P50authorEckard WimmerQ106692
P2093author name stringYing Liu
Aniko V Paul
Edison Mejia
Haekyung Lee
P2860cites workDeterminants of membrane association for poliovirus protein 3AB.Q46288229
Targeting of C-Terminal (Tail)-Anchored Proteins: Understanding how Cytoplasmic Activities are Anchored to Intracellular MembranesQ55113495
Expression of poliovirus nonstructural proteins in Escherichia coli cells. Modification of membrane permeability induced by 2B and 3AQ67854948
A membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptideQ72922743
Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitroQ24292814
Direct interaction between nucleolin and hepatitis C virus NS5BQ24317623
cis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genomeQ24563876
Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raftQ24600344
A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replicationQ24629747
Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coliQ27469346
De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virusQ27469625
De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymeraseQ27469633
Mutational analysis of bovine viral diarrhea virus RNA-dependent RNA polymerase.Q27469753
Oligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA PolymeraseQ27472872
The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segmentQ27472921
Thermodynamic and phylogenetic prediction of RNA secondary structures in the coding region of hepatitis C virusQ27472963
Automatic detection of conserved RNA structure elements in complete RNA virus genomesQ27473247
Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell CultureQ27473345
Protein-Protein Interactions between Hepatitis C Virus Nonstructural ProteinsQ27473469
Topology of the Membrane-Associated Hepatitis C Virus Protein NS4BQ27473470
Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic RepliconsQ27473471
Identification of a C-Terminal Regulatory Motif in Hepatitis C Virus RNA-Dependent RNA Polymerase: Structural and Biochemical AnalysisQ27477707
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activityQ27480890
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virusQ27486092
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active siteQ27619818
Efficient initiation of HCV RNA replication in cell cultureQ27860520
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell lineQ27860561
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virusQ29619471
An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5AQ29620628
Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replicationQ30014846
Interaction of hepatitis C virus proteins with host cell membranes and lipidsQ34160337
Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complexQ35593057
cis-acting lesions targeted to the hydrophobic domain of a poliovirus membrane protein involved in RNA replicationQ36702292
High frequency of single-base transitions and extreme frequency of precise multiple-base reversion mutations in poliovirusQ36907660
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replicationQ37596480
Inhibition of cellular protein secretion by poliovirus proteins 2B and 3AQ37694671
Similar structural basis for membrane localization and protein priming by an RNA-dependent RNA polymeraseQ38291516
Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activityQ38292825
The essential role of C-terminal residues in regulating the activity of hepatitis C virus RNA-dependent RNA polymerase.Q38361069
Complete protein linkage map of poliovirus P3 proteins: interaction of polymerase 3Dpol with VPg and with genetic variants of 3AB.Q39579789
Sequence determinants of 3A-mediated resistance to enviroxime in rhinoviruses and enterovirusesQ39875351
Characterization of the hepatitis C virus RNA replication complex associated with lipid raftsQ40543432
The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivoQ40579166
Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus repliconQ40584601
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymeraseQ40594605
Replication of hepatitis C virus RNA occurs in a membrane-bound replication complex containing nonstructural viral proteins and RNA.Q40633768
Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymeraseQ40780476
Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virusQ42987114
Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequenceQ42997275
Oligomeric interaction of hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymeraseQ43774982
Functional conservation of the hydrophobic domain of polypeptide 3AB between human rhinovirus and poliovirusQ45017267
Hepatitis C virus core protein binds to a C-terminal region of NS5B RNA polymeraseQ45733072
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectHepatitis C virusQ708693
virologyQ7215
PoliovirusQ70923324
hydrophobicityQ41854968
P304page(s)11343-54
P577publication date2006-11-01
P1433published inJournal of VirologyQ1251128
P1476titleThe C-Terminal Hydrophobic Domain of Hepatitis C Virus RNA Polymerase NS5B Can Be Replaced with a Heterologous Domain of Poliovirus Protein 3A
P478volume80

Reverse relations

cites work (P2860)
Q34190661Hepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNA-dependent RNA polymerase
Q38302903Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication
Q36827264Systematic analysis of enhancer and critical cis-acting RNA elements in the protein-encoding region of the hepatitis C virus genome

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