Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

scientific article

Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BMCL.2009.07.150
P932PMC publication ID2776708
P698PubMed publication ID19703770
P5875ResearchGate publication ID26763933

P50authorAlex StronginQ40290093
P2093author name stringBoris I Ratnikov
Sergey A Shiryaev
Ying Su
Nicholas D P Cosford
Ananda Herath
Shyama Sidique
P2860cites workIdentification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput ScreenQ27486814
Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput DockingQ27487538
Substrate inhibition kinetic model for West Nile virus NS2B-NS3 proteaseQ27487970
Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assaysQ33291906
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virusQ33313623
West Nile virus: Uganda, 1937, to New York City, 1999.Q34498833
West Nile virus in the vertebrate worldQ36015896
West Nile Virus NS2B/NS3 protease as an antiviral targetQ37320270
Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease.Q40456251
Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activityQ42981076
West Nile virusQ64127859
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectorganic chemistryQ11351
West Nile virusQ158856
clinical chemistryQ849994
drug discoveryQ1418791
allosteric inhibitorQ70361704
P304page(s)5773-7
P577publication date2009-10-01
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleStructure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase
P478volume19

Reverse relations

cites work (P2860)
Q400454853D-QSAR pharmacophore-based virtual screening, molecular docking and molecular dynamics simulation toward identifying lead compounds for NS2B-NS3 protease inhibitors
Q27680467Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus
Q38866173An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection
Q30145664Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists
Q91842125Crystal structure of ethyl 2-(5-amino-1-benzene-sulfonyl-3-oxo-2,3-di-hydro-1H-pyrazol-2-yl)acetate
Q63740164Design, Synthesis, Antiviral Evaluation, and SAR Studies of New 1-(Phenylsulfonyl)-1-Pyrazol-4-yl-Methylaniline Derivatives
Q34253261Discovery, synthesis, and in vitro evaluation of West Nile virus protease inhibitors based on the 9,10-dihydro-3H,4aH-1,3,9,10a-tetraazaphenanthren-4-one scaffold
Q35871359Identification of covalent active site inhibitors of dengue virus protease
Q50200220Iodine-catalyzed sulfenylation of pyrazolones using dimethyl sulfoxide as an oxidant
Q28480947Probing of exosites leads to novel inhibitor scaffolds of HCV NS3/4A proteinase
Q62485460Proteases from dengue, West Nile and Zika viruses as drug targets
Q33852451Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus
Q54557941Strategies Towards Protease Inhibitors for Emerging Flaviviruses.
Q39817292Structural and functional parameters of the flaviviral protease: a promising antiviral drug target
Q64286903Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library
Q40333119Structure-guided fragment-based in silico drug design of dengue protease inhibitors.
Q37118271Suzuki-Miyaura cross-coupling of potassium trifluoro(N-methylheteroaryl)borates with aryl and heteroaryl halides
Q48253186Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review
Q34836970Synthesis and in vitro evaluation of West Nile virus protease inhibitors based on the 1,3,4,5-tetrasubstituted 1H-pyrrol-2(5H)-one scaffold
Q31116042Synthesis and in vitro evaluation of West Nile virus protease inhibitors based on the 2-{6-[2-(5-phenyl-4H-{1,2,4]triazol-3-ylsulfanyl)acetylamino]benzothiazol-2-ylsulfanyl}acetamide scaffold
Q46187258Synthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl-N-substituted amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones.
Q34657530The flavivirus protease as a target for drug discovery
Q33738041Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase
Q37666750West Nile virus drug discovery

Search more.