Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts

scientific article

Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID1220881
P698PubMed publication ID10677374

P2093author name stringR H Begent
M K Boehm
S J Perkins
B J Sutton
P A Keep
J D Thornton
M K Sohi
T Wan
A L Corper
K A Chester
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A single chain Fv fragment of P-glycoprotein-specific monoclonal antibody C219. Design, expression, and crystal structure at 2.4 A resolutionQ27747537
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Solvent content of protein crystalsQ27860807
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Automated classification of antibody complementarity determining region 3 of the heavy chain (H3) loops into canonical forms and its application to protein structure prediction.Q30430828
Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coliQ33638891
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An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarityQ36270017
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Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial libraryQ36816741
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Domain association in immunoglobulin molecules. The packing of variable domainsQ44715886
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Extended glycoprotein structure of the seven domains in human carcinoembryonic antigen by X-ray and neutron solution scattering and an automated curve fitting procedure: implications for cellular adhesionQ47629306
Anatomy of an antibody molecule: structure, kinetics, thermodynamics and mutational studies of the antilysozyme antibody D1.3.Q47700146
Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences.Q52641055
Recombinant anti-sialidase single-chain variable fragment antibody. Characterization, formation of dimer and higher-molecular-mass multimers and the solution of the crystal structure of the single-chain variable fragment/sialidase complex.Q54636019
Identification of specificity-determining residues in antibodiesQ57985940
On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligandsQ67656994
Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin formsQ68141138
Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion moleculeQ69579655
Structural patterns at residue positions 9, 18, 67 and 82 in the VH framework regions of human and murine immunoglobulinsQ70602546
Structural classification of CDR-H3 in antibodiesQ71937510
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
crystal structureQ895901
P304page(s)519-28
P577publication date2000-03-01
P1433published inBiochemical JournalQ864221
P1476titleCrystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts
P478volume346 Pt 2

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