scholarly article | Q13442814 |
P50 | author | Martin Noble | Q37391812 |
Doris Marko | Q42314581 | ||
P2093 | author name string | J A Endicott | |
G Eisenbrand | |||
L Meijer | |||
P Tunnah | |||
T G Davies | |||
P2860 | cites work | Improved methods for building protein models in electron density maps and the location of errors in these models | Q26776980 |
Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity | Q27617593 | ||
The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases | Q27620372 | ||
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent | Q27621242 | ||
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles | Q27626674 | ||
Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine | Q27729294 | ||
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex | Q27729793 | ||
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2 | Q27746054 | ||
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors | Q27764855 | ||
Refinement of macromolecular structures by the maximum-likelihood method | Q27861011 | ||
The CCP4 suite: programs for protein crystallography | Q27861090 | ||
The regulation of E2F by pRB-family proteins | Q28278789 | ||
Prediction of binding constants of protein ligands: a fast method for the prioritization of hits obtained from de novo design or 3D database search programs | Q28285760 | ||
Cyclin-dependent kinases: engines, clocks, and microprocessors | Q29614786 | ||
MOLREP: an Automated Program for Molecular Replacement | Q29642797 | ||
A computational procedure for determining energetically favorable binding sites on biologically important macromolecules | Q30406755 | ||
Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors | Q33604662 | ||
Chemical inhibitors of cyclin-dependent kinases: insights into design from X-ray crystallographic studies. | Q33716140 | ||
Anticancer drug targets: cell cycle and checkpoint control. | Q33801116 | ||
Preclinical and clinical development of cyclin-dependent kinase modulators | Q33852851 | ||
Where the cell cycle and histones meet | Q34037995 | ||
The Rb/E2F pathway: expanding roles and emerging paradigms | Q34052659 | ||
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists | Q35124562 | ||
Cell-cycle regulators and cancer | Q40514881 | ||
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases | Q40918567 | ||
Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity | Q40939103 | ||
Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint | Q42818873 | ||
Inhibition of cyclin-dependent kinases by purine analogues. | Q49090586 | ||
CHARMM: A program for macromolecular energy, minimization, and dynamics calculations | Q53340989 | ||
Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition | Q77310904 | ||
P433 | issue | 5 | |
P921 | main subject | crystal structure | Q895901 |
P304 | page(s) | 389-397 | |
P577 | publication date | 2001-05-01 | |
P1433 | published in | Structure | Q15709970 |
P1476 | title | Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate | |
P478 | volume | 9 |
Q40279500 | 7-Bromoindirubin-3'-oxime induces caspase-independent cell death |
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Q80467476 | Can we use docking and scoring for hit-to-lead optimization? |
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Q35185330 | Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents. |
Q27640893 | Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop |
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