Solution Structure of the Ras Binding Domain of the Protein Kinase Byr2 from Schizosaccharomyces pombe

scientific article published on November 1, 2001

Solution Structure of the Ras Binding Domain of the Protein Kinase Byr2 from Schizosaccharomyces pombe is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0969-2126(01)00671-2
P953full work available at URLhttp://www.cell.com/article/S0969212601006712/pdf
https://api.elsevier.com/content/article/PII:S0969212601006712?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0969212601006712?httpAccept=text/xml
P698PubMed publication ID11709167
P5875ResearchGate publication ID11646257

P50authorHans Robert KalbitzerQ19284863
P2093author name stringC. Herrmann
F. Huber
W. Gronwald
S. Wohlgemuth
P. Grünewald
M. Spörner
P2860cites workA gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast.Q35980184
Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombeQ36562776
Multiple Regulatory Domains on the Byr2 Protein KinaseQ36573071
Isolation and characterization of a gene encoding a G-protein alpha subunit from Schizosaccharomyces pombe: involvement in mating and sporulation pathwaysQ37542439
Overcoming the problems associated with poor spectra quality of the protein kinase Byr2 using residual dipolar couplingsQ38272016
Computer assisted assignment of 13C or 15N edited 3D-NOESY-HSQC spectra using back calculated and experimental spectraQ39488230
Theste4+ gene, essential for sexual differentiation ofSchizosaccharomyces pombe, encodes a protein with a leucine zipper motifQ40525573
Discrimination of Amino Acids Mediating Ras Binding from Noninteracting Residues Affecting Raf Activation by Double Mutant AnalysisQ41075527
Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factorQ41214472
SAM: a novel motif in yeast sterile and Drosophila polyhomeotic proteinsQ42215107
AURELIA, a program for computer-aided analysis of multidimensional NMR spectra.Q47740933
A robust method for determining the magnitude of the fully asymmetric alignment tensor of oriented macromolecules in the absence of structural informationQ47879770
Relax, a flexible program for the back calculation of NOESY spectra based on complete-relaxation-matrix formalismQ51648952
RFAC, a program for automated NMR R-factor estimationQ52075973
Constrained multiple sequence alignment using XALIGN.Q52365021
Role of a ras homolog in the life cycle of Schizosaccharomyces pombeQ52489610
Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.Q53005285
Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex†Q59663003
Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurementsQ70793466
Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivoQ71011188
Indirect Referencing of 31P and 19F NMR SpectraQ71859634
Protein kinase Byr2 is a target of Ras1 in the fission yeast Schizosaccharomyces pombeQ72465920
Characterization of magnetically oriented phospholipid micelles for measurement of dipolar couplings in macromoleculesQ77622935
Improved dilute bicelle solutions for high-resolution NMR of biological macromoleculesQ77622959
Structural and biochemical analysis of Ras-effector signaling via RalGDSQ77889147
Ras/Rap effector specificity determined by charge reversalQ24315941
Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solutionQ24649924
Crystallography & NMR System: A New Software Suite for Macromolecular Structure DeterminationQ26778405
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gammaQ27629132
Dynamic properties of the Ras switch I region and its importance for binding to effectorsQ27631350
The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeastQ27636232
Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surfaceQ27730250
Three-dimensional structure of the Ras-interacting domain of RalGDSQ27741370
Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signallingQ27743813
Structure Determination of the Ras-Binding Domain of the Ral-Specific Guanine Nucleotide Exchange Factor Rlf,Q27765367
Solution structure of the Ras-binding domain of RGLQ27766685
Nuclear magnetic resonance and molecular dynamics studies on the interactions of the Ras-binding domain of Raf-1 with wild-type and mutant Ras proteinsQ27766877
AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMRQ27860778
MOLMOL: a program for display and analysis of macromolecular structuresQ27860873
Protein backbone angle restraints from searching a database for chemical shift and sequence homologyQ27861108
Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamilyQ28142888
Direct Measurement of Distances and Angles in Biomolecules by NMR in a Dilute Liquid Crystalline MediumQ28253146
The GTPase superfamily: a conserved switch for diverse cell functionsQ28302983
ras genesQ29547799
1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effectsQ29616506
Involvement of ras in sexual differentiation but not in growth control in fission yeast.Q33880767
Complex formation between RAS and RAF and other protein kinasesQ34351032
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectSchizosaccharomyces pombeQ2236682
MAP kinase kinase kinaseQ6714442
Schizosaccharomyces pombe proteinsQ78440957
solution structureQ99235426
P304page(s)1029-41
P577publication date2001-11-01
P1433published inStructureQ15709970
P1476titleSolution structure of the Ras binding domain of the protein kinase Byr2 from Schizosaccharomyces pombe
Solution Structure of the Ras Binding Domain of the Protein Kinase Byr2 from Schizosaccharomyces pombe
P478volume9

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cites work (P2860)
Q45050798A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues
Q31046716A general method for the unbiased improvement of solution NMR structures by the use of related X-ray data, the AUREMOL-ISIC algorithm
Q28474223Association rate constants of ras-effector interactions are evolutionarily conserved
Q77840676Bibliography. Current awareness on yeast
Q42199071Ca2+-dependent conformational changes in a C-terminal cytosolic domain of polycystin-2.
Q41129970Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis
Q58788156E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form
Q49913698Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating
Q54620743Intrinsic allosteric inhibition of signaling proteins by targeting rare interaction states detected by high-pressure NMR spectroscopy
Q42613429Intrinsic disorder in the common N-terminus of human adenovirus 5 E1B-55K and its related E1BN proteins indicated by studies on E1B-93R.
Q36677528Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions
Q45181623Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy
Q30381751Protein structure calculation with data imputation: the use of substitute restraints.
Q35083712Ras Signaling in Yeast
Q35064547Ras-effector interactions: after one decade
Q36523098Specific Conformational States of Ras GTPase upon Effector Binding
Q36587920Structurally unique interaction of RBD-like and PH domains is crucial for yeast pheromone signaling
Q53060825The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases
Q27636232The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast

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