Structural basis of EZH2 recognition by EED

scientific article

Structural basis of EZH2 recognition by EED is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.STR.2007.08.007
P3181OpenCitations bibliographic resource ID2024733
P698PubMed publication ID17937919
P5875ResearchGate publication ID5907375

P2093author name stringMin Hu
Jijie Chai
Peiyuan Liu
Xinmiao Xing
Yin Zhang
Zhifu Han
P2860cites workCrystallography & NMR System: A New Software Suite for Macromolecular Structure DeterminationQ26778405
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectEmbryonic ectoderm developmentQ21981822
P304page(s)1306-15
P577publication date2007-10-01
P1433published inStructureQ15709970
P1476titleStructural basis of EZH2 recognition by EED
P478volume15

Reverse relations

cites work (P2860)
Q28259120A novel mutation in EED associated with overgrowth
Q34302726A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
Q38718859An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
Q27665361Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)
Q46288028Computational characterization of substrate and product specificities, and functionality of S-adenosylmethionine binding pocket in histone lysine methyltransferases from Arabidopsis, rice and maize
Q34996482Computational prediction of associations between long non-coding RNAs and proteins
Q46252089Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.
Q36299135DDB2 modulates TGF-β signal transduction in human ovarian cancer cells by downregulating NEDD4L.
Q48675669Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors
Q36245610Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.
Q43125467Dominant alleles identify SET domain residues required for histone methyltransferase of Polycomb repressive complex 2.
Q48727279EED-associated overgrowth in a second male patient
Q34393753EZH2: biology, disease, and structure-based drug discovery
Q33610902EZH2: not EZHY (easy) to deal.
Q34691625EZH2: novel therapeutic target for human cancer
Q91216637Engaging chromatin: PRC2 structure meets function
Q39261435Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma
Q36810306Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
Q47726221First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor.
Q21198854Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression
Q38906678H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer
Q58830255Histone Recognition by WD40 Proteins
Q34255738Inner workings and regulatory inputs that control Polycomb repressive complex 2
Q41878428Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED.
Q29614511Mechanisms of polycomb gene silencing: knowns and unknowns
Q38180674Mind the methyl: methyllysine binding proteins in epigenetic regulation
Q30570945Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives
Q21128799Molecular architecture of human polycomb repressive complex 2
Q33533377Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells
Q28115469PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1
Q92254249PRC2 is high maintenance
Q34185471Perspectives on the discovery of small-molecule modulators for epigenetic processes
Q36918656Polycomb and the emerging epigenetics of pancreatic cancer
Q27319398Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
Q91880620Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis
Q35894532Pseudomonas syringae effector protein AvrB perturbs Arabidopsis hormone signaling by activating MAP kinase 4.
Q93207151Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding
Q27657483Role of the polycomb protein EED in the propagation of repressive histone marks
Q37941688Structural Chemistry of Human SET Domain Protein Methyltransferases
Q27702306Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2
Q39245946Structure of the PRC2 complex and application to drug discovery.
Q47948466Structure, mechanism, and regulation of polycomb repressive complex 2.
Q41942526Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer
Q27664983The Effect of Asp-His-Ser/Thr-Trp Tetrad on the Thermostability of WD40-Repeat Proteins
Q38344853The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression
Q33815083The central role of EED in the orchestration of polycomb group complexes.
Q61810737The ezh2(sa1199) mutant zebrafish display no distinct phenotype
Q26782196The interplay of histone modifications - writers that read
Q35955196Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer

Search more.