Structural basis for inhibition of homologous recombination by the RecX protein

scientific article

Structural basis for inhibition of homologous recombination by the RecX protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMBOJ.2008.145
P3181OpenCitations bibliographic resource ID2019618
P932PMC publication ID2500204
P698PubMed publication ID18650935
P5875ResearchGate publication ID51424466

P50authorNicholas FurnhamQ62675223
P2093author name stringLuca Pellegrini
Joseph D Maman
Stefania Ragone
P2860cites workElectrostatics of nanosystems: application to microtubules and the ribosomeQ24555224
ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structuresQ24812180
Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structuresQ27650665
Coot: model-building tools for molecular graphicsQ27860505
Phasercrystallographic softwareQ27860930
Refinement of macromolecular structures by the maximum-likelihood methodQ27861011
ARP/wARP and automatic interpretation of protein electron density mapsQ27861049
Initiation of genetic recombination and recombination-dependent replicationQ28141289
Chromosomal stability and the DNA double-stranded break connectionQ28205315
RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: a universal step of recombinational repairQ28207059
Molecular views of recombination proteins and their controlQ28207872
Mechanism of homologous recombination: mediators and helicases take on regulatory functionsQ28259452
PsiB polypeptide prevents activation of RecA protein in Escherichia coliQ70240940
RecA protein filaments: end-dependent dissociation from ssDNA and stabilization by RecO and RecR proteinsQ73107375
Recombinational DNA repair: the RecF and RecR proteins limit the extension of RecA filaments beyond single-strand DNA gapsQ73863469
RecA protein filaments disassemble in the 5' to 3' direction on single-stranded DNAQ74562095
Characterization of Xanthomonas oryzae pv. oryzae recX, a gene that is required for high-level expression of recAQ77308172
Intein-mediated affinity-fusion purification of the Escherichia coli RecA proteinQ78597832
SSB protein limits RecOR binding onto single-stranded DNAQ79710654
Cation-pi interactions in structural biologyQ29617384
Complexes of RecA with LexA and RecX differentiate between active and inactive RecA nucleoprotein filamentsQ30311887
Knowledge-based real-space explorations for low-resolution structure determination.Q30356243
RecA protein: structure, function, and role in recombinational DNA repairQ30427530
The RecOR proteins modulate RecA protein function at 5' ends of single-stranded DNAQ34085368
RecX protein abrogates ATP hydrolysis and strand exchange promoted by RecA: insights into negative regulation of homologous recombinationQ34155282
Roles of DNA polymerase V and RecA protein in SOS damage-induced mutation.Q34492397
Real-time observation of RecA filament dynamics with single monomer resolution.Q34556173
Direct observation of individual RecA filaments assembling on single DNA moleculesQ34567581
The bacterial RecA protein and the recombinational DNA repair of stalled replication forksQ34667410
Antipairing and strand transferase activities of E. coli helicase II (UvrD).Q34991211
Fueling protein DNA interactions inside porous nanocontainers.Q35921608
Double helicase II (uvrD)-helicase IV (helD) deletion mutants are defective in the recombination pathways of Escherichia coliQ36103598
Biochemical interaction of the Escherichia coli RecF, RecO, and RecR proteins with RecA protein and single-stranded DNA binding proteinQ36268715
Thermodynamics and kinetics of co-operative protein-nucleic acid binding. I. General aspects of analysis of dataQ36632564
Motoring along with the bacterial RecA proteinQ36710001
Regulation of bacterial RecA protein functionQ36761497
The RecF protein antagonizes RecX function via direct interactionQ37489660
Protein interactions in genetic recombination in Escherichia coli. Interactions involving RecO and RecR overcome the inhibition of RecA by single-stranded DNA-binding proteinQ38302209
The DinI protein stabilizes RecA protein filamentsQ38341316
Expression, purification, and DNA-binding activity of the Herbaspirillum seropedicae RecX proteinQ38341395
Transcriptional and mutational analyses of the Streptomyces lividans recX gene and its interference with RecA activityQ39500237
The RdgC protein of Escherichia coli binds DNA and counters a toxic effect of RecFOR in strains lacking the replication restart protein PriA.Q39698943
Role of the recA-related gene adjacent to the recA gene in Pseudomonas aeruginosaQ39928069
UvrD helicase, unlike Rep helicase, dismantles RecA nucleoprotein filaments in Escherichia coli.Q40919283
Mycobacterial recA is cotranscribed with a potential regulatory gene called recX.Q42655329
recX, a new SOS gene that is co-transcribed with the recA gene in Escherichia coliQ42693458
Quantitative analysis of the kinetics of end-dependent disassembly of RecA filaments from ssDNA.Q44082228
Escherichia coli RecX inhibits RecA recombinase and coprotease activities in vitro and in vivoQ44213423
Inhibition of RecA protein by the Escherichia coli RecX protein: modulation by the RecA C terminus and filament functional stateQ45091854
NADH-coupled microplate photometric assay for kinetic studies of ATP-hydrolyzing enzymes with low and high specific activitiesQ46131370
DNA strand exchange proteins: a biochemical and physical comparison.Q47956058
Evolutionary comparisons of RecA-like proteins across all major kingdoms of living organismsQ48050696
Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.Q52904158
A RecA filament capping mechanism for RecX protein.Q54500245
Assembly and disassembly of RecA protein filaments occur at opposite filament ends. Relationship to DNA strand exchange.Q54712336
Properties of recA441 protein-catalyzed DNA strand exchange can be attributed to an enhanced ability to compete with SSB protein.Q54716042
Kinetic studies of recA protein binding to a fluorescent single-stranded polynucleotide.Q54765740
Effects of Escherichia coli SSB protein on the single-stranded DNA-dependent ATPase activity of Escherichia coli RecA protein. Evidence that SSB protein facilitates the binding of RecA protein to regions of secondary structure within single-strandedQ54768170
[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.Q55059918
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)2259-69
P577publication date2008-08-20
P1433published inThe EMBO JournalQ1278554
P1476titleStructural basis for inhibition of homologous recombination by the RecX protein
P478volume27

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cites work (P2860)
Q41630028Bacillus subtilis RecA with DprA-SsbA antagonizes RecX function during natural transformation
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Q30392766Cpl-7, a lysozyme encoded by a pneumococcal bacteriophage with a novel cell wall-binding motif
Q36848871DNA Metabolism in Balance: Rapid Loss of a RecA-Based Hyperrec Phenotype
Q33396659Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12.
Q30503604Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques.
Q36276407Factors limiting SOS expression in log-phase cells of Escherichia coli
Q28485128Less is more: Neisseria gonorrhoeae RecX protein stimulates recombination by inhibiting RecA
Q34510132Mechanical force antagonizes the inhibitory effects of RecX on RecA filament formation in Mycobacterium tuberculosis
Q24630140Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systems
Q27012760Multiple cellular mechanisms prevent chromosomal rearrangements involving repetitive DNA
Q88181286RECX Interacts with Mitochondrial RECA to Maintain Mitochondrial Genome Stability
Q64899459RecA Regulation by RecU and DprA During Bacillus subtilis Natural Plasmid Transformation.
Q34531271RecX facilitates homologous recombination by modulating RecA activities
Q33964219Repression of recA induction by RecX is independent of the RecA protein in Deinococcus radiodurans
Q38308902Structure of RecX protein complex with the presynaptic RecA filament: Molecular dynamics simulations and small angle neutron scattering.
Q37377958Suppression of constitutive SOS expression by recA4162 (I298V) and recA4164 (L126V) requires UvrD and RecX in Escherichia coli K-12.
Q93185974The SOS system: A complex and tightly regulated response to DNA damage
Q27013056The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery
Q30426870Two modes of binding of DinI to RecA filament provide a new insight into the regulation of SOS response by DinI protein

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