Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2

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Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2 is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1009384436
P356DOI10.1007/S10969-010-9091-X
P698PubMed publication ID20454865

P50authorTakanori KigawaQ48035017
Takuma KasaiQ58338172
Seizo KoshibaQ88491486
Takashi YabukiQ114316251
Yoko MotodaQ114320795
Tadashi TomizawaQ114320796
Naoya TochioQ114320797
Takushi HaradaQ114320798
Mikako ShirouzuQ28036542
Shigeyuki YokoyamaQ37376039
P2093author name stringHua Li
Tadashi Yamamoto
Akiko Tanaka
Satoru Watanabe
P2860cites workNovel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteinsQ24313489
Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesisQ24317141
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiationQ24522542
Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicityQ24522838
FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptorsQ24554326
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)Q24595848
Structural basis of SNT PTB domain interactions with distinct neurotrophic receptorsQ27628653
Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domainQ27732609
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancerQ27851410
Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANAQ27860611
Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.Q40160132
Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cellsQ40543147
Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphomaQ40761648
Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesisQ40815965
Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathwayQ40838398
Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformationQ42833922
Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells.Q43719933
Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicityQ44620758
Preparation of Escherichia coli cell extract for highly productive cell-free protein expressionQ44642283
Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.Q53605317
Improving cell-free protein synthesis for stable-isotope labeling.Q53934066
Cell-free production and stable-isotope labeling of milligram quantities of proteinsQ57663114
Latent and active p53 are identical in conformationQ58002479
Structure validation by Calpha geometry: phi,psi and Cbeta deviationQ27860657
Automated NMR structure calculation with CYANAQ27860754
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Torsion angle dynamics for NMR structure calculation with the new program DYANAQ27860808
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
MOLMOL: a program for display and analysis of macromolecular structuresQ27860873
NMR View: A computer program for the visualization and analysis of NMR dataQ27860951
Protein backbone angle restraints from searching a database for chemical shift and sequence homologyQ27861108
The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiationQ28139721
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell deathQ28202067
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathwayQ28240585
Recognition of errors in three-dimensional structures of proteinsQ28249658
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphomaQ28250347
Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3Q28253494
Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinaseQ28253852
Assessment of protein models with three-dimensional profilesQ28283805
A novel approach for sequential assignment of 1H, 13C, and 15N spectra of proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to calmodulinQ28291817
The emerging normal and disease-related roles of anaplastic lymphoma kinaseQ28297119
ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiationQ28564190
Evaluating protein structures determined by structural genomics consortiaQ29547577
An improved double-tuned and isotope-filtered pulse scheme based on a pulsed field gradient and a wide-band inversion shaped pulseQ30176722
Influence of the completeness of chemical shift assignments on NMR structures obtained with automated NOE assignment.Q30336300
KUJIRA, a package of integrated modules for systematic and interactive analysis of NMR data directed to high-throughput NMR structure studies.Q30362931
NMR methods for the study of protein structure and dynamicsQ30427593
CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical featuresQ34088464
Alk+ CD30+ lymphomas: a distinct molecular genetic subtype of non-Hodgkin's lymphomaQ34266303
Protein NMR recall, precision, and F-measure scores (RPF scores): structure quality assessment measures based on information retrieval statisticsQ34392409
Translocations involving anaplastic lymphoma kinase (ALK).Q34405439
Structural and evolutionary division of phosphotyrosine binding (PTB) domains.Q35965222
SNT, a Differentiation-Specific Target of Neurotrophic Factor-Induced Tyrosine Kinase Activity in Neurons and PC12 CellsQ36678095
ALK is a novel dependence receptor: potential implications in development and cancerQ36870536
P433issue2
P921main subjectphosphorylationQ242736
P304page(s)125-41
P577publication date2010-06-01
P1433published inJournal of Structural and Functional GenomicsQ15764584
P1476titleStructural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2
P478volume11

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cites work (P2860)
Q112978397ALK fusions bind FRS
Q34244067Applications of isothermal titration calorimetry in pure and applied research--survey of the literature from 2010.
Q89752884Impact of the Protein Data Bank on antineoplastic approvals

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