Structural basis for high-affinity HER2 receptor binding by an engineered protein

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Structural basis for high-affinity HER2 receptor binding by an engineered protein is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PNAS..10715039E
P356DOI10.1073/PNAS.1005025107
P3181OpenCitations bibliographic resource ID1213388
P932PMC publication ID2930565
P698PubMed publication ID20696930
P5875ResearchGate publication ID45583375

P50authorTorleif HärdQ5819684
Anatoly DubnovitskyQ58460772
Charles EigenbrotQ28037170
Mark UltschQ28050881
P2093author name stringLars Abrahmsén
P2860cites workThe stability and unfolding of an IgG binding protein based upon the B domain of protein A from Staphylococcus aureus probed by tryptophan substitution and fluorescence spectroscopyQ72154686
Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941Q24321567
An affibody in complex with a target protein: Structure and coupled foldingQ27640525
Structure of the extracellular region of HER2 alone and in complex with the Herceptin FabQ27640593
The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptorsQ27640631
Stabilization of a  -hairpin in monomeric Alzheimer's amyloid-  peptide inhibits amyloid formationQ27650192
Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding siteQ27654214
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancerQ27851414
The ErbB signaling network: receptor heterodimerization in development and cancerQ29617919
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Structural basis for molecular recognition in an affibody:affibody complexQ33245590
Engineered affinity proteins--generation and applicationsQ33442549
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Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domainQ34435244
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Affibody molecules for in vivo characterization of HER2-positive tumors by near-infrared imagingQ36100348
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Clinical activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancerQ38419271
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor modelsQ39771295
Dimeric HER2-specific affibody molecules inhibit proliferation of the SKBR-3 breast cancer cell lineQ39928084
Radionuclide therapy of HER2-positive microxenografts using a 177Lu-labeled HER2-specific Affibody molecule.Q40158333
The application of circular dichroism to studies of protein folding and unfoldingQ41452511
Interaction of Alzheimer's A beta peptide with an engineered binding protein--thermodynamics and kinetics of coupled folding-bindingQ44381867
Parameters of helix-coil transition theory for alanine-based peptides of varying chain lengths in waterQ44844504
Conformational stabilization of an engineered binding protein.Q51186216
Thermodynamics of folding, stabilization, and binding in an engineered protein--protein complex.Q51618944
A synthetic IgG-binding domain based on staphylococcal protein A.Q54412437
Mutational analysis of the interaction between staphylococcal protein A and human IgG1.Q54656660
Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In- or 68Ga-labeled affibody molecules.Q54673289
P433issue34
P407language of work or nameEnglishQ1860
P304page(s)15039-44
P577publication date2010-08-24
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleStructural basis for high-affinity HER2 receptor binding by an engineered protein
P478volume107