Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation

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Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PNTD.0001164
P8608Fatcat IDrelease_ceohv3b6nnhs7iipgzzw4oo7wi
P3181OpenCitations bibliographic resource ID4510855
P932PMC publication ID3101181
P698PubMed publication ID21629723
P5875ResearchGate publication ID51181520

P50authorLeonardo ScapozzaQ58448519
P2093author name stringJason Greenwald
Dirk Kostrewa
Remo Perozzo
Shaheen Ahmed
Sabine Kuettel
P2860cites workThe Protein Data BankQ24515306
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Crystal structure of adenosine kinase from Toxoplasma gondii at 1.8 Å resolutionQ27622365
Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug bindingQ27622402
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Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinaseQ27643613
High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzymeQ27646464
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Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomicsQ28475966
Identification and Characterization of a Unique Adenosine Kinase from Mycobacterium tuberculosisQ28486351
Overexpression, purification and crystallographic analysis of a unique adenosine kinase from Mycobacterium tuberculosisQ28486848
Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constantsQ29546524
Human African trypanosomiasisQ33811349
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Arsenical-resistant trypanosomes lack an unusual adenosine transporterQ38933302
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Ligand binding affinity determined by temperature-dependent circular dichroism: cyclin-dependent kinase 2 inhibitorsQ42039902
Properties of rat heart adenosine kinaseQ42847756
Adenosine kinase and ribokinase--the RK family of proteinsQ46534681
Adenosine kinase mediates high affinity adenosine salvage in Trypanosoma bruceiQ46802933
Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolutionQ46900260
High-level expression and purification of human thymidine kinase 1: quaternary structure, stability, and kineticsQ46940880
Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivativesQ46941302
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Characterization of a Nucleoside/Proton Symporter in ProcyclicTrypanosoma brucei bruceiQ58850888
Reaction kinetics and inhibition of adenosine kinase from Leishmania donovaniQ69830928
Adenosine kinase from bovine adrenal medullaQ70096384
Adenosine kinase from human erythrocytes: kinetic studies and characterization of adenosine binding sitesQ70181763
Purine metabolism in the bloodstream forms of Trypanosoma gambiense and Trypanosoma rhodesienseQ71638120
Human placental adenosine kinase. Kinetic mechanism and inhibitionQ72849997
Adenosine kinase from Trypanosoma cruziQ72956261
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectinfectious diseaseQ18123741
crystal structureQ895901
P304page(s)e1164
P577publication date2011-05-01
P1433published inPLoS Neglected Tropical DiseasesQ3359737
P1476titleCrystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation
P478volume5

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