Structural basis for Marburg virus VP35-mediated immune evasion mechanisms

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Structural basis for Marburg virus VP35-mediated immune evasion mechanisms is …
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scholarly articleQ13442814

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P819ADS bibcode2012PNAS..10920661R
P356DOI10.1073/PNAS.1213559109
P3181OpenCitations bibliographic resource ID581448
P932PMC publication ID3528546
P698PubMed publication ID23185024
P5875ResearchGate publication ID233775209

P50authorZbyszek OtwinowskiQ9388794
Dominika BorekQ47451345
Gaya K. AmarasingheQ52360446
Christopher F BaslerQ54188848
Daisy W LeungQ88424073
Megan C EdwardsQ95645917
Parameshwaran RamananQ115627243
Ariel C Endlich-FrazierQ117254613
Reed S ShabmanQ37374407
P2093author name stringGai Liu
Juyoung Huh
P2860cites workDRBP76 associates with Ebola virus VP35 and suppresses viral polymerase functionQ24292964
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virusQ24310706
Homo-oligomerization facilitates the interferon-antagonist activity of the ebolavirus VP35 protein.Q38287391
Sequence-based human leukocyte antigen-B typing of patients infected with Ebola virus in Uganda in 2000: identification of alleles associated with fatal and nonfatal disease outcomesQ38877091
Basic residues within the ebolavirus VP35 protein are required for its viral polymerase cofactor functionQ39671255
Homo-oligomerization of Marburgvirus VP35 is essential for its function in replication and transcriptionQ39796970
RIG-I activation inhibits ebolavirus replicationQ39821574
A C-terminal basic amino acid motif of Zaire ebolavirus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the NS1 protein of influenza A virusQ40508331
Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1Q24318342
Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviationsQ24620453
Marburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola VirusQ27490714
Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppressionQ27646608
Structure of the Ebola VP35 interferon inhibitory domainQ27653329
Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea PigsQ27658947
Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35Q27659023
MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNAQ27677137
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphatesQ27861007
Pathogen recognition by the innate immune systemQ29615592
The Ebola virus VP35 protein is a suppressor of RNA silencingQ33288729
Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signalingQ33558506
Comparison of the transcription and replication strategies of marburg virus and Ebola virus by using artificial replication systemsQ33653597
Three of the four nucleocapsid proteins of Marburg virus, NP, VP35, and L, are sufficient to mediate replication and transcription of Marburg virus-specific monocistronic minigenomesQ33785253
Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteinsQ33902145
Molecular mechanisms of viral inhibitors of RIG-I-like receptorsQ34253570
Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulenceQ34434866
VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in miceQ34509643
Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signalingQ34648134
Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulationQ34648461
Ebolavirus VP35 is a multifunctional virulence factorQ34700463
Marburg virus VP40 antagonizes interferon signaling in a species-specific manner.Q35076858
The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.Q35105093
Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.Q35239001
The Ebola virus VP35 protein functions as a type I IFN antagonist.Q35422223
The VP35 protein of Ebola virus inhibits the antiviral effect mediated by double-stranded RNA-dependent protein kinase PKR.Q35634367
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognitionQ35641310
Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virusQ36484103
The marburg virus 3' noncoding region structurally and functionally differs from that of ebola virusQ37157191
Ebola virus VP35 antagonizes PKR activity through its C-terminal interferon inhibitory domainQ37333731
Evasion of interferon responses by Ebola and Marburg virusesQ37582945
Structural insights into RNA recognition and activation of RIG-I-like receptorsQ38007663
P433issue50
P407language of work or nameEnglishQ1860
P921main subjectMarburg virus diseaseQ167264
MarburgvirusQ15728844
evasion of host immune responseQ1660157
Marburg marburgvirusQ6755280
P304page(s)20661-6
P577publication date2012-12-11
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleStructural basis for Marburg virus VP35-mediated immune evasion mechanisms
P478volume109

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