Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening.

scientific article

Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JM201098N
P932PMC publication ID3668559
P698PubMed publication ID22047606
P5875ResearchGate publication ID51764635

P50authorR. Kiplin GuyQ67426629
Ka Hong ChanQ101225083
P2093author name stringPaul S Rennie
Nathan A Lack
Artem Cherkasov
Eric LeBlanc
Peyman Tavassoli
Emma Tomlinson Guns
Clementine Feau
Peter Axerio-Cilies
Frank Q Han
P2860cites workThe ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptorsQ24304094
A surface on the androgen receptor that allosterically regulates coactivator bindingQ27648698
ZINC--a free database of commercially available compounds for virtual screeningQ27656255
Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screeningQ27671786
Phasercrystallographic softwareQ27860930
Refinement of macromolecular structures by the maximum-likelihood methodQ27861011
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracyQ28251042
eHiTS: a new fast, exhaustive flexible ligand docking systemQ28253448
Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation functionQ31806771
'Inductive' charges on atoms in proteins: comparative docking with the extended steroid benchmark set and discovery of a novel SHBG ligand.Q33227835
Using molecular docking, 3D-QSAR, and cluster analysis for screening structurally diverse data sets of pharmacological interestQ33371746
Epigenetic mechanisms for progression of prostate cancerQ33715206
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cellsQ33951397
In vivo amplification of the androgen receptor gene and progression of human prostate cancerQ34314274
Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancerQ35888364
20-year outcomes following conservative management of clinically localized prostate cancerQ36115855
Emerging therapies in castrate-resistant prostate cancerQ37442526
Differential transactivation by the androgen receptor in prostate cancer cellsQ38334030
In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors.Q39899629
Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells.Q39980433
Rapid, non-destructive, cell-based screening assays for agents that modulate growth, death, and androgen receptor activation in prostate cancer cellsQ40183878
Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progressionQ40213078
Mutational analysis of the androgen receptor AF-2 (activation function 2) core domain reveals functional and mechanistic differences of conserved residues compared with other nuclear receptorsQ40847186
Steroid requirement for androgen receptor dimerization and DNA binding. Modulation by intramolecular interactions between the NH2-terminal and steroid-binding domains.Q41528424
Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model systemQ41827081
A high-throughput ligand competition binding assay for the androgen receptor and other nuclear receptors.Q42118114
A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapyQ43627769
A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer.Q45996199
Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663.Q47759846
Distant metastases from prostatic carcinoma express androgen receptor protein.Q54015736
Hsp90 Regulates Androgen Receptor Hormone Binding Affinityin VivoQ62059794
Detection of discrete androgen receptor epitopes in prostate cancer by immunostaining: measurement by color video image analysisQ71634118
Intermittent androgen suppression for prostate cancer: rationale and clinical experienceQ77686135
Progressive docking: a hybrid QSAR/docking approach for accelerating in silico high throughput screeningQ79409344
P2507corrigendum / erratumCorrection to Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual ScreeningQ106812605
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectdrug discoveryQ1418791
virtual screeningQ4112105
P304page(s)8563-8573
P577publication date2011-11-18
P1433published inJournal of Medicinal ChemistryQ900316
P1476titleTargeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening
P478volume54

Reverse relations

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