Characterization and Structure of the Vaccinia Virus NF-κB Antagonist A46

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Characterization and Structure of the Vaccinia Virus NF-κB Antagonist A46 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.512756
P932PMC publication ID3916572
P698PubMed publication ID24356965

P50authorTim SkernQ56056868
Irina GrishkovskayaQ57662231
P2093author name stringEuripedes de Almeida Ribeiro
Sofiya Fedosyuk
P2860cites workToll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...Q24297037
Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic proteinQ24305049
Electrostatics of nanosystems: application to microtubules and the ribosomeQ24555224
Toll-like receptor signallingQ24570126
MolProbity: all-atom structure validation for macromolecular crystallographyQ24649111
PHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than ApoptosisQ27651621
Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signalingQ27655822
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protectionQ27672321
Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 SignalingQ27678387
XDSQ27860472
Coot: model-building tools for molecular graphicsQ27860505
Substructure solution with SHELXDQ27860593
Overview of the CCP4 suite and current developmentsQ27860782
Efficient selection for high-expression transfectants with a novel eukaryotic vectorQ27860810
Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7Q27860936
T-Coffee: A novel method for fast and accurate multiple sequence alignmentQ27860999
Refinement of macromolecular structures by the maximum-likelihood methodQ27861011
PRIMUS: a Windows PC-based system for small-angle scattering data analysisQ57091059
1H, 13C, and 15N resonance assignment of the TIR domain of human MyD88Q58480700
The dimerization of Pseudomonas putida cytochrome P450cam: practical consequences and engineering of a monomeric enzymeQ74445725
IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitinationQ28249343
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-betaQ28506630
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signalingQ28593045
The family of five: TIR-domain-containing adaptors in Toll-like receptor signallingQ29615457
Innate immunityQ29618949
Lysine methylation as a routine rescue strategy for protein crystallizationQ29619069
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteinsQ33295379
Kinetics and intracellular location of intramolecular disulfide bond formation mediated by the cytoplasmic redox system encoded by vaccinia virusQ33664851
Molecular interaction studies using microscale thermophoresisQ33980465
Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditionsQ34319793
Achieving reliability and high accuracy in automated protein docking: ClusPro, PIPER, SDU, and stability analysis in CAPRI rounds 13-19Q34522304
Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors.Q35571248
Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactionsQ36080307
Viral infection: an evolving insight into the signal transduction pathways responsible for the innate immune responseQ36246428
How Toll-like receptors signal: what we know and what we don't knowQ36339101
The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defenseQ36370571
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulenceQ36403362
Recognition and signaling by toll-like receptors.Q36527707
Molecular basis of NF-κB signalingQ36918115
Signaling to NF-kappaB by Toll-like receptorsQ37009320
Viral evasion and subversion of pattern-recognition receptor signallingQ37319381
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.Q37421291
The interferon system and vaccinia virus evasion mechanismsQ37587172
How vaccinia virus has evolved to subvert the host immune response.Q37855047
Innate and adaptive immune responses to viral infection and vaccinationQ37996191
Poxvirus antagonism of innate immunity by Bcl-2 fold proteins.Q38058659
Research methods: Know when your numbers are significantQ38067061
DAMMIF, a program for rapid ab-initio shape determination in small-angle scatteringQ39388340
The vaccinia virus-encoded Bcl-2 homologues do not act as direct Bax inhibitorsQ39455647
Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor moleculeQ39662113
A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activationQ39711054
Identification of a peptide derived from vaccinia virus A52R protein that inhibits cytokine secretion in response to TLR-dependent signaling and reduces in vivo bacterial-induced inflammation.Q40455030
Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.Q41763836
A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary historyQ42717454
Heme ligand binding properties and intradimer interactions in the full-length sensor protein dos from Escherichia coli and its isolated heme domain.Q42952015
A novel inhibitory peptide of Toll-like receptor signaling limits lipopolysaccharide-induced production of inflammatory mediators and enhances survival in miceQ43692467
Crystal contacts as nature's docking solutionsQ47863999
Poxvirus A46 protein binds to TIR domain-containing Mal/TIRAP via an α-helical sub-domain.Q54065182
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
NF-κBQ411114
Vaccinia virusQ1986297
P304page(s)3749-3762
P577publication date2013-12-19
P1433published inJournal of Biological ChemistryQ867727
P1476titleCharacterization and structure of the vaccinia virus NF-κB antagonist A46
P478volume289

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cites work (P2860)
Q41491559An in silico approach towards the identification of novel inhibitors of the TLR-4 signaling pathway
Q89889589Leaky scanning translation generates a second A49 protein that contributes to vaccinia virus virulence
Q50533334Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory.
Q37296099Multiple Bcl-2 family immunomodulators from vaccinia virus regulate MAPK/AP-1 activation
Q64092200NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation
Q33870595Structure of vaccinia virus A46, an inhibitor of TLR4 signaling pathway, shows the conformation of VIPER motif
Q26823990Surfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI Inhibitors
Q34646268TRAM is required for TLR2 endosomal signaling to type I IFN induction
Q41922877The Bcl-2 Family in Host-Virus Interactions.
Q92662243The Bcl-2 Family: Ancient Origins, Conserved Structures, and Divergent Mechanisms
Q36223863Vaccinia Virus Immunomodulator A46: A Lipid and Protein-Binding Scaffold for Sequestering Host TIR-Domain Proteins
Q30370948Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein family
Q38986293Vaccinia virus virulence factor N1 can be ubiquitylated on multiple lysine residues

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