MR1 presents microbial vitamin B metabolites to MAIT cells

scientific article

MR1 presents microbial vitamin B metabolites to MAIT cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1049113074
P356DOI10.1038/NATURE11605
P3181OpenCitations bibliographic resource ID425715
P698PubMed publication ID23051753

P50authorGeorge N. KhairallahQ42849078
Jérôme Le NoursQ43376315
Bronwyn S MeehanQ55089356
Lyudmila KostenkoQ55297859
Alexandra J. CorbettQ55297861
Ligong LiuQ56765870
Dale I GodfreyQ56957983
Jamie RossjohnQ28036336
Lars Kjer-NielsenQ28036388
James McCluskeyQ28355179
Anthony W. PurcellQ38523862
David P. FairlieQ40192238
Nicholas A. WilliamsonQ40376378
P2093author name stringMalcolm J McConville
Onisha Patel
Zhenjun Chen
Richard A J O'Hair
Mugdha Bhati
Nadine L Dudek
Rangsima Reantragoon
P2860cites workStructure of the human class I histocompatibility antigen, HLA-A2Q24297966
Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptorQ24336313
Structure, function and diversity of the healthy human microbiomeQ24626370
MolProbity: all-atom contacts and structure validation for proteins and nucleic acidsQ24684673
Interactions between the microbiota and the immune systemQ27028155
The structure of HLA-B8 complexed to an immunodominant viral determinant: peptide-induced conformational changes and a mode of MHC class I dimerizationQ27639867
A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I moleculeQ27643687
Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitopeQ27656096
Structure of a Classical MHC Class I Molecule That Binds “Non-Classical” LigandsQ27666285
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptorQ27678022
Immune self-reactivity triggered by drug-modified HLA-peptide repertoireQ27681301
Specificity pockets for the side chains of peptide antigens in HLA-Aw68Q27700642
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptideQ27731272
Ultraviolet photodegradation of folic acidQ46553167
LIGSITE: automatic and efficient detection of potential small molecule-binding sites in proteinsQ47687247
Modulation of Valpha19 NKT cell immune responses by alpha-mannosyl ceramide derivatives consisting of a series of modified sphingosines.Q51983654
Fighting infection with your MAITsQ56916832
The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognitionQ56917578
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1Q59071944
Coot: model-building tools for molecular graphicsQ27860505
The CCP4 suite: programs for protein crystallographyQ27861090
The biology of NKT cellsQ28277482
Host-gut microbiota metabolic interactionsQ29615104
Where do MAIT cells fit in the family of unconventional T cells?Q33425414
Human mucosal associated invariant T cells detect bacterially infected cellsQ33627502
Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interfaceQ33927547
Conservation of mucosal associated invariant T (MAIT) cells and the MR1 restriction element in ruminants, and abundance of MAIT cells in spleenQ33960683
Antimicrobial activity of mucosal-associated invariant T cellsQ34022899
An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammalsQ36367869
MR1 uses an endocytic pathway to activate mucosal-associated invariant T cellsQ36640043
Endogenous MHC-related protein 1 is transiently expressed on the plasma membrane in a conformation that activates mucosal-associated invariant T cellsQ36745770
HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptidesQ36954248
The fidelity, occasional promiscuity, and versatility of T cell receptor recognitionQ37110406
MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolutionQ37208551
Antigen recognition by CD1d-restricted NKT T cell receptors.Q37640899
Mucosal-associated invariant T cells: unconventional development and functionQ37860732
Biosynthesis of water-soluble vitaminsQ39901803
Evidence for MR1 antigen presentation to mucosal-associated invariant T cellsQ40440555
The crystal structure of human CD1d with and without alpha-galactosylceramideQ42661990
P433issue7426
P407language of work or nameEnglishQ1860
P921main subjectvitaminQ34956
6,7-dimethyl-8-(1-D-ribityl)lumazineQ4641523
vitamin BQ183206
7-hydroxy-6-methyl-8-(1-D-ribityl)lumazineQ27103208
reduced 6-(hydroxymethyl)-8-(1-D-ribityl)lumazineQ27139232
P304page(s)717-23
P577publication date2012-11-29
P1433published inNatureQ180445
P1476titleMR1 presents microbial vitamin B metabolites to MAIT cells
P478volume491

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cites work (P2860)
Q92784708'Bohemian Rhapsody' of MR1T cells
Q44693283A 'GEM' of a cell
Q59341125A Co-culture Model of PBMC and Stem Cell Derived Human Nasal Epithelium Reveals Rapid Activation of NK and Innate T Cells Upon Influenza A Virus Infection of the Nasal Epithelium
Q92071899A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus
Q36119419A Distinctive Cytoplasmic Tail Contributes to Low Surface Expression and Intracellular Retention of the Patr-AL MHC Class I Molecule
Q55287219A Jurkat 76 based triple parameter reporter system to evaluate TCR functions and adoptive T cell strategies.
Q41918765A Specialist Macaque MHC Class I Molecule with HLA-B*27-like Peptide-Binding Characteristics
Q35190832A comprehensive analysis of teleost MHC class I sequences
Q27678457A conserved human T cell population targets mycobacterial antigens presented by CD1b
Q27684762A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells
Q36160718A new high-throughput sequencing method for determining diversity and similarity of T cell receptor (TCR) α and β repertoires and identifying potential new invariant TCR α chains
Q35990524A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant
Q39157735A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis
Q38217703A prominent role for invariant T cells in the amphibian Xenopus laevis tadpoles
Q42084270A robust synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin.
Q40499915A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.
Q37564579Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development
Q58556398Activates Human Mucosal-Associated Invariant T Cells
Q91997783Activation and Impaired Tumor Necrosis Factor-α Production of Circulating Mucosal-Associated Invariant T Cells in Patients with Trauma
Q90162887Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality
Q42270075Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells.
Q38568857Activation of human T cells by CD1 and self-lipids.
Q90084055Activation of mucosal-associated invariant T cells in the lungs of sarcoidosis patients
Q37697841Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus
Q36087086Activation, Impaired Tumor Necrosis Factor-α Production, and Deficiency of Circulating Mucosal-Associated Invariant T Cells in Patients with Scrub Typhus
Q36619693Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection
Q58563254Activity-Based Protein Profiling-Enabling Multimodal Functional Studies of Microbial Communities
Q38587715Adipose tissue inflammation in the pathogenesis of type 2 diabetes.
Q26998503Adoptive T Cell Therapy Targeting CD1 and MR1
Q35018923Altered CD161 bright CD8+ mucosal associated invariant T (MAIT)-like cell dynamics and increased differentiation states among juvenile type 1 diabetics
Q99608499Alternative splicing of MR1 regulates antigen presentation to MAIT cells
Q37644275Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset
Q99711554Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries
Q101038988Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease
Q27680179Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
Q38890709Are human iNKT cells keeping tabs on lipidome perturbations triggered by oxidative stress in the blood?
Q35752258Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection
Q90290433Association Between Impaired Vα7.2+CD161++CD8+ (MAIT) and Vα7.2+CD161-CD8+ T-Cell Populations and Gut Dysbiosis in Chronically HIV- and/or HCV-Infected Patients
Q37649829Associations between serum folate and vitamin D levels and incident mouse sensitization in adults
Q37440890B cells modulate mucosal associated invariant T cell immune responses.
Q40120789Bacterial deception of MAIT cells in a cloud of superantigen and cytokines
Q90737346Bile Acid Profile and its Changes in Response to Cefoperazone Treatment in MR1 Deficient Mice
Q36770339Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1.
Q41996396Biochemical Mechanisms of Pathogen Restriction by Intestinal Bacteria
Q98394885Boosting MAIT cells as immunotherapy: context is everything
Q28076184Brief review of the chicken Major Histocompatibility Complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance
Q52738900Building conventions for unconventional lymphocytes.
Q27685257Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells
Q39029042Butyrophilin 3A1 presents phosphoantigens to human γδ T cells: the fourth model of antigen presentation in the immune system
Q50535290C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation.
Q40059465CD161 Expression on Mucosa-Associated Invariant T Cells is Reduced in HIV-Infected Subjects Undergoing Antiretroviral Therapy Who Do Not Recover CD4+ T Cells
Q34605938CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.
Q39098086CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner
Q26796132CD1d- and MR1-Restricted T Cells in Sepsis
Q27686847CD1d-lipid antigen recognition by the γδ TCR
Q47131315CD335 (NKp46)+ T-Cell Recruitment to the Bovine Upper Respiratory Tract during a Primary Bovine Herpesvirus-1 Infection
Q48648923CD8⁺ MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis
Q64121498Casting a wider net: Immunosurveillance by nonclassical MHC molecules
Q36606978Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans
Q43851750Characterisation of non-classical MHC class I genes in the Tasmanian devil (Sarcophilus harrisii).
Q91432435Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells
Q91432474Characterization of Human Mucosal-associated Invariant T (MAIT) Cells
Q57797176Characterization of major histocompatibility complex-related molecule 1 sequence variants in non-human primates
Q33630962Check MAIT.
Q92022466Chronically stimulated human MAIT cells are unexpectedly potent IL-13 producers
Q64228549Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly
Q36536034Circulating and tumor-infiltrating mucosal associated invariant T (MAIT) cells in colorectal cancer patients
Q34075150Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses
Q28066226Close Encounters of Lymphoid Cells and Bacteria
Q38062281Co-dependents: MR1-restricted MAIT cells and their antimicrobial function
Q26797242Coevolution of T-cell receptors with MHC and non-MHC ligands
Q33578547Commensal bacteria at the interface of host metabolism and the immune system
Q38713387Commensal gut bacteria modulate phosphorylation-dependent PPARγ transcriptional activity in human intestinal epithelial cells.
Q89171057Common ground: shared risk factors for type 1 diabetes and celiac disease
Q50134129Conservation of sequence motifs suggests that the nonclassical MHC class I lineages CD1/PROCR and UT were established before the emergence of tetrapod species.
Q52598286Contribution of APCs to mucosal-associated invariant T cell activation in infectious disease and cancer.
Q38747458Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations.
Q27683716Crystallographic and kinetic study of riboflavin synthase fromBrucella abortus, a chemotherapeutic target with an enhanced intrinsic flexibility
Q37048910Current Knowledge and Future Research Directions on Fecal Bacterial Patterns and Their Association with Asthma
Q38303479Cytokine crowdsourcing: multicellular production of TH17-associated cytokines
Q42695808Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes
Q93047925DNA Methylation Biomarkers Predict Objective Responses to PD-1/PD-L1 Inhibition Blockade
Q35553709Deficiencies of Circulating Mucosal-associated Invariant T Cells and Natural Killer T Cells in Patients with Acute Cholecystitis
Q37740450Deficiencies of Circulating Mucosal-associated Invariant T Cells and Natural Killer T Cells in Patients with Multiple Trauma.
Q92249413Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice
Q38170500Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells
Q59304306Development of mucosal-associated invariant T cells
Q47094084Dietary and Microbial Metabolites in the Regulation of Host Immunity
Q64062946Differences in the molecular signatures of mucosal-associated invariant T cells and conventional T cells
Q90183549Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease
Q88758055Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection
Q54243192Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered in Xenopus.
Q37016414Distinct activation thresholds of human conventional and innate-like memory T cells
Q64051873Diverse MR1-restricted T cells in mice and humans
Q47174198Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways.
Q64914702Does MHC heterozygosity influence microbiota form and function?
Q26768699Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?
Q38922079Donor-unrestricted T cells in the human CD1 system
Q38717713Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.
Q92642986Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection
Q26800118Early innate responses to pathogens: pattern recognition by unconventional human T-cells
Q90627972Early-onset inflammatory bowel disease as a model disease to identify key regulators of immune homeostasis mechanisms
Q40860044Editorial: CD1- and MR1-Restricted T Cells in Antimicrobial Immunity
Q92857778Editorial: Role of CD1- and MR1-Restricted T Cells in Immunity and Disease
Q66678733Elevated frequencies of total and MAIT cell subsets in patients with knee osteoarthritis
Q92886852Emerging roles of bile acids in mucosal immunity and inflammation
Q99593633Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens
Q27314968Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells
Q37101168Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells
Q36054037Enhanced Th1/Th17 Functions of CD161+ CD8+ T Cells in Mucosal Tissues of Rhesus Macaques.
Q37227889Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling
Q52668568Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma.
Q38883502Evolution of innate-like T cells and their selection by MHC class I-like molecules
Q34527136Evolution of nonclassical MHC-dependent invariant T cells
Q39228326Exceptionally high conservation of the MHC class I-related gene, MR1, among mammals.
Q64093795Expansion of IL-17A-secreting CD8 mucosa-associated invariant T cells in peripheral blood following stem cell mobilization
Q39673078Exploring the functions of nonclassical MHC class Ib genes in Xenopus laevis by the CRISPR/Cas9 system
Q39248532Expression and trafficking of MR1.
Q38804267Extensive Phenotypic Analysis, Transcription Factor Profiling, and Effector Cytokine Production of Human MAIT Cells by Flow Cytometry.
Q64912367Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells.
Q37334837FolC2-mediated folate metabolism contributes to suppression of inflammation by probiotic Lactobacillus reuteri
Q47727880Folic acid prevented cognitive impairment in experimental pneumococcal meningitis
Q35815577Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.
Q89495082Functional MAIT Cells Are Associated With Reduced Simian-Human Immunodeficiency Virus Infection
Q38852261Functional role of mucosal-associated invariant T cells in HIV infection.
Q38778174Functionally diverse human T cells recognize non-microbial antigens presented by MR1.
Q92784716Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1
Q91223925Graded diacylglycerol kinases α and ζ activities ensure mucosal-associated invariant T-cell development in mice
Q41986469Graft-Derived Reconstitution of Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation
Q92650360Gut Microbiome Biomarkers and Functional Diversity Within an Amazonian Semi-Nomadic Hunter-Gatherer Group
Q35170535Gut microbiota-generated metabolites in animal health and disease
Q36112685HIV-Infected Children Have Lower Frequencies of CD8+ Mucosal-Associated Invariant T (MAIT) Cells that Correlate with Innate, Th17 and Th22 Cell Subsets
Q40147542HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells
Q37152701Hallmarks of Tissue-Resident Lymphocytes
Q64051922Harnessing donor unrestricted T-cells for new vaccines against tuberculosis
Q58714915High MDR-1 expression by MAIT cells confers resistance to cytotoxic but not immunosuppressive MDR-1 substrates
Q38902093High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells
Q36351062Homeostatic Immunity and the Microbiota
Q89576459How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets
Q88587892How MAIT cells get their start
Q59355728Human MAIT cells are rapidly activated by Aspergillus spp. in an APC-dependent manner
Q37098070Human MAIT-cell responses to Escherichia coli: activation, cytokine production, proliferation, and cytotoxicity
Q58697400Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity
Q37188416Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens
Q102144613Human Tumor-Infiltrating MAIT Cells Display Hallmarks of Bacterial Antigen Recognition in Colorectal Cancer
Q50045500Human blood MAIT cell subsets defined using MR1 tetramers.
Q98222243Human endometrial MAIT cells are transiently tissue resident and respond to Neisseria gonorrhoeae
Q40093495Human mucosal-associated invariant T (MAIT) cells possess capacity for B-cell help
Q37247617Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation
Q89794792Human unconventional T cells in Plasmodium falciparum infection
Q52608541Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection.
Q34157945ID'ing innate and innate-like lymphoid cells
Q40866100IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions
Q89948602IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia
Q49713185IL-7 treatment supports CD8+ MAIT cell restoration in HIV-1 infected patients on ART.
Q52717941IL13Rα2 expression identifies tissue-resident IL-22 producing PLZF+ innate T cells in the human liver.
Q36344921IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
Q37271875Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells.
Q36069872Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer
Q35824188Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers
Q42129294Immune parameters to consider when choosing T-cell receptors for therapy
Q102379530Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells
Q56911915Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection
Q91820033Immunology of Mycobacterium tuberculosis Infections
Q52716582In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.
Q64258527Infant Complementary Feeding of Prebiotics for theMicrobiome and Immunity
Q52628809Influence of post-transplant mucosal-associated invariant T cell recovery on the development of acute graft-versus-host disease in allogeneic bone marrow transplantation.
Q45715422Innate Immune Recognition: Implications for the Interaction of Francisella tularensis with the Host Immune System
Q50034841Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine.
Q90559897Innate T cells in the intensive care unit
Q35947771Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms
Q48316500Innate immune cells for immunotherapy of autoimmune and cancer disorders.
Q34399419Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases.
Q52654737Innate-like CD8+ T-cells and NK cells: converging functions and phenotypes.
Q34075522Innate-like and conventional T cell populations from hemodialyzed and kidney transplanted patients are equally compromised
Q55717169Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells.
Q91900309Interactions between Intestinal Microflora/Probiotics and the Immune System
Q96953883Interleukin-17 producing mucosal associated invariant T cells - emerging players in chronic inflammatory diseases?
Q52366720Interleukin-18 Is Critical for Mucosa-Associated Invariant T Cell Gamma Interferon Responses to Francisella Species In Vitro but Not In Vivo.
Q35912366Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
Q40093638Intra-hepatic Depletion of Mucosal Associated Invariant T cells in Hepatitis C Virus-induced Liver Inflammation
Q38169040Key roles of adjuvants in modern vaccines
Q57464740LFA-1 Ligation by High-Density ICAM-1 Is Sufficient To Activate IFN-γ Release by Innate T Lymphocytes
Q55408012Latent Mycobacterium tuberculosis Infection Is Associated With a Higher Frequency of Mucosal-Associated Invariant T and Invariant Natural Killer T Cells.
Q98735537Leveraging Public Single-Cell and Bulk Transcriptomic Datasets to Delineate MAIT Cell Roles and Phenotypic Characteristics in Human Malignancies
Q42001435Lineage-Specific Effector Signatures of Invariant NKT Cells Are Shared amongst γδ T, Innate Lymphoid, and Th Cells
Q64934343Linking the gut and liver: crosstalk between regulatory T cells and mucosa-associated invariant T cells.
Q38590013Lipid and small-molecule display by CD1 and MR1.
Q58588189Low mucosal-associated invariant T-cell number in peripheral blood of patients with immune thrombocytopenia and their response to prednisolone
Q61797503Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
Q99711502MAIT Cells at the Fetal-Maternal Interface During Pregnancy
Q27680211MAIT Recognition of a Stimulatory Bacterial Antigen Bound to MR1
Q89505978MAIT cell activation in adolescents is impacted by bile acid concentrations and body weight
Q48223629MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A.
Q34558727MAIT cell recognition of MR1 on bacterially infected and uninfected cells
Q38667181MAIT cells accumulate in placental intervillous space and display a highly cytotoxic phenotype upon bacterial stimulation
Q47551345MAIT cells and Viruses
Q49928718MAIT cells and microbial immunity.
Q38244066MAIT cells and pathogen defense
Q27469032MAIT cells are activated during human viral infections
Q47550378MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection
Q48254188MAIT cells are chronically activated in patients with autoimmune liver disease and promote pro-fibrogenic hepatic stellate cell activation
Q37104082MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection
Q41687115MAIT cells are depleted early but retain functional cytokine expression in HIV infection
Q89506412MAIT cells are enriched and highly functional in ascites of patients with decompensated liver cirrhosis
Q34890728MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets.
Q36338406MAIT cells are reduced in frequency and functionally impaired in human T lymphotropic virus type 1 infection: Potential clinical implications
Q58568564MAIT cells contribute to protection against lethal influenza infection in vivo
Q27332162MAIT cells detect and efficiently lyse bacterially-infected epithelial cells
Q89999319MAIT cells in metabolic diseases
Q48291527MAIT cells in type 1 diabetes: a good friend turned bad.
Q33817263MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immun
Q37415246MAIT cells promote inflammatory monocyte differentiation into dendritic cells during pulmonary intracellular infection.
Q58722526MAIT cells protect against pulmonary Legionella longbeachae infection
Q33390770MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation
Q28073095MAIT cells: new guardians of the liver
Q38890712MAIT, MR1, microbes and riboflavin: a paradigm for the co-evolution of invariant TCRs and restricting MHCI-like molecules?
Q46541186MAITs onstage in mice and men with three acts for development
Q26770048MHC and Evolution in Teleosts
Q38910293MR1 discovery
Q90101984MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage
Q64082742MR1 recycling and blockade of endosomal trafficking reveal distinguishable antigen presentation pathways between Mycobacterium tuberculosis infection and exogenously delivered antigens
Q90701082MR1-Independent Activation of Human Mucosal-Associated Invariant T Cells by Mycobacteria
Q26852490MR1-Restricted Mucosal-Associated Invariant T Cells and Their Activation during Infectious Diseases
Q93199363MR1-dependent antigen presentation
Q33964230MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage
Q27016137MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis
Q33580780MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates
Q39185888MR1B, a natural spliced isoform of the MHC-related 1 protein, is expressed as homodimers at the cell surface and activates MAIT cells
Q54224083MX2: a high-flux undulator microfocus beamline serving both the chemical and macromolecular crystallography communities at the Australian Synchrotron.
Q57286623Macrophage-microbe interaction: lessons learned from the pathogen Mycobacterium tuberculosis
Q54779554Manipulation of Innate and Adaptive Immunity by Staphylococcal Superantigens.
Q89030672Mass cytometry of Hodgkin lymphoma reveals a CD4+ regulatory T-cell-rich and exhausted T-effector microenvironment
Q94563407Massively parallel interrogation and mining of natively paired human TCRαβ repertoires
Q47116194Maternal nutritional status during pregnancy and infant immune response to routine childhood vaccinations
Q64076713Mechanisms of Bacterial Superinfection Post-influenza: A Role for Unconventional T Cells
Q34560345Metabolic engineering of Salmonella vaccine bacteria to boost human Vγ2Vδ2 T cell immunity.
Q64105300Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity
Q37151353Metabolites: messengers between the microbiota and the immune system
Q35179505Metagenomic sequencing reveals altered metabolic pathways in the oral microbiota of sailors during a long sea voyage
Q99635125MicroRNA miR-181-A Rheostat for TCR Signaling in Thymic Selection and Peripheral T-Cell Function
Q34218508Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells
Q38935534Microbiota as a mediator of cancer progression and therapy.
Q90329866Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection
Q92283947Mining the microbiota for microbial and metabolite-based immunotherapies
Q35280550Modeling T cell receptor recognition of CD1-lipid and MR1-metabolite complexes
Q40061831Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity
Q88619078Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation
Q36153599Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection: A Case-Control Study
Q47728419Molecular recognition of microbial lipid-based antigens by T cells.
Q34723826Molecules in medicine mini review: the αβ T cell receptor
Q36811942Mucosa-Associated Invariant T Cells Are Systemically Depleted in Simian Immunodeficiency Virus-Infected Rhesus Macaques
Q40097622Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment.
Q35558518Mucosal Immune Development in Early Life: Setting the Stage
Q92058744Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond
Q26741117Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease
Q58748503Mucosal associated invariant T cells from human breast ducts mediate a Th17-skewed response to bacterially exposed breast carcinoma cells
Q36739969Mucosal associated invariant T cells: don't forget your vitamins
Q36014529Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies
Q91868533Mucosal-Associated Invariant T Cell Features and TCR Repertoire Characteristics During the Course of Multiple Sclerosis
Q49204780Mucosal-Associated Invariant T Cell Interactions with Commensal and Pathogenic Bacteria: Potential Role in Antimicrobial Immunity in the Child
Q64234755Mucosal-Associated Invariant T Cell Levels Are Reduced in the Peripheral Blood and Lungs of Children With Active Pulmonary Tuberculosis
Q54963446Mucosal-Associated Invariant T Cells Are Depleted and Exhibit Altered Chemokine Receptor Expression and Elevated Granulocyte Macrophage-Colony Stimulating Factor Production During End-Stage Renal Disease.
Q92239466Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma
Q47194084Mucosal-Associated Invariant T Cells Display a Poor Reconstitution and Altered Phenotype after Allogeneic Hematopoietic Stem Cell Transplantation
Q90265871Mucosal-Associated Invariant T Cells Expressing the TRAV1-TRAJ33 Chain Are Present in Pigs
Q58764790Mucosal-Associated Invariant T Cells Improve Nonalcoholic Fatty Liver Disease Through Regulating Macrophage Polarization
Q92745001Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal Inflammation
Q55301095Mucosal-Associated Invariant T Cells in Autoimmune Diseases.
Q54268263Mucosal-Associated Invariant T Cells in Chronic Inflammatory Liver Disease.
Q26781518Mucosal-Associated Invariant T Cells in Multiple Sclerosis: The Jury is Still Out
Q47241753Mucosal-Associated Invariant T Cells in Regenerative Medicine
Q89613156Mucosal-Associated Invariant T Cells in Tumors of Epithelial Origin
Q47133613Mucosal-Associated Invariant T Cells: New Insights into Antigen Recognition and Activation
Q89519675Mucosal-Associated Invariant T cell in liver diseases
Q35408930Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients
Q35829274Mucosal-associated invariant T cell-rich congenic mouse strain allows functional evaluation.
Q90514963Mucosal-associated invariant T cells and Vδ2+ γδ T cells in community acquired pneumonia: association of abundance in sputum with clinical severity and outcome
Q91904779Mucosal-associated invariant T cells and disease
Q64060086Mucosal-associated invariant T cells and oral microbiome in persistent apical periodontitis
Q54969856Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver.
Q38891491Mucosal-associated invariant T cells are numerically and functionally deficient in patients with mycobacterial infection and reflect disease activity
Q26750384Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases
Q26771558Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease
Q97692581Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
Q40688729Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals.
Q40100401Mucosal-associated invariant T-cell frequency and function in blood and liver of HCV mono- and HCV/HIV co-infected patients with advanced fibrosis.
Q34305082Mucosal-associated invariant T-cells: new players in anti-bacterial immunity
Q39420793Multiple Sclerosis: Immunopathology and Treatment Update
Q33887115Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines.
Q35245286Mycobacterium tuberculosis metabolism
Q46236111NKT cells: the smoking gun in fungal-induced asthma?
Q57171137Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections
Q91063214Neonatal intestinal immune regulation by the commensal bacterium, P. UF1
Q92683823Neutrophils suppress mucosal-associated invariant T cells in humans
Q37124529Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis
Q36043783Nonclassical MHC Ib-restricted CD8+ T Cells Recognize Mycobacterium tuberculosis-Derived Protein Antigens and Contribute to Protection Against Infection
Q27007035Nonclassical T cells and their antigens in tuberculosis
Q50852086OMIP-021: Simultaneous quantification of human conventional and innate-like T-cell subsets.
Q54256962OMIP-046: Characterization of invariant T cell subset activation in humans.
Q92116605OMIP-058: 30-Parameter Flow Cytometry Panel to Characterize iNKT, NK, Unconventional and Conventional T Cells
Q48232467Ontogeny of human mucosal-associated invariant T cells and related T cell subsets
Q47180559Operational Experience of an Open-Access, Subscription-Based Mass Spectrometry and Proteomics Facility
Q42215094Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire.
Q35016866Persistent changes in circulating and intestinal γδ T cell subsets, invariant natural killer T cells and mucosal-associated invariant T cells in children and adults with coeliac disease.
Q57300020Positive & Negative Roles of Innate Effector Cells in Controlling Cancer Progression
Q57107709Primary sclerosing cholangitis leads to dysfunction and loss of MAIT cells
Q37081221Probiotic Lactobacilli Modulate Staphylococcus aureus-Induced Activation of Conventional and Unconventional T cells and NK Cells
Q54214704Proteomic definition of human mucosal-associated invariant T cells determines their unique molecular effector phenotype.
Q64062638Qa-1-Restricted CD8 T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection
Q103028792Rab6 regulates recycling and retrograde trafficking of MR1 molecules
Q98735502Re-education of the Tumor Microenvironment With Targeted Therapies and Immunotherapies
Q54239585Recipient mucosal-associated invariant T cells control GVHD within the colon.
Q37088000Recognition of CD1d-restricted antigens by natural killer T cells
Q26795468Recognition of Microbial Glycolipids by Natural Killer T Cells
Q36381877Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells
Q27685209Recognition of vitamin B metabolites by mucosal-associated invariant T cells
Q40497285Recovery of mucosal-associated invariant T cells after myeloablative chemotherapy and autologous peripheral blood stem cell transplantation
Q64973520Recruitment of MAIT Cells to the Intervillous Space of the Placenta by Placenta-Derived Chemokines.
Q34439411Regional specialization within the intestinal immune system
Q26797333Regulation of Lipid Specific and Vitamin Specific Non-MHC Restricted T Cells by Antigen Presenting Cells and Their Therapeutic Potentials
Q47744427Resolving the mystery of pyrophosphate antigen presentation
Q48194957Riboflavin Metabolism Variation Among Clinical Isolates of Streptococcus pneumoniae Results in Differential Activation of MAIT Cells
Q58698386Role of CD1d- and MR1-Restricted T Cells in Asthma
Q34482936Role of Innate T Cells in Anti-Bacterial Immunity
Q63362830Role of MAIT cells in pulmonary bacterial infection
Q27026700Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus
Q57028269SOX4 controls invariant NKT cell differentiation by tuning TCR signaling
Q35671239STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function
Q39298329Sepsis and the innate-like response
Q40044893Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets.
Q52630399Significant transcriptome and cytokine changes in hepatitis B vaccine non-responders revealed by genome-wide comparative analysis.
Q42250131Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections.
Q37692182Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells.
Q37421441Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection
Q38905675Structure and function of the non-classical major histocompatibility complex molecule MR1.
Q58600234Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility
Q48105713Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU).
Q35489763Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes
Q51813073T Cell Populations and Functions Are Altered in Human Obesity and Type 2 Diabetes.
Q89965779T Cell Responses to Mycobacterial Glycolipids: On the Spectrum of "Innateness"
Q46254045T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells
Q26865650T cell recognition of non-peptidic antigens in infectious diseases
Q91822570T cells in severe childhood asthma
Q27689685T-cell activation by transitory neo-antigens derived from distinct microbial pathways
Q90162779TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions
Q37631857TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells
Q64968285TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis.
Q37522519Targeting Innate-Like T Cells in Tuberculosis.
Q94545285The Activation of Mucosal-Associated Invariant T (MAIT) Cells Is Affected by Microbial Diversity and Riboflavin Utilization in vitro
Q93159444The CD4-CD8- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool
Q52324313The Contribution of Non-Professional Antigen-Presenting Cells to Immunity and Tolerance in the Liver.
Q55399719The Conventional Nature of Non-MHC-Restricted T Cells.
Q59335043The Host Microbiota Contributes to Early Protection Against Lung Colonization by
Q99237890The Immune Modulating Properties of Mucosal-Associated Invariant T Cells
Q36709380The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator
Q26751427The Importance of First Impressions: Early Events in Mycobacterium tuberculosis Infection Influence Outcome
Q41990094The MAIT conundrum - how human MAIT cells distinguish bacterial colonization from infection in mucosal barrier tissues
Q34662398The Maternal Serological Response to Intrauterine Ureaplasma sp. Infection and Prediction of Risk of Pre-Term Birth
Q57155753The Microbiome and Tuberculosis: Early Evidence for Cross Talk
Q60960298The Prenatal Microbiome: A New Player for Human Health
Q26798471The Role of Mucosal Associated Invariant T Cells in Antimicrobial Immunity
Q38370910The T cell antigen receptor: the Swiss army knife of the immune system.
Q50638746The Toll-like receptor 9 signalling pathway regulates MR1-mediated bacterial antigen presentation in B cells.
Q92579050The biology and functional importance of MAIT cells
Q38611633The burgeoning family of unconventional T cells
Q88575378The crosstalk of gut microbiota and chronic kidney disease: role of inflammation, proteinuria, hypertension, and diabetes mellitus
Q97681303The dialogue between unconventional T cells and the microbiota
Q45894561The gut as a sensory organ.
Q37057724The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders
Q38780847The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1.
Q34708375The molecular bases of δ/αβ T cell-mediated antigen recognition.
Q27677529The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins
Q89984065The molecular basis underpinning the potency and specificity of MAIT cell antigens
Q38883507The role of MHC class Ib-restricted T cells during infection
Q39427595The role of MHC genes in contagious cancer: the story of Tasmanian devils
Q39089948The role of liver sinusoidal cells in local hepatic immune surveillance
Q38955495The role of mucosal-associated invariant T cells in infectious diseases
Q35883319The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research
Q49823694The versatility of the CD1 lipid antigen presentation pathway
Q37623478The versatility of the αβ T-cell antigen receptor
Q47100584Therapeutic vaccines for allergic disease
Q55365838Thymic Program Directing the Functional Development of γδT17 Cells.
Q96683869Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
Q58102795Tissue-resident MAIT cell populations in human oral mucosa exhibit an activated profile and produce IL-17
Q97541722Tissue-resident Mucosal-associated invariant T (MAIT) cells in the human kidney represent a functionally distinct subset
Q33812840Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver
Q36358937Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors
Q27012749Transcriptional regulation of the NKT cell lineage
Q28390218Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool
Q49865220Tumor immunology viewed from alternative animal models-the Xenopus story
Q64100923Tumor-infiltrating mucosal-associated invariant T (MAIT) cells retain expression of cytotoxic effector molecules
Q90989324Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation
Q28087084Type 1 diabetes and gut microbiota: Friend or foe?
Q90683232Type I interferons are important co-stimulatory signals during T cell receptor mediated human MAIT cell activation
Q37229095Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling.
Q33035147Understanding the Apothecaries Within: The Necessity of a Systematic Approach for Defining the Chemical Output of the Human Microbiome
Q38315875Understanding the complexity and malleability of T-cell recognition
Q54217620Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T Cells.
Q26991896Universal immunity to influenza must outwit immune evasion
Q33897591Unusual evolutionary conservation and further species-specific adaptations of a large family of nonclassical MHC class Ib genes across different degrees of genome ploidy in the amphibian subfamily Xenopodinae
Q57470612Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion
Q90044629Virus-Mediated Suppression of the Antigen Presentation Molecule MR1
Q27348812Vitamin B2 as a virulence factor in Pseudogymnoascus destructans skin infection
Q37003147Vitamin-mediated regulation of intestinal immunity
Q42051386Vitamins as influenza vaccine adjuvant components
Q59081102Vitamins prime immunity
Q38809547What rheumatologists need to know about innate lymphocytes
Q37732225Will loss of your MAITs weaken your HAART [corrected]?
Q35632530αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features
Q26852046γδ T cell surveillance via CD1 molecules

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