Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids

scientific article

Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CBIC.201300228
P698PubMed publication ID23828687

P50authorPetr G. LeimanQ37837722
David GfellerQ41045293
Sergey A ButhQ58842259
Olivier MichielinQ109695497
P2093author name stringChristian Heinis
Shiyu Chen
P2860cites workProtease-resistant peptide design-empowering nature's fragile warriors against HIVQ27010058
Bicyclic peptide inhibitor reveals large contact interface with a protease targetQ27677040
Structure validation by Calpha geometry: phi,psi and Cbeta deviationQ27860657
Overview of the CCP4 suite and current developmentsQ27860782
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A simple physical model for binding energy hot spots in protein-protein complexesQ28914753
Phage display-derived peptides as therapeutic alternatives to antibodiesQ33203531
Phage-encoded combinatorial chemical libraries based on bicyclic peptidesQ33456683
The interrelationships of side-chain and main-chain conformations in proteins.Q33949755
The plasminogen activation system in tumor growth, invasion, and metastasisQ34008816
Conformations of amino acids in proteins.Q34125546
Established clinical use of octreotide and lanreotide in oncologyQ34199315
Bicyclization and tethering to albumin yields long-acting peptide antagonists.Q34454138
Opportunities in somatostatin research: biological, chemical and therapeutic aspectsQ35600019
Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agentsQ35972459
The exploration of macrocycles for drug discovery--an underexploited structural classQ37203934
MM-GBSA binding free energy decomposition and T cell receptor engineeringQ37691398
Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclizationQ37778090
Endomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugsQ37834512
An overview of the pharmacokinetics, efficacy and safety of liraglutideQ37975886
Expanding molecular modeling and design tools to non-natural sidechainsQ43745380
Exploiting the right side of the Ramachandran plot: substitution of glycines by D-alanine can significantly increase protein stabilityQ45102646
P433issue11
P304page(s)1316-22
P577publication date2013-07-22
P1433published inChemBioChemQ634395
P1476titleImproving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids
P478volume14

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cites work (P2860)
Q28834084Chemical generation and modification of peptides containing multiple dehydroalanines
Q60949391Constrained α-Helical Peptides as Inhibitors of Protein-Protein and Protein-DNA Interactions
Q47110304Engineering an Affinity-Enhanced Peptide through Optimization of Cyclization Chemistry
Q102075542Identification of highly selective covalent inhibitors by phage display
Q41127564Outwitting EF-Tu and the ribosome: translation with d-amino acids
Q27688961Peptide ligands stabilized by small molecules
Q30379255Phage Selection of Bicyclic Peptide Ligands of the Notch1 Receptor.
Q35206857Prolylcarboxypeptidase independently activates plasma prekallikrein (fletcher factor).
Q35231270Repositioning the substrate activity screening (SAS) approach as a fragment-based method for identification of weak binders
Q38767147Short peptides interfering with signaling pathways as new therapeutic tools for cancer treatment
Q38264736Strategic approaches to optimizing peptide ADME properties
Q60956243Structural Features and Binding Modes of Thioether-Cyclized Peptide Ligands

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