Old yellow enzyme at 2 A resolution: overall structure, ligand binding, and comparison with related flavoproteins

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Old yellow enzyme at 2 A resolution: overall structure, ligand binding, and comparison with related flavoproteins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0969-2126(94)00111-1
P698PubMed publication ID7881908

P50authorPaul KarplusQ67689348
P2093author name stringK M Fox
P2860cites workNuclear magnetic resonance studies of the old yellow enzyme. 1. 15N NMR of the enzyme recombined with 15N-labeled flavin mononucleotides.Q53754956
Software for a diffractometer with multiwire area detector.Q53758356
Active-site probes of flavoproteins.Q53777965
Improved Fourier coefficients for maps using phases from partial structures with errorsQ56877556
The accessible surface area and stability of oligomeric proteinsQ59059304
Structure of oxidized flavodoxin from Anacystis nidulansQ70434818
Multiwire area X-ray diffractometersQ93662896
A least-squares refinement method for isomorphous replacementQ114769656
The relation between the divergence of sequence and structure in proteinsQ24531519
Improved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresQ26778412
Phthalate dioxygenase reductase: a modular structure for electron transfer from pyridine nucleotides to [2Fe-2S]Q27641437
Molecular structure of flavocytochrome b2 at 2.4 A resolutionQ27683722
Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 A resolutionQ27700157
Refined structure of spinach glycolate oxidase at 2 A resolutionQ27703738
Refined structure of glutathione reductase at 1.54 A resolutionQ27728739
Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical featuresQ27860675
Free R value: a novel statistical quantity for assessing the accuracy of crystal structuresQ27860894
Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding ProteinQ28247386
An analysis of the structure of triose phosphate isomerase and its comparison with lactate dehydrogenaseQ28266184
An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complicationsQ28275993
Resolution of phase ambiguity in macromolecular crystallographyQ29617474
Atomic structure of ferredoxin-NADP+ reductase: prototype for a structurally novel flavoenzyme familyQ30195728
The evolution of alpha/beta barrel enzymesQ30195850
Characterization of the baiH gene encoding a bile acid-inducible NADH:flavin oxidoreductase from Eubacterium sp. strain VPI 12708.Q30451827
Crystal structure of cholesterol oxidase from Brevibacterium sterolicum refined at 1.8 A resolutionQ34118410
Structure-function relations for ferredoxin reductase.Q34329965
Low-barrier hydrogen bonds and enzymic catalysisQ34725746
Molecular recognition. Conformational analysis of limited proteolytic sites and serine proteinase protein inhibitorsQ34787907
Cloning and sequencing of a bile acid-inducible operon from Eubacterium sp. strain VPI 12708.Q36192586
On the enigma of old yellow enzyme's spectral properties.Q36597009
Candida albicans estrogen-binding protein gene encodes an oxidoreductase that is inhibited by estradiolQ36762178
Dipoles localized at helix termini of proteins stabilize chargesQ37423541
Trimethylamine dehydrogenase of bacterium W3A1. Molecular cloning, sequence determination and over-expression of the geneQ42607588
On the structure of old yellow enzyme studied by specific limited proteolysisQ42653975
The alpha-helix dipole and the properties of proteinsQ45281613
Crystallization of Old Yellow Enzyme illustrates an effective strategy for increasing protein crystal size.Q47384851
Amino/aromatic interactions in proteins: is the evidence stacked against hydrogen bonding?Q47633312
Nuclear magnetic resonance studies of the old yellow enzyme. 2. 13C NMR of the enzyme recombined with 13C-labeled flavin mononucleotides.Q53744346
P433issue11
P921main subjectligand bindingQ61659151
P304page(s)1089-1105
P577publication date1994-11-01
P1433published inStructureQ15709970
P1476titleOld yellow enzyme at 2 A resolution: overall structure, ligand binding, and comparison with related flavoproteins
P478volume2

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cites work (P2860)
Q5053669219F NMR studies with 2'-F-2'-deoxyarabinoflavoproteins.
Q7348481041 Syntheses and applications of flavin analogs as active site probes for flavoproteins
Q44540078A Rhizobium selenitireducens protein showing selenite reductase activity
Q30818797A homolog of old yellow enzyme in tomato. Spectral properties and substrate specificity of the recombinant protein.
Q27666872A site-saturated mutagenesis study of pentaerythritol tetranitrate reductase reveals that residues 181 and 184 influence ligand binding, stereochemistry and reactivity
Q57979276Active site modifications in pentaerythritol tetranitrate reductase can lead to improved product enantiopurity, decreased by-product formation and altered stereochemical outcome in reactions with α,β-unsaturated nitroolefins
Q28138654An Arabidopsis gene induced by wounding functionally homologous to flavoprotein oxidoreductases
Q27697686An engineered old yellow enzyme that enables efficient synthesis of (4R,6R)-Actinol in a one-pot reduction system
Q51019045An enoate reductase Achr-OYE4 from Achromobacter sp. JA81: characterization and application in asymmetric bioreduction of C=C bonds.
Q43187703Are the genes nadA and norB involved in formation of aflatoxin G(1)?
Q27622519Asp-170 is crucial for the redox properties of vanillyl-alcohol oxidase
Q40025162Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation.
Q52566587Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases.
Q44885006Atomic resolution structures and solution behavior of enzyme-substrate complexes of Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase. Multiple conformational states and implications for the mechanism of nitroaromatic explosive degrada
Q30192830Bacterial morphinone reductase is related to Old Yellow Enzyme
Q24672930Barrel structures in proteins: automatic identification and classification including a sequence analysis of TIM barrels
Q42698381Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes
Q28607471Biodegradation of the organic disulfide 4,4'-dithiodibutyric acid by Rhodococcus spp
Q40937713Biotransformation of explosives by the old yellow enzyme family of flavoproteins
Q43296308Bipartite recognition and conformational sampling mechanisms for hydride transfer from nicotinamide coenzyme to FMN in pentaerythritol tetranitrate reductase
Q58122594Catalytic Performance of a Class III Old Yellow Enzyme and Its Cysteine Variants
Q44378793Characterization of YqjM, an Old Yellow Enzyme homolog from Bacillus subtilis involved in the oxidative stress response
Q40634223Characterization of glycerol trinitrate reductase (NerA) and the catalytic role of active-site residues
Q42043760Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens
Q28343626Cloning and sequence analysis of two Pseudomonas flavoprotein xenobiotic reductases
Q41867200Comparative characterization and expression analysis of the four Old Yellow Enzyme homologues from Shewanella oneidensis indicate differences in physiological function
Q43795662Comparative characterization, expression pattern and function analysis of the 12-oxo-phytodienoic acid reductase gene family in rice
Q28538270Comparative structural modeling of six old yellow enzymes (OYEs) from the necrotrophic fungus Ascochyta rabiei: insight into novel OYE classes with differences in cofactor binding, organization of active site residues and stereopreferences
Q61961636Comparison of resonance Raman spectra of flavin-3,4-dihydroxybenzoate charge-transfer complexes in three flavoenzymes
Q37559667Comprehensive genome-wide analysis reveals different classes of enigmatic old yellow enzyme in fungi
Q27682645Crystal structure determination and mutagenesis analysis of the ene reductase NCR
Q24673341Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization
Q27640000Crystal structure of Escherichia coli alkanesulfonate monooxygenase SsuD
Q27639077Crystal structure of bacterial morphinone reductase and properties of the C191A mutant enzyme
Q27620661Crystal structure of reduced thioredoxin reductase from Escherichia coli: Structural flexibility in the isoalloxazine ring of the flavin adenine dinucleotide cofactor
Q27741973Crystal structures and inhibitor binding in the octameric flavoenzyme vanillyl-alcohol oxidase: the shape of the active-site cavity controls substrate specificity
Q30322162DOMPLOT: a program to generate schematic diagrams of the structural domain organization within proteins, annotated by ligand contacts.
Q27664361Determinants of Substrate Binding and Protonation in the Flavoenzyme Xenobiotic Reductase A
Q28360861Effects of environment on flavin reactivity in morphinone reductase: analysis of enzymes displaying differential charge near the N-1 atom and C-2 carbonyl region of the active-site flavin
Q64081611Engineering the Enantioselectivity of Yeast Old Yellow Enzyme OYE2y in Asymmetric Reduction of (/)-Citral to ()-Citronellal
Q41378518Engineering towards nitroreductase functionality in ene-reductase scaffolds
Q33850045Flavoenzymes: diverse catalysts with recurrent features
Q41548132Functional characterization and stability improvement of a 'thermophilic-like' ene-reductase from Rhodococcus opacus 1CP
Q27666042Geometric Restraint Drives On- and Off-pathway Catalysis by the Escherichia coli Menaquinol:Fumarate Reductase
Q44564228H-tunneling in the multiple H-transfers of the catalytic cycle of morphinone reductase and in the reductive half-reaction of the homologous pentaerythritol tetranitrate reductase.
Q27684432Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations
Q51748432In silico and in vitro studies of the reduction of unsaturated α,β bonds of trans-2-hexenedioic acid and 6-amino-trans-2-hexenoic acid - Important steps towards biobased production of adipic acid.
Q27664663Insights into Substrate Specificity of Geranylgeranyl Reductases Revealed by the Structure of Digeranylgeranylglycerophospholipid Reductase, an Essential Enzyme in the Biosynthesis of Archaeal Membrane Lipids
Q42845336Invariant glycines and prolines flanking in loops the strand beta 2 of various (alpha/beta)8-barrel enzymes: a hidden homology?
Q27638657Kinetic and structural basis of reactivity of pentaerythritol tetranitrate reductase with NADPH, 2-cyclohexenone, nitroesters, and nitroaromatic explosives
Q42692245Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding
Q28252878Molecular cloning and characterization of 12-oxophytodienoate reductase, an enzyme of the octadecanoid signaling pathway from Arabidopsis thaliana. Structural and functional relationship to yeast old yellow enzyme
Q99585096Multiple Reaction Pathways in the Morphinone Reductase-Catalyzed Hydride Transfer Reaction
Q33742133Mycobacterial F420H2-Dependent Reductases Promiscuously Reduce Diverse Compounds through a Common Mechanism.
Q40058578NAD(P)H-independent asymmetric C=C bond reduction catalyzed by ene reductases by using artificial co-substrates as the hydrogen donor
Q37537967Old yellow enzyme protects the actin cytoskeleton from oxidative stress
Q37105411Old yellow enzyme: reduction of nitrate esters, glycerin trinitrate, and propylene 1,2-dinitrate
Q37258118Old yellow enzyme: stepwise reduction of nitro-olefins and catalysis of aci-nitro tautomerization
Q27937462Old yellow enzymes, highly homologous FMN oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast
Q27766083On the active site of Old Yellow Enzyme. Role of histidine 191 and asparagine 194
Q41566784Out of the blue: the photocycle of the photoactive yellow protein
Q44397443Phosphate group binding "cup" of PLP-dependent and non-PLP-dependent enzymes: leitmotif and variations
Q42318672Proline dehydrogenase from Thermus thermophilus does not discriminate between FAD and FMN as cofactor.
Q35578715Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects
Q30176349Purification, properties, and sequence of glycerol trinitrate reductase from Agrobacterium radiobacter
Q45211670Reaction of morphinone reductase with 2-cyclohexen-1-one and 1-nitrocyclohexene: proton donation, ligand binding, and the role of residues Histidine 186 and Asparagine 189.
Q44108475Reaction of reduced flavins and flavoproteins with diphenyliodonium chloride
Q39351141Recombinant S. cerevisiae expressing Old Yellow Enzymes from non-conventional yeasts: an easy system for selective reduction of activated alkenes
Q46240072Reduction of aliphatic nitroesters and N-nitramines by Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase: quantitative structure-activity relationships.
Q37114805Reduction of polynitroaromatic compounds: the bacterial nitroreductases.
Q35632223Regioselectivity of nitroglycerin denitration by flavoprotein nitroester reductases purified from two Pseudomonas species
Q46499565Role of active site residues and solvent in proton transfer and the modulation of flavin reduction potential in bacterial morphinone reductase.
Q35082961STRUCTURAL AND FUNCTIONAL CONSEQUENCES OF CIRCULAR PERMUTATION ON THE ACTIVE SITE OF OLD YELLOW ENZYME
Q28379325Sequence and properties of pentaerythritol tetranitrate reductase from Enterobacter cloacae PB2
Q41541198Sequential Enzymatic Conversion of α-Angelica Lactone to γ-Valerolactone through Hydride-Independent C=C Bond Isomerization.
Q27656910Structural basis of substrate specificity of plant 12-oxophytodienoate reductases
Q41621923Structural insights into stereospecific reduction of α, β-unsaturated carbonyl substrates by old yellow enzyme from Gluconobacter oxydans
Q43032019Structural investigation into the C-terminal extension of the ene-reductase from Ralstonia (Cupriavidus) metallidurans.
Q34299491Structure of an Aspergillus fumigatus old yellow enzyme (EasA) involved in ergot alkaloid biosynthesis.
Q40024861Structure-Based Insight into the Asymmetric Bioreduction of the C=C Double Bond of alpha,beta-Unsaturated Nitroalkenes by Pentaerythritol Tetranitrate Reductase
Q27637446Structures of nitroreductase in three states: effects of inhibitor binding and reduction
Q74424590Synthesis and properties of 8-CN-flavin nucleotide analogs and studies with flavoproteins
Q42656301The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes
Q27733207The 1.5-A resolution crystal structure of bacterial luciferase in low salt conditions
Q27677485The Structure of Glycerol Trinitrate Reductase NerA fromAgrobacterium radiobacterReveals the Molecular Reason for Nitro- and Ene-Reductase Activity in OYE Homologues
Q27641609The crystal structure and reaction mechanism of Escherichia coli 2,4-dienoyl-CoA reductase
Q27734756The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis
Q74638069The flavin environment in old yellow enzyme. An evaluation of insights from spectroscopic and artificial flavin studies
Q27021669The flavoproteome of the yeast Saccharomyces cerevisiae
Q27635468The role of glutamine 114 in old yellow enzyme
Q36443576The role of threonine 37 in flavin reactivity of the old yellow enzyme
Q31919153Thermoregulated expression and characterization of an NAD(P)H-dependent 2-cyclohexen-1-one reductase in the plant pathogenic bacterium Pseudomonas syringae pv. glycinea.
Q27632183X-ray structure of 12-oxophytodienoate reductase 1 provides structural insight into substrate binding and specificity within the family of OYE
Q41662992alpha-Amylase family: molecular biology and evolution
Q44865454α,β-Dicarbonyl reduction is mediated by the Saccharomyces Old Yellow Enzyme

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