Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide

scientific article

Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/BI9520848
P698PubMed publication ID8573568

P2093author name stringD Eisenberg
C E Bell
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectadenineQ15277
crystal structureQ895901
niacinamideQ192423
P304page(s)1137-49
P577publication date1996-01-30
P1433published inBiochemistryQ764876
P1476titleCrystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide
P478volume35

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cites work (P2860)
Q356835743. Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia.
Q27885005A 2'-phosphotransferase implicated in tRNA splicing is essential in Saccharomyces cerevisiae
Q77772348A fluorescence investigation of the active site of Pseudomonas aeruginosa exotoxin A
Q36381146A new role for BiP: closing the aqueous translocon pore during protein integration into the ER membrane
Q33737237A unified mechanism of enzymatic synthesis of two calcium messengers: cyclic ADP-ribose and NAADP.
Q35508489ADP-Ribosylargininyl reaction of cholix toxin is mediated through diffusible intermediates
Q39587461ADP-Ribosylation of variants of Azotobacter vinelandii dinitrogenase reductase by Rhodospirillum rubrum dinitrogenase reductase ADP-ribosyltransferase
Q26866525ADP-ribosylation, a mechanism regulating nitrogenase activity
Q28082350ADP-ribosyltransferases and poly ADP-ribosylation
Q34407508ADP-ribosyltransferases: plastic tools for inactivating protein and small molecular weight targets.
Q33255208ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).
Q30328398Adenine recognition: a motif present in ATP-, CoA-, NAD-, NADP-, and FAD-dependent proteins.
Q24537346Analysis of 2'-phosphotransferase (Tpt1p) from Saccharomyces cerevisiae: evidence for a conserved two-step reaction mechanism.
Q34374455AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana
Q74405725BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation
Q33996430Biological and biochemical characterization of variant A subunits of cholera toxin constructed by site-directed mutagenesis
Q33829020Biology and molecular epidemiology of diphtheria toxin and the tox gene
Q27673416Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus
Q39587023Characterization of the enzymatic component of Clostridium perfringens iota-toxin
Q24653990Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of human ARH3, the first eukaryotic protein-ADP-ribosylhydrolase
Q53968723Comparison of the diphtheria mutant toxin, CRM197, with a Haemophilus influenzae type-b polysaccharide-CRM197 conjugate by optical spectroscopy.
Q40165299Corynebacterium diphtheriae methionine sulfoxide reductase a exploits a unique mycothiol redox relay mechanism
Q30454472Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product
Q27733836Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38
Q27733378Crystal structure of a new heat-labile enterotoxin, LT-IIb
Q27733160Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation
Q27643011Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2
Q27760510Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor
Q35116184DAB389IL2 (ONTAK) fusion protein therapy of chronic lymphocytic leukaemia
Q27689475Diphtheria toxin conformational switching at acidic pH
Q77899756Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor and Ara-C exert synergistic toxicity against human AML HL-60 cells
Q41840686Effect of pre-existing anti-diphtheria toxin antibodies on T cell depletion levels following diphtheria toxin-based recombinant anti-monkey CD3 immunotoxin treatment
Q27684215Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors
Q61807386Evolutionary Features in the Structure and Function of Bacterial Toxins
Q46656627Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry
Q27677345Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Q89577888HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
Q45018408How bacterial ADP-ribosylating toxins recognize substrates
Q38355167Identification of Regulatory Domains in ADP-ribosyltransferase-1 That Determine Transferase and NAD Glycohydrolase Activities
Q34646650Immunotoxins for targeted cancer therapy
Q79199423Immunotoxins for targeted cancer therapy
Q24816599In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)
Q55691227Ligand Selectivity between the ADP-Ribosylating Toxins: An Inverse-Docking Study for Multitarget Drug Discovery.
Q40211355ModA and ModB, two ADP-ribosyltransferases encoded by bacteriophage T4: catalytic properties and mutation analysis
Q48096971Molecular Cloning, Structural Modeling and the Production of Soluble Triple-Mutated Diphtheria Toxoid (K51E/G52E/E148K) Co-expressed with Molecular Chaperones in Recombinant Escherichia coli
Q35626584Molecular cloning of an apoptosis-inducing protein, pierisin, from cabbage butterfly: possible involvement of ADP-ribosylation in its activity
Q27639031NAD binding induces conformational changes in Rho ADP-ribosylating clostridium botulinum C3 exoenzyme
Q50333817NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains
Q38020082New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
Q34941781Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island
Q38229329Novel bacterial ADP-ribosylating toxins: structure and function
Q26827489Obstructing toxin pathways by targeted pore blockage
Q42095016PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain
Q38075305PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis
Q41890511Photoaffinity labelling of human poly(ADP-ribose) polymerase catalytic domain
Q42073445Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase
Q90645966Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity
Q48453430Poly(ADP-ribose)-polymerase-catalyzed hydrolysis of NAD+: QM/MM simulation of the enzyme reaction
Q33916416Purification and cloning of pierisin-2, an apoptosis-inducing protein from the cabbage butterfly, Pieris brassicae
Q36273796Recent Advances in the Development of Antineoplastic Agents Derived from Natural Products
Q38415707Recent developments in understanding the iron acquisition strategies of gram positive pathogens
Q37165245Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies
Q36768767Recycling nicotinamide. The transition-state structure of human nicotinamide phosphoribosyltransferase
Q47131999Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.
Q27650104Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr
Q39501759Role of the dinitrogenase reductase arginine 101 residue in dinitrogenase reductase ADP-ribosyltransferase binding, NAD binding, and cleavage
Q93017969Structural Biology and Molecular Modeling to Analyze the Entry of Bacterial Toxins and Virulence Factors into Host Cells
Q37405386Structural Implications for Selective Targeting of PARPs
Q27678604Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4
Q29977768Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein
Q27678104Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197
Q38086332Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
Q60908277Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO recognition and ADP-ribosylation
Q27733281Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken
Q27639695Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat
Q24537352Structure-function analysis of the yeast NAD+-dependent tRNA 2'-phosphotransferase Tpt1
Q24528153Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa
Q41021738Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP).
Q38104494Tankyrases as drug targets
Q38224266Tankyrases: structure, function and therapeutic implications in cancer
Q92604440Targeting ADP-ribosylation as an antimicrobial strategy
Q41591726The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation
Q34398250The Rho-ADP-ribosylating C3 exoenzyme from Clostridium botulinum and related C3-like transferases
Q73358906The aqueous pore through the translocon has a diameter of 40-60 A during cotranslational protein translocation at the ER membrane
Q34412832The influence of flanking secondary structures on amino Acid content and typical lengths of 3/10 helices
Q37899279The ins and outs of pertussis toxin
Q27650962The nature and character of the transition state for the ADP-ribosyltransferase reaction
Q35682361Transcriptional response of Atlantic salmon families to Piscirickettsia salmonis infection highlights the relevance of the iron-deprivation defence system
Q42016501Transition State Structure for the Hydrolysis of NAD Catalyzed by Diphtheria Toxin
Q34398330Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century
Q42167298Unusual conformation of nicotinamide adenine dinucleotide (NAD) bound to diphtheria toxin: a comparison with NAD bound to the oxidoreductase enzymes
Q24328797Zinc binding catalytic domain of human tankyrase 1
Q38023412mADP-RTs: versatile virulence factors from bacterial pathogens of plants and mammals.

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