HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy

scientific article

HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2009PNAS..106..474P
P356DOI10.1073/PNAS.0808930106
P3181OpenCitations bibliographic resource ID2755913
P932PMC publication ID2626727
P698PubMed publication ID19122144
P5875ResearchGate publication ID23719825

P50authorRoderick BronsonQ7356595
Matthew MeyersonQ47451221
Ignacio I WistubaQ74766086
Heidi GreulichQ32646847
Kwok Kin WongQ42687956
P2093author name stringMasaya Takahashi
Liang Chen
Sara Zaghlul
Lucian R Chirieac
Flavio Solca
Geoffrey I Shapiro
Danan Li
Hongbin Ji
Takeshi Shimamura
Robert F Padera
Maria G Raso
Christa L Borgman
Kathleyn A Brandstetter
Shigeto Kubo
Pilar Garin Chesa
Samanthi A Perera
Ulrich Guertler
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Adenosquamous carcinoma of the lung: radiologic appearanceQ72074348
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitorsQ24297102
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer modelsQ24649935
The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptorsQ27640631
Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer.Q27824805
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The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivationQ28361880
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signalingQ33886341
Lung cancer: intragenic ERBB2 kinase mutations in tumoursQ34354426
Trastuzumab in the treatment of non-small cell lung cancer.Q34563711
The role of HER2/neu expression and trastuzumab in non-small cell lung cancerQ35674579
Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?Q35908976
Association of HER-2 overexpression with prognosis in nonsmall cell lung carcinoma: a metaanalysisQ36072192
The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitorsQ36542428
Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugsQ36692592
Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapyQ40110906
The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272.Q40169126
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.Q40449400
Oncogenic potential of erbB-2 in human mammary epithelial cellsQ41677558
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectsirolimusQ32089
P304page(s)474-479
P577publication date2009-01-02
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleHER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy
P478volume106

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