Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors

scientific article

Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.3765
P3181OpenCitations bibliographic resource ID1802809
P932PMC publication ID4537048
P698PubMed publication ID25970771
P5875ResearchGate publication ID276361455

P50authorSylvie UrbéQ57063712
Judy M CoulsonQ61858338
Liam P CheesemanQ63384838
Hui Yi ChewQ88092843
P2093author name stringMichael J Clague
Joseph J Sacco
Rachel Carter
Sarah Darling
Michael Denny
Jenna Kenyani
Zohra Butt
P2860cites workAutodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2OQ24293775
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUBQ24309403
Defining the human deubiquitinating enzyme interaction landscapeQ24315885
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppressionQ24321439
The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.Q24323060
Chfr is linked to tumour metastasis through the downregulation of HDAC1Q24324032
Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1Q24329078
Germline mutations in BAP1 predispose to melanocytic tumorsQ24594891
Frequent mutation of BAP1 in metastasizing uveal melanomasQ24601069
Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanomaQ24606279
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in CancerQ24608391
Germline BAP1 mutations predispose to malignant mesotheliomaQ24635326
Somatic mutations affect key pathways in lung adenocarcinomaQ24648102
Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylationQ24793292
Prognostic significance of BRCA1-associated protein 1 in colorectal cancerQ38397568
Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesisQ38677842
The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cellsQ39051595
Frequent inactivation of the BAP1 gene in epithelioid-type malignant mesotheliomaQ39399033
Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2.Q39455093
SCG3 transcript in peripheral blood is a prognostic biomarker for REST-deficient small cell lung cancerQ39899561
Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis.Q42757408
Germline BAP1 mutations and tumor susceptibilityQ42760067
BAP1 protein is a progression factor in malignant pleural mesotheliomaQ47734004
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinomaQ57177515
Molecular Classification of Malignant Pleural Mesothelioma: Identification of a Poor Prognosis Subgroup Linked to the Epithelial-to-Mesenchymal TransitionQ60643322
BAP1 is a good prognostic factor in advanced non-small cell lung cancerQ84729943
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trialQ27851712
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategyQ27860519
Lysine acetylation targets protein complexes and co-regulates major cellular functionsQ27860589
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinomaQ27860881
Global quantification of mammalian gene expression controlQ28238103
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)Q29620605
BAP1 protein loss by immunohistochemistry: a potentially useful tool for prognostic prediction in patients with uveal melanomaQ30457154
Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinomaQ33821055
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesotheliomaQ34190027
Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesotheliomaQ34194566
Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancersQ34218657
Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testingQ34283714
BAP1 immunohistochemistry predicts outcomes in a multi-institutional cohort with clear cell renal cell carcinomaQ34373982
The pathogenesis of mesotheliomaQ34522971
Histone deacetylase inhibitors in cancer therapyQ34659283
Clinical characteristics of patients with malignant pleural mesothelioma harboring somatic BAP1 mutations.Q35129478
Novel therapies in phase II and III trials for malignant pleural mesothelioma.Q35129535
The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2Q35160462
Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancerQ35758280
Role for histone deacetylase 1 in human tumor cell proliferationQ35948150
BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITsQ36384018
Discovery and development of SAHA as an anticancer agentQ36745383
Germline BAP1 mutations predispose to renal cell carcinomasQ36909238
The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exitQ37075932
Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smokeQ37139659
Role of Hydroxamate-Based Histone Deacetylase Inhibitors (Hb-HDACIs) in the Treatment of Solid MalignanciesQ37226511
BAP1 deficiency causes loss of melanocytic cell identity in uveal melanomaQ37355644
Future developments in the management of malignant pleural mesotheliomaQ37449036
Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repairQ37474898
Loss of the tumor suppressor BAP1 causes myeloid transformationQ37545704
Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2.Q37825437
Tumours associated with BAP1 mutations.Q38070634
Toward isozyme-selective inhibitors of histone deacetylase as therapeutic agents for the treatment of cancerQ38155850
Transcription and beyond: the role of mammalian class I lysine deacetylasesQ38156341
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)13757-13771
P577publication date2015-05-30
P1433published inOncotargetQ1573155
P1476titleLoss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors
P478volume6

Reverse relations

cites work (P2860)
Q90642244Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma
Q90294125BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers
Q33890512BAP1, a tumor suppressor gene driving malignant mesothelioma
Q27612411CIViC database
Q90699123Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer
Q27908468Consensus report of the 2015 Weinman International Conference on Mesothelioma
Q37619913Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X.
Q101462858HDAC2-mediated proliferation of trophoblast cells requires the miR-183/FOXA1/IL-8 signaling pathway
Q28395597Latest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapies
Q33710012Loss of nuclear BAP1 expression is associated with poor prognosis in oral mucosal melanoma
Q42728294Malignant Mesothelioma, BAP1 Immunohistochemistry, and VEGFA: Does BAP1 Have Potential for Early Diagnosis and Assessment of Prognosis?
Q39366003Malignant Mesothelioma: Time to Translate?
Q42700777Modulating BAP1 expression affects ROS homeostasis, cell motility and mitochondrial function.
Q57112789Nuclear BAP1 loss is common in intrahepatic cholangiocarcinoma and a subtype of hepatocellular carcinoma but rare in pancreatic ductal adenocarcinoma
Q26750845Unexploited Antineoplastic Effects of Commercially Available Anti-Diabetic Drugs

Search more.