Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation

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Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-2952(96)00693-4
P698PubMed publication ID8960070

P2093author name stringT Tateishi
F P Guengerich
A J Wood
P Soucek
Y Caraco
P2860cites workColchicine intoxication: Clinical pharmacology, risk factors, features, and managementQ36948153
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ColchicineQ39940883
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Prolonged colchicine treatment in four patients with amyloidosisQ40879753
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Colchicine in the treatment of cirrhosis of the liverQ49172380
Effect of cyclosporine on colchicine secretion by a liver canalicular transporter studied in vivo.Q53943597
Metabolic transformation of colchicine, II. The metabolism of colchicine by mammalian liver microsomes.Q54475454
Colc hicine treatment of Behqet's disease in childrenQ61628572
Long-term colchicine prophylaxis in familial Mediterranean feverQ67692370
Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodeneQ68397000
Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congenersQ69701365
Purification and characterization of six cytochrome P-450 isozymes from human liver microsomesQ70458093
Radioimmunoassay of colchicine with antisera exhibiting variable cross-reactivityQ72010581
Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease after oral administration of a single dose and after long-term treatmentQ72099809
P433issue1
P407language of work or nameEnglishQ1860
P921main subject(S)-(−)-colchicineQ326224
P304page(s)111-6
P577publication date1997-01-10
P1433published inBiochemical PharmacologyQ864229
P1476titleColchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation
P478volume53

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cites work (P2860)
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