Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling

scientific article

Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M510233200
P3181OpenCitations bibliographic resource ID2227247
P698PubMed publication ID16608852

P50authorStephan LudwigQ39997705
Stephan PleschkaQ123614404
P2093author name stringRalf Wagner
Christina Ehrhardt
Oliver Planz
Henju Marjuki
Hans-D Klenk
Mohammad I Alam
P2860cites work3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathwaysQ24647721
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONQ25939000
Functional rafts in cell membranesQ27860768
Receptor binding and membrane fusion in virus entry: the influenza hemagglutininQ27861017
Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascadeQ27863694
Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusionQ27863777
Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediatesQ27863792
Assembly and budding of influenza virusQ27863797
Lipid rafts and signal transductionQ28131735
The ins and outs of Raf kinasesQ28307284
Cholesterol depletion reduces apical transport capacity in epithelial Madin-Darby canine kidney cellsQ28367183
Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient SystemsQ29039793
Functions of lipid rafts in biological membranesQ29616845
Mitogen-activated protein kinase pathwaysQ29618431
Regulation of transcription by MAP kinase cascadesQ29618477
Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteinsQ29618490
Role of protein kinase C betaII in influenza virus entry via late endosomesQ30453163
A fatal relationship--influenza virus interactions with the host cellQ33758234
New insights into the control of MAP kinase pathwaysQ33783573
Influenza virus assembly and lipid raft microdomains: a role for the cytoplasmic tails of the spike glycoproteinsQ33804501
Trafficking of viral genomic RNA into and out of the nucleus: influenza, Thogoto and Borna disease virusesQ34223092
Visna Virus-Induced Activation of MAPK Is Required for Virus Replication and Correlates with Virus-Induced NeuropathologyQ34358595
Novel protein serine/threonine phosphatases: Variety is the spice of lifeQ34435200
The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathwayQ34453600
MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization productsQ34756212
Influenza-virus-induced signaling cascades: targets for antiviral therapy?Q35076991
Aggregation of lipid rafts accompanies signaling via the T cell antigen receptorQ36326042
Ringing the alarm bells: signalling and apoptosis in influenza virus infected cellsQ36392204
Role for Influenza Virus Envelope Cholesterol in Virus Entry and InfectionQ37059788
Comparison of complete amino acid sequences and receptor-binding properties among 13 serotypes of hemagglutinins of influenza A virusesQ38334967
Inhibition of CD3/CD28-mediated activation of the MEK/ERK signaling pathway represses replication of X4 but not R5 human immunodeficiency virus type 1 in peripheral blood CD4(+) T lymphocytesQ39589753
MEK-specific inhibitor U0126 blocks spread of Borna disease virus in cultured cellsQ39602816
Caspase 3 activation is essential for efficient influenza virus propagationQ39764205
Acylation-mediated membrane anchoring of avian influenza virus hemagglutinin is essential for fusion pore formation and virus infectivityQ40429726
Parallel signal processing among mammalian MAPKsQ40501929
Active NF-kappaB signalling is a prerequisite for influenza virus infection.Q40532649
Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3.Q40549133
NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagationQ40556029
MEK inhibition impairs influenza B virus propagation without emergence of resistant variantsQ40580039
Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathwayQ40794150
p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cellsQ40895310
Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylationQ40969412
Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated.Q40977491
Influenza viruses select ordered lipid domains during budding from the plasma membraneQ40980312
Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domainQ41089300
Influence of infection with an influenza A virus (fowl plague) on Ca++-uptake and lipid metabolism of chick embryo cells in cultureQ41528943
Biosynthesis of the influenza virus envelope in abortive infectionQ41543256
Cholesterol is required for surface transport of influenza virus hemagglutininQ41816953
The Vesicular Stomatitis Virus Matrix Protein Inhibits Glycoprotein 130-Dependent STAT ActivationQ43775078
Verapamil inhibits influenza A virus replicationQ44800421
Activation of ERK2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8.Q45744731
Influenza virus hemagglutinin stimulates the protein kinase C activity of human polymorphonuclear leucocytesQ45752288
Abortive replication of influenza virus A/WSN/33 in HeLa229 cells: defective viral entry and budding processesQ45782709
Abortive replication of influenza A viruses in HeLa 229 cellsQ70257968
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
influenza A virusQ834390
P304page(s)16707-15
P577publication date2006-06-16
P1433published inJournal of Biological ChemistryQ867727
P1476titleMembrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling
P478volume281

Reverse relations

cites work (P2860)
Q39403320A DNA vaccine expressing PB1 protein of influenza A virus protects mice against virus infection
Q41844700A candidate anti-HIV reservoir compound, auranofin, exerts a selective 'anti-memory' effect by exploiting the baseline oxidative status of lymphocytes.
Q36864524Actin Mediates the Nanoscale Membrane Organization of the Clustered Membrane Protein Influenza Hemagglutinin
Q38925051Actin-myosin network is required for proper assembly of influenza virus particles.
Q59803698Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats
Q39195555Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A and B viruses in vitro
Q30358429Antiviral agents active against influenza A viruses.
Q38202012Antiviral strategies against influenza virus: towards new therapeutic approaches
Q38270617At the centre: influenza A virus ribonucleoproteins
Q36808656CK2beta gene silencing increases cell susceptibility to influenza A virus infection resulting in accelerated virus entry and higher viral protein content
Q47551585Cathepsin B plays a key role in optimal production of the influenza A virus
Q38977610Caveolin-1 limits human influenza A virus (H1N1) propagation in mouse embryo-derived fibroblasts
Q28833828Chemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress Response as a Cellular Target for Influenza Virus Inhibition
Q28085400Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part I: Influenza life-cycle and currently available drugs
Q38100551Development of cellular signaling pathway inhibitors as new antivirals against influenza
Q33508793Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor
Q37913363Disruption of virus-host cell interactions and cell signaling pathways as an anti-viral approach against influenza virus infections
Q64277586Emerging Regulatory Roles of Dual-Specificity Phosphatases in Inflammatory Airway Disease
Q21089600Emerging roles for the influenza A virus nuclear export protein (NEP)
Q58180784Exploited defense: how influenza viruses take advantage of antiviral signaling responses
Q41137782Extracellular signal-regulated kinase (ERK) activation is required for porcine epidemic diarrhea virus replication
Q39724559Function of Membrane Rafts in Viral Lifecycles and Host Cellular Response
Q40093256HSP90: a promising broad-spectrum antiviral drug target.
Q26700091Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1
Q36419847Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade.
Q37831216Host cellular signaling induced by influenza virus
Q26852062Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens
Q35363365Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus
Q35943693Identification and characterization of three novel nuclear export signals in the influenza A virus nucleoprotein
Q34785589Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs.
Q28541723In vitro anti-influenza virus activities of a new lignan glycoside from the latex of Calotropis gigantea
Q40119647Influence of calcium/calmodulin on budding of Ebola VLPs: implications for the involvement of the Ras/Raf/MEK/ERK pathway
Q64251661Influenza Virus Infections and Cellular Kinases
Q91655502Influenza hemagglutinin modulates phosphatidylinositol 4,5-bisphosphate membrane clustering
Q37883002Influenza virus and cell signaling pathways
Q41929307Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.
Q37316167Influenza virus morphogenesis and budding
Q42198095Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS.
Q30151464Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway
Q28478705Inhibition of MLC Phosphorylation Restricts Replication of Influenza Virus—A Mechanism of Action for Anti-Influenza Agents
Q27489605Innate immunity to influenza virus: implications for future therapy
Q39743011JNK and p38 mitogen-activated protein kinase pathways contribute to porcine epidemic diarrhea virus infection
Q55354051Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound.
Q40106501Mitogen-activated protein kinase signalling pathways triggered by the hepatitis C virus envelope protein E2: implications for the prevention of infection
Q42662963Molecular cloning and characterization of a cDNA encoding extracellular signal-regulated kinase from Litopenaeus vannamei
Q41821502NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host response
Q41821865Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay
Q58745484Newcastle Disease Virus V Protein Promotes Viral Replication in HeLa Cells through the Activation of MEK/ERK Signaling
Q30423206Overview of Influenza Viruses
Q54249876Oxymatrine Inhibits Influenza A Virus Replication and Inflammation via TLR4, p38 MAPK and NF-κB Pathways
Q30356527Pandemic H1N1 influenza A directly induces a robust and acute inflammatory gene signature in primary human bronchial epithelial cells downstream of membrane fusion.
Q91863997Porcine deltacoronavirus activates the Raf/MEK/ERK pathway to promote its replication
Q39694317Porcine reproductive and respiratory syndrome virus replication is suppressed by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway
Q37247071RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade
Q56427023Replication Cycle of Influenza Viruses
Q54232278Role of the ERK1/2 Signaling Pathway in the Replication of Junín and Tacaribe Viruses
Q39461398Role of the p21-activated kinases (PAKs) in influenza A virus replication
Q39378516Stress-activated protein kinases are involved in porcine reproductive and respiratory syndrome virus infection and modulate virus-induced cytokine production
Q38090250Structure and assembly of the influenza A virus ribonucleoprotein complex
Q34674604Sulfatide Regulates Caspase-3-Independent Apoptosis of Influenza A Virus through Viral PB1-F2 Protein
Q36673169Sulfatide is required for efficient replication of influenza A virus
Q39977595Suppression of astrovirus replication by an ERK1/2 inhibitor
Q58180699Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy
Q28831377The activation of p38MAPK and JNK pathways in bovine herpesvirus 1 infected MDBK cells
Q41867971The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells
Q37271683Transport of the influenza virus genome from nucleus to nucleus
Q47221720Vemurafenib Limits Influenza A Virus Propagation by Targeting Multiple Signaling Pathways
Q50289496vRNP Export through the nuclear pore

Search more.