STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae

scientific article

STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.272.44.27671
P698PubMed publication ID9346907
P5875ResearchGate publication ID13882019

P2093author name stringJ Heitman
M E Cardenas
N S Cutler
P2860cites workCloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinaseQ24318156
The cloning and sequence of the C isoform of PtdIns4P 5-kinaseQ24322823
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene productQ24337388
Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeastQ24619173
PIK-related kinases: DNA repair, recombination, and cell cycle checkpointsQ27934828
Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiaeQ27936464
Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viabilityQ27939746
New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiaeQ28131599
Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinaseQ28281559
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reactionQ28378871
The mechanism of action of cyclosporin A and FK506Q30014847
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domainQ33777007
A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipidsQ34210092
The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinasesQ34318366
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunitsQ34339415
The putative phosphoinositide-specific phospholipase C gene, PLC1, of the yeast Saccharomyces cerevisiae is important for cell growthQ36132888
A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregationQ36691222
Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.Q40478337
Phosphoinositides and calcium as regulators of cellular actin assembly and disassemblyQ40660648
Phosphatidylinositol 3-kinaseQ40702617
Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cellsQ41360732
Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cellsQ41485226
Phosphatidylinositol 3-kinase binds to alpha-actinin through the p85 subunitQ41964209
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.Q41966849
The phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C translocation in rat adipocytesQ42160299
Multipurpose vectors designed for the fast generation of N- or C-terminal epitope-tagged proteinsQ42674193
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cellsQ46524862
Genetic interactions among genes involved in the STT4-PKC1 pathway of Saccharomyces cerevisiaeQ48084395
Characterization of a soluble adrenal phosphatidylinositol 4-kinase reveals wortmannin sensitivity of type III phosphatidylinositol kinasesQ49054230
A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase.Q52543268
P433issue44
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
1-phosphatidylinositol 4-kinase STT4 YLR305CQ27547675
P304page(s)27671-7
P577publication date1997-10-31
P1433published inJournal of Biological ChemistryQ867727
P1476titleSTT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae
P478volume272

Reverse relations

cites work (P2860)
Q36324115A cycle of Vam7p release from and PtdIns 3-P-dependent rebinding to the yeast vacuole is required for homotypic vacuole fusion
Q42059155A plant 126-kDa phosphatidylinositol 4-kinase with a novel repeat structure. Cloning and functional expression in baculovirus-infected insect cells
Q30528924A steep phosphoinositide bis-phosphate gradient forms during fungal filamentous growth
Q28343624Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action
Q77784495Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae
Q33939988Cell wall integrity signaling in Saccharomyces cerevisiae
Q34121202Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments
Q37083249Contribution of natural inhibitors to the understanding of the PI3K/PDK1/PKB pathway in the insulin-mediated intracellular signaling cascade
Q42047553Differential regulation of two Arabidopsis type III phosphatidylinositol 4-kinase isoforms. A regulatory role for the pleckstrin homology domain
Q39952263Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha
Q27933485Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics
Q42974886FgTep1p is linked to the phosphatidylinositol-3 kinase signalling pathway and plays a role in the virulence of Fusarium graminearum on wheat.
Q27937941GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro
Q35693908Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis
Q44660964Hypo-osmotic stress activates Plc1p-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol Hexakisphosphate accumulation in yeast
Q33836143Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases
Q30885679Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
Q54502637Localization of two distinct type III phosphatidylinositol 4-kinase enzyme mRNAs in the rat.
Q24548569MAP kinase pathways in the yeast Saccharomyces cerevisiae
Q34920283Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces cerevisiae
Q27933722Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin
Q42578149PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast
Q34689234Phosphatidylinositol 4,5-bisphosphate regulates two steps of homotypic vacuole fusion
Q28609607Phosphatidylinositol 4-kinases
Q27936338Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p
Q27935369Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis
Q27012953Phosphoinositides: tiny lipids with giant impact on cell regulation
Q27933594Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy
Q36901880Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast
Q28362379PtdIns(4,5)P(2) and phospholipase C-independent Ins(1,4,5)P(3) signals induced by a nitrogen source in nitrogen-starved yeast cells
Q27933247Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast
Q35620450Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway
Q45212986Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase
Q92210473Role of MCC/Eisosome in Fungal Lipid Homeostasis
Q27940183Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation
Q33914389Sac phosphatase domain proteins.
Q57363820Signal-transduction cascades as targets for therapeutic intervention by natural products
Q90198761Specific Recruitment of Phosphoinositide Species to the Plant-Pathogen Interfacial Membrane Underlies Arabidopsis Susceptibility to Fungal Infection
Q27936707Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade
Q36768641Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae
Q27938872TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation
Q27938509The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activity
Q34129670Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum.

Search more.