Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I.

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Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M006628200
P698PubMed publication ID10967121

P50authorMarc R. GartenbergQ42413433
P2093author name stringA Saleem
T Dennis
E H Rubin
T K Edwards
C Gerigk
E Oliveros
J A Shaman
P2860cites workInteraction between human topoisomerase I and a novel RING finger/arginine-serine proteinQ22009920
Interaction between the N-terminus of human topoisomerase I and SV40 large T antigenQ24547088
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNAQ27748892
A model for the mechanism of human topoisomerase IQ27748893
A34.5, a nonessential component of yeast RNA polymerase I, cooperates with subunit A14 and DNA topoisomerase I to produce a functional rRNA synthesis machineQ27930522
Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II.Q27933954
Cloning, characterization, and sequence of the yeast DNA topoisomerase I geneQ27934775
Yeast virus propagation depends critically on free 60S ribosomal subunit concentrationQ27936971
Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complexQ27937157
Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrityQ27937617
The NSR1 gene encodes a protein that specifically binds nuclear localization sequences and has two RNA recognition motifsQ27939355
Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregationQ27939683
Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288CQ28131625
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyraseQ28170377
Identification of a nucleolin binding site in human topoisomerase IQ28273677
The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interactionQ28284025
Human DNA helicase IV is nucleolin, an RNA helicase modulated by phosphorylationQ28295537
Association of DNA topoisomerase I and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcriptionQ28570763
Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeastQ29618547
Transcriptional silencing of Ty1 elements in the RDN1 locus of yeastQ29618830
DNA topoisomerasesQ29619953
Major nucleolar proteins shuttle between nucleus and cytoplasmQ29620425
Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.Q33552740
DNA topoisomerase-targeting antitumor drugs can be studied in yeastQ33654182
Yeast telomeric sequences function as chromosomal anchorage points in vivoQ33886066
Processing of topoisomerase I cleavable complexes into DNA damage by transcription.Q34642113
The relationship between mRNA stability and length in Saccharomyces cerevisiaeQ35055614
Interrelations between the maturation of a 100 kDa nucleolar protein and pre rRNA synthesis in CHO cellsQ35273226
Persistence of an alternate chromatin structure at silenced loci in the absence of silencersQ36090378
Low-level resistance to camptothecin in a human small-cell lung cancer cell line without reduction in DNA topoisomerase I or drug-induced cleavable complex formationQ36293009
Formation of a complex between nucleolin and replication protein A after cell stress prevents initiation of DNA replicationQ36327063
NSR1 is required for pre-rRNA processing and for the proper maintenance of steady-state levels of ribosomal subunitsQ36699462
Simian virus 40 large T antigen binds to topoisomerase I.Q36819634
Camptothecin sensitivity is mediated by the pleiotropic drug resistance network in yeast.Q36855683
Microinjection of anti-topoisomerase I immunoglobulin G into nuclei of Chironomus tentans salivary gland cells leads to blockage of transcription elongationQ36925078
Positive supercoiling of DNA greatly diminishes mRNA synthesis in yeastQ37325327
Ribosome Formation is Blocked by Camptothecin, a Reversible Inhibitor of RNA SynthesisQ37493717
High affinity interactions of nucleolin with G-G-paired rDNA.Q38324508
Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugsQ38550011
Characterization of topotecan-mediated redistribution of DNA topoisomerase I by digital imaging microscopyQ39469521
Association of eukaryotic DNA topoisomerase I with nucleosomes and chromosomal proteins.Q40490060
DNA topoisomerases: essential enzymes and lethal targetsQ40678987
Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cellsQ40911243
Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I.Q41199860
Characterization of camptothecin-resistant chinese hamster lung cellsQ41619991
Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcriptionQ41731151
DNA topoisomerase I is involved in both repression and activation of transcriptionQ42508509
Nucleolin functions in the first step of ribosomal RNA processing.Q42639990
Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigenQ45757122
Selective interruption of high molecular weight RNA synthesis in HeLa cells by camptothecin.Q47374804
Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecinQ47956236
A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena R-chromatin.Q52457341
Modulation of DNA Topoisomerase I Activity byp53Q57259136
Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNAQ59078548
Topoisomerases and yeast rRNA transcription: negative supercoiling stimulates initiation and topoisomerase activity is required for elongationQ67491941
A subthreshold level of DNA topoisomerases leads to the excision of yeast rDNA as extrachromosomal ringsQ69351023
Characterization of a 48-kDa nucleic-acid-binding fragment of nucleolinQ69953186
The Self-Cleaving Activity of Nucleolin Determines Its Molecular Dynamics in Relation to Cell ProliferationQ72092681
Casein kinase II stimulates Xenopus laevis DNA topoisomerase I by physical associationQ72773517
Functional expression of human DNA topoisomerase I and its subcellular localization in HeLa cellsQ73692839
Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecinQ73717910
Identification and characterization of the genes for two topoisomerase I-interacting proteins from Saccharomyces cerevisiaeQ74460326
Nucleolar proteins that bind NLSs: a role in nuclear import or ribosome biogenesis?Q75293246
Curing Saccharomyces cerevisiae of the 2 micron plasmid by targeted DNA damageQ77567869
P433issue46
P407language of work or nameEnglishQ1860
P921main subjectDNA topoisomerase 1 YOL006CQ27551244
P304page(s)36181-36188
P577publication date2000-11-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleRole for nucleolin/Nsr1 in the cellular localization of topoisomerase I
P478volume275

Reverse relations

cites work (P2860)
Q27933133A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae
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Q21266635Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I
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Q48181924MDM2 Degrades Deacetylated Nucleolin Through Ubiquitination to Promote Glioma Stem-Like Cell Enrichment for Chemotherapeutic Resistance.
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Q40714419Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin
Q41376096The L1TD1 protein interactome reveals the importance of post-transcriptional regulation in human pluripotency
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Q34793398The Nucleolus Takes Control of Protein Trafficking Under Cellular Stress
Q27933060The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase
Q52735441The interplay between G-quadruplex and Transcription.
Q24299024Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
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