The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters

scientific article (publication date: 30 December 2011)

The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.286054
P932PMC publication ID3247980
P698PubMed publication ID21998306

P50authorAlexis NzilaQ28913763
Sanjeev KrishnaQ30513217
Giancarlo BiaginiQ41938978
P2093author name stringDavid Johnson
Edwin Ochong
J Enrique Salcedo-Sora
Patrick G Bray
Paul A Stocks
Paul M O'Neill
Stephen A Ward
Susan Beveridge
P2860cites workOptimal concentration of p-aminobenzoic acid and folic acid in the in vitro assay of antifolates against Plasmodium falciparumQ61703686
Continuous cultivation and improved drug responsiveness of Plasmodium falciparum in p-aminobenzoic acid-deficient mediumQ61703701
An endogenous carrier-mediated uptake system for folate in oocytes of Xenopus laevisQ68329979
The enzymic synthesis of dihydropteroate and dihydrofolate by Plasmodium bergheiQ68667533
Antagonism of sulfadoxine and pyrimethamine antimalarial activity in vitro by p-aminobenzoic acid, p-aminobenzoylglutamic acid and folic acidQ69887088
Milk, p-aminobenzoate, and malaria of rats and monkeysQ73390932
T(E)Xtopo: shaded membrane protein topology plots in LAT(E)X2epsilonQ73399719
Characterization of Mutations That Allow p -Aminobenzoyl-Glutamate Utilization by Escherichia coliQ110079523
GenBankQ22065976
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis toolsQ24248165
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorptionQ24320048
Major facilitator superfamilyQ24548616
Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integraseQ24603699
The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorptionQ24682055
The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparumQ24797363
Insights into antifolate resistance from malarial DHFR-TS structuresQ27641016
Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coliQ27641769
Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation methodQ27972602
Human malaria parasites in continuous cultureQ28131626
The HMMTOP transmembrane topology prediction serverQ28190632
Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat modelQ28576740
PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational dataQ30760703
Identification of transport-critical residues in a folate transporter from the folate-biopterin transporter (FBT) familyQ30893248
Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responsesQ33719930
Transfection of the human malaria parasite Plasmodium falciparumQ33730143
Characterization of mutations that allow p-aminobenzoyl-glutamate utilization by Escherichia coli.Q33743397
The major facilitator superfamilyQ34004285
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.Q34145273
New perspectives on folate catabolismQ34262903
Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cellsQ34300268
Auxotrophs of Plasmodium falciparum dependent on p-aminobenzoic acid for growthQ35222960
Escherichia coli abg genes enable uptake and cleavage of the folate catabolite p-aminobenzoyl-glutamate.Q35759750
Mechanisms of resistance of malaria parasites to antifolatesQ36056329
Exploring the folate pathway in Plasmodium falciparumQ36104143
Plasmodium falciparum in continuous culture: a new medium for the in vitro test for sulfadoxine sensitivityQ36874600
Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coliQ37204080
A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for functionQ38289981
Chemosensitization of Plasmodium falciparum by probenecid in vitroQ39776217
In vitro activities of and mechanisms of resistance to antifol antimalarial drugsQ39849631
Use of the tac promoter and lacIq for the controlled expression of Zymomonas mobilis fermentative genes in Escherichia coli and Zymomonas mobilisQ39939751
Open randomized study of pyrimethamine-sulphadoxine vs. pyrimethamine-sulphadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in childrenQ40534758
Genetic and metabolic analysis of folate salvage in the human malaria parasite Plasmodium falciparumQ41913663
Utilization of exogenous folate in the human malaria parasite Plasmodium falciparum and its critical role in antifolate drug synergyQ41923816
Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screeningQ42112205
Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancerQ42154950
Evidence for the shikimate pathway in apicomplexan parasites.Q42541237
Characterisation of exogenous folate transport in Plasmodium falciparumQ42721596
Structure-function analysis of the highly conserved charged residues of the membrane protein FT1, the main folic acid transporter of the protozoan parasite LeishmaniaQ43297533
Intracellular trafficking/membrane targeting of human reduced folate carrier expressed in Xenopus oocytesQ43797545
Cloning and functional expression of an MIP (AQP0) homolog from killifish (Fundulus heteroclitus) lensQ43797602
De novo and salvage biosynthesis of pteroylpentaglutamates in the human malaria parasite, Plasmodium falciparumQ44219537
Effect of dietary p-aminobenzoic acid on murine Plasmodium yoelii infectionQ44669554
Quantitation of in vivo human folate metabolismQ45024898
Growth phase regulation of the main folate transporter of Leishmania infantum and its role in methotrexate resistanceQ45091641
Blood folate levels: the latest NHANES results.Q46039074
Liquid chromatography-tandem mass spectrometry analysis of folate and folate catabolites in human serumQ46054745
Higher plant plastids and cyanobacteria have folate carriers related to those of trypanosomatids.Q46703079
The susceptibility of Plasmodium falciparum to sulfadoxine and pyrimethamine: correlation of in vivo and in vitro resultsQ47918053
The importance of p-aminobenzoic acid to the course and immunity of malaria in animals (Plasmodium berghei) and in man (Pl. falciparum). II. Studies on naturally fed small childrenQ47949553
The importance of p-aminobenzoic acid to the course and immunity of malaria in animals (Plasmodium berghei) and in man (Pl. falciparum). 3. Studies on children experimentally fed on milkQ47949566
The importance of p-aminobenzoic acid to the course and immunity of malaria in animals (Plasmodium berghei) and in man (Pl. falciparum). I. Studies on NMRI miceQ47970153
The methionine synthesis cycle and salvage of methyltetrahydrofolate from host red cells in the malaria parasite (Plasmodium falciparum).Q48020701
A modified in vitro sulfadoxine susceptibility assay for Plasmodium falciparum suitable for investigating Fansidar resistanceQ48037412
Maintenance of Xenopus laevis and oocyte injectionQ50795431
TEXshade: shading and labeling of multiple sequence alignments using LATEX2 epsilon.Q52077703
Plasmodium falciparum: variations in p-aminobenzoic acid requirements as related to sulfadoxine sensitivity.Q54496745
Suppression of malaria (P. berghei) by milk.Q55072069
Effect of milk diet on P. cynomolgi infections in monkeys.Q55501534
P433issue52
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
folic acidQ127060
Plasmodium falciparumQ311383
folate transporter 1, putativeQ59997500
folate transporter 2, putativeQ61614794
folate transporter 1Q56567216
folate transporter 2Q56574421
folate transporter 1, putativeQ56723455
folate transporter 2, putativeQ56733008
folate transporter 1, putativeQ59733285
folate transporter 1, putativeQ59911074
folate transporter 2Q59914112
folate transporter 2, putativeQ59969459
folate transporter 2, putativeQ59969644
folate transporter 1, putativeQ59972848
folate transporter 1, putativeQ59984472
P304page(s)44659-68
P577publication date2011-12-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters
P478volume286

Reverse relations

described by source (P1343)
Q56567216folate transporter 1
Q56723455folate transporter 1, putative
Q59733285folate transporter 1, putative
Q59911074folate transporter 1, putative
Q59972848folate transporter 1, putative
Q59984472folate transporter 1, putative
Q59997500folate transporter 1, putative
Q56574421folate transporter 2
Q56733008folate transporter 2, putative
Q59969644folate transporter 2, putative

cites work (P2860)
Q40823145A mathematical model of microbial folate biosynthesis and utilisation: implications for antifolate development
Q43244960Decreased activity of folate transporters in lipid rafts resulted in reduced hepatic folate uptake in chronic alcoholism in rats
Q47752429Evidence for potential underestimation of clinical folate deficiency in resource-limited countries using blood tests
Q38152693Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate
Q42109446Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by natural product rubreserine.
Q38170172Membrane transport in the malaria parasite and its host erythrocyte
Q90317498Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor
Q38671679Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance
Q38066991Plasmodium cell biology should inform strategies used in the development of antimalarial transmission-blocking drugs
Q59359518Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate Biosynthesis
Q34469058Structure and function of Neisseria gonorrhoeae MtrF illuminates a class of antimetabolite efflux pumps
Q38104752Targeting the vitamin biosynthesis pathways for the treatment of malaria
Q26781634The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs
Q35513977The molecular basis of antifolate resistance in Plasmodium falciparum: looking beyond point mutations
Q38187860The role of antioxidants treatment on the pathogenesis of malarial infections: a review
Q38693321The role of folate in malaria - implications for home fortification programmes among children aged 6-59 months
Q38210207Transport proteins of parasitic protists and their role in nutrient salvage.

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