Artemisinin and Its Derivatives as a Repurposing Anticancer Agent: What Else Do We Need to Do?

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Artemisinin and Its Derivatives as a Repurposing Anticancer Agent: What Else Do We Need to Do? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/MOLECULES21101331
P932PMC publication ID6272993
P698PubMed publication ID27739410

P50authorZhe LiQ57050772
P2093author name stringJun Wu
Qin Li
Zhe Li
Junxian Yu
Manyuan Wang
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Dihydroartemisinin Exerts Its Anticancer Activity through Depleting Cellular Iron via Transferrin Receptor-1Q34382566
Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and functionQ34449959
Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin.Q34580333
Safety and efficacy field study of artesunate for dogs with non-resectable tumoursQ39156030
LyP-1 modification to enhance delivery of artemisinin or fluorescent probe loaded polymeric micelles to highly metastatic tumor and its lymphaticsQ39304213
Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cellsQ39379002
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Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phaseQ39476200
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Dihydroartemisinin inhibits angiogenesis in pancreatic cancer by targeting the NF-κB pathway.Q39561270
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Artesunate mitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthaseQ39618459
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Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.Q39731808
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Effect of artesunate on inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NFkappaB p65.Q39804120
The role of downstream signaling pathways of the epidermal growth factor receptor for Artesunate's activity in cancer cells.Q39886511
Artesunate derived from traditional Chinese medicine induces DNA damage and repair.Q39976238
Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of beta-catenin and E-cadherinQ39986800
Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen speciesQ39991619
Calcium and survivin are involved in the induction of apoptosis by dihydroartemisinin in human lung cancer SPC-A-1 cellsQ40161891
Artesunate in the treatment of metastatic uveal melanoma--first experiencesQ40374633
Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system.Q40381469
Repurposing drugs in oncology (ReDO)-cimetidine as an anti-cancer agentQ41668110
Dihydroartemisinin targets VEGFR2 via the NF-κB pathway in endothelial cells to inhibit angiogenesisQ41719685
Dihydroartemisinin inhibits vascular endothelial growth factor-induced endothelial cell migration by a p38 mitogen-activated protein kinase-independent pathwayQ42074384
The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarialsQ42571291
Synergistic inhibition of angiogenesis by artesunate and captopril in vitro and in vivoQ42923682
Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo.Q43170838
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Molecular modes of action of artesunate in tumor cell lines.Q44517624
Population pharmacokinetics of artesunate and dihydroartemisinin during long-term oral administration of artesunate to patients with metastatic breast cancer.Q44872854
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A multifunctional polymeric nanotheranostic system delivers doxorubicin and imaging agents across the blood-brain barrier targeting brain metastases of breast cancerQ47581209
Dihydroartemisinin is an inhibitor of ovarian cancer cell growthQ47776445
Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cellsQ47992452
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Case report of a pituitary macroadenoma treated with artemetherQ34653053
Artemether Combined with shRNA Interference of Vascular Cell Adhesion Molecule-1 Significantly Inhibited the Malignant Biological Behavior of Human Glioma CellsQ34674201
Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species productionQ34675798
Creation and revelation: two different routes to advancement in the biomedical sciencesQ34698856
Dihydroartemisinin promotes angiogenesis during the early embryonic development of zebrafishQ34740860
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Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumorsQ35079731
Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapyQ35832111
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Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression.Q37068031
The production and exportation of artemisinin-derived drugs in China: current status and existing challengesQ37099773
In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisininQ37119350
The antiviral activities of artemisinin and artesunate.Q37242654
Novel classes of dimer antitumour drug candidates.Q37387578
The activation of c-Jun NH₂-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cellsQ37514559
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.Q37543714
Severe embryotoxicity of artemisinin derivatives in experimental animals, but possibly safe in pregnant women.Q37683339
Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials.Q37996239
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Effects of artesunate on cytokinesis and G₂/M cell cycle progression of tumour cells and budding yeast.Q38338694
Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells.Q38832397
Clinical and non-clinical safety of artemisinin derivatives in pregnancyQ38923227
Direct binding of arsenic trioxide to AMPK and generation of inhibitory effects on acute myeloid leukemia precursorsQ38945222
In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery.Q38968099
Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cellsQ39024885
Cytotoxicity of dihydroartemisinin toward Molt-4 cells attenuated by N-tert-butyl-alpha-phenylnitrone and deferoxamineQ39079492
Artemisinin rewires the protein interaction network in cancer cells: network analysis, pathway identification, and target predictionQ39089032
Arteether exerts antitumor activity and reduces CD4+CD25+FOXP3+ T-reg cells in vivoQ39090250
Lymphoma and myeloma cells are highly sensitive to growth arrest and apoptosis induced by artesunateQ39123470
Novel artemisinin derivatives with potential usefulness against liver/colon cancer and viral hepatitis.Q39150213
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectorganic chemistryQ11351
artemisininQ426921
neoplasmQ1216998
antineoplasticQ2853144
P304page(s)1331
P577publication date2016-10-07
P13046publication type of scholarly workreview articleQ7318358
P1433published inMoleculesQ151332
P1476titleArtemisinin and Its Derivatives as a Repurposing Anticancer Agent: What Else Do We Need to Do?
P478volume21

Reverse relations

cites work (P2860)
Q48179606Alkenyl and Aryl Peroxides
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Q88249511FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation
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Q89989620New drugs are not enough‑drug repositioning in oncology: An update
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Q93083365Synthesis of Artemisinin-Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer
Q94566921Synthesis of Tamoxifen-Artemisinin and Estrogen-Artemisinin Hybrids Highly Potent Against Breast and Prostate Cancer

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