Properdin: a tightly regulated critical inflammatory modulator

scientific article

Properdin: a tightly regulated critical inflammatory modulator is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/IMR.12466
P3181OpenCitations bibliographic resource ID2723230
P932PMC publication ID5096056
P698PubMed publication ID27782331

P2093author name stringAdam Z. Blatt
Viviana P. Ferreira
Sabina Pathan
P2860cites workCathepsin G activates protease-activated receptor-4 in human plateletsQ22253276
Bivalent and co-operative binding of complement factor H to heparan sulfate and heparinQ24311571
Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complementQ24529520
Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndromeQ24543850
Control of the amplification convertase of complement by the plasma protein beta1HQ24561671
Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseasesQ24632001
The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1Q24673214
Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solutionQ24684822
Structural and functional characterization of the product of disease-related factor H gene conversionQ27677168
Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndromeQ28168804
The role of selectins in inflammation and diseaseQ28182332
The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomenaQ28210676
A new map of glycosaminoglycan and C3b binding sites on factor HQ28289935
Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structureQ28301693
Polyanion-induced self-association of complement factor H.Q37181643
Interleukin 18 in the heartQ37194396
Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3(H2O).Q37200463
The C-terminus of complement factor H is essential for host cell protectionQ37238656
Cyclosporine induces endothelial cell release of complement-activating microparticlesQ37260192
Dense deposit disease and C3 glomerulopathyQ37286653
Complement activation: an emerging player in the pathogenesis of cardiovascular diseaseQ37288362
Rational engineering of a minimized immune inhibitor with unique triple-targeting propertiesQ37300691
Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activationQ37319631
Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodiesQ37349469
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factorQ37373855
Properdin: emerging roles of a pattern-recognition molecule.Q37641361
Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection.Q37701996
Platelet–Leukocyte Interactions in Cardiovascular Disease and BeyondQ37808902
Native properdin binds to Chlamydia pneumoniae and promotes complement activationQ37851796
Platelets and the immune continuumQ37857647
Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agentsQ37897674
Platelet-leukocyte interactions in thrombosisQ37954861
Platelet-leukocyte deregulated interactions foster sterile inflammation and tissue damage in immune-mediated vessel diseases.Q37975846
The tick-over theory revisited: is C3 a contact-activated protein?Q38042224
Properdin in complement activation and tissue injuryQ38118454
Molecular Interactions between Complement Factor H and Its Heparin and Heparan Sulfate Ligands.Q38205436
Complement and platelets: Mutual interference in the immune networkQ38426499
The membrane attack complex as an inflammatory triggerQ38468111
Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding siteQ38596477
The many faces of Mac-1 in autoimmune diseaseQ38673428
Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in VitroQ38770928
Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdinQ38785657
Properdin provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6-dependent mannerQ38905276
Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).Q39093865
Mapping of the domains required for decay acceleration activity of the human factor H-like protein 1 and factor H.Q39154806
Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1.Q39154817
Complement activation by tubular cells is mediated by properdin bindingQ39946407
Properdin binds to late apoptotic and necrotic cells independently of C3b and regulates alternative pathway complement activationQ39980543
Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activationQ40161972
TREM-1 ligand expression on platelets enhances neutrophil activationQ40220719
Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-SurfacesQ40775694
Activation of the alternative pathway of human complement by autologous cells expressing transmembrane recombinant properdinQ40840566
Identification of complement regulatory domains in human factor HQ71700078
Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domainQ71746765
Identification of a heparin binding domain in the seventh short consensus repeat of complement factor HQ71860156
Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophilsQ73287589
Beta(3)-integrin-deficient mice but not P-selectin-deficient mice develop intimal hyperplasia after vascular injury: correlation with leukocyte recruitment to adherent platelets 1 hour after injuryQ73919572
Properdin, the positive regulator of complement, is highly C-mannosylatedQ73947959
Inhibition of complement alternative pathway function with anti-properdin monoclonal antibodiesQ74128109
Inhibition of complement, neutrophil, and platelet activation by an anti-factor D monoclonal antibody in simulated cardiopulmonary bypass circuitsQ74131707
Expression and characterisation of the thrombospondin type I repeats of human properdinQ74403037
Identification of the second heparin-binding domain in human complement factor HQ74412035
Expression of properdin in complete and incomplete deficiency: normal in vitro synthesis by monocytes in two cases with properdin deficiency type II due to distinct mutationsQ77117463
Role of C3 cleavage in monocyte activation during extracorporeal circulationQ78077727
Selectin blockade reduces neutrophil interaction with platelets at the site of deep arterial injury by angioplasty in pigsQ78111883
Selective blockade of membrane attack complex formation during simulated extracorporeal circulation inhibits platelet but not leukocyte activationQ78199173
Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfacesQ79287502
Leukocyte effects of C5a-receptor blockade during simulated extracorporeal circulationQ79447205
A novel mechanism of complement inhibition unmasked by a tick salivary protein that binds to properdinQ80825305
The dimeric and trimeric solution structures of the multidomain complement protein properdin by X-ray scattering, analytical ultracentrifugation and constrained modellingQ80877982
The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activationQ81009325
Circulating platelet-leukocyte aggregates: a marker of microvascular injury in diabetic patientsQ81159456
Properdin deficiency in murine models of nonseptic shockQ81206638
Complement alternative pathway acts as a positive feedback amplification of neutrophil activationQ82382595
Functional significance of factor H binding to Neisseria meningitidisQ83918204
The role of neutrophils in severe sepsisQ95807322
Complement and its receptors: new insights into human diseaseQ28307316
Analysis of the interactions between properdin, the third component of complement (C3), and its physiological activation productsQ28610971
Molecular architecture of human properdin, a positive regulator of the alternative pathway of complementQ28610991
Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathwayQ28611040
Complement: a key system for immune surveillance and homeostasisQ29615484
Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E.Q30310323
The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.Q30377280
Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritisQ30415634
CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injuryQ30441065
Platelet-neutrophil-interactions: linking hemostasis and inflammationQ30441637
Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.Q30543168
Clustering of missense mutations in the C-terminal region of factor H in atypical hemolytic uremic syndrome.Q33335833
Molecular modelling of the C-terminal domains of factor H of human complement: a correlation between haemolytic uraemic syndrome and a predicted heparin binding siteQ33341100
Cutting edge: localization of the host recognition functions of complement factor H at the carboxyl-terminal: implications for hemolytic uremic syndromeQ33344817
Structural and functional characterization of factor H mutations associated with atypical hemolytic uremic syndromeQ33345226
Factor H binds to washed human platelets.Q33364421
Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domainsQ33375335
Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.Q33377799
Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activationQ33378612
Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndromeQ33384039
Platelet-associated complement factor H in healthy persons and patients with atypical HUS.Q33385950
Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1Q33388175
Complement activation on platelets: implications for vascular inflammation and thrombosisQ33390662
Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndromeQ33394691
Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regionsQ33405609
Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndromeQ33430961
Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H.Q33558301
A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.Q33568131
Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damageQ33680856
Contribution of chondroitin sulfate A to the binding of complement proteins to activated plateletsQ33707764
Identification of tubular heparan sulfate as a docking platform for the alternative complement component properdin in proteinuric renal diseaseQ33764140
Properdin deficiency: molecular basis and disease associationQ33852651
Complement control protein factor H: the good, the bad, and the inadequate.Q34067107
Kinetic studies on the interactions of heparin and complement proteins using surface plasmon resonanceQ34068498
Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathyQ40873835
The C-terminus of factor H: monoclonal antibodies inhibit heparin binding and identify epitopes common to factor H and factor H-related proteinsQ41044029
Properdin Regulation of Complement Activation Affects Colitis in Interleukin 10 Gene-Deficient Mice.Q41261204
Characterization of complement factor H binding to Yersinia enterocolitica serotype O:3.Q41442818
Properdin, a positive regulator of complement activation, is expressed in human T cell lines and peripheral blood T cellsQ41529943
The C3 convertase of the alternative pathway of human complement. Enzymic properties of the bimolecular proteinaseQ41761011
Interaction of C3b(2)--IgG complexes with complement proteins properdin, factor B and factor H: implications for amplificationQ41822812
Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37.Q41825787
Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytesQ41894352
Resolution and analysis of 'native' and 'activated' properdinQ42065766
Complete primary structure of human properdin: a positive regulator of the alternative pathway of the serum complement systemQ42137607
Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase.Q42144043
Relation of putative thioester bond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complementQ42242306
The role of properdin in zymosan- and Escherichia coli-induced complement activationQ42285785
Effect of complement proteins C5b-9 on blood platelets. Evidence for reversible depolarization of membrane potentialQ42435868
An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy.Q42625961
Factor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity.Q43222930
Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H.Q43292217
Myeloperoxidase influences the complement regulatory function of modified C-reactive proteinQ43702621
Genetic and environmental factors influencing the human factor H plasma levelsQ43958315
Synthesis of platelet-activating factor by polymorphonuclear neutrophils stimulated with interleukin-8.Q44135612
Circulating platelet-leukocyte aggregates in patients with inflammatory bowel diseaseQ44315190
Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assemblyQ44441855
Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activationQ44781829
P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophilsQ44951891
Platelet activation in cystic fibrosisQ45261261
The role of properdin in murine zymosan-induced arthritisQ45411990
The complement factor properdin induces formation of platelet-leukocyte aggregates via leukocyte activationQ46367570
Neutron and X-ray scattering studies on the human complement protein properdin provide an analysis of the thrombospondin repeatQ46764067
The role of properdin in the assembly of the alternative pathway C3 convertases of complementQ46814862
High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib.Q47443298
Molecular characterization of properdin deficiency type III: dysfunction produced by a single point mutation in exon 9 of the structural gene causing a tyrosine to aspartic acid interchange.Q48059014
An evaluation of the role of properdin in alternative pathway activation on Neisseria meningitidis and Neisseria gonorrhoeaeQ34105747
Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injuryQ34162118
Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complementQ34172424
A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2Q34185817
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.Q34344501
Complement System Part I - Molecular Mechanisms of Activation and RegulationQ34481071
Metabolism of properdin in normal subjects and patients with renal diseaseQ34482222
The role of the anaphylatoxins in health and diseaseQ34983578
Molecular intercommunication between the complement and coagulation systemsQ35067949
Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injuryQ35097512
Protective role for properdin in progression of experimental murine atherosclerosis.Q35131403
Anti-mouse properdin TSR 5/6 monoclonal antibodies block complement alternative pathway-dependent pathogenesisQ35149952
Linkage specificity and role of properdin in activation of the alternative complement pathway by fungal glycansQ35187024
Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activityQ35187629
Leukocytes and coronary heart diseaseQ35622165
The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammationQ35659039
Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulationQ35763398
Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysmQ35787311
Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding proteinQ35850975
Properdin Contributes to Allergic Airway Inflammation through Local C3a GenerationQ35864604
Factor H mediated cell surface protection from complement is critical for the survival of PNH erythrocytes.Q35990700
Role of C5a in inflammatory responsesQ36072464
The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular trapsQ36229261
The reaction mechanism of beta-1C-globulin (C'3) in immune hemolysisQ36267933
Formation of a hemolytically active cellular intermediate by the interaction between properdin factors B and D and the activated third component of complementQ36272704
The human complement system in thrombin-mediated platelet functionQ36340436
Human complement in thrombin-mediated platelet function: uptake of the C5b-9 complexQ36342752
Identification of a C3bi-specific membrane complement receptor that is expressed on lymphocytes, monocytes, neutrophils, and erythrocytes.Q36346014
Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertaseQ36358434
Modulation of the alternative complement pathways by beta 1 H globulinQ36359984
Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)Q36368770
Platelet activation leads to activation and propagation of the complement systemQ36403387
Complement and properidin deficiencies in meningococcal diseaseQ36411073
Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18.Q51741449
C3b deposition during activation of the alternative complement pathway and the effect of deposition on the activating surfaceQ52162401
Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional propertiesQ52735864
A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways.Q53598537
Blood platelets activate the classical pathway of human complement.Q53600476
Early and transient release of leukocyte pentraxin 3 during acute myocardial infarction.Q53708193
Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs.Q53958156
Myeloperoxidase directs properdin-mediated complement activation.Q54416095
Properdin plays a protective role in polymicrobial septic peritonitis.Q54426191
Human polymorphonuclear leukocytes produce and express functional tissue factor upon stimulation.Q54601092
Atypical hemolytic uremic syndromeQ56591965
Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor HQ57089510
Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic PlaquesQ57132361
Platelet/polymorphonuclear leukocyte interaction: P-selectin triggers protein-tyrosine phosphorylation-dependent CD11b/CD18 adhesion: role of PSGL-1 as a signaling moleculeQ58411952
Platelet/polymorphonuclear leukocyte interaction in dynamic conditions: evidence of adhesion cascade and cross talk between P-selectin and the beta 2 integrin CD11b/CD18Q58411981
Generation of C5a in the absence of C3: a new complement activation pathwayQ58523865
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent plateletsQ59065667
The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplificationQ63728042
Characterization of the initial C3 convertase of the alternative pathway of human complement.Q64902892
On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activityQ67273787
Localization of the heparin-binding site on complement factor HQ67902469
Properdin binds to sulfatide [Gal(3-SO4)beta 1-1 Cer] and has a sequence homology with other proteins that bind sulfated glycoconjugatesQ68708720
Induction of prostanoid synthesis in human platelets by the late complement components C5b-9 and channel forming antibiotic nystatin: inhibition of the reacylation of liberated arachidonic acidQ68934597
Analysis of the natural polymeric forms of human properdin and their functions in complement activationQ69934718
Effect of platelet-activating factor (PAF) on human plateletsQ70218005
Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18Q71249326
Increased neutrophil-platelet adhesion in patients with unstable anginaQ71571191
Anti-complement activity of the Ixodes scapularis salivary protein Salp20.Q36422019
Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiencyQ36509318
Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement.Q36540594
Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis.Q36633356
Characterization of mutant forms of recombinant human properdin lacking single thrombospondin type I repeats. Identification of modules important for function.Q36672763
Essential role of surface-bound complement factor H in controlling immune complex-induced arthritisQ36714001
The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis.Q36752476
Platelet-leukocyte interactions in inflammation and atherothrombosisQ36752801
Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole BloodQ36955789
Platelet mediated complement activationQ37088046
Complement activation triggered by chondroitin sulfate released by thrombin receptor-activated plateletsQ37170034
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
thrombosisQ261327
globulinsQ321710
blood proteinsQ425056
complement system proteinsQ67999591
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)172-190
P577publication date2016-11-01
P1433published inImmunological ReviewsQ15724582
P1476titleProperdin: a tightly regulated critical inflammatory modulator
P478volume274

Reverse relations

described by source (P1343)
Q107603134Alternative pathway C3 convertase complex C3bBb
Q107603133Alternative pathway fluid-phase C3 convertase complex C3(H2O)Bb
Q107603137Alternative pathway pathogen cell-bound C3 convertase complex C3bBbP
Q107603138Alternative pathway pathogen cell-bound C5 convertase complex C3bBbC3bP
Q107603136Alternative pathway solid-phase C5 convertase complex C3bBbC3b

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