Organization, evolution and functions of the human and mouse Ly6/uPAR family genes

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Organization, evolution and functions of the human and mouse Ly6/uPAR family genes is …
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P6179Dimensions Publication ID1035042155
P356DOI10.1186/S40246-016-0074-2
P3181OpenCitations bibliographic resource ID2185105
P932PMC publication ID4839075
P698PubMed publication ID27098205
P5875ResearchGate publication ID301573018

P50authorElspeth A BrufordQ30504320
P2093author name stringShivalingappa K. Swamynathan
Sudha Swamynathan
Chelsea L. Loughner
Emili E. Delp
Monica S. McAndrews
P2860cites workIsolation and characterization of a new member of the human Ly6 gene family (LY6H)Q22004257
A urokinase receptor-associated protein with specific collagen binding propertiesQ22011054
Mutations in the gene encoding SLURP-1 in Mal de MeledaQ24291082
Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de MeledaQ24295039
Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defectsQ24298184
ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de MeledaQ24304524
A proteome-scale map of the human interactome networkQ24307146
Differential mRNA expression of urokinase-type plasminogen activator, plasminogen activator receptor and plasminogen activator inhibitor type-2 in normal human endometria and endometrial carcinomasQ73153357
Generation of antibodies to the urokinase receptor (uPAR) by DNA immunization of uPAR knockout mice: membrane-bound uPAR is not required for an antibody responseQ73889409
Complement regulatory proteins on the sperm surface: relevance to sperm motilityQ74466985
Identification of recurrent mutations in the ARS (component B) gene encoding SLURP-1 in two families with mal de MeledaQ78817145
Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitisQ79314618
Coordinated regulation of human trophoblast invasiveness by macrophages and interleukin 10Q79411522
Transcriptional regulation of SLURP2, a psoriasis-associated gene, is under control of IL-22 in the skin: A special reference to the nested gene LYNX1Q85274645
RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cellQ24316562
PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activityQ24316881
Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivityQ24321855
The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesionQ24323115
Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipaseQ24323221
Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammationQ24338135
Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easyQ24603196
Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic reviewQ24614787
Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activityQ24633333
Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cellsQ24671344
Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamilyQ24672686
Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancerQ24673693
Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicronsQ24677013
The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexesQ24678932
CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cellsQ24681862
Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interactionQ24683196
Ly6 family proteins in neutrophil biologyQ26852085
The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferiQ27316838
Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complexQ27644794
Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxinsQ27729364
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal OmegaQ27860809
A review of the new HGNC gene family resourceQ28077631
SLURP-1 modulates corneal homeostasis by serving as a soluble scavenger of urokinase-type plasminogen activatorQ28115141
Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de MeledaQ28119056
Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancerQ28138355
Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumorsQ28145415
Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinomaQ28202012
Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1Q28268341
Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 familyQ28286959
Acute lymphoid leukemia cells with greater stem cell antigen-1 (Ly6a/Sca-1) expression exhibit higher levels of metalloproteinase activity and are more aggressive in vivoQ35106493
The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy.Q35144575
Comparison of genome-wide gene expression in suture- and alkali burn-induced murine corneal neovascularization.Q35209209
Members of the murine Pate family are predominantly expressed in the epididymis in a segment-specific fashion and regulated by androgens and other testicular factorsQ35339268
Expression of C4.4A, a structural uPAR homolog, reflects squamous epithelial differentiation in the adult mouse and during embryogenesisQ35440794
Aged men share the sperm protein PATE1 defect with young asthenozoospermia patientsQ35552344
A suppressor of multiple extracellular matrix-degrading proteases and cancer metastasis.Q35893470
Involvement of the prostate and testis expression (PATE)-like proteins in sperm-oocyte interactionQ35896523
Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine ReceptorQ35932193
Soluble urokinase activator receptor (suPAR) in stem cell mobilizationQ36061778
Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1Q36064401
Ly6G ligation blocks recruitment of neutrophils via a β2-integrin-dependent mechanismQ36177942
Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasminQ36222838
Sequence-specific 1H-NMR assignments and folding topology of human CD59.Q36277854
Sca-1 knockout impairs myocardial and cardiac progenitor cell functionQ36295027
The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epitheliumQ36312490
Altered proliferative response by T lymphocytes of Ly-6A (Sca-1) null miceQ36380511
Corneal Expression of SLURP-1 by Age, Sex, Genetic Strain, and Ocular Surface HealthQ36380577
The regulatory mechanism of the LY6K gene expression in human breast cancer cellsQ36385900
Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr miceQ36426921
Downregulated expression of Ly-6-ThB on developing T cells marks CD4+CD8+ subset undergoing selection in the thymusQ36511402
Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epitheliumQ36592948
Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell developmentQ36757623
Neutrophil-specific antigen HNA-2a, NB1 glycoprotein, and CD177.Q36953106
Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblastsQ37085627
Basic and clinical aspects of non-neuronal acetylcholine: biological and clinical significance of non-canonical ligands of epithelial nicotinic acetylcholine receptorsQ37088832
The urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia.Q37255861
Participation of the urokinase receptor in neutrophil efferocytosis.Q37275898
Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degenerationQ37331431
Generation and characterization of urokinase receptor-deficient miceQ37351869
Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptorQ37372571
Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activatorQ37561638
Regulation of cell signalling by uPAR.Q37660895
Down-regulation of prostate stem cell antigen (PSCA) by Slug promotes metastasis in nasopharyngeal carcinomaQ38297810
A role for LYNX2 in anxiety-related behaviorQ28507664
Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein familyQ28509139
Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1Q28513258
Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell developmentQ28513360
Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59bQ28588525
SSLP-1, a secreted Ly-6 protein purified from mouse seminal vesicle fluidQ28588923
Identification of Ly-6K as a novel marker for mouse plasma cellsQ28589202
Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient miceQ28589893
Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6.Q28591810
GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in miceQ28593061
Accelerated evolution of nervous system genes in the origin of Homo sapiensQ29618491
SLURP-2: A novel cholinergic signaling peptide in human mucocutaneous epithelium.Q29871473
Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's diseaseQ30032674
SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interactionQ30310897
Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen familyQ30381781
Human SP-10: acrosomal distribution, processing, and fate after the acrosome reactionQ30465560
Lynx1, a cholinergic brake, limits plasticity in adult visual cortexQ30519473
Water-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors.Q30616588
Cloning of the human homologue of the metastasis-associated rat C4.4A.Q30652851
Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium.Q30658020
Palmoplantar Keratoderma in Slurp2-Deficient MiceQ30665199
SLURP-2, a novel member of the human Ly-6 superfamily that is up-regulated in psoriasis vulgarisQ30885593
A novel epitope of CD59 expressed by primitive human hematopoietic progenitorsQ31032811
Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligandsQ32874868
The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cellsQ33199829
Intestinal epithelial cell up-regulation of LY6 molecules during colitis results in enhanced chemokine secretionQ33322650
Cloning and characterization of a human LYPD7, a new member of the Ly-6 superfamilyQ33325211
PredGPI: a GPI-anchor predictorQ33371364
Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagusQ33379614
Identification and characterization of human LYPD6, a new member of the Ly-6 superfamilyQ33490176
A mouse knockout library for secreted and transmembrane proteins.Q33609631
Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and SLURP-2 on human intestinal epithelial cells and immunocytesQ33625260
N-linked glycosylation of the ligand-binding domain of the human urokinase receptor contributes to the affinity for its ligandQ38319087
Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral to dorsal telencephalonQ38498293
Congenital CD59 DeficiencyQ38515960
suPAR: A New Biomarker for Cardiovascular Disease?Q38539294
suPAR: The unspecific marker for disease presence, severity and prognosisQ38646817
IFN-stimulated gene LY6E in monocytes regulates the CD14/TLR4 pathway but inadequately restrains the hyperactivation of monocytes during chronic HIV-1 infection.Q38956177
Urokinase receptor orchestrates the plasminogen system in airway epithelial cell function.Q39194903
Membrane-bound and exosomal metastasis-associated C4.4A promotes migration by associating with the α(6)β(4) integrin and MT1-MMP.Q39376527
C4.4A is associated with tumor budding and epithelial-mesenchymal transition of colorectal cancerQ39382631
Lymphocyte antigens: Ly-4, Ly-6, and Ly-7Q39439488
Metastatic effect of LY-6K gene in breast cancer cells.Q39819611
Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands.Q40173572
SLURP-1 and -2 in normal, immortalized and malignant oral keratinocytesQ40174409
Tissue expression, structure and function of the murine Ly-6 family of moleculesQ40378956
The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated proteinQ40441337
Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infectionQ40867377
Induction of apoptosis in T98G glioblastoma cells by transfection of GML, a p53 target geneQ40922304
CD2-mediated CD59 stimulation in keratinocytes results in secretion of IL-1alpha, IL-6, and GM-CSF: implications for the interaction of keratinocytes with intraepidermal T lymphocytesQ40952222
Ly-6-domain proteins--new insights and new members: a C-terminal Ly-6 domain in sperm acrosomal protein SP-10.Q41179255
Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteinsQ41184719
Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice.Q41232530
Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domainsQ41412758
Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanismsQ41588972
NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophilsQ41792377
Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent mannerQ41954957
Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysisQ41955255
Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC.Q42001617
The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31).Q42152390
Analysis Tool Web Services from the EMBL-EBI.Q42265365
Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertilityQ42437284
Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditionsQ42973991
Expression of prostate stem cell antigen (PSCA) in prostate cancer: a tissue microarray study of Iranian patientsQ45391754
Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formationQ45884595
Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand.Q46028574
Expression of SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells.Q46035494
A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction.Q46157128
Novel genes associated with malignant melanoma but not benign melanocytic lesionsQ46226262
Identification of mouse Ly6H and its expression in normal tissueQ47925385
lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS.Q47948454
A novel mouse gene, HemT, encoding an hematopoietic cell-specific transcriptQ47966944
Characterization of two novel Ly-6 genes. Protein sequence and potential structural similarity to alpha-bungarotoxin and other neurotoxinsQ48115357
Identification, cloning, and initial characterization of a novel mouse testicular germ cell-specific antigenQ48380638
The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivoQ48430464
A monoclonal antibody to human SP-10 inhibits in vitro the binding of human sperm to hamster oolemma but not to human Zona pellucidaQ48892474
Borrelia burgdorferi and other bacterial products induce expression and release of the urokinase receptor (CD87).Q50117815
Genome wide analysis of DNA copy number neutral loss of heterozygosity (CNNLOH) and its relation to gene expression in esophageal squamous cell carcinomaQ33721447
The plasminogen (fibrinolytic) systemQ33799992
Klf4 regulates the expression of Slurp1, which functions as an immunomodulatory peptide in the mouse corneaQ33961178
Prostate stem cell antigen: a Jekyll and Hyde molecule?Q34001130
PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approachQ34016309
A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrenceQ34046527
Urokinase plasminogen activator receptor: Prognostic biomarker for endometrial cancerQ34075406
Guidelines for human gene nomenclatureQ34123167
Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice formsQ34134754
uPAR: a versatile signalling orchestratorQ34162183
Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab EmiratesQ34165010
Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda.Q34179592
A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect.Q34202904
Membrane complement regulatory proteins: insight from animal studies and relevance to human diseasesQ34257510
Postnatal gene expression in the normal mouse cornea by SAGE.Q34292743
Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinasesQ34304838
Paroxysmal nocturnal hemoglobinuriaQ34431429
The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and diseaseQ34445051
Expression of LY6D is induced at the surface of MCF10A cells by X-ray irradiationQ34449743
Three-finger snake neurotoxins and Ly6 proteins targeting nicotinic acetylcholine receptors: pharmacological tools and endogenous modulatorsQ34455011
Enhancement in motor learning through genetic manipulation of the Lynx1 geneQ34471759
Biological effects of SLURP-1 on human keratinocytesQ34476314
PHTS, a novel putative tumor suppressor, is involved in the transformation reversion of HeLaHF cells independently of the p53 pathwayQ34484618
Expression of the Ly6/uPAR-domain proteins C4.4A and Haldisin in non-invasive and invasive skin lesionsQ35009805
Characterization of a novel mouse model with genetic deletion of CD177Q35034567
No obvious phenotypic abnormalities in mice lacking the Pate4 gene.Q50945585
Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia.Q51723107
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer.Q51789044
Ly-6 superfamily members Ly-6A/E, Ly-6C, and Ly-6I recognize two potential ligands expressed by B lymphocytes.Q51842269
A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis.Q51947873
Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development.Q52036481
Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation.Q53326599
Progression of Barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcriptional programs of epidermal differentiation.Q53358861
Modification of kidney barrier function by the urokinase receptor.Q53510545
SLURP1 Is a Late Marker of Epidermal Differentiation and Is Absent in Mal de MeledaQ56592208
Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuriaQ57089549
Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophilsQ57375059
Comparative studies of glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1: evidence for a eutherian mammalian origin for the GPIHBP1 gene from an LY6-like geneQ59292267
Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayersQ67672469
Biochemical characterization of the neutrophil-specific antigen NB1Q68447373
High-level expression of a novel epitope of CD59 identifies a subset of CD34+ bone marrow cells highly enriched for pluripotent stem cellsQ71215296
Expression of the complement regulatory protein CD59 on human spermatozoa: Characterization and role in gametic interactionQ71647838
Identity of a peptide domain of human C9 that is bound by the cell-surface complement inhibitor, CD59Q71650792
Cell surface antigen phenotypes and enzyme expression patterns of two murine T-cell lymphomas derived from early and/or mature thymus cellsQ72114728
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmembrane proteinQ423042
cell surface receptorQ2476074
multigene familyQ71148070
P304page(s)10
P577publication date2016-04-21
P1433published inHuman genomicsQ26842690
P1476titleOrganization, evolution and functions of the human and mouse Ly6/uPAR family genes
P478volume10

Reverse relations

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