New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

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New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2016/1973834
P3181OpenCitations bibliographic resource ID2920586
P932PMC publication ID5088319
P698PubMed publication ID27829982

P50authorBożena AdamczykQ89261528
Monika Adamczyk-SowaQ90194477
P2860cites workFree radicals and antioxidants in normal physiological functions and human diseaseQ21710698
In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulationQ24610713
Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune enchephalomyelitis mouseQ24630119
Free radicals: properties, sources, targets, and their implication in various diseasesQ27000071
Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammationQ27322415
Plasmatic oxidative stress biomarkers in multiple sclerosis: relation with clinical and demographic characteristicsQ44848364
Modulation of oxidative stress, apoptosis, and calcium entry in leukocytes of patients with multiple sclerosis by Hypericum perforatumQ44912998
Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cellsQ45166159
The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouseQ45895784
Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis.Q46078160
Ozone Therapy in Ethidium Bromide-Induced Demyelination in Rats: Possible Protective EffectQ46525864
Evidence of extensive RNA oxidation in normal appearing cortex of multiple sclerosis brainQ46618645
Anti-inflammatory effects and antioxidant activity of dihydroasparagusic acid in lipopolysaccharide-activated microglial cellsQ46635906
CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microgliaQ46699381
Mitoxantrone-induced suicidal erythrocyte deathQ46810020
Involvement of nitric oxide in improving stress-induced behavioural alteration by glatiramer acetate treatment in female BALB/c mice.Q46817518
Markers of oxidative stress in plasma and saliva in patients with multiple sclerosisQ46826911
Hydralazine inhibits compression and acrolein-mediated injuries in ex vivo spinal cordQ46905314
Evaluation of lovastatin effects on expression of anti-apoptotic Nrf2 and PGC-1α genes in neural stem cells treated with hydrogen peroxide.Q46951155
Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune encephalomyelitisQ46955354
Custom cerium oxide nanoparticles protect against a free radical mediated autoimmune degenerative disease in the brainQ46968494
Decreased urinary level of melatonin as a marker of disease severity in patients with multiple sclerosisQ47574569
Effect of natalizumab on oxidative damage biomarkers in relapsing-remitting multiple sclerosisQ47768496
Influence of melatonin supplementation on serum antioxidative properties and impact of the quality of life in multiple sclerosis patientsQ48033298
Dimethyl fumarate activates the prostaglandin EP2 receptor and stimulates cAMP signaling in human peripheral blood mononuclear cellsQ48056054
Demyelination: the role of reactive oxygen and nitrogen speciesQ48283279
Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxinQ48299225
Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosisQ48316974
Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE systemQ48363740
Isoprostanes in clinically isolated syndrome and early multiple sclerosis as biomarkers of tissue damage and predictors of clinical course.Q48400649
Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in catsQ48477188
Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis.Q48586779
Interplay of cannabinoid 2 (CB2) receptors with nitric oxide synthases, oxidative and nitrative stress, and cell death during remote neurodegenerationQ48638028
Interleukin-1β causes synaptic hyperexcitability in multiple sclerosisQ48693638
Protective Effect of Dimethyl Fumarate on an Oxidative Stress Model Induced by Sodium Nitroprusside in MiceQ48701678
Oxidative modification of patient's plasma proteins and its role in pathogenesis of multiple sclerosisQ48825272
Cytokine toxicity to oligodendrocyte precursors is mediated by ironQ48843970
Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in miceQ48938369
Comparative Neuroregenerative Effects of C-Phycocyanin and IFN-Beta in a Model of Multiple Sclerosis in MiceQ50239453
Melatonin reduces oxidative stress in the erythrocytes of multiple sclerosis patients with secondary progressive clinical course.Q50493390
Genetic, Immune-Inflammatory, and Oxidative Stress Biomarkers as Predictors for Disability and Disease Progression in Multiple Sclerosis.Q50945427
Elevated melatonin levels in natalizumab-treated female patients with relapsing-remitting multiple sclerosis: relationship to oxidative stress.Q51157176
Serum paraoxonase and arylesterase activity and oxidative status in patients with multiple sclerosis.Q51243760
Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: a randomized controlled clinical trial.Q51343458
Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord.Q52046430
Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia.Q52148099
Total radical-trapping antioxidant parameter in NIDDM patients.Q52275754
Oxidative damage to mitochondria at the nodes of Ranvier precedes axon degeneration in ex vivo transected axons.Q52651477
Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening.Q53001350
[Antioxidant use as dietary therapy in patients with multiple sclerosis].Q53633461
Effects of a low-fat diet with antioxidant supplementation on biochemical markers of multiple sclerosis long-term care residents.Q54311255
Erythrocytes' antioxidative capacity as a potential marker of oxidative stress intensity in neuroinflammation.Q54545951
Peroxynitrite Mediated Oxidation of Purine Bases of Nucleosides and Isolated DNAQ56919077
Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymesQ57258966
Hemoglobin as a source of iron overload in multiple sclerosis: does multiple sclerosis share risk factors with vascular disorders?Q57898104
Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosisQ61415557
Free radicals in the physiological control of cell functionQ27860480
Inflammation, Iron, Energy Failure, and Oxidative Stress in the Pathogenesis of Multiple SclerosisQ28080754
Antioxidant enzymes and human diseasesQ28142812
The molecule of the yearQ28237487
Multiple sclerosisQ28299151
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and uglyQ29547442
Axonal transection in the lesions of multiple sclerosisQ29615585
Reactive oxygen species, antioxidants, and the mammalian thioredoxin systemQ29619367
Axonal pathology in multiple sclerosis: relationship to neurologic disabilityQ30581941
Endothelial function in hypertension: the role of superoxide anionQ33752634
The role of mitochondria in reactive oxygen species metabolism and signalingQ33849198
Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent processQ33858402
Melatonin acts as antioxidant and improves sleep in MS patients.Q34006944
Hydrogen peroxide in the human body.Q34099983
Human studies related to protein oxidation: protein carbonyl content as a marker of damageQ34146688
Autophagy of mitochondria: a promising therapeutic target for neurodegenerative diseaseQ34287719
Review: Mitochondria and disease progression in multiple sclerosisQ34308687
Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergeticsQ34422726
Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and ironQ34607681
Ozone autohemotherapy induces long-term cerebral metabolic changes in multiple sclerosis patientsQ34665153
Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosisQ34720644
Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysisQ34769676
Acrolein detection: potential theranostic utility in multiple sclerosis and spinal cord injuryQ34888636
Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantificationQ35038985
Oxidative damage in multiple sclerosis lesionsQ35065674
Dimethyl fumarate modulates antioxidant and lipid metabolism in oligodendrocytesQ35594174
Relationship between the Increased Haemostatic Properties of Blood Platelets and Oxidative Stress Level in Multiple Sclerosis Patients with the Secondary Progressive StageQ35598836
Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla.Q35606720
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injuryQ35776944
Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK PathwayQ35814106
Cell type-specific Nrf2 expression in multiple sclerosis lesions.Q35856138
Nigella sativa amliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar ratsQ35918951
Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes.Q35938192
Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neuronsQ35987121
Evaluation of Delta-Aminolevulinic Dehydratase Activity, Oxidative Stress Biomarkers, and Vitamin D Levels in Patients with Multiple SclerosisQ61780781
Characterization of free radical generation by xanthine oxidase. Evidence for hydroxyl radical generationQ69349215
[Natalizumab and reduction of carbonylated proteins in patients with multiple sclerosis]Q83854528
Paraoxonase 1 activity in multiple sclerosis patients during mitoxantrone therapyQ84769917
[Cryostimulation as an antioxidative factor in sclerosis multiplex]Q85080939
Tolerability and Safety of Combined Glatiramer Acetate and N-Acetylcysteine in Relapsing-Remitting Multiple SclerosisQ85578184
Oxidative modification of serum proteins in multiple sclerosisQ85772565
Serum ferroxidase activity in patients with multiple sclerosis: a pilot studyQ85965756
Activity of liver enzymes in multiple sclerosis patients with Hot-nature diet and co-supplemented hemp seed, evening primrose oils interventionQ86121374
The patients with clinically isolated syndrome and relapsing remitting multiple sclerosis show different levels of advanced protein oxidation products and total thiol content in plasma and CSFQ86410703
α-Lipoic acid enhances endogenous peroxisome-proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis in miceQ86526742
Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing-remitting multiple sclerosisQ87103712
Disability in patients with multiple sclerosis: influence of insulin resistance, adiposity, and oxidative stressQ87209478
Monomethylfumarate reduces in vitro migration of mononuclear cellsQ87248214
Combined GSTP1 and NQO1 germline polymorphisms in the susceptibility to Multiple SclerosisQ87395533
[Biochemical markers of oxidative stress in different forms and phases of multiple sclerosis]Q95616724
Chemical, pharmacokinetic and pharmacodynamic properties of statins: an updateQ36014966
Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesisQ36067904
Phasic Treatment with Interferon Gamma Stimulates Release of Exosomes that Protect Against Spreading DepressionQ36108513
Saffron ethanolic extract attenuates oxidative stress, spatial learning, and memory impairments induced by local injection of ethidium bromideQ36209917
Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidantQ36332494
PRDX6 controls multiple sclerosis by suppressing inflammation and blood brain barrier disruptionQ36356190
Acrolein-mediated injury in nervous system trauma and diseasesQ36452743
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research.Q36457107
Oxidative stress is related to the deleterious effects of heme oxygenase-1 in an in vivo neuroinflammatory rat modelQ36711785
Comparative Analysis of Serum (Anti)oxidative Status Parаmeters in Healthy PersonsQ36790501
Oxyl radicals, redox-sensitive signalling cascades and antioxidantsQ36849942
Inhibition of Myeloperoxidase at the Peak of Experimental Autoimmune Encephalomyelitis Restores Blood-Brain-Barrier Integrity and Ameliorates Disease Severity.Q36896738
Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's DiseaseQ37091371
Nutraceuticals against Neurodegeneration: A Mechanistic InsightQ37168739
Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicityQ37236591
New insights in the pathogenesis of multiple sclerosis--role of acrolein in neuronal and myelin damageQ37291226
IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelinationQ37576782
Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injuryQ37603404
Oxidative stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatmentQ37699846
Exosomes for targeted siRNA delivery across biological barriers.Q38037911
Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotectionQ38039489
Progressive multiple sclerosis: pathology and pathogenesisQ38046113
Lipophilic fluorescent products of free radicalsQ38085166
Dimethyl fumarate : a Janus-faced substance?Q38108633
Pathology and disease mechanisms in different stages of multiple sclerosisQ38111904
Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseasesQ38133759
Remote neurodegeneration: multiple actors for one play.Q38179991
Dimethyl fumarate: a review of its use in patients with relapsing-remitting multiple sclerosisQ38195521
The role of glutamate and its receptors in multiple sclerosisQ38196367
Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis.Q38196701
The role of microglial activation in disease progressionQ38210510
Glutathione in multiple sclerosis: more than just an antioxidant?Q38212993
Remote degeneration: insights from the hemicerebellectomy modelQ38254076
Novel targets in multiple sclerosis: to oxidative stress and beyondQ38283708
Oxidative Stress and Neurobiology of DemyelinationQ38287176
Pathological mechanisms in progressive multiple sclerosisQ38378846
Synthetic and natural inhibitors of phospholipases A2: their importance for understanding and treatment of neurological disordersQ38428658
Melatonin redox activity. Its potential clinical applications in neurodegenerative disordersQ38488588
Multiple Sclerosis Relapses: Epidemiology, Outcomes and Management. A Systematic Review.Q38495935
Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related DisordersQ38531064
Over-the-counter anti-oxidant therapies for use in multiple sclerosis: A systematic review.Q38569263
The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders.Q38574561
In vitro study of the direct effect of extracellular hemoglobin on myelin componentsQ38933193
Oxidants and human disease: some new conceptsQ39153422
Alteration of prolyl oligopeptidase and activated α-2-macroglobulin in multiple sclerosis subtypes and in the clinically isolated syndrome.Q39156437
Multiple sclerosis: evaluation of purine nucleotide metabolism in central nervous system in association with serum levels of selected fat-soluble antioxidantsQ39933393
Flavonoids inhibit myelin phagocytosis by macrophages; a structure-activity relationship studyQ40665129
Dimethyl fumarate attenuates cerebral edema formation by protecting the blood-brain barrier integrity.Q41336306
The disruption of mitochondrial axonal transport is an early event in neuroinflammationQ41966044
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.Q42260800
Oxidative modification of blood serum proteins in multiple sclerosis after interferon or mitoxantrone treatment.Q43916759
TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stressQ44237193
Tumor necrosis factor is elevated in progressive multiple sclerosis and causes excitotoxic neurodegenerationQ44251663
Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell deathQ44299670
Oxidative stress induced by lipid peroxidation is related with inflammation of demyelination and neurodegeneration in multiple sclerosisQ44776045
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmultiple sclerosisQ8277
oxidative stressQ898814
pathophysiologyQ1135939
physiological phenomenonQ66615932
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)1973834
P577publication date2016-01-01
2016-10-18
P1433published inOxidative medicine and cellular longevityQ26840015
P1476titleNew Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis
P478volume2016

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cites work (P2860)
Q90721230Antioxidant Therapies for Neuroprotection-A Review
Q64259195Coenzyme Q10 supplementation reduces peripheral oxidative stress and inflammation in interferon-β1a-treated multiple sclerosis
Q93108868Differential Modulation of NF-κB in Neurons and Astrocytes Underlies Neuroprotection and Antigliosis Activity of Natural Antioxidant Molecules
Q60949388Genetic Association and Altered Gene Expression of in Multiple Sclerosis Patients
Q49829881Impaired Cardiac Function in Patients with Multiple Sclerosis by Comparison with Normal Subjects
Q95856653Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development
Q91647353Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs
Q47719110Markers of oxidative/nitrative damage of plasma proteins correlated with EDSS and BDI scores in patients with secondary progressive multiple sclerosis.
Q98619283Metformin as a Potential Agent in the Treatment of Multiple Sclerosis
Q39350409Modulating inflammation and neuroprotection in multiple sclerosis
Q97523765Oxidative Damage of Blood Platelets Correlates with the Degree of Psychophysical Disability in Secondary Progressive Multiple Sclerosis
Q64251070Oxidative Stress Related to Iron Metabolism in Relapsing Remitting Multiple Sclerosis Patients With Low Disability
Q93192934Potential role of iron in repair of inflammatory demyelinating lesions
Q45338276Redox Regulation of Inflammatory Processes Is Enzymatically Controlled.
Q59807167Silent Free Fall at Disease Onset: A Perspective on Therapeutics for Progressive Multiple Sclerosis
Q92053010The Anti-Inflammatory Effect of Sulforaphane in Mice with Experimental Autoimmune Encephalomyelitis
Q64065809The Beneficial and Debilitating Effects of Environmental and Microbial Toxins, Drugs, Organic Solvents and Heavy Metals on the Onset and Progression of Multiple Sclerosis
Q43375909The Evaluation of Oxidative Stress Parameters in Serum Patients with Relapsing-Remitting Multiple Sclerosis Treated with II-Line Immunomodulatory Therapy.
Q90523941The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing-Remitting Multiple Sclerosis Mouse Model
Q91393729Vitamin D protects human melanocytes against oxidative damage by activation of Wnt/β-catenin signaling

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