review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Melanie D Sweeney | Q67237677 |
P2093 | author name string | Berislav V Zlokovic | |
Abhay P Sagare | |||
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The genetics of Alzheimer disease | Q27026166 | ||
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Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. | Q27312746 | ||
Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele | Q27331411 | ||
Crystal structure of the human glucose transporter GLUT1 | Q27690274 | ||
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid | Q28115048 | ||
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease | Q28261647 | ||
Mfsd2a is critical for the formation and function of the blood-brain barrier | Q28507996 | ||
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease | Q28586383 | ||
Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis | Q28740917 | ||
Angiogenesis in health and disease | Q29614541 | ||
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Q29614879 | ||
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders | Q29615839 | ||
Pericytes regulate the blood-brain barrier | Q29615840 | ||
The blood-brain barrier in health and chronic neurodegenerative disorders | Q29616411 | ||
Neurovascular regulation in the normal brain and in Alzheimer's disease | Q29619659 | ||
LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β. | Q29976920 | ||
Capillary pericytes regulate cerebral blood flow in health and disease | Q30575458 | ||
A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice | Q30579707 | ||
Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease | Q36229619 | ||
Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability | Q36296333 | ||
Cerebral blood flow in Alzheimer's disease | Q36349775 | ||
Studies on the first described Alzheimer's disease amyloid beta mutant, the Dutch variant | Q36568154 | ||
Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. | Q36593210 | ||
Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis | Q36610341 | ||
Innate immunity receptor CD36 promotes cerebral amyloid angiopathy | Q36637524 | ||
Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease | Q36773984 | ||
Hypertension and cerebrovascular dysfunction | Q36777769 | ||
Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B | Q37019356 | ||
Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later | Q37035638 | ||
The APOE ɛ4/ɛ4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients | Q37073413 | ||
Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease | Q37098909 | ||
Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping | Q37108898 | ||
Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD. | Q37181246 | ||
Dissociable effects of Alzheimer disease and white matter hyperintensities on brain metabolism | Q37189385 | ||
Effectiveness of regional DTI measures in distinguishing Alzheimer's disease, MCI, and normal aging | Q37220884 | ||
Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly | Q37237593 | ||
Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease | Q37297066 | ||
S100beta induction of the proinflammatory cytokine interleukin-6 in neurons | Q37332541 | ||
Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults | Q37372458 | ||
Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre | Q37380546 | ||
Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy. | Q37398713 | ||
Abnormal blood-brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI | Q37414011 | ||
Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease | Q37480839 | ||
The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study | Q37588769 | ||
Pericyte loss influences Alzheimer-like neurodegeneration in mice. | Q37623577 | ||
Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice | Q37659809 | ||
Vascular signaling abnormalities in Alzheimer disease | Q37942551 | ||
Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative | Q37952021 | ||
Injury and repair in the neurovascular unit | Q38014161 | ||
Does vascular pathology contribute to Alzheimer changes? | Q38033859 | ||
Progress towards a consensus on biomarkers for Alzheimer's disease: a review of peripheral analytes. | Q38125769 | ||
Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study | Q38152257 | ||
Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide™. | Q48392292 | ||
Clinical and neuropathological findings in a patient with familial Alzheimer disease showing a mutation in the PSEN1 gene | Q48413505 | ||
The vascular factor in Alzheimer's disease: a study in Golgi technique and electron microscopy | Q48420632 | ||
Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone | Q48427709 | ||
Measurement of brain perfusion, blood volume, and blood-brain barrier permeability, using dynamic contrast-enhanced T(1)-weighted MRI at 3 tesla | Q48450292 | ||
Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease | Q48453732 | ||
Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine). | Q48479577 | ||
A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia | Q48480350 | ||
Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele | Q48583004 | ||
The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative | Q48588754 | ||
GLUT-1 expression in the cerebra of patients with Alzheimer's disease | Q48589517 | ||
Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier | Q48597699 | ||
CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease | Q48605528 | ||
Increased permeability of the blood-brain barrier and Alzheimer's disease-like alterations in slit-2 transgenic mice | Q48609716 | ||
Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients | Q48684554 | ||
Neuron-specific enolase, S-100 protein, myelin basic protein and lactate in CSF in dementia | Q48721686 | ||
Blood-brain barrier permeability in Alzheimer's disease: a case-control MRI study | Q48750738 | ||
Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease | Q48771318 | ||
Diminished glucose transport in Alzheimer's disease: dynamic PET studies | Q48783668 | ||
Spatial correlations between beta-amyloid (Abeta) deposits and blood vessels in familial Alzheimer's disease. | Q48787758 | ||
Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study | Q48874950 | ||
Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex | Q48883966 | ||
Cerebrospinal fluid neuron-specific enolase: a further marker of Alzheimer's disease? | Q49020317 | ||
Markedly elevated soluble intercellular adhesion molecule 1, soluble vascular cell adhesion molecule 1 levels, and blood-brain barrier breakdown in neuromyelitis optica | Q49061961 | ||
Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic FDG-PET. | Q49145622 | ||
Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience | Q30983673 | ||
Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease | Q33239536 | ||
Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system | Q33262322 | ||
Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations | Q33556372 | ||
Clinical trial of an inhibitor of RAGE-Aβ interactions in Alzheimer disease | Q33571894 | ||
Multimodal techniques for diagnosis and prognosis of Alzheimer's disease | Q33607535 | ||
Central nervous system pericytes in health and disease | Q33609398 | ||
Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown | Q33717021 | ||
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. | Q33717326 | ||
Myelin injury and degraded myelin vesicles in Alzheimer's disease | Q33791342 | ||
Biomarkers in Alzheimer's disease: past, present and future | Q33791646 | ||
Human cerebrospinal fluid fatty acid levels differ between supernatant fluid and brain-derived nanoparticle fractions, and are altered in Alzheimer's disease | Q33793583 | ||
APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging | Q33796980 | ||
Cerebrospinal fluid markers of pathogenetic processes in vascular dementia, with special reference to the subcortical subtype | Q33803161 | ||
Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats. | Q33855023 | ||
Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment | Q33894316 | ||
Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease | Q33895840 | ||
Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically verified Alzheimer disease | Q33911295 | ||
ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function | Q33926960 | ||
Blood-brain barrier: a dual life of MFSD2A? | Q33967070 | ||
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association | Q33967781 | ||
The future of blood-based biomarkers for Alzheimer's disease | Q34026317 | ||
New insights into the dementia epidemic | Q34036155 | ||
Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow | Q34042902 | ||
Transport of leucine-enkephalin across the blood-brain barrier in the perfused guinea pig brain | Q34050246 | ||
Cerebrospinal fluid and plasma biomarkers in Alzheimer disease | Q34098866 | ||
Recommendations of the Alzheimer's disease-related dementias conference | Q34135726 | ||
Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain. | Q34141162 | ||
Cerebral microvascular pathology in aging and Alzheimer's disease | Q34224715 | ||
Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview | Q34277859 | ||
Developing novel blood-based biomarkers for Alzheimer's disease | Q34394080 | ||
Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice | Q34402693 | ||
Diffusion tensor imaging of white matter degeneration in Alzheimer's disease and mild cognitive impairment | Q34407612 | ||
Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization. | Q34411401 | ||
Glial influence on the blood brain barrier. | Q38152380 | ||
Adjusting the compass: new insights into the role of angiogenesis in Alzheimer's disease | Q38172335 | ||
Alzheimer's disease genetics: from the bench to the clinic | Q38225911 | ||
Guidelines for uniform reporting of body fluid biomarker studies in neurologic disorders | Q39140817 | ||
Preventing Alzheimer's disease | Q39549596 | ||
Inhibition of angiogenesis by Abeta peptides | Q40526893 | ||
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. | Q40528558 | ||
Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier | Q40960259 | ||
White-matter lesions on CT in Alzheimer patients: relation to clinical symptomatology and vascular factors | Q41184976 | ||
Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors | Q41233432 | ||
The neurovascular unit in health and disease: introduction | Q41884816 | ||
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity | Q42272536 | ||
Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo | Q42684794 | ||
Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms | Q43102272 | ||
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain | Q43243545 | ||
Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition | Q43275099 | ||
Increased iron levels and decreased tissue integrity in hippocampus of Alzheimer's disease detected in vivo with magnetic resonance imaging | Q43509556 | ||
2014 Alzheimer's disease facts and figures | Q43520458 | ||
A derivative of myelin-associated glycoprotein in cerebrospinal fluid of normal subjects and patients with neurological disease | Q43773588 | ||
Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment | Q43859052 | ||
Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein | Q43889096 | ||
CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects | Q44115118 | ||
Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. | Q44315236 | ||
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain | Q44479225 | ||
Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele | Q44559400 | ||
Glucose transporter plasticity during memory processing. | Q45181863 | ||
Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood | Q46087723 | ||
Plastic changes in the astrocyte GLUT1 glucose transporter and beta-tubulin microtubule protein following voluntary exercise in mice | Q46302210 | ||
Vascular volume and blood-brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal controls | Q46305128 | ||
Research priority setting: a summary of the 2012 NINDS Stroke Planning Meeting Report | Q46509113 | ||
Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease | Q46839271 | ||
Age-related alteration in cerebral blood flow and energy failure is correlated with cognitive impairment in the senescence-accelerated prone mouse strain 8 (SAMP8). | Q48093325 | ||
DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial | Q48117600 | ||
Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. | Q48126715 | ||
Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease | Q48224335 | ||
Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia | Q48246691 | ||
Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease | Q48253639 | ||
Soluble adhesion molecules and angiotensin-converting enzyme in dementia | Q48290054 | ||
Elevated levels of cerebrospinal fluid neuron-specific enolase (NSE) in Alzheimer's disease | Q48310556 | ||
Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease. | Q48380741 | ||
Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis | Q34417983 | ||
Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid β-amyloid 42: a cross-validation study against amyloid positron emission tomography | Q34435040 | ||
The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease | Q34469528 | ||
Microvascular injury and blood-brain barrier leakage in Alzheimer's disease | Q34539460 | ||
Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases. | Q34549555 | ||
Microinfarct pathology, dementia, and cognitive systems | Q34590151 | ||
Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease | Q34606557 | ||
3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects | Q34637899 | ||
Imaging cerebral amyloid angiopathy with susceptibility-weighted imaging. | Q34653498 | ||
Alzheimer disease and cerebrovascular pathology: an update | Q34732659 | ||
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke | Q34747354 | ||
Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease | Q34960461 | ||
Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice | Q34976193 | ||
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls | Q35085065 | ||
Blood-brain barrier breakdown in the aging human hippocampus | Q35151019 | ||
APOE and Alzheimer disease: a major gene with semi-dominant inheritance | Q35181990 | ||
Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways | Q35222000 | ||
Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly | Q35231622 | ||
Cerebral blood flow measured by arterial spin labeling MRI as a preclinical marker of Alzheimer's disease | Q35232491 | ||
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance | Q35334161 | ||
Intrathecal inflammation precedes development of Alzheimer's disease | Q35476365 | ||
Vascular plasticity and cognition during normal aging and dementia | Q35598028 | ||
Fibrinogen-induced increased pial venular permeability in mice | Q35667573 | ||
Biomarkers for predicting cognitive decline in those with normal cognition | Q35714382 | ||
Oxidative stress signalling in Alzheimer's disease | Q35725966 | ||
A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain | Q35841946 | ||
Neurovascular mechanisms of Alzheimer's neurodegeneration | Q36088588 | ||
Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents | Q36110188 | ||
P275 | copyright license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International | Q42553662 |
P433 | issue | 7 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | biomarker | Q864574 |
dementia | Q83030 | ||
brain | Q1073 | ||
Alzheimer's disease | Q11081 | ||
cerebrospinal fluid | Q54196 | ||
nervous system | Q9404 | ||
P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
P304 | page(s) | 1055-1068 | |
P577 | publication date | 2015-04-22 | |
2015-07-01 | |||
P1433 | published in | Journal of Cerebral Blood Flow & Metabolism | Q14663525 |
P1476 | title | Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease | |
P478 | volume | 35 |
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