Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II

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Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II is …
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scholarly articleQ13442814

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P819ADS bibcode2011PNAS..10810732C
P356DOI10.1073/PNAS.1018132108
P3181OpenCitations bibliographic resource ID1512184
P932PMC publication ID3127879
P698PubMed publication ID21670302
P5875ResearchGate publication ID51216408

P50authorAlasdair J GibbQ41807364
Douglas M. LopesQ47116234
Patricia C SalinasQ55966247
Kieran A BoyleQ61039074
P2093author name stringLorenza Ciani
Macarena Sahores
Derek Anane
Ellen Dickins
P2860cites workActivity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complexQ24306062
Neurexin-neuroligin signaling in synapse developmentQ24648824
Rapid activity-dependent modifications in synaptic structure and function require bidirectional Wnt signalingQ24651888
Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neuronsQ28138276
The molecular basis of CaMKII function in synaptic and behavioural memoryQ28216850
SynCAM, a synaptic adhesion molecule that drives synapse assemblyQ28219424
Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factorsQ28247928
Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter releaseQ28513362
Control of excitatory and inhibitory synapse formation by neuroliginsQ28568459
Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrinQ28592311
Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1Q28595044
Model of autism: increased ratio of excitation/inhibition in key neural systemsQ29547530
Structural basis of long-term potentiation in single dendritic spinesQ29547598
Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortexQ30479345
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses.Q30497621
Plasticity, synaptic strength, and epilepsy: what can we learn from ultrastructural data?Q30993236
Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesisQ33899495
Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampusQ34017743
The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structureQ35748629
Calcium/calmodulin-dependent protein kinase II: an unforgettable kinase.Q35905029
Dendritic spines and long-term plasticityQ36085643
Wnt and calcium signaling: beta-catenin-independent pathwaysQ36228742
Wnts: up-and-coming at the synapseQ36404710
Anatomical and physiological plasticity of dendritic spinesQ36728838
Balancing structure and function at hippocampal dendritic spinesQ37088448
Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapsesQ37184743
Wnt signaling in neural circuit assemblyQ37193044
Neuronal activity and Wnt signaling act through Gsk3-beta to regulate axonal integrity in mature Drosophila olfactory sensory neuronsQ37204832
Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons.Q37257370
Altered Excitatory-Inhibitory Balance in the NMDA-Hypofunction Model of SchizophreniaQ37306496
Dishevelled: The hub of Wnt signalingQ37652897
Emerging roles of Wnts in the adult nervous systemQ37654778
Wnt signaling during synaptic development and plasticityQ37829071
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons.Q40032436
The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiationQ41105016
Synaptic strength of individual spines correlates with bound Ca2+-calmodulin-dependent kinase II.Q42522812
Heterosynaptic molecular dynamics: locally induced propagating synaptic accumulation of CaM kinase II.Q43135227
Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neuronsQ44047015
Fibroblast growth factor-2 increases functional excitatory synapses on hippocampal neuronsQ44197985
Calcium/calmodulin-dependent protein kinase II contributes to activity-dependent filopodia growth and spine formation.Q44662059
Activity-dependent synaptic Wnt release regulates hippocampal long term potentiationQ46254513
Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2.Q47602516
Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons.Q48154533
Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons.Q48395941
Potentiation of cortical inhibition by visual deprivation.Q48438986
A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase IIQ71935180
Ca(2+) signaling in dendritic spinesQ80200135
P433issue26
P407language of work or nameEnglishQ1860
P921main subjectdendritic spineQ902079
positive regulation of excitatory postsynaptic potentialQ14331120
Wnt family member 7AQ21159906
Dishevelled segment polarity protein 1Q21981314
Wingless-type MMTV integration site family, member 7AQ21985641
excitatory synapse assemblyQ22295014
positive regulation of excitatory synapse assemblyQ22302285
P304page(s)10732-10737
P577publication date2011-06-13
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleWnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II
P478volume108

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cites work (P2860)
Q54332448A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells.
Q45169319Activation of Wnt Signaling in Cortical Neurons Enhances Glucose Utilization through Glycolysis
Q47930676Activity-dependent Wnt 7 dendritic targeting in hippocampal neurons: plasticity- and tagging-related retrograde signaling mechanism?
Q36661665Activity-dependent spine morphogenesis: a role for the actin-capping protein Eps8
Q30417871Adult human nasal mesenchymal-like stem cells restore cochlear spiral ganglion neurons after experimental lesion.
Q37204427Altered hippocampal microRNA expression profiles in neonatal rats caused by sevoflurane anesthesia: MicroRNA profiling and bioinformatics target analysis
Q35592881Analysis of target genes regulated by chronic electroconvulsive therapy reveals role for Fzd6 in depression
Q48649826Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling.
Q38121045Axin: an emerging key scaffold at the synapse
Q36287751CaMKII regulation in information processing and storage
Q47864291Canonical Wnt signaling is necessary for object recognition memory consolidation
Q43031899Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics
Q38573790Canonical and noncanonical Wnt signaling in neural stem/progenitor cells.
Q47990298Cell Biology of Astrocyte-Synapse Interactions
Q37233597Cell biology in neuroscience: cellular and molecular mechanisms underlying presynapse formation
Q91658745Conceptual Evolution of Cell Signaling
Q27311703Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons
Q58698087Deficient Wnt Signaling and Synaptic Vulnerability in Alzheimer’s Disease: Emerging Roles for the LRP6 Receptor
Q38175135Dendritic spines: the locus of structural and functional plasticity
Q33856410Developmental lead exposure alters synaptogenesis through inhibiting canonical Wnt pathway in vivo and in vitro
Q33729314Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct?
Q35125209Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation
Q29347521Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases
Q37575507Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons
Q91657014Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans
Q37982704GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder
Q34428744Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.
Q33582361Genome-wide identification of genes probably relevant to the adaptation of schizothoracins (Teleostei: Cypriniformes) to the uplift of the Qinghai-Tibet Plateau
Q30449007Growth factors in synaptic function
Q37583883High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development.
Q38365364Hippocampal Wnt Signaling: Memory Regulation and Hormone Interactions.
Q48318094Identification of Noncanonical Wnt Receptors Required for Wnt-3a-Induced Early Differentiation of Human Neural Stem Cells.
Q50861765In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model.
Q24296778LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
Q36049592Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors
Q58794829Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease
Q35671516Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca²⁺ signaling
Q35120498Molecular profiles of parvalbumin-immunoreactive neurons in the superior temporal cortex in schizophrenia
Q38917986Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry
Q37223308Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation
Q34227170Ontogeny of small RNA in the regulation of mammalian brain development
Q90675074Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex
Q26769954Polarity Determinants in Dendritic Spine Development and Plasticity
Q38150805Postsynaptic assembly: a role for Wnt signaling
Q89900861Prediction of Alzheimer's disease using blood gene expression data
Q38868523Puzzling out presynaptic differentiation.
Q58707634Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes
Q42424715Regulation of Wnt signaling by nociceptive input in animal models
Q41507015Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus
Q38176898Role of wnt signaling in the control of adult hippocampal functioning in health and disease: therapeutic implications.
Q35626923SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway
Q38284822Spatiotemporal integration of developmental cues in neural development
Q26765504Synaptic Wnt/GSK3β Signaling Hub in Autism
Q38173456Synaptic activity-regulated Wnt signaling in synaptic plasticity, glial function and chronic pain
Q37642802The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease.
Q37972080The roles of neurotrophic factor and Wnt signaling in depression
Q48624099The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss.
Q36310513The wnt pathway in mood disorders
Q41257772Truncated tau deregulates synaptic markers in rat model for human tauopathy.
Q36527927Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
Q35978913UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit
Q38121069WNT signaling in neuronal maturation and synaptogenesis
Q36049572WNTs in synapse formation and neuronal circuitry
Q47904486Whole genome microarray analysis of neural progenitor C17.2 cells during differentiation and validation of 30 neural mRNA biomarkers for estimation of developmental neurotoxicity
Q55278739Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors.
Q88874099Wnt Signaling Pathways Are Dysregulated in Rat Female Cerebellum Following Early Methyl Donor Deficiency
Q33771988Wnt Signaling in Neurogenesis during Aging and Physical Activity
Q38113139Wnt and lithium: a common destiny in the therapy of nervous system pathologies?
Q59796856Wnt proteins as modulators of synaptic plasticity
Q38163473Wnt signaling in remyelination in multiple sclerosis: friend or foe?
Q38189240Wnt signaling in the nervous system and in Alzheimer's disease.
Q37094830Wnt signaling in the pathogenesis of human HIV-associated pain syndromes
Q38117365Wnt signaling in the regulation of adult hippocampal neurogenesis
Q27000787Wnt signaling in the vertebrate central nervous system: from axon guidance to synaptic function
Q38046770Wnt signaling in vertebrate neural development and function
Q36031855Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system
Q42561789Wnt signaling regulates experience-dependent synaptic plasticity in the adult nervous system
Q38060562Wnt signaling: role in Alzheimer disease and schizophrenia
Q38252401Wnt signalling in neuronal differentiation and development.
Q57040339Wnt signalling in the development of axon, dendrites and synapses
Q36340842Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Q37977252Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity.
Q36595988Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons
Q38758699Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation
Q89396829Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling
Q38858601Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against Aβ oligomers.
Q50418437Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene.
Q48126684Wnt7a induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines
Q36978307Wnt7a regulates multiple steps of neurogenesis
Q55450116Wnts Promote Synaptic Assembly Through T-Cell Specific Transcription Factors in Caenorhabditis elegans.
Q26823548Wnts in action: from synapse formation to synaptic maintenance
Q38172119Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

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