Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity

scientific journal article

Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.273.1.207
P698PubMed publication ID9417066
P5875ResearchGate publication ID13813323

P2093author name stringB. P. Kennedy
H. E. Claesson
P. K. Larsson
P2860cites workPurification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteinsQ24309062
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell deathQ24312157
Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally?Q28249671
Studies on the regulation and localization of 5-lipoxygenase in human B-lymphocytesQ28289034
A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifsQ28306525
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell deathQ28507741
Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrinQ28577938
Cytosolic phospholipase A2Q28609569
Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophagesQ33989590
Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and InflammationQ34254403
Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activitiesQ35230057
NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeatsQ35875812
On the expression and regulation of 5-lipoxygenase in human lymphocytes.Q36959306
Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complexQ38333812
Mammalian calcium-independent phospholipase A2.Q40375569
The I kappa B proteins: members of a multifunctional familyQ40721710
The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factorsQ40773951
The growing phospholipase A2 superfamily of signal transduction enzymesQ41341078
Function and inhibition of intracellular calcium-independent phospholipase A2.Q41509814
Human B lymphocytes possess 5-lipoxygenase activity and convert arachidonic acid to leukotriene B4.Q41674889
Identity between the Ca2+-independent phospholipase A2 enzymes from P388D1 macrophages and Chinese hamster ovary cellsQ42436218
Human myocardial cytosolic Ca(2+)-independent phospholipase A2 is modulated by ATP. Concordant ATP-induced alterations in enzyme kinetics and mechanism-based inhibitionQ42792277
Identification and purification of calcium-independent phospholipase A2 from bovine brain cytosolQ44045296
Paired Epstein-Barr virus (EBV)-negative and EBV-converted Burkitt lymphoma lines: stimulatory capacity in allogeneic mixed lymphocyte culturesQ45842380
I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B familyQ46153930
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectphospholipase A2 activityQ14905446
phospholipase A2 group VIQ21126834
P304page(s)207–214
P577publication date1998-01-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleMultiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity
P478volume273

Reverse relations

cites work (P2860)
Q37963183A PLA1-2 punch regulates the Golgi complex
Q39776402A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols
Q22254197A novel intracellular membrane-bound calcium-independent phospholipase A(2)
Q44556049A requirement for calcium-independent phospholipase A2 in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells
Q30497505ADP Ribosylation Factors 1 and 4 and Group VIA Phospholipase A2Regulate Morphology and Intraorganellar Traffic in the Endoplasmic Reticulum–Golgi Intermediate Compartment
Q50521928Activation by P2X7 agonists of two phospholipases A2 (PLA2) in ductal cells of rat submandibular gland. Coupling of the calcium-independent PLA2 with kallikrein secretion.
Q34782165Activation of group VI phospholipase A2 isoforms in cardiac endothelial cells
Q36512269Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice
Q38722497Analyses of Calcium-Independent Phospholipase A2beta (iPLA2β) in Biological Systems
Q35423551Analysis of two major intracellular phospholipases A(2) (PLA(2)) in mast cells reveals crucial contribution of cytosolic PLA(2)α, not Ca(2+)-independent PLA(2)β, to lipid mobilization in proximal mast cells and distal fibroblasts
Q34206288Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.
Q33595339Asthma and leukotrienes: antileukotrienes as novel anti-asthmatic drugs.
Q50293881CL is hydrolyzed to MLCL by PLA2G6 (IM)
Q44209209Ca2+-independent phospholipase A2 is required for agonist-induced Ca2+ sensitization of contraction in vascular smooth muscle
Q34083751Calcium-independent phospholipase A(2): structure and function.
Q33699583Calcium-independent phospholipase A2 in rabbit ventricular myocytes
Q35994344Calcium-independent phospholipases A2 and their roles in biological processes and diseases.
Q37199186Calcium-independent phospholipases in the heart: mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunction
Q44905130Cell cycle dependence of group VIA calcium-independent phospholipase A2 activity
Q28248355Characterization of the human patatin-like phospholipase family
Q37130148Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme
Q35763978Clearance of apoptotic cells: getting rid of the corpses.
Q28315639Clinical and genetic delineation of neurodegeneration with brain iron accumulation
Q93103175Combined targeted Omic and Functional Assays Identify Phospholipases A₂ that Regulate Docking/Priming in Calcium-Triggered Exocytosis
Q47877765Complex transcriptional and translational regulation of iPLAgamma resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization
Q48848896Conditioning training and retrieval increase phospholipase A(2) activity in the cerebral cortex of rats.
Q30785490Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships
Q40287484Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides
Q34049279Disruption of G1-phase phospholipid turnover by inhibition of Ca2+-independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase
Q35868876Disruption of Golgi morphology and altered protein glycosylation in PLA2G6-associated neurodegeneration
Q35793998Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells
Q39334780Diverse regulation of retinal pigment epithelium phagocytosis of photoreceptor outer segments by calcium-independent phospholipase A₂, group VIA and secretory phospholipase A₂, group IB.
Q34212477Diversity and regulatory functions of mammalian secretory phospholipase A2s.
Q42037362Effects of biological oxidants on the catalytic activity and structure of group VIA phospholipase A2
Q36302173Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells
Q73626672Electrospray ionization/mass spectrometric analyses of human promonocytic U937 cell glycerolipids and evidence that differentiation is associated with membrane lipid composition changes that facilitate phospholipase A2 activation
Q28201886Enzymatic properties of human cytosolic phospholipase A(2)gamma
Q37462762Establishment of an improved mouse model for infantile neuroaxonal dystrophy that shows early disease onset and bears a point mutation in Pla2g6.
Q48021878Expression profile and structural divergence of novel human annexin 31.
Q28248992Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cells
Q40978833Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways
Q92042954Furosine, a Maillard Reaction Product, Triggers Necroptosis in Hepatocytes by Regulating the RIPK1/RIPK3/MLKL Pathway
Q33886495Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death
Q38532119Group VIA phospholipase A2 mediates enhanced macrophage migration in diabetes mellitus by increasing expression of nicotinamide adenine dinucleotide phosphate oxidase 4.
Q39877154HL-1 mouse cardiomyocyte injury and death after simulated ischemia and reperfusion: roles of pH, Ca2+-independent phospholipase A2, and Na+/H+ exchange
Q33238930Highly selective hydrolysis of fatty acyl-CoAs by calcium-independent phospholipase A2beta. Enzyme autoacylation and acyl-CoA-mediated reversal of calmodulin inhibition of phospholipase A2 activity
Q28139679Human Pancreatic Islets Express mRNA Species Encoding Two Distinct Catalytically Active Isoforms of Group VI Phospholipase A2 (iPLA2) [etc.]
Q74241715Human calcium-independent phospholipase A2 mediates lymphocyte proliferation
Q36511361Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease
Q44014781Implication of three isoforms of PLA(2) in human T-cell proliferation.
Q64899416Infantile neuroaxonal dystrophy caused by PLA2G6 gene mutation in a Chinese patient: A case report.
Q28581430Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory
Q53317312Inhibition of phospholipase A2 in rat brain decreases the levels of total Tau protein.
Q28534839Insertion of the Ca²⁺-independent phospholipase A₂ into a phospholipid bilayer via coarse-grained and atomistic molecular dynamics simulations
Q36097167Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.
Q34555536Interferon gamma-induced gene expression of the novel secretory phospholipase A2 type IID in human monocyte-derived macrophages is inhibited by lipopolysaccharide
Q35641753Islet complex lipids: involvement in the actions of group VIA calcium-independent phospholipase A(2) in beta-cells
Q47133692Lipoquality control by phospholipase A2 enzymes
Q37358176Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry
Q33681195Mammalian lysophospholipases.
Q34198990Mammalian phospholipases A(2): mediators of inflammation, proliferation and apoptosis
Q36945608Membrane and inhibitor interactions of intracellular phospholipases A2.
Q49248448Mutations in the Drosophila homolog of human PLA2G6 give rise to age-dependent loss of psychomotor activity and neurodegeneration
Q21129274Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms
Q26821831Neuronal phospholipid deacylation is essential for axonal and synaptic integrity
Q33695148New developments in phospholipase A2.
Q92093905Novel allelic variation in the Phospholipase D alpha1 gene (OsPLDα1) of wild Oryza species implies to its low expression in rice bran
Q28592582On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes
Q77317915On the expression of cytosolic calcium-independent phospholipase A2 (88kDa) in immature and mature myeloid cells and its role in leukotriene synthesis in human granulocytes
Q50293818PC is hydrolyzed to 1-acyl LPC by PLA2[5]
Q50293780PE is hydrolyzed to 1-acyl LPE by PLA2[2]
Q35221441PLA2G6 mutation underlies infantile neuroaxonal dystrophy
Q34568479PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron
Q33722781PLA2G6-associated neurodegeneration (PLAN): further expansion of the clinical, radiological and mutation spectrum associated with infantile and atypical childhood-onset disease
Q33195299Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript
Q34852161Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease
Q38830281Phospholipase A2 as a Molecular Determinant of Store-Operated Calcium Entry.
Q28297979Phospholipase A2 biochemistry
Q28609770Phospholipase A2 enzymes
Q26997377Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention
Q35202874Phospholipase A2 expression in tumours: a target for therapeutic intervention?
Q37658843Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases.
Q33833653Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.
Q34004751Purification and characterization of a cytosolic Ca(2+)-independent phospholipase A(2) from bovine brain
Q35042360Pyrimidinoceptor potentiation of macrophage PGE(2) release involved in the induction of nitric oxide synthase
Q41687052Regional distribution, ontogeny, purification, and characterization of the Ca2+-independent phospholipase A2 from rat brain
Q44862176Regulation of phosphatidylcholine homeostasis by calcium-independent phospholipase A2.
Q26995761Regulation of the Golgi complex by phospholipid remodeling enzymes
Q48387193Requirement of hippocampal phospholipase A2 activity for long-term memory retrieval in rats
Q36800670Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories.
Q44094421Role of an endoplasmic reticulum Ca(2+)-independent phospholipase A(2) in oxidant-induced renal cell death
Q46825749Role of calcium-independent phospholipase A2 in complement-mediated glomerular epithelial cell injury
Q40611926Role of secretory and cytosolic phospholipase A(2) enzymes in lysophosphatidylcholine-stimulated monocyte arachidonic acid release
Q43001896Roles of various phospholipases A2 in providing lysophospholipid acceptors for fatty acid phospholipid incorporation and remodelling
Q37240112Skeletal muscle group VIA phospholipase A2 (iPLA2beta): expression and role in fatty acid oxidation
Q43719219Studies of phospholipid metabolism, proliferation, and secretion of stably transfected insulinoma cells that overexpress group VIA phospholipase A2.
Q42467888Study on the activation of phospholipases A2 by purinergic agonists in rat submandibular ductal cells.
Q28609761The expanding superfamily of phospholipase A(2) enzymes: classification and characterization
Q28295918The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cells
Q28144429The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene
Q34348429The molecular biology of the group VIA Ca2+-independent phospholipase A2.
Q31080755The role of phospholipase A2 in neuronal homeostasis and memory formation: implications for the pathogenesis of Alzheimer's disease
Q50282174The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization
Q58609392iPLAβ and its role in male fertility, neurological disorders, metabolic disorders, and inflammation

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