Feedback control of mitosis in budding yeast

scientific article (publication date: 9 August 1991)

Feedback control of mitosis in budding yeast is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/0092-8674(81)90015-5
P953full work available at URLhttps://api.elsevier.com/content/article/PII:0092867481900155?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:0092867481900155?httpAccept=text/xml
P3181OpenCitations bibliographic resource ID3186163
P698PubMed publication ID1651172
P5875ResearchGate publication ID21504908

P2093author name stringR. Li
A. W. Murray
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Two functional alpha-tubulin genes of the yeast Saccharomyces cerevisiae encode divergent proteinsQ27939614
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Alpha-lactalbumin possesses a novel calcium binding loop.Q34190575
The role of cyclin synthesis and degradation in the control of maturation promoting factor activityQ34667889
Intracellular free calcium and mitosis in mammalian cells: anaphase onset is calcium modulated, but is not triggered by a brief transientQ36221303
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Mammalian growth-associated H1 histone kinase: a homolog of cdc2+/CDC28 protein kinases controlling mitotic entry in yeast and frog cellsQ36760442
Dominoes and clocks: the union of two views of the cell cycleQ38718174
Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolinQ41580625
Calcium rises abruptly and briefly throughout the cell at the onset of anaphaseQ42525633
The events of the midblastula transition in Xenopus are regulated by changes in the cell cycleQ43959579
Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in XenopusQ44539608
A novel calcium binding site in the galactose-binding protein of bacterial transport and chemotaxisQ44735965
Intracellular free calcium rise triggers nuclear envelope breakdown in the sea urchin embryoQ46320730
Premature of chromosome condensation in a ts DNA- mutant of BHK cells.Q52475462
Pedigree analysis of plasmid segregation in yeastQ52701854
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The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggsQ59057264
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Germinal vesicle components are not required for the cell-cycle oscillator of the early starfish embryoQ68145361
Chromosome length controls mitotic chromosome segregation in yeastQ68876909
Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replicationQ68929092
Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cellsQ68961888
Exposure to caffeine and suppression of DNA replication combine to stabilize the proteins and RNA required for premature mitotic eventsQ68991667
Cyclic activation of histone H1 kinase during sea urchin egg mitotic divisionsQ69814103
Growth and the cell cycle of the yeast Saccharomyces cerevisiae. I. Slowing S phase or nuclear division decreases the G1 cell cycle periodQ70300672
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttransport proteinQ2111029
P304page(s)519-31
P577publication date1991-08-09
P1433published inCellQ655814
P1476titleFeedback control of mitosis in budding yeast
P478volume66

Reverse relations

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Q24299555Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1
Q24682987Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores
Q24536263Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication
Q24569635Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression
Q24336250Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
Q24290711Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores
Q39322531Human papillomavirus type 16 E7 oncoprotein engages but does not abrogate the mitotic spindle assembly checkpoint
Q39869741Hybrids of aneuploid human cancer cells permit complementation of simple and complex cancer defects
Q27939815IBD2 encodes a novel component of the Bub2p-dependent spindle checkpoint in the budding yeast Saccharomyces cerevisiae
Q77343497Ibd1p, a possible spindle pole body associated protein, regulates nuclear division and bud separation in Saccharomyces cerevisiae
Q27935756Identification and cloning of the CHL4 gene controlling chromosome segregation in yeast.
Q27938555Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae
Q24321983Identification of a MAD2-binding protein, CMT2, and its role in mitosis
Q36259420Identification of a mid-anaphase checkpoint in budding yeast
Q27935018Identification of a mutation causing a defective spindle assembly checkpoint in high ethyl caproate-producing sake yeast strain K1801.
Q24550894Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation
Q78103256Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers
Q33924502Identification of genes potentially involved in LMO2-induced leukemogenesis
Q27931376Identification of protein complexes required for efficient sister chromatid cohesion
Q27935697Identification of yeast component A: reconstitution of the geranylgeranyltransferase that modifies Ypt1p and Sec4p
Q36254875Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response
Q28595006Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein
Q24291921Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas
Q36239496In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal
Q28593938Inactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferation
Q41975129Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes
Q34733119Inducing precocious anaphase in cultured mammalian cells
Q40876361Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer
Q24291451Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1
Q34602644Integrating functions at the kinetochore
Q27935628Interactions between Centromere Complexes inSaccharomyces cerevisiae
Q42949353Interactions between Mad1p and the nuclear transport machinery in the yeast Saccharomyces cerevisiae
Q41201215Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment
Q27939198Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.
Q27934486Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.
Q42580772Isolation of a Schizosaccharomyces pombe rad21ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: possible involvement of Rad21 in ubiquitin-mediated proteolysis.
Q52957887Isolation of a spontaneous cerulenin-resistant sake yeast with both high ethyl caproate-producing ability and normal checkpoint integrity.
Q33965797Isolation of mutants of Saccharomyces cerevisiae requiring DNA topoisomerase I.
Q37349399Key players in chromosome segregation in Caenorhabditis elegans
Q35081235Kinesin family member 4A: a potential predictor for progression of human oral cancer
Q27932374Kinesin-related proteins required for assembly of the mitotic spindle
Q30305838Kinetochore "memory" of spindle checkpoint signaling in lysed mitotic cells
Q30442219Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint
Q29618221Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
Q30448761Kinetochore localization of spindle checkpoint proteins: who controls whom?
Q34298395Kinetochore motility after severing between sister centromeres using laser microsurgery: Evidence that kinetochore directional instability and position is regulated by tension
Q37598776Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p
Q30312214Kinetochores, microtubules and the metaphase checkpoint
Q30483272Latrunculin A delays anaphase onset in fission yeast by disrupting an Ase1-independent pathway controlling mitotic spindle stability
Q24548054Lesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiae
Q30476312Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control
Q29620330Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
Q45040800Localization of mitotic arrest deficient 1 (MAD1) in mouse oocytes during the first meiosis and its functions as a spindle checkpoint protein
Q39456488Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation
Q27334868Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint
Q37264051Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice
Q55308042MAD1: Kinetochore Receptors and Catalytic Mechanisms.
Q24648493MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity
Q27935794MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p
Q59061245Mad Bet for Rab
Q24672331Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
Q34168724Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension.
Q35751334Mad2 and Mad3 cooperate to arrest budding yeast in mitosis
Q36178158Mad2 and p27 expression profiles in colorectal cancer and its clinical significance
Q36309195Mad2 and p53 expression profiles in colorectal cancer and its clinical significance
Q36289100Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation
Q24534571Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint
Q34708764Mad2 haploinsufficiency protects hematopoietic progenitor cells subjected to cell-cycle stress in vivo and to inhibition of redox function of Ape1/Ref-1 in vitro
Q35642838Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells
Q24682864Mad2 transiently associates with an APC/p55Cdc complex during mitosis
Q34166856Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex.
Q34101240Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.
Q41843920Mad2-independent spindle assembly checkpoint activation and controlled metaphase-anaphase transition in Drosophila S2 cells.
Q24635263Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints
Q37033768Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age.
Q37371435Meiotic recombination and the crossover assurance checkpoint in Caenorhabditis elegans
Q49068196Metaphase arrest in newly matured or microtubule-depleted mouse eggs after calcium stimulation.
Q41824169Metaphase arrest with centromere separation in polo mutants of Drosophila
Q30442107Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase
Q30442229Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase
Q38069082Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
Q24679267Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling
Q36234789Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells
Q34451728Microtubule stability in budding yeast: characterization and dosage suppression of a benomyl-dependent tubulin mutant
Q34368625Microtubule-associated proteins and their essential roles during mitosis.
Q34123562Mitosis: a history of division
Q41312009Mitosis: don't get mad, get even
Q40352474Mitotic DNA damage and replication checkpoints in yeast
Q42254103Mitotic Kinases and p53 Signaling
Q42180607Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors
Q37971550Mitotic checkpoint control and chromatin remodeling.
Q37619395Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae
Q52536019Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.
Q55171502Mitotic checkpoint protein hsMAD2 as a marker predicting liver metastasis of human gastric cancers.
Q35228797Mitotic checkpoints
Q33926467Mitotic chromosomal instability and cancer: mouse modelling of the human disease.
Q36370029Mitotic spindle integrity and kinetochore function linked by the Duo1p/Dam1p complex
Q37778008Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability
Q46889398Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing
Q37279001Molecular alterations associated with bladder cancer initiation and progression
Q40799396Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer
Q55034501Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers.
Q30810456Molecular basis of APC/C regulation by the spindle assembly checkpoint
Q28202760Molecular cloning and characterization of the human budding uninhibited by benomyl (BUB3) promoter
Q37000269Molecular mechanisms underlying the MiT translocation subgroup of renal cell carcinomas
Q37818590Monitoring spindle orientation: Spindle position checkpoint in charge.
Q40852235Mos and the cell cycle: the molecular basis of the transformed phenotype
Q34154624Motility proteins and the origin of the nucleus
Q43680754Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.
Q52740155Mps1 promotes chromosome meiotic chromosome bi-orientation through Dam1.
Q35925170Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests
Q48503928Multiple Duties for Spindle Assembly Checkpoint Kinases in Meiosis.
Q30591637Multiple mechanisms determine the order of APC/C substrate degradation in mitosis
Q40944054Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines
Q55239937Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma.
Q30326722Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines.
Q33961348Mutation in the bimD gene of Aspergillus nidulans confers a conditional mitotic block and sensitivity to DNA damaging agents
Q27934947Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior.
Q52536820Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers.
Q33964830Mutations affecting donor preference during mating type interconversion in Saccharomyces cerevisiae
Q39687193Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint
Q36382112Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
Q24320018Mutations of mitotic checkpoint genes in human cancers
Q74247121Mutations of the CDC28 gene and the radiation sensitivity of Saccharomyces cerevisiae
Q27931536NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast
Q24310671NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling
Q36864195New alleles of the yeast MPS1 gene reveal multiple requirements in spindle pole body duplication
Q67785116New nucleotide sequence data on the EMBL File Server
Q27932226New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability.
Q36559708Novel checkpoint pathway organization promotes genome stability in stationary-phase yeast cells
Q42144842Novel mad2 alleles isolated in a Schizosaccharomyces pombe gamma-tubulin mutant are defective in metaphase arrest activity, but remain functional for chromosome stability in unperturbed mitosis
Q37725706Nuclear transport and the mitotic apparatus: an evolving relationship
Q34455685Nup2 requires a highly divergent partner, NupA, to fulfill functions at nuclear pore complexes and the mitotic chromatin region
Q29619455On the road to cancer: aneuploidy and the mitotic checkpoint
Q39877190Oncogenic Adenomatous polyposis coli mutants impair the mitotic checkpoint through direct interaction with Mad2.
Q36235409Oocyte activation and passage through the metaphase/anaphase transition of the meiotic cell cycle is blocked in clams by inhibitors of HMG-CoA reductase activity
Q27335480Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores.
Q36149288PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores
Q35133777Pds1/Esp1-dependent and -independent sister chromatid separation in mutants defective for protein phosphatase 2A.
Q34375310Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).
Q41381141Phenotypic Diagnosis of Lineage and Differentiation During Sake Yeast Breeding.
Q45057829Phenyl hydroquinone, an Ames test-negative carcinogen, induces Hog1-dependent stress response signaling
Q27932398Phospholipase C is involved in kinetochore function in Saccharomyces cerevisiae
Q43799855Phosphorylation of gamma-tubulin regulates microtubule organization in budding yeast
Q22009360Phosphorylation of human MAD1 by the BUB1 kinase in vitro
Q28478060Phosphorylation of the yeast γ-tubulin Tub4 regulates microtubule function
Q36532077Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis
Q30496569Polo kinase interacts with RacGAP50C and is required to localize the cytokinesis initiation complex.
Q33829619Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system
Q93348582Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division
Q41558814Positive Feedback Keeps Duration of Mitosis Temporally Insulated from Upstream Cell-Cycle Events
Q24685871Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.
Q28214604Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis
Q37247590Profile of Andrew W. Murray
Q39038787Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma
Q24304123Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase
Q52724818Protein arginine methylation: an emerging regulator of the cell cycle.
Q46108071Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast
Q40746403Protein prenylation in eukaryotic microorganisms: genetics, biology and biochemistry
Q88875566Purification of kinetochores from the budding yeast Saccharomyces cerevisiae
Q33969321RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage.
Q47770267Radiosensitivity and oxidative signalling in ataxia telangiectasia: an update
Q24299702Re-evaluating the role of Tao1 in the spindle checkpoint
Q64058303Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores
Q27936495Receptors determine the cellular localization of a gamma-tubulin complex and thereby the site of microtubule formation
Q30452748Recognizing chromosomes in trouble: association of the spindle checkpoint protein Bub3p with altered kinetochores and a unique defective centromere
Q34040203Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint.
Q35102601Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis
Q57028061Regulated reconstitution of spindle checkpoint arrest and silencing through chemically induced dimerisation
Q28216974Regulation of APC-Cdc20 by the spindle checkpoint
Q33805690Regulation of APC/C activators in mitosis and meiosis
Q34010063Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae.
Q92106577Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective
Q89719971Regulation of Mitotic Exit by Cell Cycle Checkpoints: Lessons From Saccharomyces cerevisiae
Q27931654Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p
Q37035104Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation
Q38496747Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints.
Q34720135Regulation of the cell cycle by protein phosphatase 2A in Saccharomyces cerevisiae
Q38612159Regulation of the cyclin B degradation system by an inhibitor of mitotic proteolysis
Q33816797Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells
Q24657489Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae
Q57009269Requirement of Chromatid Cohesion Proteins Rad21/Scc1 and Mis4/Scc2 for Normal Spindle-Kinetochore Interaction in Fission Yeast
Q27935461Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint
Q35552257Retention of the BUB3 checkpoint protein on lagging chromosomes
Q21562380Reverse engineering of the spindle assembly checkpoint
Q27303046Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function
Q27932711Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesion
Q35822970Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells
Q27940146Role of calmodulin and Spc110p interaction in the proper assembly of spindle pole body compenents
Q89394572Role of the BUB3 protein in phragmoplast microtubule reorganization during cytokinesis
Q43037807Rong Li: tipping the balance in cell biology. Interview by Caitlin Sedwick
Q36123872SAC-ing mitotic errors: how the spindle assembly checkpoint (SAC) plays defense against chromosome mis-segregation
Q30484120SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans
Q33963575SPO13 negatively regulates the progression of mitotic and meiotic nuclear division in Saccharomyces cerevisiae
Q42147135Saccharomyces CDK1 phosphorylates Rad53 kinase in metaphase, influencing cellular morphogenesis
Q64389726Saccharomyces cerevisiae cells lacking the homologous pairing protein p175SEP1 arrest at pachytene during meiotic prophase
Q27931214Saccharomyces cerevisiae cells with defective spindle pole body outer plaques accomplish nuclear migration via half-bridge-organized microtubules
Q27931564Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways
Q73270846Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers
Q36555047Segregation of unreplicated chromosomes in Saccharomyces cerevisiae reveals a novel G1/M-phase checkpoint
Q33594202Separating sister chromatids
Q48065169Sequence of ptb1, a gene for the beta subunit of the type-II geranylgeranyltransferase from the fission yeast Schizosaccharomyces pombe
Q27939072Sfh1p, a component of a novel chromatin-remodeling complex, is required for cell cycle progression
Q38258850Signalling dynamics in the spindle checkpoint response
Q24530007Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint
Q35773951Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity
Q42673791Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage
Q35033329Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton
Q35019961Spatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulans
Q38588713Spatial rule-based modeling: a method and its application to the human mitotic kinetochore
Q38611058Spc98p directs the yeast gamma-tubulin complex into the nucleus and is subject to cell cycle-dependent phosphorylation on the nuclear side of the spindle pole body
Q24676152Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2
Q79291199Spindle Checkpoint Component Mad2 Contributes to Biorientation of Homologous Chromosomes
Q58798794Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells
Q44052102Spindle assembly checkpoint component CaMad2p is indispensable for Candida albicans survival and virulence in mice
Q36570686Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans
Q30497012Spindle assembly checkpoint genes reveal distinct as well as overlapping expression that implicates MDF-2/Mad2 in postembryonic seam cell proliferation in Caenorhabditis elegans
Q33497326Spindle assembly checkpoint protein dynamics reveal conserved and unsuspected roles in plant cell division
Q28478743Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo development
Q37956287Spindle assembly checkpoint: the third decade
Q36685486Spindle checkpoint function and cellular sensitivity to antimitotic drugs
Q53628480Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1.
Q40322565Spindle checkpoint protein Bub1 corrects mitotic aberrancy induced by human T-cell leukemia virus type I Tax.
Q24679269Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity
Q24682946Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
Q36321836Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast
Q34510907Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae
Q30431071Spindle poisons and cell fate: a tale of two pathways.
Q35647368Spindles, mitochondria and redox potential in ageing oocytes
Q39859976Spo13 protects meiotic cohesin at centromeres in meiosis I.
Q30858730Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.
Q47807712Stochastic Modeling Yields a Mechanistic Framework for Spindle Attachment Error Correction in Budding Yeast Mitosis.
Q41345432Stopping and starting the meiotic cell cycle
Q24305233Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction
Q27653321Structural and mechanistic insights into Mps1 kinase activation
Q34283356Structural maintenance of chromosome (SMC) proteins link microtubule stability to genome integrity
Q30497439Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex
Q27678130Structure of the mitotic checkpoint complex
Q35564845Structure, Function, and Regulation of Budding Yeast Kinetochores
Q36316609Stu2 promotes mitotic spindle elongation in anaphase.
Q50643285Studying Kinetochores In Vivo Using FLIM-FRET.
Q37148422Suppression of genomic instabilities caused by chromosome mis-segregation: a perspective from studying BubR1 and Sgo1.
Q36232176Suppression of the bimC4 mitotic spindle defect by deletion of klpA, a gene encoding a KAR3-related kinesin-like protein in Aspergillus nidulans
Q40241760Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p
Q35757666Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans
Q40366333Symmetric cell division in pseudohyphae of the yeast Saccharomyces cerevisiae
Q37544007Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors
Q42986632Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components
Q30485999Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches
Q40454087Systems Biology Modeling of Five Pathways for Regulation and Potent Inhibition of the Anaphase-Promoting Complex (APC/C): Pivotal Roles for MCC and BubR1.
Q40242633TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast
Q40381344Tension sensing by Aurora B kinase is independent of survivin-based centromere localization.
Q35220804Tethering sister centromeres to each other suggests the spindle checkpoint detects stretch within the kinetochore
Q45985430The 1.1-angstrom structure of the spindle checkpoint protein Bub3p reveals functional regions.
Q27931517The 14-3-3 protein Bmh1 functions in the spindle position checkpoint by breaking Bfa1 asymmetry at yeast centrosomes
Q33565078The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function
Q34166850The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.
Q34069561The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis
Q74191133The Bub2p spindle checkpoint links nuclear migration with mitotic exit
Q41716201The C-terminal domains of human neurofibromin and its budding yeast homologs Ira1 and Ira2 regulate the metaphase to anaphase transition
Q27938665The C-terminal half of Saccharomyces cerevisiae Mad1p mediates spindle checkpoint function, chromosome transmission fidelity and CEN association
Q28756446The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae
Q36531724The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset
Q27931658The JNM1 gene in the yeast Saccharomyces cerevisiae is required for nuclear migration and spindle orientation during the mitotic cell cycle
Q61735093The Kinetochore of Higher Eucaryotes: A Molecular View
Q24611018The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation
Q34585694The Mub1/Ubr2 ubiquitin ligase complex regulates the conserved Dsn1 kinetochore protein
Q21145727The Oxytricha trifallax macronuclear genome: a complex eukaryotic genome with 16,000 tiny chromosomes
Q29620201The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
Q47135529The Power of Xenopus Egg Extract for Reconstitution of Centromere and Kinetochore Function.
Q27940101The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae
Q34618699The Role of Cdh1p in Maintaining Genomic Stability in Budding Yeast
Q34054674The S. pombe cdc16 gene is required both for maintenance of p34cdc2 kinase activity and regulation of septum formation: a link between mitosis and cytokinesis?
Q24607689The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase
Q42837122The Saccharomyces cerevisiae kinesin-related motor Kar3p acts at preanaphase spindle poles to limit the number and length of cytoplasmic microtubules
Q27939738The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint
Q24683919The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex
Q33195000The Spindle Assembly and Spindle Position Checkpoints
Q39939839The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells
Q34354307The art and design of genetic screens: yeast
Q35164326The biochemistry of mitosis
Q27931138The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7).
Q28365645The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint
Q36335566The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin.
Q27938729The calcium-binding protein cell division cycle 31 of Saccharomyces cerevisiae is a component of the half bridge of the spindle pole body
Q24601346The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
Q51121163The chk1 pathway is required to prevent mitosis following cell-cycle arrest at 'start'.
Q37052271The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae
Q37063126The composition, functions, and regulation of the budding yeast kinetochore
Q27937537The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast
Q27000924The current view for the silencing of the spindle assembly checkpoint
Q89649028The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress
Q33255128The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization
Q35916037The fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised
Q40388135The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpoint
Q30477171The fission yeast transforming acidic coiled coil-related protein Mia1p/Alp7p is required for formation and maintenance of persistent microtubule-organizing centers at the nuclear envelope.
Q33467385The function of a spindle checkpoint gene bub-1 in C. elegans development
Q40873279The gene as theme in the paradigm of cancer
Q40525099The genetics of cell cycle checkpoints
Q30310388The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity
Q24314385The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
Q24306626The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments
Q34739115The interaction between Ran and NTF2 is required for cell cycle progression
Q37294890The interplay between chromosome stability and cell cycle control explored through gene-gene interaction and computational simulation
Q30856850The kinetochore protein Ndc10p is required for spindle stability and cytokinesis in yeast.
Q30442066The maize homologue of the cell cycle checkpoint protein MAD2 reveals kinetochore substructure and contrasting mitotic and meiotic localization patterns
Q34060695The metaphase II arrest in mouse oocytes is controlled through microtubule-dependent destruction of cyclin B in the presence of CSF.
Q33700992The metaphase to anaphase transition: a case of productive destruction
Q41678505The metaphase-to-anaphase transition: avoiding a mid-life crisis
Q41146841The mitotic checkpoint complex (MCC): looking back and forth after 15 years
Q28188970The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins
Q27933128The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase
Q35004928The mitotic spindle is required for loading of the DASH complex onto the kinetochore
Q42827088The mouse Mps1p-like kinase regulates centrosome duplication
Q37467150The nature of cell-cycle checkpoints: facts and fallacies
Q35013042The property of DNA polymerase zeta: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control
Q27938593The protein phosphatase 2A functions in the spindle position checkpoint by regulating the checkpoint kinase Kin4
Q24645774The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein
Q37037122The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair
Q41193565The role of DNA repair in the prevention of cancer
Q48074421The role of Saccharomyces cerevisiae Cdc40p in DNA replication and mitotic spindle formation and/or maintenance
Q36333350The role of centromere-binding factor 3 (CBF3) in spindle stability, cytokinesis, and kinetochore attachment.
Q35622956The role of mitotic checkpoint in maintaining genomic stability
Q27935576The roles of MAD1, MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes
Q45044181The scaffolding A/Tpd3 subunit and high phosphatase activity are dispensable for Cdc55 function in the Saccharomyces cerevisiae spindle checkpoint and in cytokinesis
Q37421316The signaling network that silences the spindle assembly checkpoint upon the establishment of chromosome bipolar attachment
Q41239083The spindle assembly checkpoint
Q37306927The spindle assembly checkpoint in Caenorhabditis elegans: one who lacks Mad1 becomes mad one
Q46317065The spindle assembly checkpoint in budding yeast
Q36322881The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes
Q41076740The spindle assembly checkpoint regulates the phosphorylation state of a subset of DNA checkpoint proteins in Saccharomyces cerevisiae
Q30557537The spindle assembly checkpoint works like a rheostat rather than a toggle switch
Q36456381The spindle assembly checkpoint: preventing chromosome mis-segregation during mitosis and meiosis
Q56951146The spindle checkpoint
Q27932971The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins
Q35160717The spindle checkpoint protein Mad2 regulates APC/C activity during prometaphase and metaphase of meiosis I in Saccharomyces cerevisiae
Q33976673The spindle checkpoint, aneuploidy, and cancer
Q27931883The spindle checkpoint.
Q35853950The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation
Q35563514The spindle checkpoint: from normal cell division to tumorigenesis.
Q34931754The spindle checkpoint: structural insights into dynamic signalling
Q30305518The spindle checkpoint: two transitions, two pathways
Q27334674The spindle pole bodies facilitate nuclear envelope division during closed mitosis in fission yeast
Q27860766The spindle-assembly checkpoint in space and time
Q34775279The tumor suppressor CDKN3 controls mitosis
Q28071855The unconventional kinetoplastid kinetochore: from discovery toward functional understanding
Q27936786The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein
Q36273872The yeast motor protein, Kar3p, is essential for meiosis I
Q47978899Three BUB1 and BUBR1/MAD3-related spindle assembly checkpoint proteins are required for accurate mitosis in Arabidopsis
Q30450971Three-dimensional analysis and ultrastructural design of mitotic spindles from the cdc20 mutant of Saccharomyces cerevisiae
Q27931369Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae
Q33641351Two genes required for the binding of an essential Saccharomyces cerevisiae kinetochore complex to DNA.
Q36657172Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation
Q74010958Uncoupling of the order of the S and M phases: effects of staurosporine on human cell cycle kinases
Q24541554Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres
Q35882315Under Tension: Kinetochores and Basic Research
Q36366483Unraveling cell division mechanisms with small-molecule inhibitors
Q40883498Unravelling the tangled web at the microtubule-organizing center
Q28756062Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion
Q28253087Variation in crossover frequencies perturb crossover assurance without affecting meiotic chromosome segregation in Saccharomyces cerevisiae
Q36293815Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells
Q47105112Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).
Q41352428When checkpoints fail
Q40361712YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity
Q27932982Ybp2 associates with the central kinetochore of Saccharomyces cerevisiae and mediates proper mitotic progression
Q36895837Yeast Dam1p is required to maintain spindle integrity during mitosis and interacts with the Mps1p kinase
Q27934121Yeast Rrp14p is required for ribosomal subunit synthesis and for correct positioning of the mitotic spindle during mitosis
Q36181404Yeast as a model system for anticancer drug discovery
Q24608777Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication
Q24299625Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions
Q77116066[When chromosomal dynamics control cell division]
Q46968710beta-Tubulin mutation suppresses microtubule dynamics in vitro and slows mitosis in vivo
Q33958873c-Myc overexpression uncouples DNA replication from mitosis
Q34044907gamma-Tubulin of budding yeast
Q36237019gamma-Tubulin-like Tub4p of Saccharomyces cerevisiae is associated with the spindle pole body substructures that organize microtubules and is required for mitotic spindle formation
Q74406181hBUB1 defects in leukemia and lymphoma cells
Q35551712p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment
Q41438652p53 and ATM: cell cycle, cell death, and cancer.
Q24290396p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase
Q35746700polo Is Identified as a Suppressor of bubR1 Nondisjunction in a Deficiency Screen of the Third Chromosome in Drosophila melanogaster
Q36821940pp39mos is associated with p34cdc2 kinase in c-mosxe-transformed NIH 3T3 cells

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