Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14

scientific article (publication date: 9 December 1999)

Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1006/BBRC.1999.1796
P698PubMed publication ID10581185

P2093author name stringQ Zhang
Q Liu
C T Caskey
S R George
R Wang
Z Zeng
C P Austin
D L Williams
C Bai
J F Evans
T P McDonald
M Davidoff
S S Pong
A D Howard
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
P304page(s)174-8
P577publication date1999-12-09
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleIdentification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14
P478volume266

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cites work (P2860)
Q36492706A closer look at the role of urotensin II in the metabolic syndrome
Q89884928Association between Plasma Urotensin II and Risk of Hypertension: Findings from a Prospective Study
Q42667921Behavioral effects of urotensin-II centrally administered in mice
Q28260943Biochemical and functional characterization of high-affinity urotensin II receptors in rat cortical astrocytes
Q35043105Cardiostimulant effects of urotensin-II in human heart in vitro
Q54708765Cellular distribution of GPR14 and the positive inotropic role of urotensin II in the myocardium in adult rat.
Q34204062Characterization of the true ortholog of the urotensin II-related peptide (URP) gene in teleosts
Q35191049Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons
Q34479147Comparative genomics provides evidence for close evolutionary relationships between the urotensin II and somatostatin gene families
Q42215972Deletion of the UT receptor gene results in the selective loss of urotensin-II contractile activity in aortae isolated from UT receptor knockout mice
Q43264253Depressor and regionally-selective vasodilator effects of human and rat urotensin II in conscious rats
Q58855829Design, Synthesis, Conformational Analysis, and Biological Studies of Urotensin-II Lactam Analogues
Q42059806Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey
Q28188986Discovery and mapping of ten novel G protein-coupled receptor genes
Q34677468Discovery of recently adopted orphan receptors for apelin, urotensin II, and ghrelin identified using novel radioligands and functional role in the human cardiovascular system.
Q34260110Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity
Q73307200Effect of human urotensin-II infusion on hemodynamics and cardiac function
Q39018162Effect of urotensin II on apolipoprotein B100 and apolipoprotein A-I expression in HepG2 cell line
Q93551696G Protein-Coupled Receptors
Q43229377Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery.
Q28140469Human urotensin II mediates vasoconstriction via an increase in inositol phosphates
Q43927991Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists
Q47855077Human urotensin-II enhances plasma extravasation in specific vascular districts in Wistar rats
Q34204725Human urotensin-II, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardiovascular disease
Q24629423Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R
Q28577654Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception
Q35047377Identification and pharmacological characterization of native, functional human urotensin-II receptors in rhabdomyosarcoma cell lines
Q98629482Identification and signaling characterization of four urotensin II receptor subtypes in the western clawed frog, Xenopus tropicalis
Q28199576Identification of four novel human G protein-coupled receptors expressed in the brain
Q22254611Identification of receptors for neuromedin U and its role in feeding
Q28208515Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain
Q34546327Impact of gene/genome duplications on the evolution of the urotensin II and somatostatin families.
Q24672927Is urotensin-II the new endothelin?
Q48675996Localization of the urotensin II receptor in the rat central nervous system
Q40735770Molecular and pharmacological characterization of genes encoding urotensin-II peptides and their cognate G-protein-coupled receptors from the mouse and monkey
Q28574132Murine and rat cavernosal responses to endothelin-1 and urotensin-II Vasoactive Peptide Symposium
Q34837608Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets
Q28202637Novel human G-protein-coupled receptors
Q34442018Orphan G protein-coupled receptors in the CNS.
Q34175467Orphan G-protein-coupled receptors and natural ligand discovery
Q24674639Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1
Q35128456Potential Clinical Implications of the Urotensin II Receptor Antagonists
Q34001118Protein expression of urotensin II, urotensin-related peptide and their receptor in the lungs of patients with lymphangioleiomyomatosis
Q39084425RGS2 regulates urotensin II-induced intracellular Ca2+ elevation and contraction in glomerular mesangial cells.
Q28182651Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects
Q37737495Role of urotensin II in health and disease
Q30658328Singular contributions of fish neuroendocrinology to mammalian regulatory peptide research
Q58448612Somatostatin receptors
Q34278176Somatostatins and their receptors in fish
Q38533390State-dependent calcium mobilization by urotensin-II in cultured human endothelial cells
Q30486707The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
Q33599835The G Protein-Coupled Receptor UT of the Neuropeptide Urotensin II Displays Structural and Functional Chemokine Features
Q28241656The expression of urotensin II receptor (U2R) is up-regulated by interferon-gamma
Q35100902The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems
Q34066190The relationship between urotensin II and its receptor and the clinicopathological parameters of breast cancer
Q24675590The role of urotensin II in cardiovascular and renal physiology and diseases
Q28211211The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat
Q42213734The vasoactive peptide urotensin II stimulates spontaneous release from frog motor nerve terminals
Q43146165The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation
Q38196857Therapeutic implications of peptide interactions with G-protein-coupled receptors in diabetic vasculopathy
Q36760529Therapeutic potential of blockade of the urotensin II system in systemic hypertension
Q37082781Therapeutic targets in hypertension: is there a place for antagonists of the most potent vasoconstrictors?
Q51970096Transcriptional profiling of the megabladder mouse: a unique model of bladder dysmorphogenesis.
Q73746130UROTENSIN II: BETTER THAN SOMATOSTATIN FOR PORTAL HYPERTENSION?
Q41767436Update on the urotensinergic system: new trends in receptor localization, activation, and drug design
Q41819007Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta
Q28576132Urotensin II and renal function in the rat
Q44654245Urotensin II causes fatal circulatory collapse in anesthesized monkeys in vivo: a “vasoconstrictor” with a unique hemodynamic profile
Q33378279Urotensin II in chronic liver disease: in vivo effect on vascular tone
Q36384743Urotensin II in invertebrates: from structure to function in Aplysia californica
Q48627768Urotensin II inhibits carotid sinus baroreflex in anesthetized male rats
Q44463826Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney
Q58949856Urotensin II is an inverse predictor of incident cardiovascular events in end-stage renal disease
Q43268409Urotensin II modulates hepatic fibrosis and portal hemodynamic alterations in rats
Q28584202Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons
Q50796108Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes.
Q42876530Urotensin II receptor antagonist attenuates monocrotaline-induced cardiac hypertrophy in rats.
Q40470611Urotensin II stimulates plasma extravasation in mice via UT receptor activation.
Q48877778Urotensin II-immunoreactivity in the brainstem and spinal cord of the rat.
Q78700092Urotensin II-induced activation of extracellular signal-regulated kinase in cultured vascular smooth muscle cells: involvement of cell adhesion-mediated integrin signaling
Q74531840Urotensin II: a new mediator in cardiopulmonary regulation?
Q40166897Urotensin II: a novel vasoactive mediator linked to chronic liver disease and portal hypertension
Q28250440Urotensin II: ancient hormone with new functions in vertebrate body fluid regulation
Q33846563Urotensin II: fish neuropeptide catches orphan receptor
Q37148984Urotensin II: lessons from comparative studies for general endocrinology.
Q93498779Urotensin-II
Q35779239Urotensin-II and the cardiovascular system--the importance of developing modulators
Q64940598Urotensin-II gene rs228648 polymorphism associated with the risk of diabetes mellitus.
Q42418210Urotensin-II: More Than a Mediator for Kidney
Q35536658Vasoconstrictive effects of endothelin-1, endothelin-3, and urotensin II in isolated perfused human lungs and isolated human pulmonary arteries
Q74162696Vasodilator effect of urotensin II, one of the most potent vasoconstricting factors, on rat coronary arteries

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