CBP-independent activation of CREM and CREB by the LIM-only protein ACT

scientific article (publication date: 11 March 1999)

CBP-independent activation of CREM and CREB by the LIM-only protein ACT is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1032958025
P356DOI10.1038/18237
P698PubMed publication ID10086359

P2093author name stringP Sassone-Corsi
D De Cesare
G M Fimia
P2860cites workXenopus embryos regulate the nuclear localization of XMyoDQ72718764
Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1Q24312053
Activation of cAMP and mitogen responsive genes relies on a common nuclear factorQ24313652
Muscle LIM protein promotes myogenesis by enhancing the activity of MyoDQ24319090
Nuclear protein CBP is a coactivator for the transcription factor CREBQ24319801
The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cellsQ24564060
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Phosphorylated CREB binds specifically to the nuclear protein CBPQ28265019
LIM domains: multiple roles as adapters and functional modifiers in protein interactionsQ28271283
Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant miceQ28276031
Severe impairment of spermatogenesis in mice lacking the CREM geneQ28276042
Transcription factors responsive to cAMPQ28283603
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133Q29617856
CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcriptionQ33334154
The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complexQ35033954
Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV geneQ36567294
cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription.Q37232479
Functional differences between mammalian transcription activation domains at the yeast GAL1 promoter.Q37628456
Developmental switch of CREM function during spermatogenesis: from antagonist to activatorQ38331149
The functional versatility of CREM is determined by its modular structure.Q40872353
The acetyltransferase activity of CBP stimulates transcriptionQ41036218
Transcriptional checkpoints determining the fate of male germ cellsQ41329177
Transcriptional regulation by cyclic AMP.Q41550266
DeLIMiting developmentQ41721616
CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinasesQ45137410
Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressorQ48088135
P433issue6723
P407language of work or nameEnglishQ1860
P921main subjectFour and a half LIM domains 5Q21985367
P304page(s)165-9
P577publication date1999-03-11
P1433published inNatureQ180445
P1476titleCBP-independent activation of CREM and CREB by the LIM-only protein ACT
P478volume398

Reverse relations

cites work (P2860)
Q49351018A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773).
Q24515126A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM
Q42826508A small-scale survey identifies selective and quantitative nucleo-cytoplasmic shuttling of a subset of CREM transcription factors
Q47582585A specific programme of gene transcription in male germ cells
Q30829987A testis-specific transcription factor IIA (TFIIAtau) stimulates TATA-binding protein-DNA binding and transcription activation
Q36986331Abnormal sperm in mice with targeted deletion of the act (activator of cAMP-responsive element modulator in testis) gene
Q33707445Activation of CREB/ATF sites by polyomavirus large T antigen
Q24679485Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function
Q28506488Aym1, a mouse meiotic gene identified by virtue of its ability to activate early meiotic genes in the yeast Saccharomyces cerevisiae
Q38887019CBP/p300 acetyltransferase activity in hematologic malignancies
Q35192842CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex
Q35056039CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects
Q34083280CREM, a master-switch of the transcriptional cascade in male germ cells
Q28145063CREM: a master-switch regulating the balance between differentiation and apoptosis in male germ cells
Q52544290CaMKIV/Gr is dispensable for spermatogenesis and CREM-regulated transcription in male germ cells.
Q33709917Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells
Q42659506Comparative genomics reveals gene-specific and shared regulatory sequences in the spermatid-expressed mammalian Odf1, Prm1, Prm2, Tnp1, and Tnp2 genes
Q46726198Crem activator isoforms in normal and impaired human spermatogenesis analyzed by real time RT-PCR.
Q24683786DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis
Q54752495Different CREM-isoform gene expression between equine and human normal and impaired spermatogenesis
Q43649095Differential expression of the C(s) and Calpha1 isoforms of the catalytic subunit of cyclic 3',5'-adenosine monophosphate-dependent protein kinase testicular cells
Q28512091Dynamic distribution of Spatial during mouse spermatogenesis and its interaction with the kinesin KIF17b
Q39730409Effects of Fluoride on Expression of P450, CREM and ACT Proteins in Rat Testes.
Q36310399Epigenetic mechanisms and gene networks in the nervous system.
Q44889142Evidence that phosphorylation by the mitotic kinase Cdk1 promotes ICER monoubiquitination and nuclear delocalization
Q44707416Expression of the soluble adenylyl cyclase during rat spermatogenesis: evidence for cytoplasmic sites of cAMP production in germ cells
Q24601620FHL2, a novel tissue-specific coactivator of the androgen receptor
Q28507893FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly
Q24528158FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1
Q33205331FHL5, a novel actin-binding protein, is highly expressed in eel gill pillar cells and responds to wall tension.
Q33947126Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts
Q38348693Fhl5/Act, a CREM-binding transcriptional activator required for normal sperm maturation and morphology, is not essential for testicular gene expression
Q29619559Function and regulation of CREB family transcription factors in the nervous system
Q33196649Functional analysis of transcription factors CREB and CREM.
Q24290342Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors
Q34001722Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation.
Q36339270Gene regulation in spermatogenesis
Q36037693Genetic control of spermiogenesis: insights from the CREM gene and implications for human infertility
Q34354292Germ cell nuclear factor relieves cAMP-response element modulator tau-mediated activation of the testis-specific promoter of human mitochondrial glycerol-3-phosphate dehydrogenase
Q40334418HMGA1a trapping of U1 snRNP at an authentic 5' splice site induces aberrant exon skipping in sporadic Alzheimer's disease
Q28585706HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm
Q45265139Human adipose angiotensinogen gene expression and secretion are stimulated by cyclic AMP via increased DNA cyclic AMP responsive element binding activity
Q51992881Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysis.
Q28216665Identification of the LIM protein FHL2 as a coactivator of beta-catenin
Q40486121Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin
Q33594057Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis
Q33242012K-SPMM: a database of murine spermatogenic promoters modules & motifs.
Q42180532Krüppel-like factor 4, a "pluripotency transcription factor" highly expressed in male postmeiotic germ cells, is dispensable for spermatogenesis in the mouse
Q28143453LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor
Q52132287Late arrest of spermiogenesis and germ cell apoptosis in mice lacking the TBP-like TLF/TRF2 gene.
Q35015948Many facets of mammalian lanosterol 14alpha-demethylase from the evolutionarily conserved cytochrome P450 family CYP51.
Q34099654Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB.
Q37213847MicroRNA-433 inhibits liver cancer cell migration by repressing the protein expression and function of cAMP response element-binding protein
Q90323117Migraine Genetic Variants Influence Cerebral Blood Flow
Q55129504Molecular biological features of male germ cell differentiation.
Q40586604Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression
Q36908690Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation
Q39677785Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB- and CREB binding protein-independent mechanism
Q40592239Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes
Q50529762Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117.
Q35209640Possible predictive factors for ICSI? Molecular biology techniques in combination with therapeutic testicular biopsies
Q42510336Prostaglandin E2 signalling pathway in human T lymphocytes from healthy and conjunctiva basal cell carcinoma-bearing subjects
Q28207756Protein profile of tax-associated complexes
Q35578422RNA granules in germ cells
Q36529383Regulation of gene expression in post-meiotic male germ cells: CREM-signalling pathways and male fertility
Q37179102Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives
Q35014009Regulation of transcription factors by neuronal activity.
Q37222247Role of basic leucine zipper proteins in transcriptional regulation of the steroidogenic acute regulatory protein gene
Q40426734Roles of LIM proteins in cardiac hypertrophy
Q47171939SOX30 is required for male fertility in mice
Q35123986Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behavior
Q33677015Signaling routes to CREM and CREB: plasticity in transcriptional activation.
Q28201542Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces alpha 5 beta 1-integrin-dependent myocyte elongation
Q35982119Specialized rules of gene transcription in male germ cells: the CREM paradigm.
Q28508820Sperm associated antigen 8 (SPAG8), a novel regulator of activator of CREM in testis during spermatogenesis
Q33969391Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin
Q28214481Structure and promoter activity of the gene encoding ornithine decarboxylase antizyme expressed exclusively in haploid germ cells in testis (OAZt/Oaz3)
Q28588119TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice
Q50482500TEX13 is a novel male germ cell-specific nuclear protein potentially involved in transcriptional repression.
Q36676439TauCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of Activator and Repressor Isoforms of the Cyclic AMP-Responsive Element Modulator (CREM) in Mouse Testis.
Q34317218The LIM domain protein FHL2 interacts with the NR5A family of nuclear receptors and CREB to activate the inhibin-α subunit gene in ovarian granulosa cells
Q28137861The LIM domain: regulation by association
Q28205922The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2
Q64078688The LIM-Only Protein FHL2 is involved in Autophagy to Regulate the Development of Skeletal Muscle Cell
Q22254650The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes
Q28216196The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein
Q31113643The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts
Q34184539The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1.
Q34628865The amphibian testis as model to study germ cell progression during spermatogenesis
Q55194935The arginine methyltransferase CARM1 represses p300•ACT•CREMτ activity and is required for spermiogenesis.
Q42797722The enigma of ATCE1, an acrosome-associated transcription factor
Q28216432The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis
Q33357676The four and a half LIM domain protein 2 interacts with and regulates the HERG channel
Q37948971The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic malignancies
Q39646594The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus
Q55041456Transcription factors governing male fertility.
Q53628861Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation.
Q31002803Transcriptional Control in Male Germ Cells: General Factor TFIIA Participates in CREM-Dependent Gene Activation
Q36254862Transcriptional and post-transcriptional gene regulation of HTLV-1.
Q33952455Transcriptional cascades during spermatogenesis: pivotal role of CREM and ACT.
Q33851832Transcriptional regulation by cyclic AMP-responsive factors
Q28210623Transcriptional regulation by the phosphorylation-dependent factor CREB
Q35059459Unique aspects of transcription regulation in male germ cells
Q73274235cAMP increases the expression of human angiotensinogen gene through a combination of cyclic AMP responsive element binding protein and a liver specific transcription factor
Q24810390cAMP-responsive element in TATA-less core promoter is essential for haploid-specific gene expression in mouse testis
Q28589737miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis