Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection

scientific article (publication date: September 1999)

Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S1074-5521(99)80107-0
P698PubMed publication ID10467124

P2093author name stringM F Carlier
D Pantaloni
A Ducruix
P2860cites workStructure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' proteinQ22009957
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerizationQ24309118
SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium developmentQ24311769
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cellsQ24312369
The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formationQ24313611
Ras/Rap effector specificity determined by charge reversalQ24315941
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASPQ24318478
Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneriQ24533240
Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodiaQ24682164
Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assemblyQ27618321
Rho GTPases and the actin cytoskeletonQ27860579
Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family proteinQ27933457
Bee1, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeletonQ27938066
Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndromeQ28289697
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complexQ28293934
Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenesQ28301594
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assemblyQ28609843
Self-polarization and directional motility of cytoplasmQ34487647
Mechanism of Cdc42-induced actin polymerization in neutrophil extractsQ36255700
Cell motility: complex dynamics at the leading edgeQ41480422
The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complexQ41667056
Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleationQ46673303
Use of a fluorescence spectroscopic readout to characterize the interactions of Cdc42Hs with its target/effector, mPAK-3.Q54570875
Actin cytoskeleton: the Arp2/3 complex gets to the pointQ77310775
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)R235-40
P577publication date1999-09-01
P1433published inChemistry and BiologyQ15758410
P1476titleSignalling to actin: the Cdc42-N-WASP-Arp2/3 connection
P478volume6

Reverse relations

cites work (P2860)
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Q28139787A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization
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Q28590934Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells
Q45206429Activation of the Arp2/3 complex by N-WASp is required for actin polymerization and contraction in smooth muscle
Q36774995Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway
Q47070830Ciboulot regulates actin assembly during Drosophila brain metamorphosis
Q44477015Downregulation of profilin with antisense oligodeoxynucleotides inhibits force development during stimulation of smooth muscle
Q28571789Formation of cellular projections in neural progenitor cells depends on SK3 channel activity
Q35014198Frontier of epilepsy research - mTOR signaling pathway
Q28142883GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex
Q34560866How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2.
Q45443442Human T-lymphotropic virus, type 1, tax protein triggers microtubule reorientation in the virological synapse
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Q47193426Ignition of a cellular machine
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Q39157220PrP(C) regulates epidermal growth factor receptor function and cell shape dynamics in Neuro2a cells.
Q28207756Protein profile of tax-associated complexes
Q28576605Regulated exocytosis in neuroendocrine cells: a role for subplasmalemmal Cdc42/N-WASP-induced actin filaments
Q34178584Regulation of actin dynamics in rapidly moving cells: a quantitative analysis
Q41873543Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells.
Q39588446Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors
Q116166336Role of ARP2/3 Complex-Driven Actin Polymerization in RSV Infection
Q27310707Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons
Q56567433Structure of the N-WASP EVH1 Domain-WIP Complex
Q30168083The Dictyostelium CARMIL protein links capping protein and the Arp2/3 complex to type I myosins through their SH3 domains
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Q34525887The modular logic of signaling proteins: building allosteric switches from simple binding domains
Q33964064The putative pocket protein binding site of Autographa californica nucleopolyhedrovirus BV/ODV-C42 is required for virus-induced nuclear actin polymerization
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Q33341456Wiskott-Aldrich syndrome
Q53163810p21-Activated kinase (Pak) regulates airway smooth muscle contraction by regulating paxillin complexes that mediate actin polymerization.

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