Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

scientific article (publication date: 20 April 2000)

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-9822(00)00447-4
P3181OpenCitations bibliographic resource ID1611816
P698PubMed publication ID10801416
P5875ResearchGate publication ID12516933

P50authorJan HoeijmakersQ15820773
P2093author name stringM Muijtjens
A de Klein
A M Carr
B Smit
A R Lehmann
R van Os
Y Verhoeven
P2860cites workA role for ATR in the DNA damage-induced phosphorylation of p53Q22008733
Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrestQ24317123
The Schizosaccharomyces pombe rad3 checkpoint geneQ24561779
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint proteinQ24568188
A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP poolsQ27938474
Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23Q28115834
Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF geneQ28507914
Atm-deficient mice: a paradigm of ataxia telangiectasiaQ29619532
Localization of an ataxia-telangiectasia gene to chromosome 11q22-23.Q34169664
Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint controlQ36490482
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpointsQ41063544
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.Q41164271
Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway.Q41345405
Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase familyQ41441663
The genetic defect in ataxia-telangiectasiaQ41464274
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.Q42631867
The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.Q45345463
Circular chromosome formation in a fission yeast mutant defective in two ATM homologuesQ48016421
Dual roles of ATM in the cellular response to radiation and in cell growth control.Q52521591
Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.Q52524907
atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicityQ73552961
Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in miceQ77227965
DNA damage and checkpoint pathways: molecular anatomy and interactions with repairQ77313425
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)479-82
P577publication date2000-04-20
P1433published inCurrent BiologyQ1144851
P1476titleTargeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
P478volume10