Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

scientific article (publication date: July 2003)

Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2002-11-3610
P3181OpenCitations bibliographic resource ID3742232
P698PubMed publication ID12637325
P5875ResearchGate publication ID10856631

P50authorWolfgang StremmelQ50772068
Thomas HerrmannQ96756126
P2093author name stringHasan Kulaksiz
Sven G Gehrke
Hans-Dieter Riedel
Claudia Veltkamp
Karin Bents
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)371-376
P577publication date2003-03-13
P1433published inBloodQ885070
P1476titleExpression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
P478volume102

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cites work (P2860)
Q37175611A new mutation in the hepcidin promoter impairs its BMP response and contributes to a severe phenotype in HFE related hemochromatosis
Q82772379A novel monoclonal antibody immunoassay for the detection of human serum hepcidin
Q36267869A precious metal: Iron, an essential nutrient for all cells
Q47849648Adaptive changes of duodenal iron transport proteins in celiac disease.
Q42596912Altered hepatic BMP signaling pathway in human HFE hemochromatosis
Q47374646Ankaferd Influences mRNA Expression of Iron-Regulated Genes During Iron-Deficiency Anemia.
Q41871982BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
Q58793890Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis
Q46349398Consumption of a High-Iron Diet Disrupts Homeostatic Regulation of Intestinal Copper Absorption in Adolescent Mice
Q28388662Cross-sectional study of expression of divalent metal transporter-1, transferrin, and hepcidin in blood of smelters who are occupationally exposed to manganese
Q37207754Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes
Q38132275Diagnosis and treatment of hereditary hemochromatosis: an update
Q37928941Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice
Q89927769Disorders of metal metabolism
Q37294246Duodenal expression of iron transport molecules in patients with hereditary hemochromatosis or iron deficiency
Q96132565Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women
Q46906546Effect of penicillamine and zinc on iron metabolism in Wilson's disease
Q50460423Effects of different doses and duration of iron supplementation on curing iron deficiency anemia: an experimental study
Q37002231Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha
Q28471913Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors
Q36041975Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice
Q42619912Function of the hemochromatosis protein HFE: Lessons from animal models
Q47398332Functional differences between hepcidin 1 and 2 in transgenic mice
Q39537220GATA-4 transcription factor regulates hepatic hepcidin expression
Q28581159Gene chip analyses reveal differential genetic responses to iron deficiency in rat duodenum and jejunum
Q91962671Genetic Disorders Associated with Metal Metabolism
Q38608744HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication.
Q88273092Haemochromatosis
Q36948509Hemochromatosis: an endocrine liver disease.
Q36069473Hepcidin and cytokines in anaemia
Q27690828Hepcidin and iron regulation, 10 years later
Q35745009Hepcidin and its role in iron absorption
Q46909240Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease.
Q37122273Hepcidin modulation in human diseases: from research to clinic.
Q39051483Hepcidin production in response to iron is controlled by monocyte-derived humoral factors
Q41845987Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency.
Q45790281Hepcidin-25 concentrations are markedly increased in patients with chronic kidney disease and are inversely correlated with estimated glomerular filtration rates.
Q26800198Hepcidin: regulation of the master iron regulator
Q36106775High-Iron Consumption Impairs Growth and Causes Copper-Deficiency Anemia in Weanling Sprague-Dawley Rats
Q39762114Huh-7: a human "hemochromatotic" cell line.
Q28575734Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum
Q34658174Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
Q35538677Iron Deficiency and Erythropoiesis: New Diagnostic Approaches
Q39285336Iron Metabolism and the Inflammatory Response.
Q104471840Iron elevates mesenchymal and metastatic biomarkers in HepG2 cells
Q34651570Iron imports. IV. Hepcidin and regulation of body iron metabolism
Q57397536Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin
Q56487598Iron storage disease (hemochromatosis) and hepcidin response to iron load in two species of pteropodid fruit bats relative to the common vampire bat
Q35990728Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.
Q46406998Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo.
Q37141378Is serum hepcidin causative in hemochromatosis? Novel analysis from a liver transplant with hemochromatosis
Q36677136Known and potential roles of transferrin in iron biology
Q61638660Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload
Q36177913Liver iron transport
Q47375355Liver transplantation: an "in vivo" model for the pathophysiology of hemochromatosis?
Q36923162Liver-gut axis in the regulation of iron homeostasis.
Q44620754Localization of iron metabolism–related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes
Q28581235Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes
Q90652303Low-molecular-mass iron complexes in blood plasma of iron-deficient pigs do not originate directly from nutrient iron
Q37658680Mammalian iron metabolism
Q36304041Mechanisms of disease: The role of hepcidin in iron homeostasis--implications for hemochromatosis and other disorders
Q27010510Mechanisms of mammalian iron homeostasis
Q36419082Molecular insights into the pathogenesis of hereditary haemochromatosis
Q36845145Molecular regulation of hepatic expression of iron regulatory hormone hepcidin
Q34516972New insights into the regulation of iron homeostasis
Q60163251Non-HFE hemochromatosis
Q24648028Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin
Q35596487Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia
Q34785164Prohepcidin levels in refractory anaemia caused by lead poisoning
Q36753973Proton pump inhibitors suppress absorption of dietary non-haem iron in hereditary haemochromatosis
Q37320318Regulation of iron absorption in hemoglobinopathies.
Q24301632Regulation of transferrin receptor 2 protein levels by transferrin
Q57486984Role of HAMP Genetic Variants on Pathophysiology of Iron Deficiency Anemia
Q35628117Screening for hemochromatosis: patients with liver disease, families, and populations.
Q51071449Serum hepcidin levels and muscle iron proteins in humans injected with low- or high-dose erythropoietin.
Q50704396Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women.
Q35316703The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes
Q26798153The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease
Q28211300The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression
Q39787443The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells
Q39688547Transferrin receptor 2 is crucial for iron sensing in human hepatocytes.
Q57375964Transferrin receptor 2 is emerging as a major player in the control of iron metabolism
Q45294458Transferrin receptor 2 mediates a biphasic pattern of transferrin uptake associated with ligand delivery to multivesicular bodies
Q44826224Type 3 hemochromatosis and beta-thalassemia trait
Q81798890[HFE hemochromatosis: pathogenic and diagnostic approach]
Q80234073[Update on hemochromatosis]

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