| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S1521-6926(03)00062-8 |
| P698 | PubMed publication ID | 12935958 |
| P50 | author | Jonathan D Licht | Q42315828 |
| Arthur Zelent | Q95995847 | ||
| P2093 | author name string | Ari Melnick | |
| Andres Sirulnik | |||
| P2860 | cites work | Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling | Q22001449 |
| Transcriptional Repression by the Promyelocytic Leukemia Protein, PML | Q41071228 | ||
| Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors | Q41602857 | ||
| Oncogenic Transcription Factors in the Human Acute Leukemias | Q41628889 | ||
| Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers. | Q41745269 | ||
| Effects of actinomycin D analogs on nucleolar phosphoprotein B23 (37,000 daltons/pI 5.1). | Q42149831 | ||
| Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. | Q42819246 | ||
| Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies | Q44072008 | ||
| Alterations of the FLT3 gene in acute promyelocytic leukemia: association with diagnostic characteristics and analysis of clinical outcome in patients treated with the Italian AIDA protocol | Q44194162 | ||
| Essential role for the dimerization domain of NuMA-RARalpha in its oncogenic activities and localization to NuMA sites within the nucleus | Q44313516 | ||
| The morphological relationship in electron microscopy between NOR-silver proteins and intranucleolar chromatin | Q45275223 | ||
| Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein | Q47814142 | ||
| In vitro response to all-trans retinoic acid of acute promyelocytic leukemias with nonreciprocal PML/RARA or RARA/PML fusion genes | Q47981327 | ||
| Nucleolar protein B23 stimulates nuclear import of the HIV-1 Rev protein and NLS-conjugated albumin | Q50335728 | ||
| Sequence-specific DNA Binding and Transcriptional Regulation by the Promyelocytic Leukemia Zinc Finger Protein | Q52192845 | ||
| Deregulation of NPM and PLZF in a variant t(5;17) case of acute promyelocytic leukemia | Q52533879 | ||
| UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML. | Q53381686 | ||
| Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation. | Q53408223 | ||
| The RAR alpha-PLZF chimera associated with Acute Promyelocytic Leukemia has retained a sequence-specific DNA-binding domain | Q53445195 | ||
| Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. | Q54147247 | ||
| 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia | Q66694390 | ||
| Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts | Q67991465 | ||
| Interaction of nucleolar phosphoprotein B23 with nucleic acids | Q69126058 | ||
| Translocation of nucleolar phosphoprotein B23 (37 kDa/pI 5.1) induced by selective inhibitors of ribosome synthesis | Q69921322 | ||
| Role of Protein Phosphorylation in Post-translational Regulation of Protein B23 during Programmed Cell Death in the Prostate Gland | Q72054829 | ||
| Nucleophosmin/B23 (NPM) oligomer is a major and stable entity in HeLa cells | Q72291803 | ||
| Immunofluorescence studies on proteins B23 and C23 in nucleoli of human lymphocytes | Q72730151 | ||
| The impact of differential binding of wild-type RARalpha, PML-, PLZF- and NPM-RARalpha fusion proteins towards transcriptional co-activator, RIP-140, on retinoic acid responses in acute promyelocytic leukemia | Q73359070 | ||
| Secondary cytogenetic changes in acute promyelocytic leukemia--prognostic importance in patients treated with chemotherapy alone and association with the intron 3 breakpoint of the PML gene: a Cancer and Leukemia Group B study | Q73368620 | ||
| Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid | Q73470291 | ||
| Acute promyelocytic leukaemia with t(11;17)(q23;q12‐21) and a good initial response to prolonged ATRA and combination chemotherapy | Q74263483 | ||
| A study of correlation between NPM-translocation and apoptosis in cells induced by daunomycin | Q77407634 | ||
| The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia | Q78109251 | ||
| Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication | Q24290438 | ||
| The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases | Q24290948 | ||
| Role of PML and PML-RARalpha in Mad-mediated transcriptional repression | Q24291380 | ||
| PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA. | Q24291551 | ||
| The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth | Q24293421 | ||
| Nucleophosmin regulates the stability and transcriptional activity of p53 | Q24300176 | ||
| Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis | Q24305262 | ||
| Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein | Q24308811 | ||
| Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies | Q24311314 | ||
| Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins | Q24313028 | ||
| Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a | Q24324559 | ||
| The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein | Q24523980 | ||
| The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase | Q24548870 | ||
| PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors | Q24563942 | ||
| Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia | Q24597732 | ||
| SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia | Q24653689 | ||
| Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling | Q24674185 | ||
| Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid | Q27729334 | ||
| Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha | Q27730245 | ||
| The nuclear receptor superfamily: the second decade | Q27860725 | ||
| The POZ domain: a conserved protein-protein interaction motif | Q28115868 | ||
| Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML | Q28118823 | ||
| Two critical hits for promyelocytic leukemia | Q28139515 | ||
| The function of PML in p53-dependent apoptosis | Q28140732 | ||
| Atmospheric carbon dioxide concentrations over the past 60 million years | Q28144787 | ||
| Functional interaction of p53 and BLM DNA helicase in apoptosis | Q28201136 | ||
| PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA1 protein | Q28202849 | ||
| The acute promyelocytic leukemia–associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D3–induced monocytic differentiation of U937 cells through a physical interaction with vitamin D3receptor | Q28206964 | ||
| CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia | Q28209517 | ||
| Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways | Q28212269 | ||
| Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling | Q28212389 | ||
| The role of PML in tumor suppression | Q28217779 | ||
| Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor | Q28217975 | ||
| The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus | Q28241824 | ||
| Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia | Q28248385 | ||
| Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma | Q28250347 | ||
| Role of the histone deacetylase complex in acute promyelocytic leukaemia | Q28263534 | ||
| Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13 | Q28264488 | ||
| Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | Q28273724 | ||
| Components of the SMRT Corepressor Complex Exhibit Distinctive Interactions with the POZ Domain Oncoproteins PLZF, PLZF-RARα, and BCL-6 | Q28284917 | ||
| Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system | Q28304840 | ||
| Characterization of three RXR genes that mediate the action of 9-cis retinoic acid | Q28343068 | ||
| Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins | Q28344657 | ||
| Function of retinoic acid receptor gamma in the mouse | Q28507388 | ||
| Positive and negative regulation of granulopoiesis by endogenous RARalpha | Q28510557 | ||
| Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity | Q28586849 | ||
| Plzf regulates limb and axial skeletal patterning | Q28587392 | ||
| Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses | Q28592023 | ||
| Role of PML in cell growth and the retinoic acid pathway | Q28593138 | ||
| Stats: transcriptional control and biological impact | Q29547776 | ||
| Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia | Q29616211 | ||
| Altered Hox expression and segmental identity in Mll-mutant mice | Q29620391 | ||
| Major nucleolar proteins shuttle between nucleus and cytoplasm | Q29620425 | ||
| Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis | Q30175784 | ||
| Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient | Q33177365 | ||
| Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia | Q33178068 | ||
| Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus | Q33334769 | ||
| Neutrophil maturation and the role of retinoic acid | Q33729975 | ||
| CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment | Q33854193 | ||
| The role of Stat5a and Stat5b in signaling by IL-2 family cytokines | Q33941389 | ||
| In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions | Q33965235 | ||
| PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model | Q34032333 | ||
| PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR | Q34057370 | ||
| Deconstructing PML-induced premature senescence | Q34089507 | ||
| Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors. | Q34324111 | ||
| Function of RARα during the maturation of neutrophils | Q34435515 | ||
| Translocations of the RARalpha gene in acute promyelocytic leukemia | Q34435522 | ||
| The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite | Q34517403 | ||
| The role of nucleophosmin in centrosome duplication | Q34526870 | ||
| Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain | Q34580344 | ||
| Advances in the understanding and management of acute promyelocytic leukemia | Q34680944 | ||
| Reciprocal products of chromosomal translocations in human cancer pathogenesis: key players or innocent bystanders? | Q34750188 | ||
| The role of retinoids and retinoic acid receptors in normal hematopoiesis | Q34926555 | ||
| Finding a role for PML in APL pathogenesis: a critical assessment of potential PML activities | Q34926571 | ||
| Acute promyelocytic leukemia: a model for the role of molecular diagnosis and residual disease monitoring in directing treatment approach in acute myeloid leukemia | Q34926666 | ||
| Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation | Q35906417 | ||
| A PMLRARalpha transgene initiates murine acute promyelocytic leukemia | Q36049975 | ||
| Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body. | Q36062156 | ||
| Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene | Q36116474 | ||
| NuMA is required for the proper completion of mitosis. | Q36383071 | ||
| A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage | Q36452885 | ||
| Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice | Q36771988 | ||
| A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia | Q36781396 | ||
| Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia | Q37031781 | ||
| Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha | Q37206203 | ||
| Identification of a nuclear domain with deacetylase activity. | Q37242624 | ||
| BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor | Q37477121 | ||
| The Promyelocytic Leukemia Zinc Finger Protein Affects Myeloid Cell Growth, Differentiation, and Apoptosis | Q39576033 | ||
| Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling. | Q40023123 | ||
| NuMA, a nuclear protein involved in mitosis and nuclear reformation. | Q40626418 | ||
| DNA damage-induced translocation of the Werner helicase is regulated by acetylation | Q40696914 | ||
| Constitutively active STAT5 variants induce growth and survival of hematopoietic cells through a PI 3-kinase/Akt dependent pathway. | Q40804665 | ||
| The promyelocytic leukemia (PML) protein suppresses cyclin D1 protein production by altering the nuclear cytoplasmic distribution of cyclin D1 mRNA. | Q40887272 | ||
| The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies | Q41042313 | ||
| Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. | Q41065048 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | leukemia | Q29496 |
| pathogenesis | Q372016 | ||
| P304 | page(s) | 387-408 | |
| P577 | publication date | 2003-09-01 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Best Practice and Research: Clinical Haematology | Q15755888 |
| P1476 | title | Molecular pathogenesis of acute promyelocytic leukaemia and APL variants | |
| P478 | volume | 16 |
| Q38581414 | A new transcriptional variant and small azurophilic granules in an acute promyelocytic leukemia case with NPM1/RARA fusion gene. |
| Q89718115 | A phase II study evaluating the role of bortezomib in the management of relapsed acute promyelocytic leukemia treated upfront with arsenic trioxide |
| Q35640734 | Acute promyelocytic leukemia: an experience on 95 greek patients treated in the all-trans-retinoic Acid era |
| Q55362655 | Arsenic Trioxide Enhances the NK Cell Cytotoxicity Against Acute Promyelocytic Leukemia While Simultaneously Inhibiting Its Bio-Genesis. |
| Q36546255 | Assays for pharmacodynamic analysis of histone deacetylase inhibitors |
| Q33279222 | Cytodifferentiation by retinoids, a novel therapeutic option in oncology: rational combinations with other therapeutic agents |
| Q82990470 | Design of a sandwich-mode amperometric biosensor for detection of PML/RARα fusion gene using locked nucleic acids on gold electrode |
| Q36970179 | Epigenetic regulation of normal and malignant hematopoiesis |
| Q37818248 | Gemtuzumab ozogamicin for the treatment of acute promyelocytic leukemia: mechanisms of action and resistance, safety and efficacy |
| Q36219726 | Histone deacetylase inhibitors: insights into mechanisms of lethality |
| Q57224260 | Inclusion of hemoglobin level in prognostic score provides better prognostic stratification in patients with acute promyelocytic leukemia (APL) |
| Q42878314 | Interstitial insertion ofRARαgene intoPMLgene in a patient with acute promyelocytic leukemia (APL) lacking the classic t(15;17) |
| Q26991440 | Perspectives of differentiation therapies of acute myeloid leukemia: the search for the molecular basis of patients' variable responses to 1,25-dihydroxyvitamin d and vitamin d analogs |
| Q36238093 | RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation |
| Q84079085 | Relapsed APL patient with variant NPM-RARalpha fusion responded to arsenic trioxide-based therapy and achieved long-term survival |
| Q37863271 | Transcriptional and epigenetic networks in haematological malignancy |
| Q38269931 | Unlocking the potential of retinoic acid in anticancer therapy |
Search more.