Alteration of intracellular structure and function of glyceraldehyde-3-phosphate dehydrogenase: a common phenotype of neurodegenerative disorders?

scientific article (publication date: October 2002)

Alteration of intracellular structure and function of glyceraldehyde-3-phosphate dehydrogenase: a common phenotype of neurodegenerative disorders? is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/S0161-813X(02)00062-1
P698PubMed publication ID12428732

P2093author name stringJennifer L Mazzola
Michael A Sirover
P2860cites workAtrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcriptionQ24290194
Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathwayQ24291938
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neuronsQ24317574
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Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenylQ28263664
Spinocerebellar ataxia type-1 and spinobulbar muscular atrophy gene products interact with glyceraldehyde-3-phosphate dehydrogenaseQ28293728
Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated formQ28509836
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like mannerQ28510317
Parkin is associated with cellular vesiclesQ28578692
Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organellesQ28589989
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic miceQ29615357
New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase.Q30322264
Reduction of glyceraldehyde-3-phosphate dehydrogenase activity in Alzheimer's disease and in Huntington's disease fibroblastsQ32034809
Moonlighting proteins.Q33543960
Genetics of Parkinsonism: a reviewQ34293891
Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeatQ34662620
Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell deathQ36605673
Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionationQ36823776
Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological lengthQ36826440
Glyceraldehyde-3-phosphate dehydrogenase antisense oligodeoxynucleotides protect against cytosine arabinonucleoside-induced apoptosis in cultured cerebellar neuronsQ37368739
Genetics and molecular biology of Huntington's diseaseQ40399297
Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinolQ40783945
alpha-Synuclein forms a complex with transcription factor Elk-1.Q40816103
Glyceraldehyde-3-phosphate dehydrogenase is required for vesicular transport in the early secretory pathwayQ40849095
In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.Q40981007
The influence of huntingtin protein size on nuclear localization and cellular toxicity.Q41035353
Trinucleotide instability: a repeating theme in human inherited disordersQ41036331
Huntington disease: new insights into the relationship between CAG expansion and diseaseQ41170305
Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation.Q41429343
Aberrant proteolysis of the beta-amyloid precursor protein in familial Alzheimer's disease lymphoblastoid cellsQ41524470
Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.Q42438521
Amyloid precursor protein metabolism in fibroblasts from individuals with one, two or three copies of the amyloid precursor protein (APP) geneQ42993144
The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in cultureQ43735231
Alteration of nuclear glyceraldehyde-3-phosphate dehydrogenase structure in Huntington's disease fibroblastsQ43991317
Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.Q45291767
Glyceraldehyde 3-phosphate dehydrogenase abnormality in metabolically stressed Huntington disease fibroblasts.Q45296630
Brain glyceraldehyde-3-phosphate dehydrogenase activity in human trinucleotide repeat disordersQ45296636
Biochemical abnormalities and excitotoxicity in Huntington's disease brain.Q45297145
Fibroblast models of neurological disorders: fluorescence measurement studiesQ47888489
Parieto-occipital glucose hypometabolism in Parkinson's disease with autonomic failureQ48185492
Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase isoforms during neuronal apoptosisQ48275909
Motor correlates of occipital glucose hypometabolism in Parkinson's disease without dementiaQ48279827
Increased glyceraldehyde 3-phosphate dehydrogenase levels in the brain of patients with Down's syndromeQ48279897
Rat brain glyceraldehyde-3-phosphate dehydrogenase interacts with the recombinant cytoplasmic domain of Alzheimer's beta-amyloid precursor proteinQ48291777
Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic miceQ48373570
Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosisQ48477126
Subcellular distribution of glyceraldehyde-3-phosphate dehydrogenase in cerebellar granule cells undergoing cytosine arabinoside-induced apoptosisQ48544021
Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson's diseaseQ48939047
Parkin is associated with actin filaments in neuronal and nonneural cellsQ58856664
Fluorodopa uptake and glucose metabolism in early stages of corticobasal degenerationQ59858824
Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's diseaseQ64767727
Glyceraldehyde-3-phosphate dehydrogenase is over-expressed during apoptotic death of neuronal cultures and is recognized by a monoclonal antibody against amyloid plaques from Alzheimer's brainQ71041832
Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease casesQ74665994
P433issue4-5
P407language of work or nameEnglishQ1860
P921main subjectneurodegenerationQ1755122
P304page(s)603-9
P577publication date2002-10-01
P1433published inNeuroToxicologyQ15098069
P1476titleAlteration of intracellular structure and function of glyceraldehyde-3-phosphate dehydrogenase: a common phenotype of neurodegenerative disorders?
P478volume23

Reverse relations

cites work (P2860)
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