SH2-Bbeta is a Rac-binding protein that regulates cell motility

scientific article (publication date: 22 March 2002)

SH2-Bbeta is a Rac-binding protein that regulates cell motility is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M111138200
P3181OpenCitations bibliographic resource ID1753003
P698PubMed publication ID11786545

P50authorMaria DiakonovaQ59157673
P2093author name stringChristin Carter-Su
James Herrington
David R Gunter
P2860cites workActivation of Rac1 by a Crk SH3-binding protein, DOCK180Q22007972
PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesisQ22011152
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modulesQ24323939
Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbetaQ24554240
The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteinsQ24554429
Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signalingQ24644273
Cell migration: a physically integrated molecular processQ27860682
The small GTP-binding protein rac regulates growth factor-induced membrane rufflingQ27861063
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodiaQ27861126
A brain serine/threonine protein kinase activated by Cdc42 and Rac1Q28249559
Identification and characterization of novel substrates of Trk receptors in developing neuronsQ28291632
Small GTP-binding proteins and the regulation of the actin cytoskeletonQ28586463
Temporal and spatial distribution of activated Pak1 in fibroblastsQ28647602
Rho GTPases control polarity, protrusion, and adhesion during cell movementQ29614244
A role for p21-activated kinase in endothelial cell migration.Q30175310
Modular peptide recognition domains in eukaryotic signalingQ30176687
Signaling to actin dynamicsQ33699981
Proteins that regulate dynamic actin remodeling in response to membrane signaling minireview seriesQ33769041
Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteinsQ33769047
Actin machinery: pushing the envelope.Q33840347
Signaling from Ras to Rac and beyond: not just a matter of GEFsQ33931717
Platelet-derived growth factor in chemotactic for fibroblastsQ36205866
p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblastsQ36256616
Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2.Q36389814
SH2-B and APS are multimeric adapters that augment TrkA signalingQ39457885
Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.Q40387432
Jaks and Stats in signaling by the cytokine receptor superfamilyQ40506662
The phagokinetic tracks of 3T3 cellsQ40796669
Growth hormone (GH) stimulates protein synthesis in cells transfected with GH receptor complementary DNA.Q41713287
SH2-B is required for growth hormone-induced actin reorganizationQ42802819
Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascadeQ42807716
Properties of growth hormone receptors in relation to the adipose conversion of 3T3 cellsQ42823307
Platelet-derived growth factor (PDGF) stimulates the association of SH2-Bbeta with PDGF receptor and phosphorylation of SH2-BbetaQ42827514
Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapterQ48039922
Morphological alterations of Xenopus oocytes induced by valine-14 p21rho depend on isoprenylation and are inhibited by Clostridium botulinum C3 ADP-ribosyltransferase.Q50803510
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectSH2B adaptor protein 1Q21988194
P304page(s)10669-77
P577publication date2002-03-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleSH2-Bbeta is a Rac-binding protein that regulates cell motility
P478volume277

Reverse relations

cites work (P2860)
Q40763332Adapter protein SH2-B beta undergoes nucleocytoplasmic shuttling: implications for nerve growth factor induction of neuronal differentiation
Q35913642Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion
Q35073608Adapter protein SH2B1beta binds filamin A to regulate prolactin-dependent cytoskeletal reorganization and cell motility
Q37244857Adapter protein SH2B1beta cross-links actin filaments and regulates actin cytoskeleton
Q34132466Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice.
Q46263456Diversity in peptide recognition by the SH2 domain of SH2B1.
Q51022775Downregulation of the growth hormone-induced Janus kinase 2/signal transducer and activator of transcription 5 signaling pathway requires an intact actin cytoskeleton.
Q34068321Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1
Q36096515Genome-wide association study revealed genomic regions related to white/red earlobe color trait in the Rhode Island Red chickens
Q34722214Growth hormone signal transduction.
Q53510336Growth hormone signaling pathways.
Q36497996Human SH2B1 mutations are associated with maladaptive behaviors and obesity
Q35210820Identification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number
Q28242536JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions
Q28189437Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling
Q36890487MicroRNA-361-3p suppresses tumor cell proliferation and metastasis by directly targeting SH2B1 in NSCLC.
Q64070564MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer
Q30425265PAK1-Nck regulates cyclin D1 promoter activity in response to prolactin
Q34808684Phosphorylation controls a dual-function polybasic nuclear localization sequence in the adapter protein SH2B1β to regulate its cellular function and distribution
Q36918288Phosphorylation of the adaptor protein SH2B1β regulates its ability to enhance growth hormone-dependent macrophage motility
Q36739652Recent advances in growth hormone signaling
Q37381956Research resource: identification of novel growth hormone-regulated phosphorylation sites by quantitative phosphoproteomics
Q42829566RhoA/ROCK activation by growth hormone abrogates p300/histone deacetylase 6 repression of Stat5-mediated transcription
Q24537266SH2-B is required for both male and female reproduction
Q48520033SH2B1 promotes epithelial-mesenchymal transition through the IRS1/β-catenin signaling axis in lung adenocarcinoma.
Q34023575SH2B1 regulation of energy balance, body weight, and glucose metabolism
Q42802113Src-CrkII-C3G-dependent Activation of Rap1 Switches Growth Hormone-stimulated p44/42 MAP Kinase and JNK/SAPK Activities
Q38044625The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis
Q28506708Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta
Q34173102YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling

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