Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

scientific article (publication date: 2002)

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1042502685
P356DOI10.1038/NM0102-68
P8608Fatcat IDrelease_7aer4mld6zbgxiyftry4xzob7m
P3181OpenCitations bibliographic resource ID789511
P698PubMed publication ID11786909
P5875ResearchGate publication ID11571355

P50authorEric LanderQ970550
Todd GolubQ7812388
Jill P. MesirovQ19664665
Michelle GaasenbeekQ28914670
Pablo TamayoQ59551108
Margaret A ShippQ89030667
Geraldine PinkusQ110078288
P2093author name stringJeffery L Kutok
Jon C Aster
Donna S Neuberg
T Andrew Lister
Ricardo C T Aguiar
Andrew Norton
Michael Reich
Andrew P Weng
Michael Angelo
Ken N Ross
Kim W Last
Margaret A Koval
Tane S Ray
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The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosisQ24608044
Cluster analysis and display of genome-wide expression patternsQ24644463
NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytesQ24685661
Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingQ27860529
Molecular classification of cancer: class discovery and class prediction by gene expression monitoringQ27861072
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A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors ProjectQ28251216
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Nur77 transcription activity correlates with its apoptotic function in vivoQ41701543
Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B.Q42117582
Expression of the adhesion molecule ICAM-1 in non-Hodgkin's lymphoma: relationship with tumor dissemination and prognostic importanceQ44654145
Enzymatic rationale and preclinical support for a potent protein kinase C beta inhibitor in cancer therapyQ48122829
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Apoptosis. Mitochondria--the death signal integratorsQ74257381
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmachine learningQ2539
diffuse large B-cell lymphomaQ2626074
B-cell lymphomaQ4833719
P304page(s)68-74
P577publication date2002-01-01
P1433published inNature MedicineQ1633234
P1476titleDiffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
P478volume8

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Q42538635Expression of the human germinal center-associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation
Q35770767Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL.
Q57636725Expression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcome
Q40631853Expression profiling targeting chromosomes for tumor classification and prediction of clinical behavior.
Q33378247Expression-based Pathway Signature Analysis (EPSA): mining publicly available microarray data for insight into human disease
Q30824314Extending the utility of gene profiling data by bridging microarray platforms.
Q36558024Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
Q53515118FDG-PET after 1 cycle of therapy predicts outcome in diffuse large cell lymphoma and classic Hodgkin disease.
Q36871999FOXP1: a potential therapeutic target in cancer.
Q47606657Factors predicting long-term survival in low-risk diffuse large B-cell lymphoma
Q46957617Fas and Fas ligand expression on germinal center type-diffuse large B-cell lymphoma is associated with the clinical outcome
Q36005212Feature Selection and Cancer Classification via Sparse Logistic Regression with the Hybrid L1/2 +2 Regularization
Q35756955Feature selection and molecular classification of cancer using genetic programming
Q58101114Feature selection of gene expression data for Cancer classification using double RBF-kernels
Q30478162Feature selection using Haar wavelet power spectrum
Q33526505FiGS: a filter-based gene selection workbench for microarray data
Q39328378Finding a helix in a haystack: nucleic acid cytometry with droplet microfluidics
Q34351520Finding minimum gene subsets with heuristic breadth-first search algorithm for robust tumor classification
Q35240801Finding top-k covering irreducible contrast sequence rules for disease diagnosis.
Q35008948Focus on lymphomas
Q41887389Fold change rank ordering statistics: a new method for detecting differentially expressed genes.
Q35073307From microarrays to new therapeutic approaches in bladder cancer.
Q30749843From patterns to pathways: gene expression data analysis comes of age.
Q37136999Front-line therapy for nonlocalized diffuse large B-cell lymphoma: what has been demonstrated and what is yet to be established.
Q36192439Frontline rituximab, cyclophosphamide, doxorubicin, and prednisone with bortezomib (VR-CAP) or vincristine (R-CHOP) for non-GCB DLBCL.
Q36150368Functional genomic analysis of cancer metastasis: biologic insights and clinical implications
Q39420364Functional networks inference from rule-based machine learning models.
Q42637800Functional signatures identified in B-cell non-Hodgkin lymphoma profiles.
Q52027273Fuzzy neural network applied to gene expression profiling for predicting the prognosis of diffuse large B-cell lymphoma.
Q53508384Ga-67 SPECT: ave atque vale! Or have we bid a premature farewell to a trusted friend?
Q38354055Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma
Q36440083Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death
Q33561477Gene Feature Extraction Based on Nonnegative Dual Graph Regularized Latent Low-Rank Representation
Q37738446Gene arrays in lymphoma: Where will they fit in?
Q26825706Gene expression analysis in RA: towards personalized medicine
Q36673583Gene expression array profile of human osteosarcoma
Q33381434Gene expression data classification using consensus independent component analysis
Q30724775Gene expression in cancer: the application of microarrays
Q46042728Gene expression patterns in AIDS versus non-AIDS-related diffuse large B-cell lymphoma
Q38354504Gene expression phenotypic models that predict the activity of oncogenic pathways
Q42432005Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP.
Q35661018Gene expression profiling and its application in studies of haematological malignancy.
Q38519535Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomas.
Q37074127Gene expression profiling in autoimmune noninfectious uveitis disease
Q36799850Gene expression profiling in diffuse large B-cell lymphoma
Q38513479Gene expression profiling of diffuse large B-cell lymphoma supervised by CD21 expression
Q36613726Gene expression profiling of primary cultures of ovarian epithelial cells identifies novel molecular classifiers of ovarian cancer.
Q77856791Gene expression profiling to predict lymphoma outcome
Q36050530Gene expression profiling using RNA extracted from whole blood: technologies and clinical applications
Q104795172Gene expression profiling-based risk prediction and profiles of immune infiltration in diffuse large B-cell lymphoma
Q35758712Gene expression profiling: from microarrays to medicine.
Q35573313Gene expression profiling: will it complement or replace immunophenotyping?
Q36568849Gene expression signatures and outcome prediction in mature B-cell malignancies
Q44828229Gene expression signatures in lymphoid tumours
Q36678558Gene expression-based screening for inhibitors of PDGFR signaling
Q30584472Gene selection and cancer type classification of diffuse large-B-cell lymphoma using a bivariate mixture model for two-species data
Q34173671Gene selection and classification for cancer microarray data based on machine learning and similarity measures
Q36100658Gene selection for cancer classification with the help of bees
Q31132175Gene selection for classification of microarray data based on the Bayes error
Q35208950Gene selection for multiclass prediction by weighted Fisher criterion
Q30807880Gene selection in microarray data: the elephant, the blind men and our algorithms
Q36295294Gene set enrichment analysis unveils the mechanism for the phosphodiesterase 4B control of glucocorticoid response in B-cell lymphoma
Q35146553Gene-expression profiling in human cutaneous melanoma
Q36690245Gene-expression signatures in oncology diagnostics
Q28276837Genes associated with the tumour microenvironment are differentially expressed in cured versus primary chemotherapy-refractory diffuse large B-cell lymphoma
Q24798750Genetic alteration and gene expression modulation during cancer progression
Q35985492Genomic and proteomic approaches for studying human cancer: prospects for true patient-tailored therapy
Q37363928Genomic and proteomic biomarkers for cancer: a multitude of opportunities.
Q37406963Genomic approaches to small molecule discovery
Q38042513Genomic profiling using array comparative genomic hybridization define distinct subtypes of diffuse large B-cell lymphoma: a review of the literature
Q36303896Genomics in breast cancer-therapeutic implications
Q40949651Genotyping on a thermal gradient DNA chip
Q43137033Germinal center B cell-like (GCB) and activated B cell-like (ABC) type of diffuse large B cell lymphoma (DLBCL): analysis of molecular predictors, signatures, cell cycle state and patient survival.
Q35121615Global Gene Expression Profiling in the Study of Multiple Myeloma
Q80265745Global gene expression profiling of formalin-fixed paraffin-embedded tumor samples: a comparison to snap-frozen material using oligonucleotide microarrays
Q34276961Google goes cancer: improving outcome prediction for cancer patients by network-based ranking of marker genes
Q93012478Guidelines for using sigQC for systematic evaluation of gene signatures
Q35206356HLA class II antibodies in the treatment of hematologic malignancies
Q91949197Hellinger distance-based stable sparse feature selection for high-dimensional class-imbalanced data
Q38433314Heterogeneity of protein kinase C beta(2) expression in lymphoid malignancies
Q53662425High Ki-67 expression in involved bone marrow predicts worse clinical outcome in diffuse large B cell lymphoma patients treated with R-CHOP therapy.
Q28206624High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
Q37335051High resolution array comparative genomic hybridization identifies copy number alterations in diffuse large B-cell lymphoma that predict response to immuno-chemotherapy
Q83820573High throughput tissue microarray analysis of FHIT expression in diffuse large cell B-cell lymphoma from Saudi Arabia
Q28740452High-dimensional pharmacogenetic prediction of a continuous trait using machine learning techniques with application to warfarin dose prediction in African Americans
Q58908211High-dose chemotherapy with autologous stem cell support for first-line treatment of aggressive non-Hodgkin lymphoma: a systematic review and meta-analysis based on individual patient data
Q50485002High-resolution loss of heterozygosity screening implicates PTPRJ as a potential tumor suppressor gene that affects susceptibility to Non-Hodgkin's lymphoma.
Q45899999Higher response to lenalidomide in relapsed/refractory diffuse large B-cell lymphoma in nongerminal center B-cell-like than in germinal center B-cell-like phenotype.
Q53437646History of haematopoietic stem-cell transplantation.
Q43011229How do we define Hodgkin's disease? The authors' reply
Q64121066I-Boost: an integrative boosting approach for predicting survival time with multiple genomics platforms
Q40614440INCORPORATING BIOLOGICAL INFORMATION INTO LINEAR MODELS: A BAYESIAN APPROACH TO THE SELECTION OF PATHWAYS AND GENES.
Q78427251Identification and validation of seven genes, as potential markers, for the differential diagnosis of small B cell lymphomas (small lymphocytic lymphoma, marginal zone B cell lymphoma and mantle cell lymphoma) by cDNA macroarrays analysis
Q92628694Identification of CD4+ T cell biomarkers for predicting the response of patients with relapsing‑remitting multiple sclerosis to natalizumab treatment
Q37661495Identification of Marker Genes for Cancer Based on Microarrays Using a Computational Biology Approach.
Q31109027Identification of a robust gene signature that predicts breast cancer outcome in independent data sets
Q35018604Identification of candidate B-lymphoma genes by cross-species gene expression profiling
Q43766905Identification of differentially expressed proteins in chemotherapy-sensitive and chemotherapy-resistant diffuse large B cell lymphoma by proteomic methods
Q24791397Identification of expressed genes linked to malignancy of human colorectal carcinoma by parametric clustering of quantitative expression data
Q76312993Identification of genes whose expression patterns differ in benign lymphoid tissue and follicular, mantle cell, and small lymphocytic lymphoma
Q41365240Identification of key lncRNAs in colorectal cancer progression based on associated protein-protein interaction analysis
Q36047432Identification of metastasis-suppressive microRNAs in primary melanoma
Q48332534Identification of molecular subtypes of glioblastoma by gene expression profiling
Q93079390Identifying Methylation Pattern and Genes Associated with Breast Cancer Subtypes
Q52111529Identifying distinct classes of bladder carcinoma using microarrays.
Q89811270Identifying transcriptional profiles and evaluating prognostic biomarkers of HIV-associated diffuse large B-cell lymphoma from Malawi
Q28536423Immune response to combination therapy for non-Hodgkin lymphomas
Q33700531Immunohistochemical and molecular characteristics with prognostic significance in diffuse large B-cell lymphoma
Q51514379Immunohistochemical detection of MYC protein correlates with MYC gene status in aggressive B cell lymphomas.
Q80270939Immunohistochemical detection of protein kinase C-beta (PKC-beta) in tumour specimens of patients with non-small cell lung cancer
Q45372503Immunohistochemical expression profile and prognosis in patients with diffuse large B-cell lymphoma with or without human immunodeficiency virus infection
Q44813152Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases
Q33561185Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium clinical trials 010 and 034
Q60548642Impact of ecological redundancy on the performance of machine learning classifiers in vegetation mapping
Q37831960Impact of gene expression profiling in lymphoma diagnosis and prognosis.
Q35806762Impact of microarray technology in clinical oncology
Q53112598Impact of occult bone marrow involvement on the outcome of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone therapy for diffuse large B-cell lymphoma.
Q57174076Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer
Q31105470Importance of data structure in comparing two dimension reduction methods for classification of microarray gene expression data
Q34475554Improving accuracy for cancer classification with a new algorithm for genes selection
Q33784190Improving cancer classification accuracy using gene pairs
Q39841564In Vivo Measurements of Tumor Metabolism and Growth after Administration of Enzastaurin Using Small Animal FDG Positron Emission Tomography
Q33701036In silico analyses reveal common cellular pathways affected by loss of heterozygosity (LOH) events in the lymphomagenesis of Non-Hodgkin's lymphoma (NHL).
Q81413385Incidence of diffuse large B-cell lymphoma of germinal center B-cell origin in whole diffuse large B-cell lymphoma: tissue fluorescence in situ hybridization using t(14;18) compared with immunohistochemistry
Q104795127Incidence of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) including CNS relapse in a population-based cohort of 4243 patients in Sweden
Q33800442Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma
Q31041309Independent component analysis-based penalized discriminant method for tumor classification using gene expression data
Q36318541Individualised cancer therapeutics: dream or reality?
Q44898962Infused CD34 cell dose, but not tumour cell content of peripheral blood progenitor cell grafts, predicts clinical outcome in patients with diffuse large B-cell lymphoma and follicular lymphoma grade 3 treated with high-dose therapy
Q44349388Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification
Q34860750Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma.
Q35670308Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77
Q35811338Injury research in the genomic era.
Q24645231Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis
Q35818443Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications
Q34375924Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes
Q51490388Integrated profiling of diffuse large B-cell lymphoma with 7q gain.
Q35416193Integrating biological knowledge with gene expression profiles for survival prediction of cancer
Q78512453Integrating cytogenetics and gene expression profiling in the molecular analysis of multiple myeloma
Q30854282Integrative clustering methods for high-dimensional molecular data
Q35170930Interpreting the molecular biology and clinical behavior of multiple myeloma in the context of global gene expression profiling
Q36925740Investigating the efficacy of nonlinear dimensionality reduction schemes in classifying gene and protein expression studies
Q35096214Issues and progress with protein kinase inhibitors for cancer treatment
Q33412905Iterative Bayesian Model Averaging: a method for the application of survival analysis to high-dimensional microarray data
Q35832755Joint use of over- and under-sampling techniques and cross-validation for the development and assessment of prediction models
Q31044239Kernel-based distance metric learning for microarray data classification
Q60502894Knowledge-based neural networks for gene expression data analysis, modelling and profile discovery
Q24814110L2L: a simple tool for discovering the hidden significance in microarray expression data
Q33648588LMP1+SLAMF1high cells are associated with drug resistance in Epstein-Barr virus-positive Farage cells
Q44125775Lack of prognostic significance of the germinal-center phenotype in diffuse large B-cell lymphoma patients treated with CHOP-like chemotherapy with and without rituximab
Q64916006Large-Scale Automatic Feature Selection for Biomarker Discovery in High-Dimensional OMICs Data.
Q29615223Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression
Q92236955Learning misclassification costs for imbalanced classification on gene expression data
Q36059635Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome
Q33633714Local-learning-based feature selection for high-dimensional data analysis
Q35634835Looking beyond morphology: cancer gene expression profiling using DNA microarrays
Q37406798Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - analyses of cases from two prospective randomized clinical trials
Q41092345Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma
Q35978570Loss of IRF8 Inhibits the Growth of Diffuse Large B-cell Lymphoma
Q38329996Loss of expression of the adipocyte-type fatty acid-binding protein (A-FABP) is associated with progression of human urothelial carcinomas
Q35850018Loss of major histocompatibility class II expression in non-immune-privileged site diffuse large B-cell lymphoma is highly coordinated and not due to chromosomal deletions.
Q37453629Low GILT Expression is Associated with Poor Patient Survival in Diffuse Large B-Cell Lymphoma
Q34162187Lymphoid malignancies: the dark side of B-cell differentiation
Q36959865Lymphoma microenvironment: culprit or innocent?
Q28589356M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice
Q44544162MAGE-A3 expression is an adverse prognostic factor in diffuse large B-cell lymphoma
Q63409870MALT1 directs B cell receptor–induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit
Q37470505MET/PKCbeta expression correlate with metastasis and inhibition is synergistic in lung cancer
Q38233772MYC-associated and double-hit lymphomas: a review of pathobiology, prognosis, and therapeutic approaches
Q63881018Machine Learning Methods as a Tool for Predicting Risk of Illness Applying Next‐Generation Sequencing Data
Q98164806Machine learning in oncology: a review
Q57175155Maintenance Therapy in Diffuse Large B Cell Lymphoma and Mantle Cell Lymphoma
Q78581893Mature T cell leukemias which cannot be adequately classified under the new WHO classification of lymphoid neoplasms
Q37743310Maxdenominator Reweighted Sparse Representation for Tumor Classification
Q35967033McTwo: a two-step feature selection algorithm based on maximal information coefficient
Q33928495Mechanism-derived gene expression signatures and predictive biomarkers in clinical oncology
Q35010175Medical applications of microarray technologies: a regulatory science perspective
Q31110581Meta-analysis of gene expression data: a predictor-based approach
Q97525205Metabolic Adaptations in Cancer Stem Cells
Q34008985Metastasis of tumor cells is enhanced by downregulation of Bit1.
Q39218802MicroRNA-21 regulates the sensitivity of diffuse large B-cell lymphoma cells to the CHOP chemotherapy regimen
Q24528253Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer
Q36982175Microarray analysis of gene expression of cancer to guide the use of chemotherapeutics
Q33320174Microarray based diagnosis profits from better documentation of gene expression signatures
Q34044075Microarray-based cancer prediction using single genes
Q37313817Microarray-based cancer prediction using soft computing approach
Q38326709Microarray-based classification of diffuse large B-cell lymphoma
Q24791738Microarrays and molecular markers for tumor classification
Q34836984Microarrays in pharmacogenomics--advances and future promise
Q36177378Microarrays in veterinary diagnostics
Q36680069Microarrays to identify new therapeutic strategies for cancer
Q38465717Microbial forensics: predicting phenotypic characteristics and environmental conditions from large-scale gene expression profiles
Q64085609Microbiome Learning Repo (ML Repo): A public repository of microbiome regression and classification tasks
Q35691640Microvessel density and expression of vascular endothelial growth factor and its receptors in diffuse large B-cell lymphoma subtypes
Q36868498Mining gene expression profiles: expression signatures as cancer phenotypes
Q36558011Mitochondria in hematopoiesis and hematological diseases.
Q37061820Mitogenic Effect of Orphan Receptor TR3 and Its Regulation by MEKK1 in Lung Cancer Cells
Q36344970Mobile Genome Express (MGE): A comprehensive automatic genetic analyses pipeline with a mobile device
Q31112220Model order selection for bio-molecular data clustering
Q51220498Modified signal-to-noise: a new simple and practical gene filtering approach based on the concept of projective adaptive resonance theory (PART) filtering method.
Q37185837Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues
Q34741163Molecular cancer classification using a meta-sample-based regularized robust coding method
Q35102952Molecular classification of parathyroid neoplasia by gene expression profiling
Q35670986Molecular heterogeneity of diffuse large B-cell lymphoma: implications for disease management and prognosis
Q51075776Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype.
Q35917589Molecular medicine: a clinician's primer on microarrays.
Q84767205Molecular pathogenesis of diffuse large B-cell lymphoma
Q38065892Molecular pathology of lymphoma
Q35010198Molecular portraits and the family tree of cancer
Q36381346Molecular profiling reveals prognostically significant subtypes of canine lymphoma
Q36168697Molecular prognostic factors in diffuse large B-cell lymphoma
Q79934103Molecular signatures in biopsy specimens of lung cancer
Q36007355Molecular signatures of lymphoma
Q36239669Monoclonal antibody therapy of leukaemias and lymphomas
Q38179500Moving beyond rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone for diffuse large B-cell lymphoma
Q99607473Multi-scale supervised clustering-based feature selection for tumor classification and identification of biomarkers and targets on genomic data
Q30763386Multi-task feature selection in microarray data by binary integer programming
Q24793866Multiclass classification of microarray data with repeated measurements: application to cancer
Q35747661Multicolor-FICTION: expanding the possibilities of combined morphologic, immunophenotypic, and genetic single cell analyses
Q35755485Multiparameter analysis of homogeneously R-CHOP-treated diffuse large B cell lymphomas identifies CD5 and FOXP1 as relevant prognostic biomarkers: report of the prospective SAKK 38/07 study.
Q47445559Multiple fuzzy neural network system for outcome prediction and classification of 220 lymphoma patients on the basis of molecular profiling
Q39753010Multiplex polymerase chain reaction-based prognostic models in diffuse large B-cell lymphoma patients treated with R-CHOP.
Q40438326Multiplex reverse transcription-polymerase chain reaction combined with on-chip electrophoresis as a rapid screening tool for candidate gene sets
Q36447932Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma
Q37638021NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers
Q35586784Neoadjuvant comparisons of aromatase inhibitors and tamoxifen: pretreatment determinants of response and on-treatment effect
Q89926626Network modeling of patients' biomolecular profiles for clinical phenotype/outcome prediction
Q34427904Network-based Prediction of Cancer under Genetic Storm
Q24796756Neural network analysis of lymphoma microarray data: prognosis and diagnosis near-perfect
Q31122605New insights into ADPKD molecular pathways using combination of SAGE and microarray technologies
Q91276848New machine-learning technologies for computer-aided diagnosis
Q35063883New molecular methods for classification, diagnosis and therapy prediction of hematological malignancies
Q37918027New strategies in diffuse large B-cell lymphoma: translating findings from gene expression analyses into clinical practice
Q26796428Next-generation prognostic assessment for diffuse large B-cell lymphoma
Q37457207Nodal diffuse large B-cell lymphomas in children and adolescents: immunohistochemical expression patterns and c-MYC translocation in relation to clinical outcome
Q44228664Non-Hodgkin's lymphoma in the microarray era.
Q34328089Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease
Q40863355Non-negative matrix factorization by maximizing correntropy for cancer clustering
Q37858532Novel agents for diffuse large B-cell lymphoma
Q36616528Novel approaches for the management of patients with Ewing sarcoma
Q37775632Novel disease targets and management approaches for diffuse large B-cell lymphoma
Q31028064Novel prognostic genes of diffuse large B-cell lymphoma revealed by survival analysis of gene expression data
Q36871990Novel therapeutic targets in mantle cell lymphoma
Q35111768Novel therapeutics for aggressive non-Hodgkin's lymphoma
Q36429727Novel treatment strategies for aggressive non-Hodgkin's lymphoma
Q59117821On Feature Selection and Rule Extraction for High Dimensional Data: A Case of Diffuse Large B-Cell Lymphomas Microarrays Classification
Q24645617Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas
Q37295261Oncologist's/haematologist's view on the roles of pathologists for molecular targeted cancer therapy
Q54364450Open-label, single-arm, phase II study of enzastaurin in patients with follicular lymphoma.
Q35008943Optimal gene expression analysis by microarrays
Q33822080Optimization based tumor classification from microarray gene expression data.
Q44394901Optimization of quantitative real-time RT-PCR parameters for the study of lymphoid malignancies
Q30749830Options available--from start to finish--for obtaining data from DNA microarrays II.
Q33551720Overexpression of an activated REL mutant enhances the transformed state of the human B-lymphoma BJAB cell line and alters its gene expression profile
Q37940364Overview of microarrays in drug discovery and development
Q37644833PATZ1 expression correlates positively with BAX and negatively with BCL6 and survival in human diffuse large B cell lymphomas
Q38996724PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas
Q43462759PKC-beta II expression has prognostic impact in nodal diffuse large B-cell lymphoma
Q28509628PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
Q38323206PROX1 overexpression inhibits protein kinase C beta II transcription through promoter DNA methylation
Q36713498Paraffin-based 6-gene model predicts outcome in diffuse large B-cell lymphoma patients treated with R-CHOP.
Q37403682Pathophysiology of retinal lymphoma
Q34721895Pathway activity inference for multiclass disease classification through a mathematical programming optimisation framework
Q44564603Patients with high-risk aggressive lymphoma treated with frontline intensive chemotherapy and autografting: evidence of marked differences in outcome between patients with age-adjusted International Prognostic Index scores 2 and 3.
Q38127385Pediatric lymphoma diagnosis: role of FNAC, biopsy, immunohistochemistry and molecular diagnostics
Q34695697Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer
Q42115619Pharmacological manipulation of Bcl-2 family members to control cell death
Q37554503Phospho-p70S6K and cdc2/cdk1 as therapeutic targets for diffuse large B-cell lymphoma
Q38984735Phosphodiesterase 4 inhibitors have wide-ranging activity in B-cell malignancies
Q30759423Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification
Q85804046Precision treatment of distinct molecular subtypes of diffuse large B-cell lymphoma: ascribing treatment based on the molecular phenotype
Q64085970Predicting Complete Remission of Acute Myeloid Leukemia: Machine Learning Applied to Gene Expression
Q45728735Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
Q36780164Predicting the outcome in non-Hodgkin lymphoma with molecular markers
Q30578215Predicting the survival time for diffuse large B-cell lymphoma using microarray data
Q35153794Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment
Q31134364Prediction potential of candidate biomarker sets identified and validated on gene expression data from multiple datasets.
Q40109282Predictive tests for individualization of pharmacological cancer treatment
Q38872027Presence of simian virus 40 in diffuse large B-cell lymphomas in Tunisia correlates with germinal center B-cell immunophenotype, t(14;18) translocation, and P53 accumulation
Q33598987Primary diffuse large B-cell lymphoma of the oral cavity: germinal center classification
Q35089389Profiling cancer
Q47738329Prognosis of localized diffuse large B-cell lymphoma in younger patients
Q92885779Prognostic Nomogram for Overall Survival in Patients with Diffuse Large B-Cell Lymphoma
Q36244809Prognostic efficacy of the human B-cell lymphoma prognostic genes in predicting disease-free survival (DFS) in the canine counterpart
Q35548353Prognostic factors and risk-based therapy in pediatric acute myeloid leukemia
Q34882773Prognostic factors for diffuse large B-cell lymphoma in the R(X)CHOP era.
Q37635115Prognostic immunophenotypic biomarker studies in diffuse large B cell lymphoma with special emphasis on rational determination of cut-off scores.
Q43146817Prognostic impact of protein kinase C beta II expression in R-CHOP-treated diffuse large B-cell lymphoma patients
Q35587065Prognostic significance of CD44 expression in diffuse large B cell lymphoma of activated and germinal centre B cell-like types: a tissue microarray analysis of 90 cases
Q43248488Prognostic significance of S-phase kinase-associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma: effects of rituximab
Q37706051Prognostic value of expression of nuclear factor kappa-B/p65 in non-GCB DLBCL patients.
Q37833087Prognostication of diffuse large B-cell lymphoma in the rituximab era.
Q35824980Progress in myeloma stem cells
Q73401113Progressive disease following autologous transplantation in patients with chemosensitive relapsed or primary refractory Hodgkin's disease or aggressive non-Hodgkin's lymphoma
Q79270324Promoter hypermethylation of the DNA-repair gene O6-methylguanine-DNA methyltransferase and p53 mutation in diffuse large B-cell lymphoma
Q80413450Proof concept for clinical justification of network mapping for personalized cancer therapeutics
Q35833866Pros and cons of microarray technology in allergy research
Q42807725Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.
Q37020881Protein kinase C beta in malignant pleural mesothelioma
Q43275999Protein kinase C-beta II expression in diffuse large B-cell lymphoma predicts for inferior outcome of anthracycline-based chemotherapy with and without rituximab
Q35634280Protein kinase C-beta inhibition induces apoptosis and inhibits cell cycle progression in acquired immunodeficiency syndrome-related non-hodgkin lymphoma cells
Q41971372Protein kinase C: an attractive target for cancer therapy.
Q33569854Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.
Q33197095Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury.
Q35725628Proteomics and the haematologist.
Q37696313Protocol for qRT-PCR analysis from formalin fixed paraffin embedded tissue sections from diffuse large b-cell lymphoma: Validation of the six-gene predictor score.
Q36757502Quantitative image analysis in the assessment of diffuse large B-cell lymphoma
Q38430790Quantitative nuclease protection assay in paraffin-embedded tissue replicates prognostic microarray gene expression in diffuse large-B-cell lymphoma
Q38699741RGIFE: a ranked guided iterative feature elimination heuristic for the identification of biomarkers
Q42376068RIFS: a randomly restarted incremental feature selection algorithm.
Q33357619RNA expression analysis from formalin fixed paraffin embedded tissues
Q57277018RNA expression analysis of formalin-fixed paraffin-embedded tumors
Q33941314RNA: state memory and mediator of cellular phenotype
Q28397762Random generalized linear model: a highly accurate and interpretable ensemble predictor
Q28834535Rapid Prediction of Bacterial Heterotrophic Fluxomics Using Machine Learning and Constraint Programming
Q39982575Ratio adjustment and calibration scheme for gene-wise normalization to enhance microarray inter-study prediction
Q37234623Rational combined targeting of phosphodiesterase 4B and SYK in DLBCL
Q36150374Recent advances in the molecular diagnosis of diffuse large B-cell lymphoma
Q34487811Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.
Q38210641Relapsed/refractory diffuse large B-cell lymphoma: review of the management of transplant-eligible patients
Q24289394Reliability and reproducibility issues in DNA microarray measurements
Q90077233Remaining challenges in predicting patient outcomes for diffuse large B-cell lymphoma
Q28131820Repeated observation of breast tumor subtypes in independent gene expression data sets
Q39938060Results of a multicentre UK-wide retrospective study evaluating the efficacy of pixantrone in relapsed, refractory diffuse large B cell lymphoma
Q35750976Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents
Q37598771Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting
Q35652930Retrospective analysis of protein kinase C-beta (PKC-beta) expression in lymphoid malignancies and its association with survival in diffuse large B-cell lymphomas
Q34308389Revisiting global gene expression analysis
Q35499320Risk Factors of Non-Hodgkin Lymphoma
Q33407974Robust methods for accurate diagnosis using pan-microbiological oligonucleotide microarrays
Q35740262Robust two-gene classifiers for cancer prediction
Q40496898Role of CD21 antigen in diffuse large B-cell lymphoma and its clinical significance
Q33256872Role of ancillary techniques in diagnosing and subclassifying non-Hodgkin's lymphomas on fine needle aspiration cytology
Q55717558Role of microarray in cancer diagnosis.
Q30605582SMOTE for high-dimensional class-imbalanced data
Q24295903STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas
Q39472422Safety and Pharmacodynamics of the PDE4 Inhibitor Roflumilast in Advanced B-cell Malignancies
Q48458182Safety, tolerability, QTc evaluation, and pharmacokinetics of single and multiple doses of enzastaurin HCl (LY317615), a protein kinase C-beta inhibitor, in healthy subjects.
Q51335591Selection of causal gene sets for lymphoma prognostication from expression profiling and construction of prognostic fuzzy neural network models.
Q35098956Selective model averaging with bayesian rule learning for predictive biomedicine
Q24804682Semi-supervised methods to predict patient survival from gene expression data
Q36471600Semiautomated multiplexed quantum dot-based in situ hybridization and spectral deconvolution
Q33312689Serum diagnosis of diffuse large B-cell lymphomas and further identification of response to therapy using SELDI-TOF-MS and tree analysis patterning
Q86022539Serum profiling by mass spectrometry combined with bioinformatics for the biomarkers discovery in diffuse large B-cell lymphoma
Q91579802ShinyLearner: A containerized benchmarking tool for machine-learning classification of tabular data
Q37829224Signal transduction inhibitor therapy for lymphoma
Q35666703Signaling in transitional type 2 B cells is critical for peripheral B-cell development
Q38150876Signaling pathways in lymphoma: pathogenesis and therapeutic targets
Q41735339Simple decision rules for classifying human cancers from gene expression profiles
Q34777109Sparse logistic regression with a L1/2 penalty for gene selection in cancer classification
Q33419874Sparse representation for classification of tumors using gene expression data
Q37616792Sparse representation for tumor classification based on feature extraction using latent low-rank representation.
Q51806652Spontaneous high-titered IgG antibody responses against BCL-2 in patients with aggressive lymphomas.
Q35518656Sputnik: ad hoc distributed computation.
Q89751386State-of-the-Art Machine Learning Techniques Aiming to Improve Patient Outcomes Pertaining to the Cardiovascular System
Q24678378Statistical analysis of an RNA titration series evaluates microarray precision and sensitivity on a whole-array basis
Q37284250Statistical challenges in preprocessing in microarray experiments in cancer
Q35789866Statistical considerations for immunohistochemistry panel development after gene expression profiling of human cancers
Q35984039Structured feature selection using coordinate descent optimization.
Q44704125Studies of the potential utility of Ki67 as a predictive molecular marker of clinical response in primary breast cancer
Q35080295Study of suboptimum treatment response: lessons from breast cancer
Q31137364Subclass mapping: identifying common subtypes in independent disease data sets
Q37179385Subgraph augmented non-negative tensor factorization (SANTF) for modeling clinical narrative text
Q39375022Super-SILAC allows classification of diffuse large B-cell lymphoma subtypes by their protein expression profiles
Q31043807Support vector machines for dyadic data
Q33259095Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction.
Q42702972Surface-antigen expression profiling of B cell chronic lymphocytic leukemia: from the signature of specific disease subsets to the identification of markers with prognostic relevance
Q58776059Survival associated alternative splicing events in diffuse large B-cell lymphoma
Q44864120Survival prediction of diffuse large-B-cell lymphoma based on both clinical and gene expression information
Q47300115Synergistic targeting of the regulatory and catalytic subunits of PI3Kδ in mature B cell malignancies
Q24298072TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells
Q89867359TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma
Q41908005TSG: a new algorithm for binary and multi-class cancer classification and informative genes selection
Q37766121Targeted treatment and new agents in diffuse large B cell lymphoma
Q34588195Targeting Nur77 translocation
Q35628888Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).
Q38184819The 'omics' of adrenocortical tumours for personalized medicine.
Q36812744The Influence of the Global Gene Expression Shift on Downstream Analyses
Q41909242The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas
Q34622215The SUV and FLT PET: a tasty alphabet soup or a dog's breakfast?
Q34956078The T-cell response in patients with cancer
Q91658641The Unsolved Puzzle of c-Rel in B Cell Lymphoma
Q53153100The absolute monocyte and lymphocyte prognostic score predicts survival and identifies high-risk patients in diffuse large-B-cell lymphoma.
Q27681982The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain
Q34313320The biology of human lymphoid malignancies revealed by gene expression profiling.
Q53258385The burden of scientific progress: growing inequalities in the delivery of cancer care.
Q28241767The c-Rel transcription factor and B-cell proliferation: a deal with the devil
Q35122837The classification of lymphomas: a new beginning or the end of an era?
Q46796219The contribution of HGAL/GCET2 in immunohistological algorithms: a comparative study in 424 cases of nodal diffuse large B-cell lymphoma
Q33490384The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data
Q54643114The differential expression of Galectin-1 and Galectin-3 in normal lymphoid tissue and non-Hodgkin's and Hodgkin's lymphomas.
Q37174123The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab.
Q53222182The expression of anamorsin in diffuse large B cell lymphoma: possible prognostic biomarker for low IPI patients.
Q35821001The expression of the aurora-A gene and its significance with tumorgenesis in non-Hodgkin's lymphoma
Q36331576The feasibility of gene expression profiling generated in fine-needle aspiration specimens from patients with follicular lymphoma and diffuse large B-cell lymphoma
Q39566639The gene expression profile of unstimulated dendritic cells can be used as a predictor of function.
Q36280547The histological and biological spectrum of diffuse large B-cell lymphoma in the World Health Organization classification
Q33268949The impact of sample imbalance on identifying differentially expressed genes.
Q77476882The microarray way to tailored cancer treatment
Q37815142The molecular background of aggressive B cell lymphomas as a basis for targeted therapy
Q36939043The molecular characterization and clinical management of multiple myeloma in the post-genome era.
Q34530992The molecular classification of multiple myeloma
Q39986126The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines.
Q33495401The ordering of expression among a few genes can provide simple cancer biomarkers and signal BRCA1 mutations
Q36120552The parameter sensitivity of random forests
Q34371078The pre-B-cell receptor associated protein VpreB3 is a useful diagnostic marker for identifying c-MYC translocated lymphomas
Q34688223The promise of biomarkers in cancer screening and detection
Q36670881The role of angiogenesis in human non-Hodgkin lymphomas
Q39102576The serine-threonine kinase p90RSK is a new target of enzastaurin in follicular lymphoma cells
Q34047455The significance of FOXP1 in diffuse large B-cell lymphoma
Q48027386The therapeutic effect of rituximab on CD5-positive and CD5-negative diffuse large B-cell lymphoma
Q36964732The therapeutic role of targeting protein kinase C in solid and hematologic malignancies
Q34411134The top-scoring 'N' algorithm: a generalized relative expression classification method from small numbers of biomolecules
Q36169994The transcriptome's drugable frequenters
Q35188517The use of genetic microarray analysis to classify and predict prognosis in haematological malignancies.
Q36773687The use of transcriptomic biomarkers for personalized medicine
Q74308249The value of microarray techniques for quantitative gene profiling in molecular diagnostics
Q53368295Tissue microarrays in diffuse large B-cell lymphomas: are they really able to identify distinct prognostic groups in lymphomas of both nodal and extranodal origin?
Q37385810Toward a systems biology approach to investigate cellular networks in normal and malignant B cells
Q42696739Towards Clinically More Relevant Dissection of Patient Heterogeneity via Survival based Bayesian Clustering
Q35569564Towards molecular diagnosis and targeted therapy of lymphoid malignancies
Q24554209Transcriptional analysis of the B cell germinal center reaction
Q42320170Transcriptional mechanism of vascular endothelial growth factor-induced expression of protein kinase CβII in chronic lymphocytic leukaemia cells.
Q34387585Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain
Q27939633Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents
Q35129723Transducing signals from antigen receptors to nuclear factor kappaB.
Q31062604Translating microarray data for diagnostic testing in childhood leukaemia
Q27006062Treatment of diffuse large B cell lymphoma
Q28290155Tumor cell-mediated induction of the stromal factor stromelysin-3 requires heterotypic cell contact-dependent activation of specific protein kinase C isoforms
Q33642188Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis.
Q39965971Tyrosine kinase inhibition in diffuse large B-cell lymphoma: molecular basis for antitumor activity and drug resistance of dasatinib.
Q33299950Unravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering
Q37705417Unresolved issues in diffuse large B-cell lymphomas
Q36269919Update on lymphoma management: diffuse large B-cell NHL.
Q38888510Upregulation of long noncoding RNA PEG10 associates with poor prognosis in diffuse large B cell lymphoma with facilitating tumorigenicity
Q47392520Use of Expression Analysis to Predict Outcome After Radical Prostatectomy
Q30992230Use of extreme patient samples for outcome prediction from gene expression data.
Q33196034Use of proteomic analysis to monitor responses to biological therapies
Q35543889Using DNA microarrays for diagnostic and prognostic prediction
Q47971165Using Gene Expression Ratios to Predict Outcome Among Patients With Mesothelioma
Q28386273Using rule-based machine learning for candidate disease gene prioritization and sample classification of cancer gene expression data
Q36743357Using the information embedded in the testing sample to break the limits caused by the small sample size in microarray-based classification
Q37293519Utility of subsequent conventional dose chemotherapy in relapsed/refractory transplant-eligible patients with diffuse large B-cell lymphoma failing platinum-based salvage chemotherapy.
Q36741637Utilization of pathway signatures to reveal distinct types of B lymphoma in the Emicro-myc model and human diffuse large B-cell lymphoma
Q34646755Utilization of the Eμ-Myc mouse to model heterogeneity of therapeutic response
Q47373475VEGF121, is predictor for survival in activated B-cell-like diffuse large B-cell lymphoma and is related to an immune response gene signature conserved in cancers
Q36194645Validation of tissue microarray immunohistochemistry staining and interpretation in diffuse large B-cell lymphoma
Q51897815Variable selection in penalized model-based clustering via regularization on grouped parameters.
Q33369633Very Important Pool (VIP) genes--an application for microarray-based molecular signatures
Q31116629Visualization-based cancer microarray data classification analysis
Q36168226Wealth of opportunity - the C1 domain as a target for drug development
Q34032697Weighted Area Under the Receiver Operating Characteristic Curve and Its Application to Gene Selection
Q37316548Why does cytotoxic chemotherapy cure only some cancers?
Q53362281[The genetics of glioma: molecular classification].
Q34958884c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
Q36088278cDNA microarrays: revolutionary technology for the diagnosis, prognosis, and treatment of cutaneous T-cell lymphoma
Q36152713hemaClass.org: Online One-By-One Microarray Normalization and Classification of Hematological Cancers for Precision Medicine
Q35863651iRDA: a new filter towards predictive, stable, and enriched candidate genes
Q36558001p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction

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