Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies

scientific article (publication date: 16 December 2002)

Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies is …
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scholarly articleQ13442814

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P356DOI10.1016/S0960-894X(02)00798-9
P698PubMed publication ID12443774
P5875ResearchGate publication ID11024493

P50authorAntonio CarrieriQ40809535
Stefano ChimichiQ60161661
Angelo CarottiQ64857534
Pierre-Alain CarruptQ86835912
Bernard TestaQ96013808
P2093author name stringAndrea Carotti
Barbara Cosimelli
Carmela Gnerre
Marco Boccalini
P2860cites workcDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic propertiesQ24647273
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disordersQ27637040
Quantitative structure-metabolism relationship analyses of MAO-mediated toxication of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and analoguesQ28318368
Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potentialQ34401363
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's diseaseQ34475645
Cytoskeleton-interacting activity of geiparvarin, diethylstilbestrol and conjugatesQ40779204
Geiparvarin analogues. 4. Synthesis and cytostatic activity of geiparvarin analogues bearing a carbamate moiety or a furocoumarin fragment on the alkenyl side chainQ41453884
Antioxidant activity of the monoamine oxidase B inhibitor lazabemideQ43505805
Coumarins with monoamine oxidase inhibitory activity and antioxidative coumarino-lignans from Hibiscus syriacusQ43750027
Determination of regions important for monoamine oxidase (MAO) A and B substrate and inhibitor selectivitiesQ46273413
Tissue distribution of human monoamine oxidase A and B mRNA.Q46320171
Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidasesQ48105537
Substituted xanthones as selective and reversible monoamine oxidase A (MAO-A) inhibitorsQ48234790
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationshipsQ48390091
Biochemistry and pharmacology of moclobemide, a prototype RIMAQ57382336
Synthesis and antiulcer activity of novel 5-(2-ethenyl substituted)-3(2H)-furanonesQ68091955
Monoamine oxidase inhibitor efficacy in depression and the "cheese effect"Q71564901
Inhibition of monoamine oxidase-B by 5H-indeno[1,2-c]pyridazines: biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARsQ71751304
Inhibition of monoamine oxidase by isoquinoline derivatives. Qualitative and 3D-quantitative structure-activity relationshipsQ71781014
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARsQ73313598
Identification of kaempferol as a monoamine oxidase inhibitor and potential Neuroprotectant in extracts of Ginkgo biloba leavesQ73797826
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectGeijera parvifloraQ596715
geiparvarinQ5530160
P304page(s)3551-3555
P577publication date2002-12-01
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleNatural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies
P478volume12