| scholarly article | Q13442814 |
| P356 | DOI | 10.1126/SCIENCE.1683006 |
| P953 | full work available at URL | https://syndication.highwire.org/content/doi/10.1126/science.1683006 |
| P698 | PubMed publication ID | 1683006 |
| P5875 | ResearchGate publication ID | 21472770 |
| P50 | author | Robert May, Baron May of Oxford | Q336397 |
| P2093 | author name string | R. M. Anderson | |
| R. M. May | |||
| J. Goudsmit | |||
| A. R. McLean | |||
| M. A. Nowak | |||
| T. F. Wolfs | |||
| P2860 | cites work | Journal of Animal Ecology | Q1709829 |
| Advances in Chemical Physics | Q2686137 | ||
| Selforganization of matter and the evolution of biological macromolecules | Q28248277 | ||
| Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT) | Q28340342 | ||
| The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle | Q29616074 | ||
| Mathematical biology of HIV infections: antigenic variation and diversity threshold | Q33344856 | ||
| Prolonged zidovudine therapy in patients with AIDS and advanced AIDS-related complex. AZT Collaborative Working Group | Q33429246 | ||
| Evolution of sequences encoding the principal neutralization epitope of human immunodeficiency virus 1 is host dependent, rapid, and continuous | Q33927239 | ||
| Concurrent evolution of human immunodeficiency virus type 1 in patients infected from the same source: rate of sequence change and low frequency of inactivating mutations | Q36796303 | ||
| Pathogenesis of lentivirus infections | Q38164170 | ||
| Replicative capacity, cytopathic effect and cell tropism of HIV. | Q38242198 | ||
| HIV genome variability in vivo | Q38317660 | ||
| Naturally occurring mutations within HIV-1 V3 genomic RNA lead to antigenic variation dependent on a single amino acid substitution | Q38332760 | ||
| Measurement of human immunodeficiency virus load and its relation to disease progression | Q38624522 | ||
| Factors associated with the pathogenesis of AIDS. | Q39509929 | ||
| Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene | Q41699910 | ||
| Extensive variation of human immunodeficiency virus type-1 in vivo | Q43913496 | ||
| Immunodominance and antigenic variation of the principal neutralization domain of HIV-1. | Q43956263 | ||
| Antigenic variation in trypanosomes | Q44562876 | ||
| Antigenic Drift in Visna: Virus Variation During Long-term Infection of Icelandic Sheep | Q45798231 | ||
| Type-Restricted Neutralization of Molecular Clones of Human Immunodeficiency Virus | Q45832058 | ||
| Quantitation of human immunodeficiency virus type 1 in the blood of infected persons | Q45844274 | ||
| Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases | Q45853622 | ||
| Structural and serological evidence for a novel mechanism of antigenic variation in foot-and-mouth disease virus | Q45860075 | ||
| Serial CD4 lymphocyte counts and development of AIDS | Q45880499 | ||
| Multiple cross-reactivities amongst antigens of Plasmodium falciparum impair the development of protective immunity against malaria | Q47921163 | ||
| Error thresholds of replication in finite populations mutation frequencies and the onset of Muller's ratchet. | Q51656360 | ||
| The accuracy of reverse transcriptase from HIV-1. | Q54738770 | ||
| Biologically diverse molecular variants within a single HIV-1 isolate | Q57998184 | ||
| Immunological changes in primary HIV-1 infection | Q68635842 | ||
| Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations | Q69355758 | ||
| P433 | issue | 5034 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | HIV/AIDS | Q12199 |
| P304 | page(s) | 963-9 | |
| P577 | publication date | 1991-11-15 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Antigenic diversity thresholds and the development of AIDS | |
| Antigenic Diversity Thresholds and the Development of AIDS | |||
| P478 | volume | 254 |
| Q51864038 | A mathematical design of vector vaccine against autoimmune disease. |
| Q52437610 | A mathematical model of vaccination against HIV to prevent the development of AIDS |
| Q33905201 | A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment. |
| Q45754378 | A pharmacokinetic-pharmacodynamic model of chemotherapy of human immunodeficiency virus infection that relates development of drug resistance to treatment intensity |
| Q36297936 | A proposal for a new approach to a preventive vaccine against human immunodeficiency virus type 1 |
| Q35655811 | A simple relationship between viral load and survival time in HIV-1 infection |
| Q33806524 | Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence |
| Q27477742 | Adherence and drug resistance: predictions for therapy outcome |
| Q36702206 | Alterations in potential sites for glycosylation predominate during evolution of the simian immunodeficiency virus envelope gene in macaques |
| Q24797088 | An algorithm for mapping positively selected members of quasispecies-type viruses |
| Q72800969 | An application of population genetic theory to synonymous gene sequence evolution in the human immunodeficiency virus (HIV) |
| Q36641676 | Analysis of the cross-reactive anti-gp120 antibody population in human immunodeficiency virus-infected asymptomatic individuals |
| Q35669397 | Antigenic cooperation among intrahost HCV variants organized into a complex network of cross-immunoreactivity |
| Q52284559 | Antigenic diversity thresholds and hazard functions. |
| Q45869472 | Antigenic oscillations and shifting immunodominance in HIV-1 infections. |
| Q37726799 | Antigenic variation and the within-host dynamics of parasites |
| Q36374300 | Antiretroviral dynamics determines HIV evolution and predicts therapy outcome |
| Q35899105 | Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation. |
| Q36640639 | B epitopes and selection pressures in feline immunodeficiency virus envelope glycoproteins |
| Q45867615 | Causes of HIV diversity |
| Q35917416 | Certain HLA-DR5 and -DR6 major histocompatibility complex class II alleles are associated with a CD8 lymphocytic host response to human immunodeficiency virus type 1 characterized by low lymphocyte viral strain heterogeneity and slow disease progres |
| Q71648182 | Changes in the level of blood suppressor CD8+C57+ lymphocytes, when HIV1 p24 antigen reappears in the blood |
| Q33393641 | Characterization of a new simian immunodeficiency virus strain in a naturally infected Pan troglodytes troglodytes chimpanzee with AIDS related symptoms |
| Q36050129 | Characterization of circulating HIV type 1 env genes in plasma of two antiretroviral-naive slow progressing patients with broad neutralizing antibody response with evidence of recombination. |
| Q34943390 | Clostridium difficile exposure as an insidious source of infection in healthcare settings: an epidemiological model |
| Q43463539 | Coexistence and competition in HIV infections |
| Q36232089 | Comparative clonal analysis of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ and CD8+ cytolytic T lymphocytes isolated from seronegative humans immunized with candidate HIV-1 vaccines |
| Q52242901 | Complex dynamic behaviours in the interaction between parasite population and the host's immune system. |
| Q33825654 | Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection |
| Q36367508 | Contrasting life strategies of viruses that infect photo- and heterotrophic bacteria, as revealed by viral tagging |
| Q37031589 | Convergent and divergent sequence evolution in the surface envelope glycoprotein of human immunodeficiency virus type 1 within a single infected patient |
| Q30416671 | Convergent evolution within the V3 loop domain of human immunodeficiency virus type 1 in association with disease progression |
| Q26852626 | Current perspectives on HIV-1 antiretroviral drug resistance |
| Q52020759 | Cytotoxic T-lymphocyte memory, virus clearance and antigenic heterogeneity. |
| Q35886136 | Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responses |
| Q34983038 | Diversity and virulence thresholds in AIDS. |
| Q35839373 | Dual human immunodeficiency virus type 1 infection and recombination in a dually exposed transfusion recipient. The Transfusion Safety Study Group. |
| Q30714991 | Dual specificity of a human neutralizing monoclonal antibody, specific for the V3 loop of GP120 (HIV-1). |
| Q33392723 | Dynamic correlation between intrahost HIV-1 quasispecies evolution and disease progression |
| Q41917460 | Dynamic models of immune responses: what is the ideal level of detail? |
| Q52247788 | Dynamics of cytotoxic T-lymphocyte exhaustion. |
| Q42988433 | Dynamics of hypervariable region 1 variation in hepatitis C virus infection and correlation with clinical and virological features of liver disease. |
| Q33352680 | Dynamics of immune escape during HIV/SIV infection |
| Q42197906 | Dynamics of targeted cancer therapy |
| Q37388219 | Ecological theory to enhance infectious disease control and public health policy |
| Q41119832 | Effects of neutralizing antibodies on escape from CD8+ T-cell responses in HIV-1 infection |
| Q57163973 | Epidemiologia da hanseníase em coorte de contatos intradomiciliares no Rio de Janeiro (1987-1991) |
| Q30328504 | Epidemiology, evolution, and future of the HIV/AIDS pandemic. |
| Q36078628 | Estimating the risk of re-emergence after stopping polio vaccination |
| Q48130502 | Evidence of positive Darwinian selection in putative meningococcal vaccine antigens |
| Q38341030 | Evolution of a simian immunodeficiency virus pathogen. |
| Q33784911 | Evolution of envelope sequences from the genital tract and peripheral blood of women infected with clade A human immunodeficiency virus type 1. |
| Q35877849 | Evolution of human immunodeficiency virus type 1 env sequence variation in patients with diverse rates of disease progression and T-cell function |
| Q35887052 | Evolution of human immunodeficiency virus type 1 in perinatally infected infants with rapid and slow progression to disease |
| Q45423844 | Evolution of nef variants in gut associated lymphoid tissue of rhesus macaques during primary simian immunodeficiency virus infection |
| Q40288205 | Evolution of resistance during clonal expansion |
| Q31034710 | Evolution of the uniquely adaptable lentiviral envelope in a natural reservoir host |
| Q30416280 | Evolutionary dynamics of HIV at multiple spatial and temporal scales. |
| Q53905794 | Evolutionary dynamics of escape from biomedical intervention. |
| Q40873790 | Evolutionary dynamics of viral escape under antibodies stress: A biophysical model. |
| Q40837378 | Evolutionary pattern of intra-host pathogen antigenic drift: effect of cross-reactivity in immune response |
| Q40987639 | Evolutionary pressures in the spread and persistence of infectious agents in vertebrate populations |
| Q38890040 | Expansion of quasispecies diversity but no evidence for adaptive evolution of SHIV during rapid serial transfers among seronegative macaques |
| Q39579134 | Extensive diversification of human immunodeficiency virus type 1 subtype B strains during dual infection of a chimpanzee that progressed to AIDS. |
| Q35274776 | Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection |
| Q78417132 | From HIV infection to AIDS: a dynamically induced percolation transition? |
| Q36502557 | Functional diversity of HIV-1 envelope proteins expressed by contemporaneous plasma viruses |
| Q91641973 | Gauging genetic diversity of generalists: A test of genetic and ecological generalism with RNA virus experimental evolution |
| Q45882561 | Gene therapy of T helper cells in HIV infection: Mathematical model of the criteria for clinical effect |
| Q40043495 | Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses. |
| Q35885977 | Genetic drift can dominate short-term human immunodeficiency virus type 1 nef quasispecies evolution in vivo |
| Q39596475 | Genetic stability of foamy viruses: long-term study in an African green monkey population |
| Q33784708 | Genetic variation in a human immunodeficiency virus type 2 live-virus Macaca nemestrina vaccine model |
| Q33732382 | HIV evolutionary genetics. |
| Q45017663 | HIV pathogenesis. Lines drawn in epitope wars |
| Q29616404 | HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy |
| Q58035276 | HIV time hierarchy: winning the war while, loosing all the battles |
| Q55066829 | HIV-1 evolution and disease progression. |
| Q91887792 | HIV-1 genetic diversity and divergence and its correlation with disease progression among antiretroviral naïve recently infected individuals |
| Q48078114 | HIV-1 infection of monocytes is directly related to the success of HAART. |
| Q40384843 | HIV-1 reverse transcriptase. A diversity generator and quasispecies regulator. |
| Q34350944 | HIV-1 subtype C envelope characteristics associated with divergent rates of chronic disease progression |
| Q39250937 | Homogenous HIV-1 subtype B quasispecies in Brazilian men and women recently infected via heterosexual transmission |
| Q33646567 | Host-specific modulation of the selective constraints driving human immunodeficiency virus type 1 env gene evolution |
| Q51396948 | How do antigenically varying pathogens avoid cross-reactive responses to invariant antigens? |
| Q37363152 | How effectively can HIV phylogenies be used to measure heritability? |
| Q35881675 | Human immunodeficiency virus drug therapy and virus load. |
| Q51704580 | Human immunodeficiency virus evolution towards reduced replicative fitness in vivo and the development of AIDS. |
| Q36636446 | Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays. |
| Q35875709 | Human immunodeficiency virus type 1 genetic evolution in children with different rates of development of disease |
| Q38909973 | Human immunodeficiency virus type-1 group M quasispecies evolution: diversity and divergence in patients co-infected with active tuberculosis |
| Q37633631 | Human immunodeficiency viruses regulated by alternative trans-activators: genetic evidence for a novel non-transcriptional function of Tat in virion infectivity. |
| Q34657787 | Immune activation promotes evolutionary conservation of T-cell epitopes in HIV-1. |
| Q36655438 | Immune escape by human immunodeficiency virus type 1 from neutralizing antibodies: evidence for multiple pathways |
| Q37316801 | In Silico Modeling in Infectious Disease |
| Q35887476 | In vivo sequence variability of human immunodeficiency virus type 1 envelope gp120: association of V2 extension with slow disease progression |
| Q40061126 | Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals. |
| Q38175788 | Inference with viral quasispecies diversity indices: clonal and NGS approaches |
| Q80966851 | Influence of CD4+ T cell counts on viral evolution in HIV-infected individuals undergoing suppressive HAART |
| Q43036202 | Influence of viral quasispecies on effectiveness of interferon therapy in chronic hepatitis C patients |
| Q58788145 | Insight into treatment of HIV infection from viral dynamics models |
| Q92812154 | Inter- Versus Intra-Host Sequence Diversity of pH1N1 and Associated Clinical Outcomes |
| Q41888126 | Interrelationship between HIV-1 fitness and mutation rate. |
| Q35680172 | Intra-host versus inter-host selection: viral strategies of immune function impairment |
| Q39872343 | Intrahost human immunodeficiency virus type 1 evolution is related to length of the immunocompetent period |
| Q45788570 | Intrapatient Variability of the Human Immunodeficiency Virus Type 2 Envelope V3 Loop |
| Q34349322 | Intrapatient diversity and its correlation with viral setpoint in human immunodeficiency virus type 1 CRF02_A/G-IbNG infection |
| Q91649517 | Local immunodeficiency: Minimal networks and stability |
| Q40045560 | Many-trillionfold amplification of single RNA virus particles fails to overcome the Muller's ratchet effect |
| Q45783276 | Maternal antibody response at delivery and perinatal transmission of human immunodeficiency virus type 1 in African women |
| Q47574091 | Mathematical Models of HIV Latency |
| Q37653075 | Mathematical modeling of escape of HIV from cytotoxic T lymphocyte responses. |
| Q89830547 | Mathematical modeling to reveal breakthrough mechanisms in the HIV Antibody Mediated Prevention (AMP) trials |
| Q52256873 | Mathematical models of HIV pathogenesis. |
| Q45751577 | Mobilization of peripheral blood progenitor cells for human immunodeficiency virus-infected individuals |
| Q44495120 | Modeling HIV dynamics and antiviral response with consideration of time-varying drug exposures, adherence and phenotypic sensitivity |
| Q38255612 | Modeling T cell responses to antigenic challenge |
| Q33958359 | Modeling and optimization of populations subject to time-dependent mutation |
| Q27015861 | Modeling antiretroviral drug responses for HIV-1 infected patients using differential equation models |
| Q92970064 | Modeling the immune response to HIV infection |
| Q26853307 | Modelling the course of an HIV infection: insights from ecology and evolution |
| Q30992754 | Modelling the evolution and spread of HIV immune escape mutants |
| Q35266077 | Molecular insights into human immunodeficiency virus type 1 pathogenesis |
| Q34798628 | Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis |
| Q44528498 | Mutants escape from killer T cells, invade population |
| Q37422879 | Mutation-selection equilibrium in games with mixed strategies |
| Q41762826 | Mutation-selection equilibrium in games with multiple strategies |
| Q34120857 | Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication |
| Q37299477 | Neurodevelopmental outcomes of children with low-grade gliomas |
| Q27469624 | Nucleotide and amino acid complexity of hepatitis C virus quasispecies in serum and liver |
| Q41970093 | Overcoming viral escape with vaccines that generate and display antigen diversity in vivo. |
| Q41157475 | Pathogenesis of chronic hepatitis C and associated clinical manifestations |
| Q36526893 | Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline |
| Q36620176 | Persistence of four related human immunodeficiency virus subtypes during the course of zidovudine therapy: relationship between virion RNA and proviral DNA. |
| Q54453243 | Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and risk of HIV/AIDS among North Indian population. |
| Q83210498 | Population dynamics of HIV pathogenesis |
| Q43034792 | Positively selected amino acid sites in the entire coding region of hepatitis C virus subtype 1b. |
| Q30844746 | Predicting disease progression from short biomarker series using expert advice algorithm |
| Q41814480 | Probabilistic inference of viral quasispecies subject to recombination |
| Q35165357 | Production of resistant HIV mutants during antiretroviral therapy |
| Q33953001 | Quantification of intrinsic residual viral replication in treated HIV-infected patients |
| Q36686530 | Quantitation of human immunodeficiency virus type 1 infection kinetics |
| Q36756215 | Quasispecies and its impact on viral hepatitis |
| Q34030011 | Quasispecies as a matter of fact: viruses and beyond. |
| Q43449921 | Rates of amino acid change in the envelope protein correlate with pathogenicity of primate lentiviruses |
| Q28076177 | Recent advances in inferring viral diversity from high-throughput sequencing data |
| Q35866513 | Recombinant human immunodeficiency virus type 1 genomes with tat unconstrained by overlapping reading frames reveal residues in Tat important for replication in tissue culture. |
| Q38353132 | Regulation of HIV-1 long terminal repeats by interaction of C/EBP(NF-IL6) and NF-kappaB/Rel transcription factors. |
| Q37273122 | Relationship of human immunodeficiency virus type 1 sequence heterogeneity to stage of disease |
| Q35873306 | Resistance of human immunodeficiency virus type 1 to neutralization by natural antisera occurs through single amino acid substitutions that cause changes in antibody binding at multiple sites |
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| Q43549520 | Richards-like two species population dynamics model |
| Q51940005 | Role of avidity and breadth of the CD4 T cell response in progression to AIDS. |
| Q40928716 | Selective mechanisms utilized by persistent and oncogenic viruses to interfere with antigen processing and presentation |
| Q59657101 | Simulating the Immune Response on a Distributed Parallel Computer |
| Q35895520 | Slower evolution of human immunodeficiency virus type 1 quasispecies during progression to AIDS |
| Q36746170 | Specific therapy regimes could lead to long-term immunological control of HIV. |
| Q36088015 | Statistical methods for HIV dynamic studies in AIDS clinical trials |
| Q43470154 | T cell therapy of human CMV and EBV infection in immunocompromised hosts |
| Q77918151 | T-cell induced pathogenesis in HIV: bystander effects and latent infection |
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| Q33632737 | The dynamics of HTLV-I and the CTL response. |
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| Q52228583 | The effect of different immune responses on the evolution of virulent CXCR4-tropic HIV. |
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| Q33378477 | The evolutionary selective advantage of HIV-1 escape variants and the contribution of escape to the HLA-associated risk of AIDS progression |
| Q38454299 | The fastest evolutionary trajectory |
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| Q37481983 | The intra-host evolutionary and population dynamics of human immunodeficiency virus type 1: a phylogenetic perspective |
| Q38021263 | The origin of genetic diversity in HIV-1. |
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| Q52053599 | The role of antigenic stimulation and cytotoxic T cell activity in regulating the long-term immunopathogenesis of HIV: mechanisms and clinical implications. |
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| Q33538298 | The role of the viral glycoprotein in HIV-1 persistence. |
| Q54263974 | Time Intervals in Sequence Sampling, Not Data Modifications, Have a Major Impact on Estimates of HIV Escape Rates. |
| Q37020255 | Transient antiretroviral therapy selecting for common HIV-1 mutations substantially accelerates the appearance of rare mutations |
| Q36337715 | Transmission bottlenecks as determinants of virulence in rapidly evolving pathogens |
| Q41336725 | Treatment of HIV infection and its complications |
| Q43040073 | Universal peptide vaccines - optimal peptide vaccine design based on viral sequence conservation |
| Q41015614 | VIRULENCE. |
| Q41644116 | Vaccine design, evaluation, and community-based use for antigenically variable infectious agents |
| Q36274670 | Variability of HIV infections |
| Q34007753 | Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis |
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| Q29547908 | Viral dynamics in human immunodeficiency virus type 1 infection |
| Q37497318 | Viral dynamics in vivo: limitations on estimates of intracellular delay and virus decay |
| Q28472641 | Viral population estimation using pyrosequencing |
| Q35984339 | Viral quasispecies complexity measures. |
| Q36244920 | Virus dynamics and drug therapy |
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