Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man

scientific article

Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man is …
instance of (P31):
scholarly articleQ13442814

External links are
P3181OpenCitations bibliographic resource ID502225
P698PubMed publication ID8175804

P2093author name stringFukuyama R
Yagi K
Minoshima S
Shimizu N
Nishikimi M
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)13685-13688
P577publication date1994-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleCloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man
P478volume269

Reverse relations

cites work (P2860)
Q336382111H NMR-based profiling reveals differential immune-metabolic networks during influenza virus infection in obese mice
Q43247800A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among related species
Q41600968A Comparative Study on the Life-Saving Radioprotective Effects of Vitamins A, E, C and Over-the-Counter Multivitamins
Q92354023A Novel Role of Ascorbic Acid in Anti-Inflammatory Pathway and ROS Generation in HEMA Treated Dental Pulp Stem Cells
Q37291150A combination of pre- and post-exposure ascorbic acid rescues mice from radiation-induced lethal gastrointestinal damage
Q24603173A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport
Q42058457A rapid and specific microplate assay for the determination of intra- and extracellular ascorbate in cultured cells.
Q52716592A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells.
Q26776115Antioxidants in Cardiovascular Therapy: Panacea or False Hope?
Q24678375Aortic wall damage in mice unable to synthesize ascorbic acid
Q34623308Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants
Q21089771Ascorbic Acid Biosynthesis and Brackish Water Acclimation in the Euryhaline Freshwater White-Rimmed Stingray, Himantura signifer
Q39940852Ascorbic Acid and gene expression: another example of regulation of gene expression by small molecules?
Q37065736Ascorbic acid alleviates pancreatic damage induced by dibutyltin dichloride (DBTC) in rats
Q33570528Ascorbic acid and the brain: rationale for the use against cognitive decline
Q37420301Ascorbic acid insufficiency induces the severe defect on bone formation via the down-regulation of osteocalcin production
Q36675775Ascorbic acid, cognitive function, and Alzheimer's disease: a current review and future direction
Q36717267Ascorbic acid: chemistry, biology and the treatment of cancer.
Q53360662Association of increased carotid intima-media thickness and lower plasma levels of vitamin C and vitamin E in old age subjects: implications for Alzheimer's disease.
Q36062841Background-free in-vivo Imaging of Vitamin C using Time-gateable Responsive Probe
Q64107459Biosynthetic Gene Pyramiding Leads to Ascorbate Accumulation with Enhanced Oxidative Stress Tolerance in Tomato
Q36291625Body pool and synthesis of ascorbic acid in adult sea lamprey (Petromyzon marinus): an agnathan fish with gulonolactone oxidase activity
Q34505511Colloquium paper: a role for relaxed selection in the evolution of the language capacity
Q21092575Comparative genomics search for losses of long-established genes on the human lineage
Q42633800Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2.
Q36958018Conservation and Expression Patterns Divergence of Ascorbic Acid d-mannose/l-galactose Pathway Genes in Brassica rapa
Q98177791Copper-Induced Activation of MAPKs, CDPKs and CaMKs Triggers Activation of Hexokinase and Inhibition of Pyruvate Kinase Leading to Increased Synthesis of ASC, GSH and NADPH in Ulva compressa
Q37124254Determination of plasma and leukocyte vitamin C concentrations in a randomized, double-blind, placebo-controlled trial with Ester-C(®).
Q30372564Dietary modulation and structure prediction of rat mucosal pentraxin (Mptx) protein and loss of function in humans
Q34263572Does vitamin C deficiency affect cognitive development and function?
Q35381766Effect of L-ascorbate on chloride transport in freshly excised sinonasal epithelia
Q30452623Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice.
Q40460494Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold kiwifruit
Q57023966Enterotoxigenic Escherichia coli (ETEC) heat labile enterotoxin inhibits intestinal ascorbic acid uptake via a cAMP-dependent NF-κB mediated pathway
Q36239095Evaluation of the Anti-Inflammatory Effect of Locally Delivered Vitamin C in the Treatment of Persistent Gingival Inflammation: Clinical and Histopathological Study.
Q34467018Evolution of alternative biosynthetic pathways for vitamin C following plastid acquisition in photosynthetic eukaryotes
Q36985230Expression, crystallization and preliminary X-ray analysis of rice L-galactose dehydrogenase
Q28534079Expression, purification and low-resolution structure of human vitamin C transporter SVCT1 (SLC23A1)
Q35602259Fundamental shift in vitamin B12 eco-physiology of a model alga demonstrated by experimental evolution
Q21134529GLADX: an automated approach to analyze the lineage-specific loss and pseudogenization of genes
Q36709041Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants
Q50977882Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1
Q28575955Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53
Q34035839Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations
Q47113158Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes.
Q21184099Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates
Q37406673In vivo consequence of vitamin C insufficiency in liver injury: vitamin C ameliorates T-cell-mediated acute liver injury in gulo(-/-) mice
Q34153771Inactivation dates of the human and guinea pig vitamin C genes
Q36881730Inflammation in the vascular bed: importance of vitamin C
Q52720174Insights on Localized and Systemic Delivery of Redox-Based Therapeutics.
Q37456047Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction
Q28258868Intragenic deletion in the gene encoding L-gulonolactone oxidase causes vitamin C deficiency in pigs
Q64900805Light-Induced Vitamin C Accumulation in Tomato Fruits is Independent of Carbohydrate Availability.
Q21558767Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates
Q50510519Manipulation of L-ascorbic acid biosynthesis pathways in Solanum lycopersicum: elevated GDP-mannose pyrophosphorylase activity enhances L-ascorbate levels in red fruit.
Q33716885Markers of oxidative stress in erythrocytes and plasma during aging in humans
Q53176759Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer.
Q83498973Metabolic profiling of vitamin C deficiency in Gulo-/- mice using proton NMR spectroscopy
Q28751910Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of placental mammals
Q37350831MouseCyc: a curated biochemical pathways database for the laboratory mouse
Q50537080Overexpression of SlGMEs leads to ascorbate accumulation with enhanced oxidative stress, cold, and salt tolerance in tomato
Q30782787Partial purification and identification of GDP-mannose 3",5"-epimerase of Arabidopsis thaliana, a key enzyme of the plant vitamin C pathway
Q35021731Plasma concentration of vitamin C in dogs with a portosystemic shunt.
Q92619526Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations
Q37193593Progress in drug delivery to the central nervous system by the prodrug approach.
Q37714266Proteome-driven elucidation of adaptive responses to combined vitamin E and C deficiency in zebrafish
Q21134973Recent loss of vitamin C biosynthesis ability in bats
Q33417923Reconstruction of metabolic pathways for the cattle genome
Q34546786Regular vitamin C supplementation during pregnancy reduces hospitalization: outcomes of a Ugandan rural cohort study
Q26992736Regulation of vitamin C homeostasis during deficiency
Q34245269Resolution of sterile inflammation: role for vitamin C
Q38551719Selected Micronutrients in Cognitive Decline Prevention and Therapy.
Q35741096Sparing effects of selenium and ascorbic acid on vitamin C and E in guinea pig tissues
Q89388409Spatial Memory Dysfunction Induced by Vitamin C Deficiency Is Associated with Changes in Monoaminergic Neurotransmitters and Aberrant Synapse Formation
Q21129209Strategies to increase vitamin C in plants: from plant defense perspective to food biofortification
Q37357911Synthetic or food-derived vitamin C - are they equally bioavailable?
Q35897591The analysis of vitamin C concentration in organs of gulo(-/-) mice upon vitamin C withdrawal
Q36161370The chordate proteome history database
Q24628117The genetics of vitamin C loss in vertebrates
Q45956174The history of vitamin C research in India.
Q21093391The human L-threonine 3-dehydrogenase gene is an expressed pseudogene
Q48194310The influence of cellular senescence on intracellular vitamin C transport, accumulation, and function.
Q24297234The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus
Q50145996The nutritional and health attributes of kiwifruit: a review.
Q36808778The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease
Q39187348The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase
Q24595726Theodore E. Woodward award. The evolution of obesity: insights from the mid-Miocene
Q41849578Transcriptomic and functional pathways analysis of ascorbate-induced cytotoxicity and resistance of Burkitt lymphoma
Q26800853Treatment of Pancreatic Cancer with Pharmacological Ascorbate
Q35867182Unconventional Neurogenic Niches and Neurogenesis Modulation by Vitamins
Q61810332Vitamin C Content in Fruits: Biosynthesis and Regulation
Q46269475Vitamin C and Immune Function
Q24633363Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel
Q35763170Vitamin C deficiency activates the purine nucleotide cycle in zebrafish
Q26771512Vitamin C in Health and Disease: Its Role in the Metabolism of Cells and Redox State in the Brain
Q37199413Vitamin C in disease prevention and cure: an overview
Q35663476Vitamin C is a kinase inhibitor: dehydroascorbic acid inhibits IkappaBalpha kinase beta
Q37053078Vitamin C is taken up by human T cells via sodium-dependent vitamin C transporter 2 (SVCT2) and exerts inhibitory effects on the activation of these cells in vitro
Q42626878Vitamin C: a novel regulator of neutrophil extracellular trap formation