Constitutive type I interferon modulates homeostatic balance through tonic signaling

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Constitutive type I interferon modulates homeostatic balance through tonic signaling is …
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scholarly articleQ13442814

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P356DOI10.1016/J.IMMUNI.2012.01.011
P8608Fatcat IDrelease_pfjo4hheknclhfqakzlpgokdgu
P3181OpenCitations bibliographic resource ID379318
P932PMC publication ID3294371
P698PubMed publication ID22365663
P5875ResearchGate publication ID221861968

P50authorDavid E. LevyQ39631582
Ricky W JohnstoneQ42384442
Daniel J GoughQ55473952
Nicole L MessinaQ56513475
P2093author name stringChristopher J P Clarke
P2860cites workImmune response in Stat2 knockout miceQ73406523
Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domainsQ73943058
IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferationQ77658417
Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7Q77758397
Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infectionQ78346749
Type I IFN contributes to NK cell homeostasis, activation, and antitumor functionQ80427857
Genetic control directed toward spontaneous IFN-alpha/IFN-beta responses and downstream IFN-gamma expression influences the pathogenesis of a murine psoriasis-like skin diseaseQ80819716
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
Functional role of type I and type II interferons in antiviral defenseQ24276429
Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genesQ24295016
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7Q24533409
Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor modelQ24612339
Induction and function of type I and III interferon in response to viral infectionQ27010065
How cells respond to interferonsQ27861006
Interferon-γ: an overview of signals, mechanisms and functionsQ28207081
The IFN gamma receptor: a paradigm for cytokine receptor signalingQ28237623
Interferon-lambdas: the modulators of antivirus, antitumor, and immune responsesQ28238963
Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosusQ28246766
Mechanisms of type-I- and type-II-interferon-mediated signallingQ28247893
Type I interferon is selectively required by dendritic cells for immune rejection of tumorsQ28248500
Treatment of hairy cell leukemia with recombinant alpha interferon: II. In vivo down-regulation of alpha interferon receptors on tumor cellsQ69988324
Endogenous IFN-alpha beta suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-alphaQ71483492
Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-beta(C/EBP-beta)Q72999285
Gene repression by coactivator repulsionQ73221732
A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosisQ28257957
Interferons, interferon-like cytokines, and their receptorsQ28293630
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient miceQ28594052
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arraysQ28646554
Stats: transcriptional control and biological impactQ29547776
Paradoxical roles of the immune system during cancer developmentQ29614305
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosomeQ29616850
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene inductionQ29620054
Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virusQ33381621
Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cellsQ33557548
Functional crosstalk between type I and II interferon through the regulated expression of STAT1.Q33570493
Structure and function of the interferon-beta enhanceosomeQ33671579
A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responsesQ33771205
Partial impairment of cytokine responses in Tyk2-deficient miceQ33924660
Functional classification of interferon-stimulated genes identified using microarraysQ33951179
Deficiency of the type I interferon receptor protects mice from experimental lupusQ34016334
Mutational switch of an IL-6 response to an interferon-gamma-like responseQ34031049
Defining emerging roles for NF-κB in antivirus responses: revisiting the interferon-β enhanceosome paradigmQ34055270
Interferon messenger RNA is produced constitutively in the organs of normal individualsQ34641073
Distinct roles for the NF-kappa B RelA subunit during antiviral innate immune responsesQ34742996
Type 1 interferon induction of natural killer cell gamma interferon production for defense during lymphocytic choriomeningitis virus infectionQ35149011
Control of T cell viabilityQ35698562
Modulation of STAT1 protein levels: a mechanism shaping CD8 T-cell responses in vivoQ35850004
IFN-beta in rheumatoid arthritisQ35880785
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infectionQ35978569
Normal human epidermis contains an interferon-like proteinQ36215434
High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.Q36228978
Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responsesQ36315128
Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells.Q36369031
Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent miceQ36497106
Biologic Effects of InterferonsQ36612328
Interferon-beta1b in multiple sclerosisQ36752915
Endogenous interferon production by endotoxin-responsive macrophages provides an autostimulatory differentiation signalQ37076337
The transcriptional code of human IFN-beta gene expressionQ37684189
Interactions between gut microbiota and host metabolism predisposing to obesity and diabetesQ37827867
Type I interferon in organ-targeted autoimmune and inflammatory diseasesQ37838003
Regulation of effector and memory T-cell functions by type I interferonQ37841676
Genomic view of IFN-alpha response in pre-autoimmune NZB/W and MRL/lpr miceQ38298730
The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50Q39587742
NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replicationQ39683125
Expression of SOCS-1, suppressor of cytokine signalling-1, in human melanomaQ40514922
Chronic myeloid leukemia cells resistant to interferon-alpha lack STAT1 expressionQ40741810
IFN-gamma priming up-regulates IFN-stimulated gene factor 3 (ISGF3) components, augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs.Q41038934
Interferon-alpha resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression.Q41071715
Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48-ISGF3gamma.Q41082105
Is interferon produced in physiologic conditions?Q41538283
Correlation between interferon (IFN) alpha resistance and deletion of the IFN alpha/beta genes in acute leukemia cell lines suggests selection against the IFN systemQ41611115
Rheumatoid arthritis induced by alpha-interferon therapyQ41918975
GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling.Q42453025
Fos and jun proteins are specifically expressed during differentiation of human keratinocytesQ42472984
Differential expression of phosphorylated NF-kappaB/RelA in normal and psoriatic epidermis and downregulation of NF-kappaB in response to treatment with etanerceptQ42479845
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responsesQ42488424
Distinct requirements for IFNs and STAT1 in NK cell functionQ42494660
Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharideQ42499800
Psoriatic lesional skin exhibits an aberrant expression pattern of interferon regulatory factor-2 (IRF-2).Q42528591
Distinct clinical courses in type 1 diabetes mellitus induced by peg-interferon-alpha treatment for chronic hepatitis C.Q43146940
Interferon-beta is required for interferon-alpha production in mouse fibroblastsQ43412872
Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signallingQ43688291
Effect of exercise on plasma interferon levelsQ44187100
IFNalpha activates dormant haematopoietic stem cells in vivo.Q44358922
Constitutive IFN-alpha/beta signal for efficient IFN-alpha/beta gene induction by virusQ45736557
Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion.Q45988825
A critical function for type I interferons in cancer immunoeditingQ46542397
IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis.Q52550265
Interferon system defects in malignant T-cells.Q52826947
Type I IFN modulates innate and specific antiviral immunity.Q52920823
Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.Q53718320
STAT3 negatively regulates type I IFN-mediated antiviral response.Q54356093
Critical role for constitutive type I interferon signaling in the prevention of cellular transformation.Q54503356
Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease.Q54664586
Type I IFN negatively regulates CD8+ T cell responses through IL-10-producing CD4+ T regulatory 1 cellsQ56881042
Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional controlQ57055074
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-βQ57675150
Sensitization of IFN-γ Jak-STAT signaling during macrophage activationQ60595376
Type I interferons produced by dendritic cells promote their phenotypic and functional activationQ61473768
The down-regulation of alpha-interferon receptors in human lymphoblastoid cells: relation to cellular responsiveness to the antiproliferative action of alpha-interferonQ68415965
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectinfectious diseaseQ18123741
P304page(s)166-74
P577publication date2012-02-24
P1433published inImmunityQ6005457
P1476titleConstitutive type I interferon modulates homeostatic balance through tonic signaling
P478volume36

Reverse relations

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